2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T65b,We examined trends in adolescent sleep across recent decades in the United States. Data were drawn from a nationally representative study, Monitoring the Future, measurement years 1991-2023, which represented cohorts of adolescents born from approximately 1972 to 2011 (n = 401 160). Outcomes were 2 self-reported survey items, one addressing sleep duration and another on subjective sleep sufficiency. Age-period-cohort models were estimated and sociodemographic differences in trends were examined. Adolescent sleep duration declined with increasing age during every period. Adolescents at every age in the last 10 years were more likely to report inadequate sleep duration compared with teens at those same ages in earlier decades. The period 2021-2023 had the lowest prevalences of getting 7 or more hours of sleep at every age (ranging from 37.2% at age 12 or 13 to 22.3% at 18 or 19). Disparities in sleep duration between non-Hispanic Black and Hispanic/Latino adolescents and their white peers, and between teens whose parents were more vs less educated, emerged and/or grew steadily over time. For instance, Black and white adolescents in 1991-1995 were equally likely to report 7 or more hours of sleep per night (odds ratio [OR] = 0.99 [0.92, 1.07]), but by 2023, Black teens were less likely to report this (OR = 0.79 [0.67, 0.93]). For decades, adolescents' sleep had been eroding. It is concerning that youth from marginalized sociodemographic groups appear to be at an even greater risk for profoundly short sleep, given that sleep is a resource that confers advantages for health and development.31:T8ac, OBJECTIVES We examined trends in adolescent sleep across recent decades in the United States. METHODS Data were drawn from a nationally representative study, Monitoring the Future, measurement years 1991–2023, which represented cohorts of adolescents born from approximately 1972 to 2011 (n = 401 160). Outcomes were 2 self-reported survey items, one addressing sleep duration and another on subjective sleep sufficiency. Age-period-cohort models were estimated and sociodemographic differences in trends were examined. RESULTS Adolescent sleep duration declined with increasing age during every period. Adolescents at every age in the last 10 years were more likely to report inadequate sleep duration compared with teens at those same ages in earlier decades. The period 2021–2023 had the lowest prevalences of getting 7 or more hours of sleep at every age (ranging from 37.2% at age 12 or 13 to 22.3% at 18 or 19). Disparities in sleep duration between non-Hispanic Black and Hispanic/Latino adolescents and their white peers, and between teens whose parents were more vs less educated, emerged and/or grew steadily over time. For instance, Black and white adolescents in 1991–1995 were equally likely to report 7 or more hours of sleep per night (odds ratio [OR] = 0.99 [0.92, 1.07]), but by 2023, Black teens were less likely to report this (OR = 0.79 [0.67, 0.93]). CONCLUSIONS For decades, adolescents’ sleep had been eroding. It is concerning that youth from marginalized sociodemographic groups appear to be at an even greater risk for profoundly short sleep, given that sleep is a resource that confers advantages for health and development. 32:T700,Emergency department presents a distinctive challenge for implementation infection prevention and control (IPC), due to their complex and dynamic environment, diverse patient population, and unknown carrier status. The objective was to assess the compliance with a number of IPC practices among a group of healthcare workers (HCWs) working in the emergency department. An observational cross-sectional study was conducted at a large emergency department at a tertiary care hospital between 2018 and 2023. Data were gathered during observation sessions using a standardized IPC observation form. Observers were either experienced IPC professionals or trained medical students. Out of 123,947 HCW-specific practices observed, 85,542 (69.0%) were compliant and out of 41,650 unit-specific practices observed, 38,355 (92.1%) were compliant. The compliance was highest in the competence of acute respiratory infection procedures (97.3%), followed by isolation precautions (97.0%), housekeeping (96.8%), disposal of sharps (96.8%), waste management (94.5%), donning and doffing of personal protective equipment (PPE, 72.9%), use of PPE (72.3%), hand hygiene (67.2%), patient sitters (64.1%), and disinfection of medical equipment (61.2%). Nurses across all units had much better compliance than other professions. There were > 10% differences in the compliance across the units, with higher compliance in mainly pediatric compared with adult units. The compliance was highest during the COVID-19 pandemic years. There is considerable variability in implementation of IPC at the emergency department, by practice, profession, unit, and pandemic time. The findings underscore the importance of strategies to improve disinfection of medical equipment, hand hygiene, and adherence of patient sitters.33:T4ef,Emerging evidence suggests that social skills difficulties in children with ADHD are not due to difficulty learning/acquiring age-expected social skills, but instead to difficulty performing known social skills in the moment. The current study reflects the largest investigation to date to disentangle social knowledge vs. performance difficulties in children with and without ADHD, while also probing the extent to which children with ADHD exhibit strengths in specific social domains. A clinically evaluated and carefully phenotyped sample of children ages 8-13 with and without ADHD ( Acquisition difficulties were rare and idiosyncratic for both groups; parents and teachers perceived fewer than 15% of children with ADHD as missing any specific social skill. In contrast, performance difficulties were predominant in the ADHD group and occurred at significantly higher rates across informants relative to the non-ADHD group in the domains of communication, cooperation, empathy, responsibility, and self-control (all These findings are consistent with updated conceptualizations suggesting social skills difficulties in children with ADHD are not primarily due to a lack of social knowledge but rather from the inconsistent execution of known social skills.34:T7ac,Attention deficit hyperactivity disorder (ADHD) is characterized by abnormal functions of neuroendocrine systems with circadian rhythm, especially for the hypothalamic-pituitary-adrenal (HPA) axis and the melatonin-N-acetylserotonin (MEL-NAS) system and the interactions within and between them. However, the specific neuroendocrine mechanisms underlying ADHD remain poorly understood. This might be partly due to the clinical heterogeneity of the disorder and the inherent fluctuations of traditional acute biomarkers from biofluids, which fail to reflect long-term physiological homeostasis. This study utilized a cross-sectional design and recruited 106 Chinese children with ADHD (age: 6-12 years) diagnosed by physicians according to DSM-IV criteria. Cortisol (F), cortisone (E), melatonin (MEL), and N-acetylserotonin (NAS) in hair and their ratios were employed as the biomarkers of the two systems and the interactions within and between them. The ADHD symptoms were assessed with the SNAP-IV scale that includes inattention, hyperactivity/impulsivity, and oppositional symptoms and filled by children's parents. The 1-cm hair strands closest to the scalp were collected for the analysis of the four hormones with liquid chromatography-tandem mass spectrometry. Oppositional symptoms showed significantly positive association with the MEL/NAS ratio (p < 0.05). After demographic variables and oppositional symptoms were controlled, hyperactivity/impulsivity showed significantly positive association with the F/NAS and E/NAS ratios (ps < 0.05), but it was not observed for inattention. The clinical heterogeneity of ADHD core symptoms is underpinned by distinct neuroendocrine network imbalances. There was the function dominance of stress-related signaling over the NAS-mediated neuroprotection underlying the hyperactivity/impulsivity. Additionally, there was a disturbance in circadian metabolic homeostasis underlying the oppositional symptoms.35:T488,Adaptive behavior relies on the ability to translate abstract rules and goals into actions suited to the current context. Neural population activity in the prefrontal cortex (PFC) has been proposed to support such flexible computations through high-dimensional dynamics, whereas activity in the primary motor cortex (M1) is related more directly to movement execution. How contextual representations in PFC are transformed into ensuing action plans within M1 remains unknown. Previous work suggests that low-dimensional coding subspaces might organize interareal communication, but direct evidence for such population-level communication mechanisms in humans is lacking. Here we use intracranial recordings from human PFC and M1 to identify a communication subspace embedded within high-dimensional PFC activity, that selectively relays behaviorally relevant information at the single-trial level. Activity in this subspace predicts context-dependent action more strongly than either region, revealing a fundamental coding principle by which coordinated interareal population dynamics filter and relay predictive information to guide context-dependent actions.36:T7af,Social media is a common source of health information for children and young adults, yet little is known about how young patients with alopecia engage with hair loss-related content online. Direct-to-consumer (DTC) treatments are also widely marketed for alopecia, but data on their use and perceived effectiveness in pediatric populations remain limited. This study aimed to characterize social media use among patients with alopecia and examine patterns of DTC treatment use. We conducted a cross-sectional survey of patients aged ≤ 25 years with physician-diagnosed alopecia at Boston Children's Hospital dermatology clinics between November 2024 and September 2025. Surveys collected demographics, social media engagement, and use and perceived effectiveness of DTC treatments. Of 115 respondents, 65% reported social media use, with higher use reported in older age groups (90% ≥ 18 years, 72% 12-17 years, 34% < 12 years; p < 0.001). Among users, 59% encountered hair loss-related content, most often on TikTok, Instagram, and YouTube. Many reported uncertainty regarding the qualifications of content creators, and nearly one-quarter rarely or never questioned the accuracy of information presented. Among respondents exposed to hair loss-related content, 28% reported trying a treatment seen online. These treatments were associated with low satisfaction, variable costs ($0-$500+), and side effects including dryness, itching, and increased shedding. Across all respondents, 60% reported ever using at least one DTC treatment, though only 30% were current users. Perceived effectiveness was inconsistent. Social media exposure and marketing of DTC products appear to shape how youth approach alopecia management, although reported experiences were variable and often unsatisfactory. Dermatologists should inquire about online content exposure and DTC product use in clinical care while guiding families toward evidence-based management.37:Tabc,ABSTRACT Background Social media is a common source of health information for children and young adults, yet little is known about how young patients with alopecia engage with hair loss‐related content online. Direct‐to‐consumer (DTC) treatments are also widely marketed for alopecia, but data on their use and perceived effectiveness in pediatric populations remain limited. This study aimed to characterize social media use among patients with alopecia and examine patterns of DTC treatment use. Methods We conducted a cross‐sectional survey of patients aged ≤ 25 years with physician‐diagnosed alopecia at Boston Children's Hospital dermatology clinics between November 2024 and September 2025. Surveys collected demographics, social media engagement, and use and perceived effectiveness of DTC treatments. Results Of 115 respondents, 65% reported social media use, with higher use reported in older age groups (90% ≥ 18 years, 72% 12–17 years, 34% < 12 years; p < 0.001). Among users, 59% encountered hair loss‐related content, most often on TikTok, Instagram, and YouTube. Many reported uncertainty regarding the qualifications of content creators, and nearly one‐quarter rarely or never questioned the accuracy of information presented. Among respondents exposed to hair loss‐related content, 28% reported trying a treatment seen online. These treatments were associated with low satisfaction, variable costs ($0–$500+), and side effects including dryness, itching, and increased shedding. Across all respondents, 60% reported ever using at least one DTC treatment, though only 30% were current users. Perceived effectiveness was inconsistent. Conclusions Social media exposure and marketing of DTC products appear to shape how youth approach alopecia management, although reported experiences were variable and often unsatisfactory. Dermatologists should inquire about online content exposure and DTC product use in clinical care while guiding families toward evidence‐based management. 38:T408,Among 52,287 rural patients with breast cancer analyzed, 7,111 (13.6%) were diagnosed at advanced stages. Non-Hispanic Black patients had a significantly higher risk of later-stage diagnosis compared with non-Hispanic White patients (stage 2: odds ratio [OR] 1.4 [95% CI 1.26 to 1.55]; stage 3: OR 1.58 [95% CI 1.38 to 1.82]; and stage 4: OR 1.29 [95% CI 1.07 to 1.54]). Hispanic patients had increased risk of stage 3 breast cancer compared with non-Hispanic patients (OR 1.5, [95% CI 1.03 to 2.20]). Uninsured patients had a progressively higher risk of advanced-stage diagnosis than insured patients (stage 2: OR 1.37 [95% CI 1.12 to 1.68]; stage 3: OR 2.06 [95% CI 1.61 to 2.64]; stage 4: OR 3.88 [95% CI 2.94 to 5.11]). Significant geographic differences were observed, with patients in the East South Central (OR 1.28 [95% CI 1.07 to 1.52]) and West South Central (OR 1.33 [95% CI 1.03 to 1.70]) regions having a significantly higher likelihood of stage 4 breast cancer compared with patients in the West North Central region.39:T6a5,Disparities in breast cancer outcomes are prevalent in rural areas, exacerbated by barriers in access to care. We sought to identify factors associated with advanced-stage breast cancer presentation in the National Cancer Database. Patients with breast cancer residing in rural areas were selected from the National Cancer Database between 2004 and 2021. We used multinomial logistic regression to evaluate clinicopathologic factors associated with stage at diagnosis. Among 52,287 rural patients with breast cancer analyzed, 7,111 (13.6%) were diagnosed at advanced stages. Non-Hispanic Black patients had a significantly higher risk of later-stage diagnosis compared with non-Hispanic White patients (stage 2: odds ratio [OR] 1.4 [95% CI 1.26 to 1.55]; stage 3: OR 1.58 [95% CI 1.38 to 1.82]; and stage 4: OR 1.29 [95% CI 1.07 to 1.54]). Hispanic patients had increased risk of stage 3 breast cancer compared with non-Hispanic patients (OR 1.5, [95% CI 1.03 to 2.20]). Uninsured patients had a progressively higher risk of advanced-stage diagnosis than insured patients (stage 2: OR 1.37 [95% CI 1.12 to 1.68]; stage 3: OR 2.06 [95% CI 1.61 to 2.64]; stage 4: OR 3.88 [95% CI 2.94 to 5.11]). Significant geographic differences were observed, with patients in the East South Central (OR 1.28 [95% CI 1.07 to 1.52]) and West South Central (OR 1.33 [95% CI 1.03 to 1.70]) regions having a significantly higher likelihood of stage 4 breast cancer compared with patients in the West North Central region. Significant geographical differences exist in the diagnosis of late-stage breast cancer in rural populations, which are further exacerbated by demographic factors including race and insurance status.3a:T8f7, BACKGROUND: Disparities in breast cancer outcomes are prevalent in rural areas, exacerbated by barriers in access to care. We sought to identify factors associated with advanced-stage breast cancer presentation in the National Cancer Database. STUDY DESIGN: Patients with breast cancer residing in rural areas were selected from the National Cancer Database between 2004 and 2021. We used multinomial logistic regression to evaluate clinicopathologic factors associated with stage at diagnosis. RESULTS: Among 52,287 rural patients with breast cancer analyzed, 7,111 (13.6%) were diagnosed at advanced stages. Non-Hispanic Black patients had a significantly higher risk of later-stage diagnosis compared with non-Hispanic White patients (stage 2: odds ratio [OR] 1.4 [95% CI 1.26 to 1.55]; stage 3: OR 1.58 [95% CI 1.38 to 1.82]; and stage 4: OR 1.29 [95% CI 1.07 to 1.54]). Hispanic patients had increased risk of stage 3 breast cancer compared with non-Hispanic patients (OR 1.5, [95% CI 1.03 to 2.20]). Uninsured patients had a progressively higher risk of advanced-stage diagnosis than insured patients (stage 2: OR 1.37 [95% CI 1.12 to 1.68]; stage 3: OR 2.06 [95% CI 1.61 to 2.64]; stage 4: OR 3.88 [95% CI 2.94 to 5.11]). Significant geographic differences were observed, with patients in the East South Central (OR 1.28 [95% CI 1.07 to 1.52]) and West South Central (OR 1.33 [95% CI 1.03 to 1.70]) regions having a significantly higher likelihood of stage 4 breast cancer compared with patients in the West North Central region. CONCLUSIONS: Significant geographical differences exist in the diagnosis of late-stage breast cancer in rural populations, which are further exacerbated by demographic factors including race and insurance status. 3b:T68a,Chimeric antigen receptor T-cells (CAR T) are a major treatment advance for many patients with haematological malignancies, especially those with disease that has relapsed or is refractory to chemotherapy. However, currently approved commercial CAR T-cells require highly specialised manufacturing processes that contribute to high costs and limit their widespread use. In many countries, positive reimbursement recommendations by health technology assessment (HTA) bodies enable patient access to CAR T therapies. We performed a cross-sectional analysis of HTA evaluations of commercial CAR T therapies among G20 member countries plus three G20 invitees (Spain, Singapore, Switzerland) through 1 August 2025. Across the 18 CAR T-cell product-indication pairs with current FDA approval, we analysed HTA review documentation to ascertain the timing and rationale for a positive or negative recommendation. Fourteen countries with public HTA data were included in our analysis. Forty-eight percent of CAR T-indication pairs (122/252) are currently recommended for reimbursement by public health systems. The median time from FDA approval to HTA decision was 1·54 years (interquartile range 1·15-2·59 years). Common barriers to CAR T cost-effectiveness cited in HTA reports included single-arm trial designs, small study populations, and immature data regarding survival, safety, and quality of life. Our findings demonstrate substantial global disparities in access to CAR T treatments even among high- and upper middle-income countries, highlighting the urgent need for both scientific and policy approaches to reduce costs and improve access to these impactful therapies.3c:T69b,Chimeric antigen receptor T-cells (CAR T) are a major treatment advance for many patients with haematological malignancies, especially those with disease that has relapsed or is refractory to chemotherapy. However, currently approved commercial CAR T-cells require highly specialised manufacturing processes that contribute to high costs and limit their widespread use. In many countries, positive reimbursement recommendations by health technology assessment (HTA) bodies enable patient access to CAR T therapies. We performed a cross-sectional analysis of HTA evaluations of commercial CAR T therapies among G20 member countries plus three G20 invitees (Spain, Singapore, Switzerland) through 1 August 2025. Across the 18 CAR T-cell product-indication pairs with current FDA approval, we analysed HTA review documentation to ascertain the timing and rationale for a positive or negative recommendation. Fourteen countries with public HTA data were included in our analysis. Forty-eight percent of CAR T-indication pairs (122/252) are currently recommended for reimbursement by public health systems. The median time from FDA approval to HTA decision was 1·54 years (interquartile range 1·15-2·59 years). Common barriers to CAR T cost-effectiveness cited in HTA reports included single-arm trial designs, small study populations, and immature data regarding survival, safety, and quality of life. Our findings demonstrate substantial global disparities in access to CAR T treatments even among high- and upper middle-income countries, highlighting the urgent need for both scientific and policy approaches to reduce costs and improve access to these impactful therapies.3d:T4c6,The mechanisms driving immune dysregulation in long COVID disease remain elusive. Here we integrated single-cell multiome data, immunological profiling and functional assays to investigate immune alterations across multiple cohorts. A transcriptional state in circulating monocytes (LC-Mo) was enriched in individuals with mild-moderate acute infection and accompanied by persistent elevations of plasma CCL2, CXCL11 and TNF. LC-Mo showed TGFβ and WNT-β-catenin signaling and correlated with fatigue severity. Protein markers of LC-Mo were increased in individuals with pronounced fatigue or dyspnea, and those with severe respiratory symptoms showed higher LC-Mo expression. Epigenetically, LC-Mo exhibited AP-1- and NF-κB1-driven profibrotic programs. LC-Mo-like macrophages in bronchoalveolar lavage samples from individuals with severe respiratory symptoms displayed a profibrotic profile, and individuals with a high LC-Mo transcriptional state showed impaired interferon responses after stimulation. Collectively, our findings define a pathogenic monocyte transcriptional state linking systemic immune dysfunction to persistent long COVID disease, providing mechanistic insights and potential therapeutic targets.3e:T50f,Abstract The mechanisms driving immune dysregulation in long COVID disease remain elusive. Here we integrated single-cell multiome data, immunological profiling and functional assays to investigate immune alterations across multiple cohorts. A transcriptional state in circulating monocytes (LC-Mo) was enriched in individuals with mild–moderate acute infection and accompanied by persistent elevations of plasma CCL2, CXCL11 and TNF. LC-Mo showed TGFβ and WNT–β-catenin signaling and correlated with fatigue severity. Protein markers of LC-Mo were increased in individuals with pronounced fatigue or dyspnea, and those with severe respiratory symptoms showed higher LC-Mo expression. Epigenetically, LC-Mo exhibited AP-1- and NF-κB1-driven profibrotic programs. LC-Mo-like macrophages in bronchoalveolar lavage samples from individuals with severe respiratory symptoms displayed a profibrotic profile, and individuals with a high LC-Mo transcriptional state showed impaired interferon responses after stimulation. Collectively, our findings define a pathogenic monocyte transcriptional state linking systemic immune dysfunction to persistent long COVID disease, providing mechanistic insights and potential therapeutic targets.3f:T48a,While it is well established that the cellular composition of white adipose tissue (WAT) varies between depots, the functional relevance of this heterogeneity remains unclear. By combining spatial and single-nucleus RNA sequencing, we provide a comprehensive map of subcutaneous and visceral (omental, mesenteric, mesocolic, and epiploic) WAT in both men and women. Our analyses reveal shared features, such as the spatial organization of adipogenesis, alongside depot-specific characteristics, including distinct cell-type enrichments and unique cell-cell communication routes. Epiploic WAT stands out by harboring high proportions of serum amyloid A expressing fat cells (encoded by SAA1/SAA2) and several leukocyte populations. Through mechanistic studies, we demonstrate that adipocyte SAA1/SAA2 expression is induced by inflammatory signals, including lipopolysaccharide, and that SAA1 activates immune responses in adipose-resident myeloid cells. Collectively, our findings suggest that visceral WAT exhibits distinct cytoarchitectural properties, with those located near the colon adapting by developing specialized adipocytes and immune cell populations.40:T6f4,Loss of skeletal muscle mass in chronic kidney disease is strongly associated with reduced physical function and increased mortality. Although well recognized, the impact of volume overload, on physical function and muscle strength, remains understudied. This study aimed to assess the association between volume overload, physical function, and muscle strength in individuals on hemodialysis. Fifty-two individuals on hemodialysis were included. Muscle strength was assessed using hand dynamometry, defining dynapenia as muscle strength < 20 kg in women and < 30 kg in men. Physical function was measured using the short physical performance battery, with "low physical function" defined as a score ≤ 8.0. Bioelectrical impedance vector analysis z-score graph was plotted according to physical function and muscle strength classification as normal or reduced. Resistance and reactance data, normalized to height, were converted into z-scores and plotted on a z-score graph. The comparison of bioelectrical impedance vector analysis between groups was performed using Hotelling's T Bioelectrical impedance vector analysis z-score graphs showed that individuals with reduced physical function were outside the 95th percentile of the major axis, indicating volume overload, while those with normal physical function had adequate hydration status (p < 0.0001). In Model 1 of the multivariate logistic regression, volume overload was associated with low physical function. In Model 2, none of the independent variables were associated with muscle strength. Individuals on hemodialysis with reduced physical function exhibited higher volume overload. Although volume overload is associated with worse physical function, no association was observed with muscle strength.41:Tc5b,ABSTRACT Introduction Loss of skeletal muscle mass in chronic kidney disease is strongly associated with reduced physical function and increased mortality. Although well recognized, the impact of volume overload, on physical function and muscle strength, remains understudied. This study aimed to assess the association between volume overload, physical function, and muscle strength in individuals on hemodialysis. Methods Fifty‐two individuals on hemodialysis were included. Muscle strength was assessed using hand dynamometry, defining dynapenia as muscle strength < 20 kg in women and < 30 kg in men. Physical function was measured using the short physical performance battery, with “low physical function” defined as a score ≤ 8.0. Bioelectrical impedance vector analysis z ‐score graph was plotted according to physical function and muscle strength classification as normal or reduced. Resistance and reactance data, normalized to height, were converted into z ‐scores and plotted on a z ‐score graph. The comparison of bioelectrical impedance vector analysis between groups was performed using Hotelling's T 2 test. In addition, multivariate logistic regression was used to explore the association between volume overload with muscle strength and physical function. Findings Bioelectrical impedance vector analysis z ‐score graphs showed that individuals with reduced physical function were outside the 95th percentile of the major axis, indicating volume overload, while those with normal physical function had adequate hydration status ( p < 0.0001). In Model 1 of the multivariate logistic regression, volume overload was associated with low physical function. In Model 2, none of the independent variables were associated with muscle strength. Discussion Individuals on hemodialysis with reduced physical function exhibited higher volume overload. Although volume overload is associated with worse physical function, no association was observed with muscle strength. 42:T6d3,Single maintenance and reliever therapy (SMART) uses a single inhaler for daily maintenance and as-needed relief. Despite evidence that SMART is more effective in reducing exacerbations than traditional therapy, it is not widely implemented. Successful SMART implementation requires participation from school health staff (SHS), who are a critical part of pediatric asthma management. Using a descriptive convergent mixed methods design and grounded in the Consolidated Framework for Implementation Research, we conducted surveys and semi-structured interviews with SHS to explore their perspectives on SMART implementation in schools. We calculated descriptive statistics for survey items and used rapid qualitative analysis to synthesize interview data. A total of 11 SHS completed an interview and 22 completed a survey. Nearly all participants were familiar with SMART and 45% reported experience administering SMART. Most participants (59%) believed that SMART would be simpler for their students. In interviews, many participants highlighted that having one inhaler would also be simpler for them to manage. To support SMART implementation, communication with prescribing providers was highlighted as a primary need; 64% wanted a brief phone call with a provider, 59% wanted an email, and 82% wanted to receive a SMART-specific Asthma Action Plan. School health staff reported familiarity with SMART and confidence in their ability to administer it. Multilevel needs include clear communication from pediatric providers when children initiate SMART and availability of SMART inhalers. Future research should explore development and implementation of strategies to address these needs while integrating perspectives of providers and families.43:T957,ABSTRACT Introduction Single maintenance and reliever therapy (SMART) uses a single inhaler for daily maintenance and as‐needed relief. Despite evidence that SMART is more effective in reducing exacerbations than traditional therapy, it is not widely implemented. Successful SMART implementation requires participation from school health staff (SHS), who are a critical part of pediatric asthma management. Methods Using a descriptive convergent mixed methods design and grounded in the Consolidated Framework for Implementation Research, we conducted surveys and semi‐structured interviews with SHS to explore their perspectives on SMART implementation in schools. We calculated descriptive statistics for survey items and used rapid qualitative analysis to synthesize interview data. Results A total of 11 SHS completed an interview and 22 completed a survey. Nearly all participants were familiar with SMART and 45% reported experience administering SMART. Most participants (59%) believed that SMART would be simpler for their students. In interviews, many participants highlighted that having one inhaler would also be simpler for them to manage. To support SMART implementation, communication with prescribing providers was highlighted as a primary need; 64% wanted a brief phone call with a provider, 59% wanted an email, and 82% wanted to receive a SMART‐specific Asthma Action Plan. Discussion School health staff reported familiarity with SMART and confidence in their ability to administer it. Multilevel needs include clear communication from pediatric providers when children initiate SMART and availability of SMART inhalers. Future research should explore development and implementation of strategies to address these needs while integrating perspectives of providers and families. 44:T687,Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths in the United States and compiles the most recent data on population-based cancer occurrence and outcomes using data collected by central cancer registries (incidence, through 2022) and the National Center for Health Statistics (mortality, through 2023). In 2026, approximately 2,114,850 new cancer cases and 626,140 cancer deaths are projected to occur in the United States. The cancer mortality rate continued to decline through 2023, averting 4.8 million deaths since 1991, largely because of smoking reductions, earlier detection, and improved treatment. These interventions are also evident in rising 5-year relative survival, which reached a milestone 70% for diagnoses during 2015-2021 overall, 69% for regional-stage disease, and 35% for distant-stage (metastatic) disease, up from 63%, 54%, and 17%, respectively, in the mid-1990s. People with high-mortality cancers and advanced diagnoses had the largest gains, including increases from 32% to 62% for myeloma, 7% to 22% for liver cancer, 16% to 35% for metastatic melanoma, 8% to 18% for metastatic rectal cancer, 20% to 37% for regional lung cancer, and 2% to 10% for metastatic lung cancer. Nevertheless, lung cancer will cause more deaths in 2026 than second-ranking colorectal cancer and third-ranking pancreatic cancer combined. In summary, decades of scientific investment have translated to longer lives for people with even the most fatal cancers. However, continued progress is threatened by proposed federal cuts to cancer research and health insurance, which provides access to life-saving cancer treatment.45:T6e0,ABSTRACT Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths in the United States and compiles the most recent data on population‐based cancer occurrence and outcomes using data collected by central cancer registries (incidence, through 2022) and the National Center for Health Statistics (mortality, through 2023). In 2026, approximately 2,114,850 new cancer cases and 626,140 cancer deaths are projected to occur in the United States. The cancer mortality rate continued to decline through 2023, averting 4.8 million deaths since 1991, largely because of smoking reductions, earlier detection, and improved treatment. These interventions are also evident in rising 5‐year relative survival, which reached a milestone 70% for diagnoses during 2015–2021 overall, 69% for regional‐stage disease, and 35% for distant‐stage (metastatic) disease, up from 63%, 54%, and 17%, respectively, in the mid‐1990s. People with high‐mortality cancers and advanced diagnoses had the largest gains, including increases from 32% to 62% for myeloma, 7% to 22% for liver cancer, 16% to 35% for metastatic melanoma, 8% to 18% for metastatic rectal cancer, 20% to 37% for regional lung cancer, and 2% to 10% for metastatic lung cancer. Nevertheless, lung cancer will cause more deaths in 2026 than second‐ranking colorectal cancer and third‐ranking pancreatic cancer combined. In summary, decades of scientific investment have translated to longer lives for people with even the most fatal cancers. However, continued progress is threatened by proposed federal cuts to cancer research and health insurance, which provides access to life‐saving cancer treatment.46:T606,Post-COVID condition (PCCo) affects 5-10% of individuals following SARS-CoV-2 infection, with cognitive disturbances being a major feature. Central hypotheses regarding its pathophysiology include disturbed cell energy metabolism and oxidative stress pointing to mitochondrial dysfunction. However, brain energy metabolism remains unexplored. We investigated cerebral high-energy phosphate metabolism in 27 PCCo patients and 23 fully recovered controls using whole-brain PCCo patients showed a significant cluster of reduced ATP/PCr ratios centered on the cingulate cortex. Regional analysis revealed consistent reductions across anterior (ACC), mid- (MCC), and posterior (PCC) cingulate cortices. Lower ATP/PCr ratios in the ACC specifically correlated with poorer cognitive performance. Exploratory analyses revealed a trend toward higher intracellular pH in the MCC with significant negative correlation between pH and ATP/PCr observed only in patients, suggesting disease-specific alterations in pH regulation and bioenergetic homeostasis. Subgroup analysis showed similar metabolic alterations in PCCo patients meeting ME/CFS criteria. Our study provides first in vivo evidence of impaired brain energy metabolism in PCCo, with anterior cingulate dysfunction directly linked to cognitive impairment. The observed pH-ATP/PCr relationship suggests broader disruption of cellular bioenergetic regulation. These findings support mitochondrial dysfunction as a key pathophysiological mechanism and may inform targeted therapeutic strategies.47:T639,Men's use of internet pornography has been widely studied; however, the frequency with which men use different genres of pornography, and the individual differences associated with the use of different genres of pornography, has received less attention. The aim of the present research was to determine whether men's sociosexual orientation and personality traits were associated with use of different genres of internet pornography. Across three studies, men were asked to self-report the frequency with which they have used each genre of pornography (Study 1; n = 126), presented with video thumbnails representing the various genres of pornography and asked to self-report their interest in using each genre (Study 2; n = 166), and given brief descriptions for each genre and asked to report their interest in using each genre (Study 3; n = 169). These associations were examined using men's self-reported sociosexual orientation, personality traits, and use of four broad genres of pornography. Results indicated that aspects of men's sociosexual orientation and personality were correlated with men's use of various genres of pornography. Regression analyses revealed that aspects of men's sociosexual orientation and personality were uniquely predictive of their use of group sex pornography (which depicts cues to high levels of sperm competition), as well as female-specific and paraphilic pornography. Discussion considers the potential evolutionary psychological implications of these findings, as well as limitations and directions for future studies of pornography use.48:T5c2,Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have gained rapid popularity for both medical and consumer-directed weight loss. This growth has been accompanied by increased public discussion regarding facial aesthetic changes, commonly referred to as "Ozempic face," characterized by volume depletion and cutaneous laxity. To quantify temporal patterns of public search interest in a widely known GLP-1 RA and evaluate corresponding awareness of its cosmetic facial sequelae using infodemiologic methods. Google Trends data for "Ozempic" and related frequently co-searched queries were analyzed from November 2021 to December 2024. Trends in relative search volume (RSV) were examined, with particular focus on terms associated with facial aesthetics, including "Ozempic face" and "plastic surgeons Ozempic face." RSV for "Ozempic" showed a steady upward trajectory over the study period. Queries related to facial aesthetic consequences exhibited substantial proportional increases. Notably, "Ozempic face" demonstrated a 4600% rise in RSV, and searches for "plastic surgeons Ozempic face" similarly grew markedly. Public interest in GLP-1 RAs is strongly associated with rising awareness and concern about their facial aesthetic effects. These trends suggest that aesthetic practitioners should expect more patient inquiries regarding GLP-1-related facial changes and should proactively integrate counseling and corrective treatment options into clinical practice.49:T904,ABSTRACT Background Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have gained rapid popularity for both medical and consumer‐directed weight loss. This growth has been accompanied by increased public discussion regarding facial aesthetic changes, commonly referred to as “Ozempic face,” characterized by volume depletion and cutaneous laxity. Objective To quantify temporal patterns of public search interest in a widely known GLP‐1 RA and evaluate corresponding awareness of its cosmetic facial sequelae using infodemiologic methods. Methods Google Trends data for “Ozempic” and related frequently co‐searched queries were analyzed from November 2021 to December 2024. Trends in relative search volume (RSV) were examined, with particular focus on terms associated with facial aesthetics, including “Ozempic face” and “plastic surgeons Ozempic face.” Results RSV for “Ozempic” showed a steady upward trajectory over the study period. Queries related to facial aesthetic consequences exhibited substantial proportional increases. Notably, “Ozempic face” demonstrated a 4600% rise in RSV, and searches for “plastic surgeons Ozempic face” similarly grew markedly. Conclusions Public interest in GLP‐1 RAs is strongly associated with rising awareness and concern about their facial aesthetic effects. These trends suggest that aesthetic practitioners should expect more patient inquiries regarding GLP‐1–related facial changes and should proactively integrate counseling and corrective treatment options into clinical practice. 4a:T791,Individuals with colorectal polyposis are suspected to be genetically predisposed to tumor development. However, in around half of adenomatous and the vast majority of serrated polyposis patients, no explanatory pathogenic germline variant is found in routine diagnostics. Here, we aimed to improve the characterization of the early steps of polyp formation and provide clues on the tumorigenic processes involved. We performed whole-exome sequencing of colorectal tumors (n = 299) from 153 individuals with adenomatous or serrated polyposis and 16 individuals with early-onset colorectal cancer in the absence of known pathogenic germline variants. Subsequently, somatic mutations were called and a driver gene analysis for pathogenicity was performed. In addition, CpG island methylator phenotypes, tumor mutational burden, microsatellite instability, and mutational signatures were analyzed and compared with publicly available datasets of molecularly profiled colorectal cancers and polyps. Somatic mutations in APC/CTNNB1 and BRAF were significantly more frequent in adenomatous and serrated polyps, respectively. APC mosaicism was identified in 19% of individuals with adenomatous polyposis. In 9% of serrated polyps, a CpG island methylator phenotypes high methylation status was detected. Almost all polyps presented with a low tumor mutational burden and the majority were microsatellite stable. In APC/CTNNB1- and BRAF-mutated polyps, we identified a significantly lower contribution of the clock-like signature SBS1 and a significantly higher contribution of the normal colon tissue signature SBS89, respectively, compared with sporadic colorectal tumors. Our results indicate that BRAF-mutated serrated polyps are molecularly more similar to normal colon tissue than APC- and/or CTNNB1-mutated tumors. Overall, molecular tumor profiling of individuals with polyposis contributes to understanding the genetic disease etiology.25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Cross-Sectional: study design Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Cross-Sectional (study design). Clinician-written summaries and actionable practice insights. Updated daily.\",\"url\":\"https://www.reachrx.ai/hub/tag/study_design/Cross-Sectional\",\"breadcrumb\":{\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https://www.reachrx.ai\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research Hub\",\"item\":\"https://www.reachrx.ai/hub\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Study Designs\",\"item\":\"https://www.reachrx.ai/hub/tag/study_design\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Cross-Sectional\",\"item\":\"https://www.reachrx.ai/hub/tag/study_design/Cross-Sectional\"}]}}"}}]],["$","$L2f",null,{"title":"Cross-Sectional: Research & Clinical Takeaways","description":"Browse Cross-Sectional research papers with clear, practical takeaways for your clinical practice.","papers":[{"doi":"10.1542/peds.2025-074933","pmid":"42114842","title":"Sleep Duration Among US Adolescents, 1991–2023","journal_title":"Pediatrics","journal_issn":"0031-4005","published_at":"2026-05-12T00:00:00.000Z","url":"https://doi.org/10.1542/peds.2025-074933","source_score":18,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2026-05-12","doi":"10.1542/peds.2025-074933","days":"7","issn":"0031-4005","rank":"8","field":"Clinical Medicine","score":"18","category":"Pediatrics","categories":["Pediatrics"],"_categories":["Pediatrics"]},"pubmed":{"doi":"10.1542/peds.2025-074933","title":"Sleep Duration Among US Adolescents, 1991-2023.","journal":"Pediatrics","methods":"","results":"Adolescent sleep duration declined with increasing age during every period. Adolescents at every age in the last 10 years were more likely to report inadequate sleep duration compared with teens at those same ages in earlier decades. The period 2021-2023 had the lowest prevalences of getting 7 or more hours of sleep at every age (ranging from 37.2% at age 12 or 13 to 22.3% at 18 or 19). Disparities in sleep duration between non-Hispanic Black and Hispanic/Latino adolescents and their white peers, and between teens whose parents were more vs less educated, emerged and/or grew steadily over time. For instance, Black and white adolescents in 1991-1995 were equally likely to report 7 or more hours of sleep per night (odds ratio [OR] = 0.99 [0.92, 1.07]), but by 2023, Black teens were less likely to report this (OR = 0.79 [0.67, 0.93]).","abstract":"$30","keywords":[],"pubmed_id":"42114842","conclusions":"","publication_date":"2026-05-12T00:00:00"},"crossref":{"DOI":"10.1542/peds.2025-074933","URL":"https://doi.org/10.1542/peds.2025-074933","ISSN":["0031-4005","1098-4275"],"link":[{"URL":"https://publications.aap.org/pediatrics/article-pdf/doi/10.1542/peds.2025-074933/1932085/pediatrics.2025074933.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https://publications.aap.org/pediatrics/article-pdf/doi/10.1542/peds.2025-074933/1932085/pediatrics.2025074933.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Sleep Duration Among US Adolescents, 1991–2023"],"author":[{"given":"Rachel","family":"Widome","sequence":"first","affiliation":[{"name":"1Division of Epidemiology & Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota"}]},{"given":"Noah T.","family":"Kreski","sequence":"additional","affiliation":[{"name":"2Department of Epidemiology, Columbia University Mailman School of Public Health, New York, New York"}]},{"given":"Julie","family":"Maslowsky","sequence":"additional","affiliation":[{"name":"3Department of Health Behavior and Clinical Sciences, University of Michigan School of Nursing, Ann Arbor, Michigan"},{"name":"4Department of Health Behavior & Health Equity, University of Michigan School of Public Health, Ann Arbor, Michigan"},{"name":"5Institute for Social Research, University of Michigan, Ann Arbor, Michigan"}]},{"given":"Megan E.","family":"Patrick","sequence":"additional","affiliation":[{"name":"5Institute for Social Research, University of Michigan, Ann Arbor, Michigan"}]},{"given":"Katherine M.","family":"Keyes","sequence":"additional","affiliation":[{"name":"2Department of Epidemiology, Columbia University Mailman School of Public Health, New York, New York"}]}],"issued":{"date-parts":[[2026,5,12]]},"member":"417","prefix":"10.1542","source":"Crossref","volume":null,"created":{"date-time":"2026-05-12T00:02:46Z","timestamp":1778544166000,"date-parts":[[2026,5,12]]},"indexed":{"date-time":"2026-05-12T00:20:09Z","timestamp":1778545209869,"date-parts":[[2026,5,12]]},"subject":[],"abstract":"$31","language":"en","relation":{},"resource":{"primary":{"URL":"https://publications.aap.org/pediatrics/article/doi/10.1542/peds.2025-074933/207534/Sleep-Duration-Among-US-Adolescents-1991-2023"}},"subtitle":[],"deposited":{"date-time":"2026-05-12T00:02:52Z","timestamp":1778544172000,"date-parts":[[2026,5,12]]},"issn-type":[{"type":"print","value":"0031-4005"},{"type":"electronic","value":"1098-4275"}],"published":{"date-parts":[[2026,5,12]]},"publisher":"American Academy of Pediatrics (AAP)","reference":[{"DOI":"10.1111/jsr.12839","key":"2026051120024487700_r1","year":"2019","issue":"6","author":"Sawyer","volume":"28","first-page":"e12839","unstructured":null,"article-title":"Defining short and long sleep duration for future paediatric research: a systematic literature review","journal-title":"J Sleep Res.","doi-asserted-by":"crossref"},{"DOI":null,"key":"2026051120024487700_r2","year":"2026","issue":null,"author":"Bommersbach","volume":null,"first-page":"e261417","unstructured":null,"article-title":"Insufficient sleep among US adolescents across behavioral risk groups","journal-title":"JAMA.","doi-asserted-by":null},{"DOI":"10.5664/jcsm.6288","key":"2026051120024487700_r3","year":"2016","issue":"11","author":"Paruthi","volume":"12","first-page":"1549","unstructured":null,"article-title":"Consensus statement of the American Academy of Sleep Medicine on the recommended amount of sleep for healthy children: methodology and discussion","journal-title":"J Clin Sleep Med.","doi-asserted-by":"crossref"},{"DOI":"10.1001/jamanetworkopen.2024.49861","key":"2026051120024487700_r4","year":"2024","issue":"12","author":"Wang","volume":"7","first-page":"e2449861","unstructured":null,"article-title":"Race, ethnicity, and sleep in US children","journal-title":"JAMA Netw Open.","doi-asserted-by":"crossref"},{"DOI":"10.5888/pcd11.140383","key":"2026051120024487700_r5","year":"2014","issue":null,"author":"Basch","volume":"11","first-page":"E216","unstructured":null,"article-title":"Prevalence of sleep duration on an average school night among 4 nationally representative successive samples of American high school students, 2007–2013","journal-title":"Prev Chronic Dis.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.sleep.2010.07.020","key":"2026051120024487700_r6","year":"2011","issue":"3","author":"Moore","volume":"12","first-page":"239","unstructured":null,"article-title":"Correlates of adolescent sleep time and variability in sleep time: the role of individual and health related characteristics","journal-title":"Sleep Med.","doi-asserted-by":"crossref"},{"DOI":"10.1542/peds.2013-2399","key":"2026051120024487700_r7","year":"2014","issue":"5","author":"Matthews","volume":"133","first-page":"e1189","unstructured":null,"article-title":"Sleep in healthy black and white adolescents","journal-title":"Pediatrics.","doi-asserted-by":"crossref"},{"DOI":"10.1093/aje/kwac156","key":"2026051120024487700_r8","year":"2023","issue":"1","author":"Saelee","volume":"192","first-page":"51","unstructured":null,"article-title":"Racial/ethnic and sex/gender differences in sleep duration trajectories from adolescence to adulthood in a US National Sample","journal-title":"Am J Epidemiol.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.ssmph.2020.100581","key":"2026051120024487700_r9","year":"2020","issue":null,"author":"James","volume":"11","first-page":"100581","unstructured":null,"article-title":"Disparities in adolescent sleep health by sex and ethnoracial group","journal-title":"SSM Popul Health.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.jadohealth.2025.03.002","key":"2026051120024487700_r10","year":"2026","issue":"1","author":"Feldman","volume":"78","first-page":"87","unstructured":null,"article-title":"Social-ecological risk and protective factors for insufficient sleep in adolescents: a nationally representative investigation","journal-title":"J Adolesc Health.","doi-asserted-by":"crossref"},{"DOI":"10.1542/peds.2014-1696","key":"2026051120024487700_r11","year":"2014","issue":"3","author":"Owens","volume":"134","first-page":"e921","unstructured":null,"article-title":"Insufficient sleep in adolescents and young adults: an update on causes and consequences","journal-title":"Pediatrics.","doi-asserted-by":"crossref"},{"DOI":"10.1542/peds.2021-053616","key":"2026051120024487700_r12","year":"2022","issue":"3","author":"Fernandez-Mendoza","volume":"149","first-page":"e2021053616","unstructured":null,"article-title":"Trajectories of insomnia symptoms from childhood through young adulthood","journal-title":"Pediatrics.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.coemr.2020.10.007","key":"2026051120024487700_r13","year":"2021","issue":null,"author":"Okoli","volume":"17","first-page":"15","unstructured":null,"article-title":"The Relationship between Sleep, Obesity, and Metabolic Health in Adolescents - a Review","journal-title":"Curr Opin Endocr Metab Res.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.smrv.2015.09.001","key":"2026051120024487700_r14","year":"2016","issue":null,"author":"Quist","volume":"29","first-page":"76","unstructured":null,"article-title":"Sleep and cardiometabolic risk in children and adolescents","journal-title":"Sleep Med Rev.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.smrv.2020.101338","key":"2026051120024487700_r15","year":"2020","issue":null,"author":"Sun","volume":"53","first-page":"101338","unstructured":null,"article-title":"Sleep duration and cardiovascular risk factors in children and adolescents: a systematic review","journal-title":"Sleep Med Rev.","doi-asserted-by":"crossref"},{"DOI":"10.1001/jamapediatrics.2019.3089","key":"2026051120024487700_r16","year":"2019","issue":"11","author":"Cespedes Feliciano","volume":"173","first-page":"1049","unstructured":null,"article-title":"Chronotype, social jet lag, and cardiometabolic risk factors in early adolescence","journal-title":"JAMA Pediatr.","doi-asserted-by":"crossref"},{"DOI":"10.1093/sleep/zsad318","key":"2026051120024487700_r17","year":"2024","issue":"3","author":"Duraccio","volume":"47","first-page":"zsad318","unstructured":null,"article-title":"High levels of sleep disturbance across early childhood increases cardiometabolic disease risk index in early adolescence: longitudinal sleep analysis using the Health Outcomes and Measures of the Environment study","journal-title":"Sleep.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.jacadv.2025.102261","key":"2026051120024487700_r18","year":"2025","issue":"11 Pt 1","author":"Mathew","volume":"4","first-page":"102261","unstructured":null,"article-title":"Actigraphic sleep health during adolescence predicts young adult cardiovascular health","journal-title":"JACC Adv.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.smrv.2013.03.005","key":"2026051120024487700_r19","year":"2014","issue":"1","author":"Shochat","volume":"18","first-page":"75","unstructured":null,"article-title":"Functional consequences of inadequate sleep in adolescents: a systematic review","journal-title":"Sleep Med Rev.","doi-asserted-by":"crossref"},{"DOI":"10.1016/S2352-4642(22)00188-2","key":"2026051120024487700_r20","year":"2022","issue":"10","author":"Yang","volume":"6","first-page":"705","unstructured":null,"article-title":"Effects of sleep duration on neurocognitive development in early adolescents in the USA: a propensity score matched, longitudinal, observational study","journal-title":"Lancet Child Adolesc Health.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.adolescence.2018.06.001","key":"2026051120024487700_r21","year":"2018","issue":"1","author":"Crowley","volume":"67","first-page":"55","unstructured":null,"article-title":"An update on adolescent sleep: new evidence informing the perfect storm model","journal-title":"J Adolesc.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.pcl.2011.03.003","key":"2026051120024487700_r22","year":"2011","issue":"3","author":"Carskadon","volume":"58","first-page":"637","unstructured":null,"article-title":"Sleep in adolescents: the perfect storm","journal-title":"Pediatr Clin North Am.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.jadohealth.2025.01.020","key":"2026051120024487700_r23","year":"2025","issue":"6","author":"Hayes","volume":"76","first-page":"1043","unstructured":null,"article-title":"Adolescent time use and cardiometabolic health: a cross-sectional compositional analysis to explore associations between 24-hour activity behaviors and biomarkers of cardiometabolic health","journal-title":"J Adolesc Health.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.sleh.2021.10.008","key":"2026051120024487700_r24","year":"2022","issue":"1","author":"Ziporyn","volume":"8","first-page":"11","unstructured":null,"article-title":"Adolescent sleep health and school start times: setting the research agenda for California and beyond. A research summit summary","journal-title":"Sleep Health.","doi-asserted-by":"crossref"},{"DOI":"10.1542/peds.2014-2707","key":"2026051120024487700_r25","year":"2015","issue":"3","author":"Keyes","volume":"135","first-page":"460","unstructured":null,"article-title":"The great sleep recession: changes in sleep duration among US adolescents, 1991–2012","journal-title":"Pediatrics.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.sleh.2017.09.005","key":"2026051120024487700_r26","year":"2018","issue":"1","author":"Guglielmo","volume":"4","first-page":"68","unstructured":null,"article-title":"Racial/ethnic sleep disparities in US school-aged children and adolescents: a review of the literature","journal-title":"Sleep Health.","doi-asserted-by":"crossref"},{"DOI":"10.1073/pnas.2120009119","key":"2026051120024487700_r27","year":"2022","issue":"30","author":"Giddens","volume":"119","first-page":"e2120009119","unstructured":null,"article-title":"Disparities in sleep duration among American children: effects of race and ethnicity, income, age, and sex","journal-title":"Proc Natl Acad Sci U S A.","doi-asserted-by":"crossref"},{"DOI":"10.1073/pnas.2120009119","key":"2026051120024487700_r28","year":"2022","issue":"30","author":"Giddens","volume":"119","first-page":"e2120009119","unstructured":null,"article-title":"Disparities in sleep duration among American children: effects of race and ethnicity, income, age, and sex","journal-title":"Proc Natl Acad Sci USA.","doi-asserted-by":"crossref"},{"DOI":"10.1111/cdep.12465","key":"2026051120024487700_r29","year":"2022","issue":"4","author":"El-Sheikh","volume":"16","first-page":"200","unstructured":null,"article-title":"Sleep and disparities in child and adolescent development","journal-title":"Child Dev Perspect.","doi-asserted-by":"crossref"},{"DOI":"10.1093/sleep/zsaf166","key":"2026051120024487700_r30","year":"2025","issue":"10","author":"Thompson","volume":"48","first-page":"zsaf166","unstructured":null,"article-title":"Socioeconomic and racial/ethnic disparities in sleep and cognitive and academic functioning across childhood and adolescence: a meta-analytic review","journal-title":"Sleep.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.sleh.2025.04.004","key":"2026051120024487700_r31","year":"2025","issue":"4","author":"Dzierzewski","volume":"11","first-page":"543","unstructured":null,"article-title":"The impact of the 2024 US presidential election campaign on population sleep: a representative survey from National Sleep Foundation","journal-title":"Sleep Health.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.sleep.2025.106657","key":"2026051120024487700_r32","year":"2025","issue":null,"author":"Thottan","volume":"133","first-page":"106657","unstructured":null,"article-title":"Cross-sectional examination of internet addiction and sleep outcomes in U.S. children and adolescents","journal-title":"Sleep Med.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.sleh.2025.05.005","key":"2026051120024487700_r33","year":"2025","issue":"5","author":"Nagata","volume":"11","first-page":"562","unstructured":null,"article-title":"Social epidemiology of bedtime screen use behaviors and sleep outcomes in early adolescence","journal-title":"Sleep Health.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.sleep.2017.08.013","key":"2026051120024487700_r34","year":"2017","issue":null,"author":"Twenge","volume":"39","first-page":"47","unstructured":null,"article-title":"Decreases in self-reported sleep duration among U.S. adolescents 2009–2015 and association with new media screen time","journal-title":"Sleep Med.","doi-asserted-by":"crossref"},{"DOI":"10.1111/jsr.13720","key":"2026051120024487700_r35","year":"2023","issue":"1","author":"Richter","volume":"32","first-page":"e13720","unstructured":null,"article-title":"Effects of the COVID-19 pandemic on sleep quality in children and adolescents: a systematic review and meta-analysis","journal-title":"J Sleep Res.","doi-asserted-by":"crossref"},{"DOI":"10.1001/jama.2025.9855","key":"2026051120024487700_r36","year":"2025","issue":"6","author":"Forrest","volume":"334","first-page":"509","unstructured":null,"article-title":"Trends in US children’s mortality, chronic conditions, obesity, functional status, and symptoms","journal-title":"JAMA.","doi-asserted-by":"crossref"},{"DOI":null,"key":"2026051120024487700_r37","year":"2026","issue":null,"author":"Meich","volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":null,"key":"2026051120024487700_r38","year":"2025","issue":null,"author":"Miech","volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":null,"key":"2026051120024487700_r39","year":"2006","issue":null,"author":"Institute of Medicine (US) Committee on Sleep Medicine and Research","volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.3390/brainsci13040569","key":"2026051120024487700_r40","year":"2023","issue":"4","author":"Uccella","volume":"13","first-page":"569","unstructured":null,"article-title":"Sleep deprivation and insomnia in adolescence: implications for mental health","journal-title":"Brain Sci.","doi-asserted-by":"crossref"},{"DOI":null,"key":"2026051120024487700_r41","year":"2025","issue":null,"author":"Carstensen","volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.1542/peds.2019-2056I","key":"2026051120024487700_r42","year":"2020","issue":"suppl 2","author":"Kansagra","volume":"145","first-page":"S204","unstructured":null,"article-title":"Sleep disorders in adolescents","journal-title":"Pediatrics.","doi-asserted-by":"crossref"},{"DOI":"10.23736/S0026-4946.17.04914-3","key":"2026051120024487700_r43","year":"2017","issue":"4","author":"Owens","volume":"69","first-page":"326","unstructured":null,"article-title":"Insufficient sleep in adolescents: causes and consequences","journal-title":"Minerva Pediatr.","doi-asserted-by":"crossref"},{"DOI":"10.1111/jsr.14482","key":"2026051120024487700_r44","year":"2025","issue":"5","author":"Schlarb","volume":"34","first-page":"e14482","unstructured":null,"article-title":"The future of paediatric sleep medicine: a blueprint for advancing the field","journal-title":"J Sleep Res.","doi-asserted-by":"crossref"},{"DOI":null,"key":"2026051120024487700_r45","year":"2025","issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":null,"key":"2026051120024487700_r46","year":"2025","issue":null,"author":"Faverio","volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":null,"key":"2026051120024487700_r47","year":null,"issue":null,"author":"AAP","volume":null,"first-page":null,"unstructured":null,"article-title":"School Phone Policies","journal-title":null,"doi-asserted-by":null},{"DOI":null,"key":"2026051120024487700_r48","year":"2024","issue":null,"author":"Ritchie","volume":null,"first-page":null,"unstructured":null,"article-title":"Australian social media ban on under-16s approved by parliament","journal-title":null,"doi-asserted-by":null},{"DOI":"10.1001/jamapediatrics.2020.0344","key":"2026051120024487700_r49","year":"2020","issue":"7","author":"Widome","volume":"174","first-page":"697","unstructured":null,"article-title":"Association of delaying school start time with sleep duration, timing, and quality among adolescents","journal-title":"JAMA Pediatr.","doi-asserted-by":"crossref"}],"short-title":[],"article-number":"e2025074933","content-domain":{"domain":[],"crossmark-restriction":false},"original-title":[],"container-title":["Pediatrics"],"reference-count":49,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2026,5,12]]},"references-count":49,"short-container-title":[],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1542/peds.2025-074933","is_oa":false,"title":"Sleep Duration Among US Adolescents, 1991–2023","updated":"2026-05-12T08:54:10+00:00","published_date":"2026-05-12","best_oa_location":null}},"created_at":"2026-05-14T13:23:02.709Z","updated_at":"2026-05-14T15:13:26.918Z","tags":[{"paper_doi":"10.1542/peds.2025-074933","tag_type":"age_group","value":"adolescent","value_numeric":null},{"paper_doi":"10.1542/peds.2025-074933","tag_type":"category","value":"Pediatrics","value_numeric":null},{"paper_doi":"10.1542/peds.2025-074933","tag_type":"condition","value":"Adolescent Sleep Disorders","value_numeric":null},{"paper_doi":"10.1542/peds.2025-074933","tag_type":"condition","value":"Sleep Insufficiency","value_numeric":null},{"paper_doi":"10.1542/peds.2025-074933","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.1542/peds.2025-074933","tag_type":"impact_flag","value":"safety_signal","value_numeric":null},{"paper_doi":"10.1542/peds.2025-074933","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1542/peds.2025-074933","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1542/peds.2025-074933","tag_type":"sample_size","value":"n=401160","value_numeric":401160},{"paper_doi":"10.1542/peds.2025-074933","tag_type":"sample_size","value":"n=401,160","value_numeric":401160},{"paper_doi":"10.1542/peds.2025-074933","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1542/peds.2025-074933","tag_type":"study_design","value":"Cross-Sectional","value_numeric":null},{"paper_doi":"10.1542/peds.2025-074933","tag_type":"study_design","value":"Cross-Sectional Study","value_numeric":null},{"paper_doi":"10.1542/peds.2025-074933","tag_type":"warning","value":"Age-period-cohort models were used; interpreting independent effects of age, period, and cohort simultaneously involves known methodological constraints that the authors may have addressed but are not detailed in the abstract.","value_numeric":null},{"paper_doi":"10.1542/peds.2025-074933","tag_type":"warning","value":"Design is a repeated cross-sectional trend analysis with age–period–cohort modeling; classified here as Cross-Sectional.","value_numeric":null},{"paper_doi":"10.1542/peds.2025-074933","tag_type":"warning","value":"No pharmacologic or therapeutic modality is evaluated; modality/brand/generic tags are not applicable and were omitted.","value_numeric":null},{"paper_doi":"10.1542/peds.2025-074933","tag_type":"warning","value":"Summary based on abstract-level details; full methods and additional outcomes may provide further nuance.","value_numeric":null},{"paper_doi":"10.1542/peds.2025-074933","tag_type":"warning","value":"The study is observational with no intervention arm; 'level_of_evidence' is assigned as 3 (large cohort/surveillance study) rather than a lower rating given the large nationally representative sample.","value_numeric":null}],"summaries":{"what_studied":"Trends in self-reported sleep duration and subjective sufficiency among US adolescents were assessed using Monitoring the Future survey data from 1991–2023 (n=401,160) with age–period–cohort models and sociodemographic comparisons.","key_result":"Sleep duration declined with age in every period, and 2021–2023 showed the lowest prevalence of ≥7 hours/night at every age (37.2% at age 12–13; 22.3% at age 18–19); disparities widened, with Black vs White odds of reporting ≥7 hours shifting from OR 0.99 (0.92–1.07) in 1991–1995 to OR 0.79 (0.67–0.93) in 2023.","limitations":"Outcomes relied on two self-reported survey items rather than objective or detailed sleep measures; estimates derive from repeated cross-sectional data rather than longitudinal follow-up.","practice_takeaway":"Expect pervasive short sleep in today’s teens—especially older adolescents and Black, Hispanic/Latino, and lower–parental-education groups—and routinely ask about hours slept and perceived sufficiency."}},{"doi":"10.1186/s12873-026-01598-5","pmid":"42082930","title":"Adherence to infection prevention and control best practices in emergency units at a tertiary care hospital, Riyadh","journal_title":"BMC Emergency Medicine","journal_issn":"1471-227X","published_at":"2026-05-05T00:00:00.000Z","url":"https://doi.org/10.1186/s12873-026-01598-5","source_score":2,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-05-10","doi":"10.1186/s12873-026-01598-5","days":"7","issn":"1471-227X","rank":"6","field":"Clinical Medicine","score":"2","category":"Emergency Medicine","categories":["Emergency Medicine"],"_categories":["Emergency Medicine"]},"pubmed":{"doi":"10.1186/s12873-026-01598-5","title":"Adherence to infection prevention and control best practices in emergency units at a tertiary care hospital, Riyadh.","journal":"BMC emergency medicine","methods":"","results":"Out of 123,947 HCW-specific practices observed, 85,542 (69.0%) were compliant and out of 41,650 unit-specific practices observed, 38,355 (92.1%) were compliant. The compliance was highest in the competence of acute respiratory infection procedures (97.3%), followed by isolation precautions (97.0%), housekeeping (96.8%), disposal of sharps (96.8%), waste management (94.5%), donning and doffing of personal protective equipment (PPE, 72.9%), use of PPE (72.3%), hand hygiene (67.2%), patient sitters (64.1%), and disinfection of medical equipment (61.2%). Nurses across all units had much better compliance than other professions. There were > 10% differences in the compliance across the units, with higher compliance in mainly pediatric compared with adult units. The compliance was highest during the COVID-19 pandemic years.","abstract":"$32","keywords":["Compliance","Emergency department","Implementation","Infection control","Professional category"],"pubmed_id":"42082930","conclusions":"","publication_date":"2026-05-05T00:00:00"},"crossref":{"DOI":"10.1186/s12873-026-01598-5","URL":"https://doi.org/10.1186/s12873-026-01598-5","ISSN":["1471-227X"],"link":[{"URL":"https://link.springer.com/article/10.1186/s12873-026-01598-5","content-type":"text/html","content-version":"vor","intended-application":"text-mining"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Adherence to infection prevention and control best practices in emergency units at a tertiary care hospital, Riyadh"],"author":[{"given":"Majid Al","family":"Shamrani","sequence":"first","affiliation":[]},{"given":"Aiman","family":"El-Saed","sequence":"additional","affiliation":[]},{"given":"Sarah","family":"Al-Fayez","sequence":"additional","affiliation":[]},{"given":"Lolwah","family":"Almousa","sequence":"additional","affiliation":[]},{"given":"Fatema K.","family":"Alanazi","sequence":"additional","affiliation":[]},{"given":"Mouafaq","family":"Alkhodairy","sequence":"additional","affiliation":[]},{"given":"Faisal","family":"Almalki","sequence":"additional","affiliation":[]},{"given":"Abdullah F.","family":"Alanazi","sequence":"additional","affiliation":[]},{"given":"Fatimah","family":"Akkam","sequence":"additional","affiliation":[]},{"given":"Kassem Abou","family":"Yassine","sequence":"additional","affiliation":[]},{"given":"Salman","family":"Alkhodairy","sequence":"additional","affiliation":[]},{"given":"Husam","family":"Eid","sequence":"additional","affiliation":[]},{"given":"Saad","family":"Almohrij","sequence":"additional","affiliation":[]}],"issued":{"date-parts":[[2026,5,4]]},"member":"297","prefix":"10.1186","source":"Crossref","volume":null,"created":{"date-time":"2026-05-04T09:16:51Z","timestamp":1777886211000,"date-parts":[[2026,5,4]]},"indexed":{"date-time":"2026-05-05T03:20:10Z","timestamp":1777951210648,"date-parts":[[2026,5,5]]},"license":[{"URL":"https://creativecommons.org/licenses/by-nc-nd/4.0","start":{"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000,"date-parts":[[2026,5,4]]},"delay-in-days":0,"content-version":"tdm"},{"URL":"https://creativecommons.org/licenses/by-nc-nd/4.0","start":{"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000,"date-parts":[[2026,5,4]]},"delay-in-days":0,"content-version":"am"}],"subject":[],"abstract":null,"language":"en","relation":{},"resource":{"primary":{"URL":"https://link.springer.com/10.1186/s12873-026-01598-5"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"ArticleHistory","label":"Article History"},"label":"Received","order":1,"value":"29 September 2025"},{"name":"accepted","group":{"name":"ArticleHistory","label":"Article History"},"label":"Accepted","order":2,"value":"22 April 2026"},{"name":"first_online","group":{"name":"ArticleHistory","label":"Article History"},"label":"First Online","order":3,"value":"4 May 2026"},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"},"order":1},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"},"order":2,"value":"The study was conducted in accordance with the Helsinki Declaration and received the necessary ethical approvals from the Institutional Review Board (IRB) at King Abdullah International Medical Research Centre (KAIMRC), with approval number (IRB/2026/23). The IRB waived the need for informed consent due to the nature of the study."},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors’ information"},"order":3,"value":"Majid M. Alshamrani is working as the Executive Director, Infection Prevention and Control at King Abdualziz Medical City and Associate Professor, Adult Infectious Disease, King Saud bin Abdulaziz University for Health Sciences. Aiman El-Saed is working as advisor of health surveillance at King Abdualziz Medical City and Assistant Professor of Epidemiology and Biostatistics at College of Public Health and Health Informatics, King Saud bin Abdulaziz University for Health Sciences."},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"},"order":4,"value":"Not applicable."},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"},"order":5,"value":"The authors declare no competing interests."}],"deposited":{"date-time":"2026-05-04T09:16:52Z","timestamp":1777886212000,"date-parts":[[2026,5,4]]},"issn-type":[{"type":"electronic","value":"1471-227X"}],"published":{"date-parts":[[2026,5,4]]},"publisher":"Springer Science and Business Media LLC","reference":null,"short-title":[],"update-policy":"https://doi.org/10.1007/springer_crossmark_policy","alternative-id":["1598"],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"original-title":[],"container-title":["BMC Emergency Medicine"],"reference-count":0,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2026,5,4]]},"references-count":0,"short-container-title":["BMC Emerg Med"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1186/s12873-026-01598-5","is_oa":true,"title":"Adherence to infection prevention and control best practices in emergency units at a tertiary care hospital, Riyadh","updated":"2026-05-06T13:23:02+00:00","published_date":"2026-05-04","best_oa_location":{"url":"https://doi.org/10.1186/s12873-026-01598-5","pmh_id":null,"url_for_pdf":null,"url_for_landing_page":"https://doi.org/10.1186/s12873-026-01598-5"}}},"created_at":"2026-05-14T13:23:00.962Z","updated_at":"2026-05-14T15:13:26.918Z","tags":[{"paper_doi":"10.1186/s12873-026-01598-5","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1186/s12873-026-01598-5","tag_type":"category","value":"Emergency Medicine","value_numeric":null},{"paper_doi":"10.1186/s12873-026-01598-5","tag_type":"condition","value":"COVID-19","value_numeric":null},{"paper_doi":"10.1186/s12873-026-01598-5","tag_type":"condition","value":"Healthcare-Associated Infection","value_numeric":null},{"paper_doi":"10.1186/s12873-026-01598-5","tag_type":"condition","value":"Healthcare-Associated Infections","value_numeric":null},{"paper_doi":"10.1186/s12873-026-01598-5","tag_type":"impact_flag","value":"safety_signal","value_numeric":null},{"paper_doi":"10.1186/s12873-026-01598-5","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.1186/s12873-026-01598-5","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1186/s12873-026-01598-5","tag_type":"modality","value":"Infection Prevention And Control","value_numeric":null},{"paper_doi":"10.1186/s12873-026-01598-5","tag_type":"sample_size","value":"n=165597","value_numeric":165597},{"paper_doi":"10.1186/s12873-026-01598-5","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1186/s12873-026-01598-5","tag_type":"study_design","value":"Cross-Sectional","value_numeric":null},{"paper_doi":"10.1186/s12873-026-01598-5","tag_type":"study_design","value":"Observational Cross-Sectional Study","value_numeric":null},{"paper_doi":"10.1186/s12873-026-01598-5","tag_type":"warning","value":"Counts reflect observed practices, not numbers of patients or staff.","value_numeric":null},{"paper_doi":"10.1186/s12873-026-01598-5","tag_type":"warning","value":"No infection or clinical outcome data were reported.","value_numeric":null},{"paper_doi":"10.1186/s12873-026-01598-5","tag_type":"warning","value":"Observer composition (IPC professionals plus trained medical students) may introduce measurement inconsistency not fully addressed in the abstract.","value_numeric":null},{"paper_doi":"10.1186/s12873-026-01598-5","tag_type":"warning","value":"Sample size tag reflects total observed practices (123,947 HCW-specific + 41,650 unit-specific = 165,597 observations), not a count of individual HCWs, as the latter was not reported.","value_numeric":null},{"paper_doi":"10.1186/s12873-026-01598-5","tag_type":"warning","value":"Single-center, cross-sectional design limits generalizability and precludes causal inference.","value_numeric":null},{"paper_doi":"10.1186/s12873-026-01598-5","tag_type":"warning","value":"The DOI year (2026) appears consistent with the stated publication date; no anomaly noted.","value_numeric":null}],"summaries":{"what_studied":"An observational cross-sectional study in a large tertiary emergency department (2018–2023) directly observed adherence to infection prevention and control (IPC) practices by healthcare workers and unit processes using a standardized form.","key_result":"HCW-specific compliance was 69.0% (85,542/123,947) and unit-specific compliance was 92.1% (38,355/41,650). Highest rates were for acute respiratory infection procedures (97.3%) and isolation precautions (97.0%); lowest were for medical equipment disinfection (61.2%), patient sitters (64.1%), hand hygiene (67.2%), and PPE use/donning-doffing (72.3%/72.9%); nurses outperformed other professions, pediatric units exceeded adult units by >10%, and compliance peaked during COVID-19 years.","limitations":"Single-center, cross-sectional observations from one emergency department limit generalizability. Adherence was measured by observers (IPC staff or trained students) and the study reports compliance, not infection outcomes.","practice_takeaway":"Prioritize quality efforts where adherence was lowest: equipment disinfection, hand hygiene, and sitter compliance. Focus interventions on non-nursing staff and adult units, and sustain gains noted during the COVID-19 period."}},{"doi":"10.1080/15374416.2026.2660291","pmid":"42085350","title":"Are Social Problems in Children with ADHD Due to Knowledge Gaps or Performance Difficulties? An Examination of Competing Model Predictions","journal_title":"Journal of Clinical Child & Adolescent Psychology","journal_issn":"1537-4416","published_at":"2026-05-05T00:00:00.000Z","url":"https://doi.org/10.1080/15374416.2026.2660291","source_score":8,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2026-05-10","doi":"10.1080/15374416.2026.2660291","days":"7","issn":"1537-4416","rank":"9","field":"Clinical Medicine","score":"8","category":"Psychology, Clinical","categories":["Psychology, Clinical"],"_categories":["Psychology, Clinical"]},"pubmed":{"doi":"10.1080/15374416.2026.2660291","title":"Are Social Problems in Children with ADHD Due to Knowledge Gaps or Performance Difficulties? An Examination of Competing Model Predictions.","journal":"Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53","methods":"A clinically evaluated and carefully phenotyped sample of children ages 8-13 with and without ADHD (","results":"Acquisition difficulties were rare and idiosyncratic for both groups; parents and teachers perceived fewer than 15% of children with ADHD as missing any specific social skill. In contrast, performance difficulties were predominant in the ADHD group and occurred at significantly higher rates across informants relative to the non-ADHD group in the domains of communication, cooperation, empathy, responsibility, and self-control (all ","abstract":"$33","keywords":[],"pubmed_id":"42085350","conclusions":"These findings are consistent with updated conceptualizations suggesting social skills difficulties in children with ADHD are not primarily due to a lack of social knowledge but rather from the inconsistent execution of known social skills.","publication_date":"2026-05-05T00:00:00"},"crossref":{"DOI":"10.1080/15374416.2026.2660291","URL":"https://doi.org/10.1080/15374416.2026.2660291","ISSN":["1537-4416","1537-4424"],"link":[{"URL":"https://www.tandfonline.com/doi/pdf/10.1080/15374416.2026.2660291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":"1-17","type":"journal-article","issue":null,"score":1,"title":["Are Social Problems in Children with ADHD Due to Knowledge Gaps or Performance Difficulties? An Examination of Competing Model Predictions"],"author":[{"given":"Sooyun","family":"Cho","sequence":"first","affiliation":[{"name":"Florida State University"}]},{"given":"Miho O.","family":"Tatsuki","sequence":"additional","affiliation":[{"name":"Florida State University"}]},{"given":"Julia","family":"Obi","sequence":"additional","affiliation":[{"name":"Florida State University"}]},{"given":"Fatou","family":"Gaye","sequence":"additional","affiliation":[{"name":"Florida State University"}]},{"given":"Kathy","family":"Harvey","sequence":"additional","affiliation":[{"name":"Florida State University"}]},{"given":"Michael J.","family":"Kofler","sequence":"additional","affiliation":[{"name":"Florida State University"}]}],"funder":[{"id":[{"id":"10.13039/100000025","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/100000025","name":"National Institute of Mental Health","award":["R01 MH115048"],"award-info":[{"award-number":["R01 MH115048"]}],"doi-asserted-by":"publisher"}],"issued":{"date-parts":[[2026,5,5]]},"member":"301","prefix":"10.1080","source":"Crossref","volume":null,"created":{"date-time":"2026-05-05T17:21:52Z","timestamp":1778001712000,"date-parts":[[2026,5,5]]},"indexed":{"date-time":"2026-05-05T18:11:36Z","timestamp":1778004696230,"date-parts":[[2026,5,5]]},"subject":[],"abstract":null,"language":"en","relation":{},"resource":{"primary":{"URL":"https://www.tandfonline.com/doi/full/10.1080/15374416.2026.2660291"}},"subtitle":[],"assertion":[{"name":"peerreview_statement","label":"Peer Review Statement","order":1,"value":"The publishing and review policy for this title is described in its Aims & Scope."},{"URL":"http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=hcap20","name":"aims_and_scope_url","label":"Aim & Scope","order":2,"value":"http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=hcap20"},{"name":"published","group":{"name":"publication_history","label":"Publication History"},"label":"Published","order":3,"value":"2026-05-05"}],"deposited":{"date-time":"2026-05-05T17:22:08Z","timestamp":1778001728000,"date-parts":[[2026,5,5]]},"issn-type":[{"type":"print","value":"1537-4416"},{"type":"electronic","value":"1537-4424"}],"published":{"date-parts":[[2026,5,5]]},"publisher":"Informa UK Limited","reference":[{"DOI":"10.1097/01.chi.0000128797.91601.1a","key":"e_1_3_4_2_1","year":"2004","issue":"7","author":"Abikoff H.","volume":"43","first-page":"820","unstructured":"Abikoff, H., Hechtman, L., Klein, R. G., Gallagher, R., Fleiss, K., & Pollack, S. (2004). Social functioning in children with ADHD treated with long-term methylphenidate and multimodal psychosocial treatment. The Journal of the American Academy of Child & Adolescent Psychiatry, 43(7), 820–829.","article-title":"Social functioning in children with ADHD treated with long-term methylphenidate and multimodal psychosocial treatment","journal-title":"The Journal of the American Academy of Child & Adolescent Psychiatry","doi-asserted-by":"crossref"},{"DOI":"10.1007/s10862-018-9649-7","key":"e_1_3_4_3_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1176/appi.books.9780890425787","key":"e_1_3_4_4_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1177/1087054710383239","key":"e_1_3_4_5_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1080/09297049.2024.2304375","key":"e_1_3_4_6_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1177/1087054714527793","key":"e_1_3_4_7_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s10567-015-0187-5","key":"e_1_3_4_8_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.ridd.2023.104440","key":"e_1_3_4_9_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.ridd.2023.104568","key":"e_1_3_4_10_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1177/10870547211025629","key":"e_1_3_4_11_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.jpsychires.2025.08.024","key":"e_1_3_4_12_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1177/10791102009002005","key":"e_1_3_4_13_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1037/cap0000030","key":"e_1_3_4_14_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.cpr.2006.03.006","key":"e_1_3_4_15_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1017/S1355617709090481","key":"e_1_3_4_16_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1080/15374416.2019.1689825","key":"e_1_3_4_17_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s10802-016-0126-z","key":"e_1_3_4_18_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_3_4_19_1","year":"2016","issue":null,"author":"DuPaul G. J.","volume":null,"first-page":null,"unstructured":"DuPaul, G. J., Power, T. J., Anastopoulos, A. D., & Reid, R. (2016). ADHD rating scale? 5 for children and adolescents: Checklists, norms, and clinical interpretation. Guilford Publications.","article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":null,"key":"e_1_3_4_20_1","year":"2006","issue":"7","author":"DuPaul G. J.","volume":"71","first-page":"57","unstructured":"DuPaul, G. J., & White, G. P. (2006). Adhd: Behavioral, educational, and medication interventions. The Education Digest, 71(7), 57.","article-title":"Adhd: Behavioral, educational, and medication interventions","journal-title":"The Education Digest","doi-asserted-by":null},{"DOI":"10.1007/s10567-016-0216-z","key":"e_1_3_4_21_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1080/15374416.2013.850700","key":"e_1_3_4_22_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1080/15374416.2017.1390757","key":"e_1_3_4_23_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3758/BRM.41.4.1149","key":"e_1_3_4_24_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s12310-011-9060-y","key":"e_1_3_4_25_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s10862-022-09967-7","key":"e_1_3_4_26_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1177/1087054713501552","key":"e_1_3_4_27_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s10567-023-00449-0","key":"e_1_3_4_28_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1371/journal.pone.0112298","key":"e_1_3_4_29_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1177/10870547241284829","key":"e_1_3_4_30_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.cpr.2016.04.011","key":"e_1_3_4_31_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1080/21642850.2021.1920416","key":"e_1_3_4_32_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_3_4_33_1","year":"2008","issue":null,"author":"Gresham F.","volume":null,"first-page":null,"unstructured":"Gresham, F., & Elliott, S. N. (2008). Social skills improvement system (SSIS) rating scales. Pearson.","article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.1177/019874290403000101","key":"e_1_3_4_34_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1037/a0020255","key":"e_1_3_4_35_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1037/a0022662","key":"e_1_3_4_36_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1080/10888691.2021.1890592","key":"e_1_3_4_37_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s10802-007-9110-y","key":"e_1_3_4_38_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.cresp.2022.100052","key":"e_1_3_4_39_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1080/10543401003618819","key":"e_1_3_4_40_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1037/a0027205","key":"e_1_3_4_41_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s10802-015-0095-7","key":"e_1_3_4_42_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s12402-018-0272-y","key":"e_1_3_4_43_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_3_4_44_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"The Jamovi Project. (2023). Jamovi (Version 2.3) [Computer Software]. www.jamovi.org","article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.24200/jonus.vol5iss2pp303-328","key":"e_1_3_4_45_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1097/00004583-199707000-00021","key":"e_1_3_4_46_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1037/neu0000050","key":"e_1_3_4_47_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1037/neu0000416","key":"e_1_3_4_48_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s10802-011-9492-8","key":"e_1_3_4_49_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/j.1469-7610.2007.01809.x","key":"e_1_3_4_50_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.cpr.2013.06.001","key":"e_1_3_4_51_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1001/archpsyc.62.8.896","key":"e_1_3_4_52_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1080/02796015.1991.12085548","key":"e_1_3_4_53_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1002/da.22094","key":"e_1_3_4_54_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.21105/joss.03139","key":"e_1_3_4_55_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1002/pits.23375","key":"e_1_3_4_56_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_3_4_57_1","year":"2015","issue":null,"author":"McQuade J. D.","volume":null,"first-page":"210","unstructured":"McQuade, J. D., & Hoza, B. (2015). Peer relationships of children with ADHD. In R. A. Barkley (Ed.), Attention-deficit hyperactivity disorder: A handbook for diagnosis and treatment (4th ed., pp. 210–222). The Guilford Press.","article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.1037/a0029654","key":"e_1_3_4_58_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.chc.2014.05.007","key":"e_1_3_4_59_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s10802-010-9403-4","key":"e_1_3_4_60_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s40474-014-0036-0","key":"e_1_3_4_61_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1037/ccp0000607","key":"e_1_3_4_62_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s11920-017-0850-2","key":"e_1_3_4_63_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s10578-017-0776-2","key":"e_1_3_4_64_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s10802-013-9753-9","key":"e_1_3_4_65_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s10802-017-0338-x","key":"e_1_3_4_66_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s10802-013-9843-8","key":"e_1_3_4_67_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1080/15374410701818681","key":"e_1_3_4_68_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1177/1087054721997553","key":"e_1_3_4_69_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1080/07317107.2018.1522152","key":"e_1_3_4_70_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/978-1-4757-0345-0_9","key":"e_1_3_4_71_1","year":"1994","issue":null,"author":"Rapport M. D.","volume":null,"first-page":"189","unstructured":"Rapport, M. D. (1994). Attention deficit hyperactivity disorder. In M. Hersen & V. B. Van Hasselt (Eds.), Advanced abnormal psychology (pp. 189–206). Plenum Press.","article-title":null,"journal-title":null,"doi-asserted-by":"crossref"},{"DOI":null,"key":"e_1_3_4_72_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"R Core Team. (2022). R: A language and environment for statistical computing. R Foundation for Statistical Computing. URL https://www.R-project.org/","article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":null,"key":"e_1_3_4_73_1","year":"2004","issue":null,"author":"Reynolds C. R.","volume":null,"first-page":null,"unstructured":"Reynolds, C. R., & Kamphaus, R. W. (2004). BASC-2: Behavior assessment system for children (2nd ed.). Pearson.","article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":null,"key":"e_1_3_4_74_1","year":"1975","issue":"5","author":"Rogoff B.","volume":"18","first-page":"353","unstructured":"Rogoff, B., Sellers, M. J., Pirrotta, S., Fox, N., & White, S. H. (1975). Age of assignment of roles and responsibilities to children: A cross-cultural survey. Human Development, 18(5), 353–369.","article-title":"Age of assignment of roles and responsibilities to children: A cross-cultural survey","journal-title":"Human Development","doi-asserted-by":null},{"DOI":"10.1177/2515245917745629","key":"e_1_3_4_75_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1080/15374416.2016.1266644","key":"e_1_3_4_76_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s10862-021-09892-1","key":"e_1_3_4_77_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_3_4_78_1","year":"2016","issue":null,"author":"Sattler J. M.","volume":null,"first-page":null,"unstructured":"Sattler, J. M., Dumont, R., & Coalson, D. L. (2016). Assessment of children: WISC-V and WPPSI-IV. M, Sattler Jerome Publisher, Incorporated.","article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.1177/1087054708320403","key":"e_1_3_4_79_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_3_4_80_1","year":"2015","issue":"1","author":"Soucisse M. M.","volume":"41","first-page":"27","unstructured":"Soucisse, M. M., Maisonneuve, M. F., & Normand, S. (2015). Friendship problems in children with ADHD: What do we know and what can we do. Perspectives on Language and Literacy, 41(1), 27.","article-title":"Friendship problems in children with ADHD: What do we know and what can we do","journal-title":"Perspectives on Language and Literacy","doi-asserted-by":null},{"DOI":"10.1111/bjc.12398","key":"e_1_3_4_81_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1002/14651858.CD008223.pub3","key":"e_1_3_4_82_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1080/08039488.2020.1867634","key":"e_1_3_4_83_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1177/1087054716652476","key":"e_1_3_4_84_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1002/pits.10148","key":"e_1_3_4_85_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/j.1365-2214.2008.00869.x","key":"e_1_3_4_86_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s10802-014-9883-8","key":"e_1_3_4_87_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1080/15374416.2010.517172","key":"e_1_3_4_88_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s10654-019-00494-6","key":"e_1_3_4_89_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3389/fpsyg.2017.01157","key":"e_1_3_4_90_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s10578-013-0405-7","key":"e_1_3_4_91_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_3_4_92_1","year":"2014","issue":null,"author":"Wechsler D.","volume":null,"first-page":null,"unstructured":"Wechsler, D. (2014). Wechsler intelligence scale for children (5th ed.). Pearson.","article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.18637/jss.v021.i12","key":"e_1_3_4_93_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1146/annurev.med.53.082901.103945","key":"e_1_3_4_94_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s13311-012-0135-8","key":"e_1_3_4_95_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s10567-019-00291-3","key":"e_1_3_4_96_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1037/fam0000674","key":"e_1_3_4_97_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1177/25152459221095823","key":"e_1_3_4_98_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"}],"short-title":[],"update-policy":"https://doi.org/10.1080/tandf_crossmark_01","alternative-id":["10.1080/15374416.2026.2660291"],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"original-title":[],"container-title":["Journal of Clinical Child & Adolescent Psychology"],"reference-count":97,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2026,5,5]]},"references-count":97,"short-container-title":["Journal of Clinical Child & Adolescent Psychology"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1080/15374416.2026.2660291","is_oa":false,"title":"Are Social Problems in Children with ADHD Due to Knowledge Gaps or Performance Difficulties? An Examination of Competing Model Predictions","updated":"2026-05-06T13:23:02+00:00","published_date":"2026-05-05","best_oa_location":null}},"created_at":"2026-05-14T15:13:26.918Z","updated_at":"2026-05-14T15:13:26.918Z","tags":[{"paper_doi":"10.1080/15374416.2026.2660291","tag_type":"age_group","value":"pediatric","value_numeric":null},{"paper_doi":"10.1080/15374416.2026.2660291","tag_type":"category","value":"Psychology, Clinical","value_numeric":null},{"paper_doi":"10.1080/15374416.2026.2660291","tag_type":"condition","value":"Attention-Deficit/Hyperactivity Disorder","value_numeric":null},{"paper_doi":"10.1080/15374416.2026.2660291","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.1080/15374416.2026.2660291","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1080/15374416.2026.2660291","tag_type":"study_design","value":"Cross-Sectional","value_numeric":null},{"paper_doi":"10.1080/15374416.2026.2660291","tag_type":"warning","value":"Findings rely on parent/teacher perceptions; objective measures are not detailed in the provided text.","value_numeric":null},{"paper_doi":"10.1080/15374416.2026.2660291","tag_type":"warning","value":"Sample size and statistical details (e.g., effect sizes, p values) are not provided in the excerpt.","value_numeric":null},{"paper_doi":"10.1080/15374416.2026.2660291","tag_type":"warning","value":"Study design is inferred as a cross-sectional comparison; full methods are not described.","value_numeric":null}],"summaries":{"what_studied":"Compared social knowledge (acquisition) versus in-the-moment performance of social skills in children aged 8–13 with ADHD versus peers without ADHD, using parent and teacher reports across domains (communication, cooperation, empathy, responsibility, self-control).","key_result":"Fewer than 15% of children with ADHD were perceived as missing any specific social skill. Performance difficulties were common and occurred at significantly higher rates than in non-ADHD peers across these domains, according to both parents and teachers.","limitations":"Findings are based on parent and teacher perceptions rather than direct observation or testing. The clinically evaluated sample of 8–13-year-olds may limit generalizability.","practice_takeaway":"For school-age children with ADHD, prioritize interventions that help children perform known social skills in real time rather than teaching basic social skills, as knowledge gaps appear uncommon (<15%)."}},{"doi":"10.1016/j.psyneuen.2026.107871","pmid":"42068784","title":"Association of ADHD symptoms with the interactions within and between the HPA axis and melatonin system characterized by hair-based biomarkers","journal_title":"Psychoneuroendocrinology","journal_issn":"0306-4530","published_at":"2026-05-03T00:00:00.000Z","url":"https://doi.org/10.1016/j.psyneuen.2026.107871","source_score":8,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2026-05-08","doi":"10.1016/j.psyneuen.2026.107871","days":"7","issn":"0306-4530","rank":"9","field":"Clinical Medicine","score":"8","category":"Endocrinology & Metabolism","categories":["Endocrinology & Metabolism"],"_categories":["Endocrinology & Metabolism"]},"pubmed":{"doi":"10.1016/j.psyneuen.2026.107871","title":"Association of ADHD symptoms with the interactions within and between the HPA axis and melatonin system characterized by hair-based biomarkers.","journal":"Psychoneuroendocrinology","methods":"","results":"Oppositional symptoms showed significantly positive association with the MEL/NAS ratio (p < 0.05). After demographic variables and oppositional symptoms were controlled, hyperactivity/impulsivity showed significantly positive association with the F/NAS and E/NAS ratios (ps < 0.05), but it was not observed for inattention.","abstract":"$34","keywords":["ADHD","Core Symptoms","HPA Axis","Hair Hormone Ratios","MEL-NAS System","Neuroendocrine Imbalance"],"pubmed_id":"42068784","conclusions":"The clinical heterogeneity of ADHD core symptoms is underpinned by distinct neuroendocrine network imbalances. There was the function dominance of stress-related signaling over the NAS-mediated neuroprotection underlying the hyperactivity/impulsivity. Additionally, there was a disturbance in circadian metabolic homeostasis underlying the oppositional symptoms.","publication_date":"2026-05-03T00:00:00"},"crossref":{"DOI":"10.1016/j.psyneuen.2026.107871","URL":"https://doi.org/10.1016/j.psyneuen.2026.107871","ISSN":["0306-4530"],"link":[{"URL":"https://api.elsevier.com/content/article/PII:S0306453026001319?httpAccept=text/xml","content-type":"text/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https://api.elsevier.com/content/article/PII:S0306453026001319?httpAccept=text/plain","content-type":"text/plain","content-version":"vor","intended-application":"text-mining"}],"page":"107871","type":"journal-article","issue":null,"score":1,"title":["Association of ADHD symptoms with the interactions within and between the HPA axis and melatonin system characterized by hair-based biomarkers"],"author":[{"given":"Sanjun","family":"Yi","sequence":"first","affiliation":[]},{"given":"Xuliang","family":"Hou","sequence":"additional","affiliation":[]},{"given":"Guirong","family":"Xu","sequence":"additional","affiliation":[]},{"given":"Ting","family":"Zhai","sequence":"additional","affiliation":[]},{"given":"Xin","family":"Zhong","sequence":"additional","affiliation":[]},{"given":"Wei","family":"Gao","sequence":"additional","affiliation":[]},{"given":"Huihua","family":"Deng","sequence":"additional","affiliation":[]}],"issued":{"date-parts":[[2026,7]]},"member":"78","prefix":"10.1016","source":"Crossref","volume":"189","created":{"date-time":"2026-04-30T05:02:33Z","timestamp":1777525353000,"date-parts":[[2026,4,30]]},"indexed":{"date-time":"2026-05-04T15:03:26Z","timestamp":1777907006331,"date-parts":[[2026,5,4]]},"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","start":{"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000,"date-parts":[[2026,7,1]]},"delay-in-days":0,"content-version":"tdm"},{"URL":"https://www.elsevier.com/legal/tdmrep-license","start":{"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000,"date-parts":[[2026,7,1]]},"delay-in-days":0,"content-version":"tdm"},{"URL":"https://doi.org/10.15223/policy-017","start":{"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000,"date-parts":[[2026,7,1]]},"delay-in-days":0,"content-version":"stm-asf"},{"URL":"https://doi.org/10.15223/policy-037","start":{"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000,"date-parts":[[2026,7,1]]},"delay-in-days":0,"content-version":"stm-asf"},{"URL":"https://doi.org/10.15223/policy-012","start":{"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000,"date-parts":[[2026,7,1]]},"delay-in-days":0,"content-version":"stm-asf"},{"URL":"https://doi.org/10.15223/policy-029","start":{"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000,"date-parts":[[2026,7,1]]},"delay-in-days":0,"content-version":"stm-asf"},{"URL":"https://doi.org/10.15223/policy-004","start":{"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000,"date-parts":[[2026,7,1]]},"delay-in-days":0,"content-version":"stm-asf"}],"subject":[],"abstract":null,"language":"en","relation":{},"resource":{"primary":{"URL":"https://linkinghub.elsevier.com/retrieve/pii/S0306453026001319"}},"subtitle":[],"assertion":[{"name":"publisher","label":"This article is maintained by","value":"Elsevier"},{"name":"articletitle","label":"Article Title","value":"Association of ADHD symptoms with the interactions within and between the HPA axis and melatonin system characterized by hair-based biomarkers"},{"name":"journaltitle","label":"Journal Title","value":"Psychoneuroendocrinology"},{"name":"articlelink","label":"CrossRef DOI link to publisher maintained version","value":"https://doi.org/10.1016/j.psyneuen.2026.107871"},{"name":"content_type","label":"Content Type","value":"article"},{"name":"copyright","label":"Copyright","value":"© 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies."}],"deposited":{"date-time":"2026-05-01T13:28:13Z","timestamp":1777642093000,"date-parts":[[2026,5,1]]},"issn-type":[{"type":"print","value":"0306-4530"}],"published":{"date-parts":[[2026,7]]},"publisher":"Elsevier BV","reference":[{"DOI":"10.1016/j.brainres.2025.149461","key":"10.1016/j.psyneuen.2026.107871_bib1","year":"2025","issue":null,"author":"Algaidi","volume":"1851","first-page":null,"unstructured":null,"article-title":"Chronic stress-induced neuroplasticity in the prefrontal cortex: Structural, functional, and molecular mechanisms from development to aging","journal-title":"Brain Res.","doi-asserted-by":"crossref"},{"DOI":"10.1079/095442200108729052","key":"10.1016/j.psyneuen.2026.107871_bib2","year":"2000","issue":null,"author":"Allen","volume":"13","first-page":"159","unstructured":null,"article-title":"The effects of diet on circulating sex hormone levels in men","journal-title":"Nutr. Res. Rev.","doi-asserted-by":"crossref"},{"DOI":"10.1021/acs.jpcb.5b04920","key":"10.1016/j.psyneuen.2026.107871_bib3","year":"2015","issue":null,"author":"Álvarez-Diduk","volume":"119","first-page":"8535","unstructured":null,"article-title":"N-acetylserotonin and 6-hydroxymelatonin against oxidative stress: Implications for the overall protection exerted by melatonin","journal-title":"J. Phys. Chem. B","doi-asserted-by":"crossref"},{"DOI":"10.20945/2359-3997000000066","key":"10.1016/j.psyneuen.2026.107871_bib4","year":"2018","issue":null,"author":"Amaral","volume":"62","first-page":"472","unstructured":null,"article-title":"A brief review about melatonin, a pineal hormone","journal-title":"Arch. Endocrinol. Metab.","doi-asserted-by":"crossref"},{"DOI":"10.1080/07420528.2020.1835943","key":"10.1016/j.psyneuen.2026.107871_bib5","year":"2021","issue":null,"author":"van Andel","volume":"38","first-page":"260","unstructured":null,"article-title":"Effects of chronotherapy on circadian rhythm and ADHD symptoms in adults with attention-deficit/hyperactivity disorder and delayed sleep phase syndrome: A randomized clinical trial","journal-title":"Chronobiol. Int.","doi-asserted-by":"crossref"},{"DOI":"10.2174/1381612822666151214105314","key":"10.1016/j.psyneuen.2026.107871_bib6","year":"2016","issue":null,"author":"Anderson","volume":"22","first-page":"987","unstructured":null,"article-title":"Bipolar disorder: The role of the kynurenine and melatonergic pathways","journal-title":"Curr. Pharm. Des.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.msard.2014.12.001","key":"10.1016/j.psyneuen.2026.107871_bib7","year":"2015","issue":null,"author":"Anderson","volume":"4","first-page":"112","unstructured":null,"article-title":"Multiple sclerosis: The role of melatonin and N-acetylserotonin","journal-title":"Mult. Scler. Relat. Disord.","doi-asserted-by":"crossref"},{"DOI":"10.1038/nrn2648","key":"10.1016/j.psyneuen.2026.107871_bib8","year":"2009","issue":null,"author":"Arnsten","volume":"10","first-page":"410","unstructured":null,"article-title":"Stress signalling pathways that impair prefrontal cortex structure and function","journal-title":"Nat. Rev. Neurosci.","doi-asserted-by":"crossref"},{"DOI":"10.2147/CPT.S108750","key":"10.1016/j.psyneuen.2026.107871_bib9","year":"2017","issue":null,"author":"Beauvalet","volume":"7","first-page":"19","unstructured":null,"article-title":"Social jetlag in health and behavioral research: A systematic review","journal-title":"CPT","doi-asserted-by":"crossref"},{"DOI":null,"key":"10.1016/j.psyneuen.2026.107871_bib10","year":"2010","issue":null,"author":"Bendz","volume":"44","first-page":"185","unstructured":null,"article-title":"Melatonin treatment for insomnia in pediatric patients with attention-deficit/hyperactivity disorder","journal-title":"Ann. Pharm.","doi-asserted-by":null},{"DOI":"10.1038/s41398-024-02771-9","key":"10.1016/j.psyneuen.2026.107871_bib11","year":"2024","issue":null,"author":"Biener","volume":"14","first-page":"71","unstructured":null,"article-title":"Endocannabinoids, endocannabinoid-like compounds and cortisone in head hair of health care workers as markers of stress and resilience during the early COVID-19 pandemic","journal-title":"Transl. Psychiatry","doi-asserted-by":"crossref"},{"DOI":"10.1046/j.1365-2826.1997.00605.x","key":"10.1016/j.psyneuen.2026.107871_bib12","year":"1997","issue":null,"author":"Bierwolf","volume":"9","first-page":"479","unstructured":null,"article-title":"Slow wave sleep drives inhibition of pituitary-AdrenalSecretion in humans","journal-title":"J. Neuroendocrinol.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.jpsychires.2009.06.012","key":"10.1016/j.psyneuen.2026.107871_bib13","year":"2010","issue":null,"author":"Buckley","volume":"44","first-page":"69","unstructured":null,"article-title":"A pilot study of the phase angle between cortisol and melatonin in major depression – a potential biomarker?","journal-title":"J. Psychiatr. Res.","doi-asserted-by":"crossref"},{"DOI":"10.1177/1073191107313888","key":"10.1016/j.psyneuen.2026.107871_bib14","year":"2008","issue":null,"author":"Bussing","volume":"15","first-page":"317","unstructured":null,"article-title":"Parent and teacher SNAP-IV ratings of attention deficit/hyperactivity disorder symptoms: Psychometric properties and normative ratings from a school district sample","journal-title":"Assessment","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.brainres.2009.08.029","key":"10.1016/j.psyneuen.2026.107871_bib15","year":"2009","issue":null,"author":"Cao","volume":"1303","first-page":"195","unstructured":null,"article-title":"Abnormal resting-state functional connectivity patterns of the putamen in medication-naïve children with attention deficit hyperactivity disorder","journal-title":"Brain Res.","doi-asserted-by":"crossref"},{"DOI":"10.1111/cen.13391","key":"10.1016/j.psyneuen.2026.107871_bib16","year":"2017","issue":null,"author":"Ceccato","volume":"87","first-page":"500","unstructured":null,"article-title":"Diagnostic accuracy of increased urinary cortisol/cortisone ratio to differentiate ACTH-dependent cushing’s syndrome","journal-title":"Clin. Endocrinol.","doi-asserted-by":"crossref"},{"DOI":"10.1055/s-0034-1374609","key":"10.1016/j.psyneuen.2026.107871_bib17","year":"2014","issue":null,"author":"Chan","volume":"122","first-page":"356","unstructured":null,"article-title":"Measurement of cortisol and testosterone in hair of obese and non-obese human subjects","journal-title":"Exp. Clin. Endocrinol. Diabetes","doi-asserted-by":"crossref"},{"DOI":"10.1038/s41398-021-01550-0","key":"10.1016/j.psyneuen.2026.107871_bib18","year":"2021","issue":null,"author":"Chang","volume":"11","first-page":"430","unstructured":null,"article-title":"Cortisol and inflammatory biomarker levels in youths with attention deficit hyperactivity disorder (ADHD): Evidence from a systematic review with meta-analysis","journal-title":"Transl. Psychiatry","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.cnur.2020.10.012","key":"10.1016/j.psyneuen.2026.107871_bib19","year":"2021","issue":null,"author":"Chasens","volume":"56","first-page":"203","unstructured":null,"article-title":"Sleep and metabolic syndrome","journal-title":"Nurs. Clin. North Am.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.steroids.2019.05.010","key":"10.1016/j.psyneuen.2026.107871_bib20","year":"2019","issue":null,"author":"Chen","volume":"149","first-page":null,"unstructured":null,"article-title":"Determination, intercorrelation and intraindividual stability of five steroids in hair, saliva and urine among Chinese college students","journal-title":"Steroids","doi-asserted-by":"crossref"},{"DOI":"10.1177/070674370905401002","key":"10.1016/j.psyneuen.2026.107871_bib21","year":"2009","issue":null,"author":"Cherkasova","volume":"54","first-page":"651","unstructured":null,"article-title":"Neuroimaging in attention-deficit hyperactivity disorder: Beyond the frontostriatal circuitry","journal-title":"Can. J. Psychiatry Rev. Can. De. Psychiatr.","doi-asserted-by":"crossref"},{"DOI":"10.1093/ijnp/pyv027","key":"10.1016/j.psyneuen.2026.107871_bib22","year":"2015","issue":null,"author":"Corominas-Roso","volume":"18","first-page":null,"unstructured":null,"article-title":"Cortisol response to stress in adults with attention deficit hyperactivity disorder","journal-title":"Int. J. Neuropsychopharmacol.","doi-asserted-by":"crossref"},{"DOI":"10.1136/ebmental-2018-300050","key":"10.1016/j.psyneuen.2026.107871_bib23","year":"2018","issue":null,"author":"Cortese","volume":"21","first-page":"173","unstructured":null,"article-title":"Twenty years of research on attention-deficit/hyperactivity disorder (ADHD): Looking back, looking forward","journal-title":"Evid. -Based Ment. Health","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.psyneuen.2022.105802","key":"10.1016/j.psyneuen.2026.107871_bib24","year":"2022","issue":null,"author":"Del Giudice","volume":"142","first-page":null,"unstructured":null,"article-title":"Hormone ratios suffer from striking lack of robustness to measurement error","journal-title":"Psychoneuroendocrinology","doi-asserted-by":"crossref"},{"DOI":null,"key":"10.1016/j.psyneuen.2026.107871_bib25","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"Diagnostic and statistical manual of mental disorders | psychiatry online DSM Library. 〈https://www.psychiatryonline.org/doi/book/10.1176/appi.books.9780890425596〉.","article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.1016/j.biopsych.2008.05.022","key":"10.1016/j.psyneuen.2026.107871_bib26","year":"2008","issue":null,"author":"Fairchild","volume":"64","first-page":"599","unstructured":null,"article-title":"Cortisol diurnal rhythm and stress reactivity in male adolescents with early-onset or adolescence-onset conduct disorder","journal-title":"Biol. Psychiatry","doi-asserted-by":"crossref"},{"DOI":"10.1007/s13311-017-0600-5","key":"10.1016/j.psyneuen.2026.107871_bib27","year":"2018","issue":null,"author":"Farzi","volume":"15","first-page":"5","unstructured":null,"article-title":"Gut microbiota and the neuroendocrine system","journal-title":"Neurotherapeutics","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.pscychresns.2014.07.004","key":"10.1016/j.psyneuen.2026.107871_bib28","year":"2014","issue":null,"author":"Fernández-Jaén","volume":"224","first-page":"8","unstructured":null,"article-title":"Cortical thinning of temporal pole and orbitofrontal cortex in medication-naïve children and adolescents with ADHD","journal-title":"Psychiatry Res. Neuroimaging","doi-asserted-by":"crossref"},{"DOI":"10.1007/s12017-012-8202-1","key":"10.1016/j.psyneuen.2026.107871_bib29","year":"2013","issue":null,"author":"Fortier","volume":"15","first-page":"122","unstructured":null,"article-title":"Genetic evidence for the association of the hypothalamic–pituitary–adrenal (HPA) axis with ADHD and methylphenidate treatment response","journal-title":"Neuromol Med","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.psyneuen.2009.01.018","key":"10.1016/j.psyneuen.2026.107871_bib30","year":"2009","issue":null,"author":"Freitag","volume":"34","first-page":"1019","unstructured":null,"article-title":"Cortisol awakening response in healthy children and children with ADHD: Impact of comorbid disorders and psychosocial risk factors","journal-title":"Psychoneuroendocrinology","doi-asserted-by":"crossref"},{"DOI":"10.1186/s13075-016-1072-4","key":"10.1016/j.psyneuen.2026.107871_bib31","year":"2016","issue":null,"author":"Galbo","volume":"18","first-page":"174","unstructured":null,"article-title":"Circadian variations in clinical symptoms and concentrations of inflammatory cytokines, melatonin, and cortisol in polymyalgia rheumatica before and during prednisolone treatment: A controlled, observational, clinical experimental study","journal-title":"Arthritis Res. & Ther.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.psyneuen.2019.03.032","key":"10.1016/j.psyneuen.2026.107871_bib32","year":"2019","issue":null,"author":"Gao","volume":"106","first-page":"129","unstructured":null,"article-title":"Determination of thyroid hormones in human hair with online SPE LC–MS/MS: Analytical protocol and application in study of burnout","journal-title":"Psychoneuroendocrinology","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.talanta.2020.121006","key":"10.1016/j.psyneuen.2026.107871_bib33","year":"2020","issue":null,"author":"Gao","volume":"217","first-page":null,"unstructured":null,"article-title":"Determination of endocannabinoids and N-acylethanolamines in human hair with LC-MS/MS and their relation to symptoms of depression, burnout, and anxiety","journal-title":"Talanta","doi-asserted-by":"crossref"},{"DOI":"10.1002/mpr.237","key":"10.1016/j.psyneuen.2026.107871_bib34","year":"2008","issue":null,"author":"Gau","volume":"17","first-page":"35","unstructured":null,"article-title":"Psychometric properties of the Chinese version of the swanson, nolan, and pelham, version IV scale – parent form","journal-title":"Int. J. Methods Psychiatr. Res.","doi-asserted-by":"crossref"},{"DOI":"10.1037/0033-2909.133.1.149","key":"10.1016/j.psyneuen.2026.107871_bib35","year":"2007","issue":null,"author":"van Goozen","volume":"133","first-page":"149","unstructured":null,"article-title":"The evidence for a neurobiological model of childhood antisocial behavior","journal-title":"Psychol. Bull.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.jaac.2022.05.013","key":"10.1016/j.psyneuen.2026.107871_bib36","year":"2023","issue":null,"author":"Gosling","volume":"62","first-page":"244","unstructured":null,"article-title":"Association of parent-rated sleep disturbances with attention-deficit/hyperactivity disorder symptoms: 9-year follow-up of a population-based cohort study","journal-title":"J. Am. Acad. Child & Adolesc. Psychiatry","doi-asserted-by":"crossref"},{"DOI":null,"key":"10.1016/j.psyneuen.2026.107871_bib37","year":"2016","issue":null,"author":"Gregory","volume":"46","first-page":"284","unstructured":null,"article-title":"Associations between ADHD and sleep quality: Longitudinal analyses from a nationally-representative cohort of twins. Journal of clinical child and adolescent psychology: the official journal for the Society of Clinical Child and Adolescent Psychology","journal-title":"Am. Psychol. Assoc. Div. 53","doi-asserted-by":null},{"DOI":"10.1016/j.psyneuen.2008.10.026","key":"10.1016/j.psyneuen.2026.107871_bib38","year":"2009","issue":null,"author":"Hellhammer","volume":"34","first-page":"163","unstructured":null,"article-title":"Salivary cortisol as a biomarker in stress research","journal-title":"Psychoneuroendocrinology","doi-asserted-by":"crossref"},{"DOI":"10.1111/j.1600-079X.2009.00681.x","key":"10.1016/j.psyneuen.2026.107871_bib39","year":"2009","issue":null,"author":"Hoebert","volume":"47","first-page":"1","unstructured":null,"article-title":"Long-term follow-up of melatonin treatment in children with ADHD and chronic sleep onset insomnia","journal-title":"J. Pineal Res.","doi-asserted-by":"crossref"},{"DOI":null,"key":"10.1016/j.psyneuen.2026.107871_bib40","year":"2014","issue":null,"author":"Hoffman","volume":"37","first-page":null,"unstructured":null,"article-title":"Chemical processing and shampooing impact cortisol measured in human hair","journal-title":"Clin. Invest. Med. Med. Clin. Et. Exp.","doi-asserted-by":null},{"DOI":"10.1016/j.psyneuen.2024.107262","key":"10.1016/j.psyneuen.2026.107871_bib41","year":"2025","issue":null,"author":"Hou","volume":"172","first-page":null,"unstructured":null,"article-title":"Network analysis of the hair-based nine hormones from four neuroendocrine systems","journal-title":"Psychoneuroendocrinology","doi-asserted-by":"crossref"},{"DOI":"10.1111/j.1469-7610.2012.02526.x","key":"10.1016/j.psyneuen.2026.107871_bib42","year":"2012","issue":null,"author":"Imeraj","volume":"53","first-page":"782","unstructured":null,"article-title":"Time-of-day effects in arousal: Disrupted diurnal cortisol profiles in children with ADHD","journal-title":"J. Child Psychol. Psychiatry","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.jpsychires.2012.08.021","key":"10.1016/j.psyneuen.2026.107871_bib43","year":"2012","issue":null,"author":"Isaksson","volume":"46","first-page":"1398","unstructured":null,"article-title":"Cortisol levels in children with attention-deficit/hyperactivity disorder","journal-title":"J. Psychiatr. Res.","doi-asserted-by":"crossref"},{"DOI":"10.1210/jc.2018-02312","key":"10.1016/j.psyneuen.2026.107871_bib44","year":"2019","issue":null,"author":"Jayasuriya","volume":"104","first-page":"2355","unstructured":null,"article-title":"A lower maternal cortisol-to-cortisone ratio precedes clinical diagnosis of preterm and term preeclampsia by many weeks","journal-title":"J. Clin. Endocrinol. Metab.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.neuroscience.2023.02.017","key":"10.1016/j.psyneuen.2026.107871_bib45","year":"2023","issue":null,"author":"Kang","volume":"517","first-page":"18","unstructured":null,"article-title":"Neuroprotective effects of N-acetylserotonin and its derivative","journal-title":"Neuroscience","doi-asserted-by":"crossref"},{"DOI":"10.1159/000127186","key":"10.1016/j.psyneuen.2026.107871_bib46","year":"2008","issue":null,"author":"Kellner","volume":"65","first-page":"284","unstructured":null,"article-title":"Corticotropin-releasing hormone inhibits melatonin secretion in healthy volunteers – a potential link to low-melatonin syndrome in depression?","journal-title":"Neuroendocrinology","doi-asserted-by":"crossref"},{"DOI":"10.1016/B978-0-444-53702-7.00007-5","key":"10.1016/j.psyneuen.2026.107871_bib47","year":"2010","issue":null,"author":"Killgore","volume":"185","first-page":"105","unstructured":null,"article-title":"Effects of sleep deprivation on cognition","journal-title":"Prog. brain Res.","doi-asserted-by":"crossref"},{"DOI":"10.1016/S0006-3223(97)00507-6","key":"10.1016/j.psyneuen.2026.107871_bib48","year":"1998","issue":null,"author":"King","volume":"44","first-page":"72","unstructured":null,"article-title":"Attention-deficit hyperactivity disorder and the stress response","journal-title":"Biol. Psychiatry","doi-asserted-by":"crossref"},{"DOI":"10.3389/fendo.2019.00178","key":"10.1016/j.psyneuen.2026.107871_bib49","year":"2019","issue":null,"author":"Lauretta","volume":"10","first-page":"178","unstructured":null,"article-title":"Endocrine disrupting chemicals: Effects on endocrine glands","journal-title":"Front. Endocrinol.","doi-asserted-by":"crossref"},{"DOI":"10.1155/2019/4693817","key":"10.1016/j.psyneuen.2026.107871_bib50","year":"2019","issue":null,"author":"Liu","volume":"2019","first-page":null,"unstructured":null,"article-title":"Gender-specific independent and combined effects of the cortisol-to-cortisone ratio and 11-deoxycortisol on prediabetes and type 2 diabetes mellitus: From the henan rural cohort study","journal-title":"J. Diabetes Res.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.jpsychires.2022.02.041","key":"10.1016/j.psyneuen.2026.107871_bib51","year":"2022","issue":null,"author":"Llorens","volume":"149","first-page":"217","unstructured":null,"article-title":"Stress-related biomarkers and cognitive functioning in adolescents with ADHD: Effect of childhood maltreatment","journal-title":"J. Psychiatr. Res.","doi-asserted-by":"crossref"},{"DOI":"10.3389/fpsyt.2025.1697900","key":"10.1016/j.psyneuen.2026.107871_bib52","year":"2025","issue":null,"author":"Luu","volume":"16","first-page":null,"unstructured":null,"article-title":"ADHD as a circadian rhythm disorder: Evidence and implications for chronotherapy","journal-title":"Front. Psychiatry","doi-asserted-by":"crossref"},{"DOI":"10.3389/fpsyt.2024.1492126","key":"10.1016/j.psyneuen.2026.107871_bib53","year":"2024","issue":null,"author":"MacDonald","volume":"15","first-page":null,"unstructured":null,"article-title":"The dopamine hypothesis for ADHD: An evaluation of evidence accumulated from human studies and animal models","journal-title":"Front. Psychiatry","doi-asserted-by":"crossref"},{"DOI":"10.1093/cercor/bhl047","key":"10.1016/j.psyneuen.2026.107871_bib54","year":"2007","issue":null,"author":"Makris","volume":"17","first-page":"1364","unstructured":null,"article-title":"Cortical thinning of the attention and executive function networks in adults with attention-deficit/hyperactivity disorder","journal-title":"Cereb. Cortex","doi-asserted-by":"crossref"},{"DOI":null,"key":"10.1016/j.psyneuen.2026.107871_bib55","year":"2005","issue":null,"author":"Mazzoccoli","volume":"11","first-page":"CR284","unstructured":null,"article-title":"Melatonin and cortisol serum levels in lung cancer patients at different stages of disease","journal-title":"Med Sci. Monit.","doi-asserted-by":null},{"DOI":"10.1093/clinchem/36.1.70","key":"10.1016/j.psyneuen.2026.107871_bib56","year":"1990","issue":null,"author":"Meulenberg","volume":"36","first-page":"70","unstructured":null,"article-title":"Differences between concentrations of salivary cortisol and cortisone and of free cortisol and cortisone in plasma during pregnancy and postpartum","journal-title":"Clin. Chem.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.psyneuen.2022.105805","key":"10.1016/j.psyneuen.2026.107871_bib57","year":"2022","issue":null,"author":"Moody","volume":"142","first-page":null,"unstructured":null,"article-title":"Impact of hair type, hair sample weight, external hair exposures, and race on cumulative hair cortisol","journal-title":"Psychoneuroendocrinology","doi-asserted-by":"crossref"},{"DOI":"10.1037/a0018010","key":"10.1016/j.psyneuen.2026.107871_bib58","year":"2010","issue":null,"author":"Nikolas","volume":"119","first-page":"1","unstructured":null,"article-title":"Genetic and environmental influences on ADHD symptom dimensions of inattention and hyperactivity: A meta-analysis","journal-title":"J. Abnorm. Psychol.","doi-asserted-by":"crossref"},{"DOI":"10.1007/s00787-006-1003-z","key":"10.1016/j.psyneuen.2026.107871_bib59","year":"2006","issue":null,"author":"Nøvik","volume":"15","first-page":"i15","unstructured":null,"article-title":"Influence of gender on attention-deficit/hyperactivity disorder in europe – ADORE","journal-title":"Eur. Child Adolesc. Psychiatry","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.psychres.2015.08.044","key":"10.1016/j.psyneuen.2026.107871_bib60","year":"2015","issue":null,"author":"Palma","volume":"230","first-page":"227","unstructured":null,"article-title":"A four-year follow-up controlled study of stress response and symptom persistence in Brazilian children and adolescents with attention deficit disorder and hyperactivity (ADHD)","journal-title":"Psychiatry Res.","doi-asserted-by":"crossref"},{"DOI":"10.1037/ort0000424","key":"10.1016/j.psyneuen.2026.107871_bib61","year":"2020","issue":null,"author":"Palmer-Bacon","volume":"90","first-page":"193","unstructured":null,"article-title":"Stress, trauma, racial/ethnic group membership, and HPA function: Utility of hair cortisol","journal-title":"Am. J. Orthopsychiatry","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.pneurobio.2008.04.001","key":"10.1016/j.psyneuen.2026.107871_bib62","year":"2008","issue":null,"author":"Pandi-Perumal","volume":"85","first-page":"335","unstructured":null,"article-title":"Physiological effects of melatonin: Role of melatonin receptors and signal transduction pathways","journal-title":"Prog. Neurobiol.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.psyneuen.2019.104442","key":"10.1016/j.psyneuen.2026.107871_bib63","year":"2019","issue":null,"author":"Pauli-Pott","volume":"110","first-page":null,"unstructured":null,"article-title":"Low hair cortisol concentration predicts the development of attention deficit hyperactivity disorder","journal-title":"Psychoneuroendocrinology","doi-asserted-by":"crossref"},{"DOI":"10.3390/nu16101538","key":"10.1016/j.psyneuen.2026.107871_bib64","year":"2024","issue":null,"author":"Petropoulos","volume":"16","first-page":"1538","unstructured":null,"article-title":"Functional gastrointestinal symptoms in children with autism and ADHD: Profiles of hair and salivary cortisol, serum leptin concentrations and externalizing/internalizing problems","journal-title":"Nutrients","doi-asserted-by":"crossref"},{"DOI":"10.1007/s00702-016-1534-5","key":"10.1016/j.psyneuen.2026.107871_bib65","year":"2016","issue":null,"author":"Pinto","volume":"123","first-page":"991","unstructured":null,"article-title":"The aetiological association between the dynamics of cortisol productivity and ADHD","journal-title":"J. Neural Transm.","doi-asserted-by":"crossref"},{"DOI":"10.1176/ajp.2007.164.6.942","key":"10.1016/j.psyneuen.2026.107871_bib66","year":"2007","issue":null,"author":"Polanczyk","volume":"164","first-page":"942","unstructured":null,"article-title":"The worldwide prevalence of ADHD: A systematic review and metaregression analysis","journal-title":"AJP","doi-asserted-by":"crossref"},{"DOI":"10.1371/journal.pone.0291812","key":"10.1016/j.psyneuen.2026.107871_bib67","year":"2023","issue":null,"author":"Preinbergs","volume":"18","first-page":null,"unstructured":null,"article-title":"Effect of cosmetic hair treatment and natural hair colour on hair testosterone concentrations","journal-title":"PLOS ONE","doi-asserted-by":"crossref"},{"DOI":"10.1111/1469-7610.00034","key":"10.1016/j.psyneuen.2026.107871_bib68","year":"2002","issue":null,"author":"Raine","volume":"43","first-page":"417","unstructured":null,"article-title":"Annotation: The role of prefrontal deficits, low autonomic arousal, and early health factors in the development of antisocial and aggressive behavior in children","journal-title":"J. Child Psychol. Psychiatry","doi-asserted-by":"crossref"},{"DOI":"10.1007/s10578-007-0068-3","key":"10.1016/j.psyneuen.2026.107871_bib69","year":"2008","issue":null,"author":"Randazzo","volume":"39","first-page":"27","unstructured":null,"article-title":"The stress response in adolescents with inattentive type ADHD symptoms","journal-title":"Child Psychiatry Hum. Dev.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.cub.2012.03.038","key":"10.1016/j.psyneuen.2026.107871_bib70","year":"2012","issue":null,"author":"Roenneberg","volume":"22","first-page":"939","unstructured":null,"article-title":"Social jetlag and obesity","journal-title":"Curr. Biol.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.psyneuen.2011.09.009","key":"10.1016/j.psyneuen.2026.107871_bib71","year":"2012","issue":null,"author":"Russell","volume":"37","first-page":"589","unstructured":null,"article-title":"Hair cortisol as a biological marker of chronic stress: Current status, future directions and unanswered questions","journal-title":"Psychoneuroendocrinology","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.psyneuen.2016.05.021","key":"10.1016/j.psyneuen.2026.107871_bib72","year":"2016","issue":null,"author":"Salis","volume":"71","first-page":"147","unstructured":null,"article-title":"Examining the concurrent and longitudinal relationship between diurnal cortisol rhythms and conduct problems during childhood","journal-title":"Psychoneuroendocrinology","doi-asserted-by":"crossref"},{"DOI":"10.1001/archpsyc.1974.01760180079010","key":"10.1016/j.psyneuen.2026.107871_bib73","year":"1974","issue":null,"author":"Satterfield","volume":"31","first-page":"839","unstructured":null,"article-title":"Pathophysiology of the hyperactive child syndrome","journal-title":"Arch. Gen. Psychiatry","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.psyneuen.2020.105125","key":"10.1016/j.psyneuen.2026.107871_bib74","year":"2021","issue":null,"author":"Shimanoe","volume":"125","first-page":null,"unstructured":null,"article-title":"Perceived stress, depressive symptoms, and cortisol-to-cortisone ratio in spot urine in 6878 older adults","journal-title":"Psychoneuroendocrinology","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.pscychresns.2008.07.003","key":"10.1016/j.psyneuen.2026.107871_bib75","year":"2009","issue":null,"author":"Silk","volume":"172","first-page":"220","unstructured":null,"article-title":"Structural development of the basal ganglia in attention deficit hyperactivity disorder: A diffusion tensor imaging study","journal-title":"Psychiatry Res. Neuroimaging","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.psyneuen.2011.09.001","key":"10.1016/j.psyneuen.2026.107871_bib76","year":"2012","issue":null,"author":"Skoluda","volume":"37","first-page":"611","unstructured":null,"article-title":"Elevated hair cortisol concentrations in endurance athletes","journal-title":"Psychoneuroendocrinology","doi-asserted-by":"crossref"},{"DOI":null,"key":"10.1016/j.psyneuen.2026.107871_bib77","year":"2014","issue":null,"author":"Snitselaar","volume":null,"first-page":"379","unstructured":null,"article-title":"Sleep, melatonin, and circadian rhythmicity in attention deficit hyperactivity disorder","journal-title":null,"doi-asserted-by":null},{"DOI":"10.1016/j.psyneuen.2015.09.031","key":"10.1016/j.psyneuen.2026.107871_bib78","year":"2016","issue":null,"author":"Sollberger","volume":"63","first-page":"385","unstructured":null,"article-title":"How to use and interpret hormone ratios","journal-title":"Psychoneuroendocrinology","doi-asserted-by":"crossref"},{"DOI":"10.5604/01.3001.0012.1971","key":"10.1016/j.psyneuen.2026.107871_bib79","year":"2018","issue":null,"author":"Sroykham","volume":"16","first-page":"177","unstructured":null,"article-title":"Correlation of morning salivary cortisol-melatonin ratio with qeeg and delayed recall in aging","journal-title":"Acta Neuropsychol.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.psyneuen.2016.12.017","key":"10.1016/j.psyneuen.2026.107871_bib80","year":"2017","issue":null,"author":"Stalder","volume":"77","first-page":"261","unstructured":null,"article-title":"Stress-related and basic determinants of hair cortisol in humans: A meta-analysis","journal-title":"Psychoneuroendocrinology","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.neubiorev.2021.04.034","key":"10.1016/j.psyneuen.2026.107871_bib81","year":"2021","issue":null,"author":"Sumsuzzman","volume":"127","first-page":"459","unstructured":null,"article-title":"Neurocognitive effects of melatonin treatment in healthy adults and individuals with alzheimer’s disease and insomnia: A systematic review and meta-analysis of randomized controlled trials","journal-title":"Neurosci. & Biobehav. Rev.","doi-asserted-by":"crossref"},{"DOI":"10.3390/molecules201018886","key":"10.1016/j.psyneuen.2026.107871_bib82","year":"2015","issue":null,"author":"Tan","volume":"20","first-page":"18886","unstructured":null,"article-title":"Melatonin as a potent and inducible endogenous antioxidant: Synthesis and metabolism","journal-title":"Molecules","doi-asserted-by":"crossref"},{"DOI":"10.1007/s41252-020-00156-9","key":"10.1016/j.psyneuen.2026.107871_bib83","year":"2020","issue":null,"author":"Taylor","volume":"4","first-page":"227","unstructured":null,"article-title":"Emotion dysregulation and sluggish cognitive tempo as moderators of cortisol responsivity in children with ADHD","journal-title":"Adv. Neurodev. Disord.","doi-asserted-by":"crossref"},{"DOI":null,"key":"10.1016/j.psyneuen.2026.107871_bib84","year":"2012","issue":null,"author":"Tosini","volume":"18","first-page":"645","unstructured":null,"article-title":"N-acetylserotonin: Neuroprotection, neurogenesis, and the sleepy brain","journal-title":"Neurosci. a Rev. J. bringing Neurobiol. Neurol. Psychiatry","doi-asserted-by":null},{"DOI":"10.1016/j.lfs.2017.02.008","key":"10.1016/j.psyneuen.2026.107871_bib85","year":"2017","issue":null,"author":"Touitou","volume":"173","first-page":"94","unstructured":null,"article-title":"Association between light at night, melatonin secretion, sleep deprivation, and the internal clock: Health impacts and mechanisms of circadian disruption","journal-title":"Life Sci.","doi-asserted-by":"crossref"},{"DOI":"10.2174/1570159X20666220420122322","key":"10.1016/j.psyneuen.2026.107871_bib86","year":"2022","issue":null,"author":"Tseng","volume":"20","first-page":"1816","unstructured":null,"article-title":"The dose and duration-dependent association between melatonin treatment and overall cognition in alzheimer’s dementia: A network meta-analysis of randomized placebo-controlled trials","journal-title":"Curr. Neuropharmacol.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.steroids.2019.108547","key":"10.1016/j.psyneuen.2026.107871_bib87","year":"2020","issue":null,"author":"Voegel","volume":"154","first-page":null,"unstructured":null,"article-title":"Endogenous steroid hormones in hair: Investigations on different hair types, pigmentation effects and correlation to nails","journal-title":"Steroids","doi-asserted-by":"crossref"},{"DOI":"10.1016/S0379-0738(99)00146-2","key":"10.1016/j.psyneuen.2026.107871_bib88","year":"2000","issue":null,"author":"Wennig","volume":"107","first-page":"5","unstructured":null,"article-title":"Potential problems with the interpretation of hair analysis results","journal-title":"Forensic Sci. Int.","doi-asserted-by":"crossref"},{"DOI":"10.1677/joe.0.159r005","key":"10.1016/j.psyneuen.2026.107871_bib89","year":"1998","issue":null,"author":"Wheeler","volume":"159","first-page":"R5","unstructured":null,"article-title":"The measurement of testosterone in hair","journal-title":"J. Endocrinol.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.clinimag.2017.07.009","key":"10.1016/j.psyneuen.2026.107871_bib90","year":"2018","issue":null,"author":"Yang","volume":"47","first-page":"47","unstructured":null,"article-title":"Altered patterns of resting-state functional connectivity between the caudate and other brain regions in medication-naïve children with attention deficit hyperactivity disorder","journal-title":"Clin. Imaging","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.jpba.2015.09.028","key":"10.1016/j.psyneuen.2026.107871_bib91","year":"2016","issue":null,"author":"Zhao","volume":"117","first-page":"390","unstructured":null,"article-title":"A novel LC–MS/MS assay for the simultaneous determination of melatonin and its two major metabolites, 6-hydroxymelatonin and 6-sulfatoxymelatonin in dog plasma: Application to a pharmacokinetic study","journal-title":"J. Pharm. Biomed. Anal.","doi-asserted-by":"crossref"},{"DOI":null,"key":"10.1016/j.psyneuen.2026.107871_bib92","year":"2013","issue":null,"author":"Zhou","volume":"27","first-page":"424","unstructured":null,"article-title":"Reliability and validity of the Chinese version of Swanson, Nolan, and Pelham Version IV Rating Scale-Parent Form for attention-deficit/hyperactivity disorder","journal-title":"Chin. Ment. Health J.","doi-asserted-by":null},{"DOI":"10.1523/JNEUROSCI.1948-13.2014","key":"10.1016/j.psyneuen.2026.107871_bib93","year":"2014","issue":null,"author":"Zhou","volume":"34","first-page":"2967","unstructured":null,"article-title":"N-acetyl-serotonin offers neuroprotection through inhibiting mitochondrial death pathways and autophagic activation in experimental models of ischemic injury","journal-title":"J. Neurosci.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.jchromb.2022.123217","key":"10.1016/j.psyneuen.2026.107871_bib94","year":"2022","issue":null,"author":"Zhu","volume":"1196","first-page":null,"unstructured":null,"article-title":"Simultaneous LC-MS/MS quantification of glucocorticoids, melatonin and its metabolites in hair","journal-title":"J. Chromatogr. B","doi-asserted-by":"crossref"}],"short-title":[],"update-policy":"https://doi.org/10.1016/elsevier_cm_policy","alternative-id":["S0306453026001319"],"article-number":"107871","content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"original-title":[],"container-title":["Psychoneuroendocrinology"],"published-print":{"date-parts":[[2026,7]]},"reference-count":94,"published-online":null,"references-count":94,"special_numbering":"C","short-container-title":["Psychoneuroendocrinology"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1016/j.psyneuen.2026.107871","is_oa":false,"title":"Association of ADHD symptoms with the interactions within and between the HPA axis and melatonin system characterized by hair-based biomarkers","updated":"2026-05-05T11:59:32+00:00","published_date":"2026-04-30","best_oa_location":null}},"created_at":"2026-05-14T13:22:47.849Z","updated_at":"2026-05-14T15:13:26.918Z","tags":[{"paper_doi":"10.1016/j.psyneuen.2026.107871","tag_type":"age_group","value":"child","value_numeric":null},{"paper_doi":"10.1016/j.psyneuen.2026.107871","tag_type":"category","value":"Endocrinology & Metabolism","value_numeric":null},{"paper_doi":"10.1016/j.psyneuen.2026.107871","tag_type":"condition","value":"Attention Deficit Hyperactivity Disorder","value_numeric":null},{"paper_doi":"10.1016/j.psyneuen.2026.107871","tag_type":"condition","value":"Attention-Deficit/Hyperactivity Disorder","value_numeric":null},{"paper_doi":"10.1016/j.psyneuen.2026.107871","tag_type":"generic","value":"cortisol","value_numeric":null},{"paper_doi":"10.1016/j.psyneuen.2026.107871","tag_type":"generic","value":"cortisone","value_numeric":null},{"paper_doi":"10.1016/j.psyneuen.2026.107871","tag_type":"generic","value":"melatonin","value_numeric":null},{"paper_doi":"10.1016/j.psyneuen.2026.107871","tag_type":"generic","value":"N-acetylserotonin","value_numeric":null},{"paper_doi":"10.1016/j.psyneuen.2026.107871","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1016/j.psyneuen.2026.107871","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.1016/j.psyneuen.2026.107871","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1016/j.psyneuen.2026.107871","tag_type":"modality","value":"Neuroendocrine Biomarker","value_numeric":null},{"paper_doi":"10.1016/j.psyneuen.2026.107871","tag_type":"sample_size","value":"n=106","value_numeric":106},{"paper_doi":"10.1016/j.psyneuen.2026.107871","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1016/j.psyneuen.2026.107871","tag_type":"study_design","value":"Cross-Sectional","value_numeric":null},{"paper_doi":"10.1016/j.psyneuen.2026.107871","tag_type":"study_design","value":"Cross-Sectional Study","value_numeric":null},{"paper_doi":"10.1016/j.psyneuen.2026.107871","tag_type":"warning","value":"A control group is not described; associations appear within an ADHD-only sample.","value_numeric":null},{"paper_doi":"10.1016/j.psyneuen.2026.107871","tag_type":"warning","value":"DSM-IV criteria were used for diagnosis; findings may not fully align with DSM-5 ADHD classifications.","value_numeric":null},{"paper_doi":"10.1016/j.psyneuen.2026.107871","tag_type":"warning","value":"Medication status (e.g., stimulant use) is not addressed in the abstract, which could confound hair hormone levels.","value_numeric":null},{"paper_doi":"10.1016/j.psyneuen.2026.107871","tag_type":"warning","value":"Only p-values are provided in the abstract; no effect sizes are reported.","value_numeric":null},{"paper_doi":"10.1016/j.psyneuen.2026.107871","tag_type":"warning","value":"Oppositional symptoms are included in the SNAP-IV but are not a core DSM ADHD criterion; the overlap with Oppositional Defiant Disorder is not discussed.","value_numeric":null},{"paper_doi":"10.1016/j.psyneuen.2026.107871","tag_type":"warning","value":"Sex distribution is not reported in the abstract.","value_numeric":null},{"paper_doi":"10.1016/j.psyneuen.2026.107871","tag_type":"warning","value":"The sample is exclusively Chinese children from a single site, limiting ethnic and geographic generalizability.","value_numeric":null}],"summaries":{"practice_takeaway":"ADHD symptom domains may map onto distinct neuroendocrine imbalances — hyperactivity/impulsivity linked to HPA-over-NAS dominance and oppositional symptoms to circadian metabolic disruption — suggesting future targeted biomarker-guided approaches. Clinicians should be aware these are exploratory associations and not yet ready for clinical application.","what_studied":"Cross-sectional study of 106 Chinese children (6–12 years) with physician-diagnosed ADHD (DSM-IV) examining associations between parent-rated SNAP-IV symptom domains and hair biomarkers of the HPA axis (cortisol, cortisone) and melatonin system (melatonin, N-acetylserotonin) measured by LC-MS/MS.","key_result":"Oppositional symptoms were positively associated with the melatonin/N-acetylserotonin (MEL/NAS) ratio (p<0.05). After adjusting for demographics and oppositional symptoms, hyperactivity/impulsivity was positively associated with cortisol/NAS and cortisone/NAS ratios (ps<0.05); no association was seen for inattention.","limitations":"- Cross-sectional design limits causal inference.\n- Outcomes were parent-reported (SNAP-IV).\n- Sample restricted to Chinese children aged 6–12 years, which may limit generalizability."}},{"doi":"10.1038/s41593-026-02290-4","pmid":"42067701","title":"A communication subspace relays context-dependent actions from human prefrontal to motor cortex","journal_title":"Nature Neuroscience","journal_issn":"1097-6256","published_at":"2026-05-02T00:00:00.000Z","url":"https://doi.org/10.1038/s41593-026-02290-4","source_score":49,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2026-05-09","doi":"10.1038/s41593-026-02290-4","days":"7","issn":"1097-6256","rank":"10","field":"Clinical Medicine","score":"49","category":"Neurosciences","categories":["Neurosciences"],"_categories":["Neurosciences"]},"pubmed":{"doi":"10.1038/s41593-026-02290-4","title":"A communication subspace relays context-dependent actions from human prefrontal to motor cortex.","journal":"Nature neuroscience","methods":"","results":"","abstract":"$35","keywords":[],"pubmed_id":"42067701","conclusions":"","publication_date":"2026-05-02T00:00:00"},"crossref":{"DOI":"10.1038/s41593-026-02290-4","URL":"https://doi.org/10.1038/s41593-026-02290-4","ISSN":["1097-6256","1546-1726"],"link":[{"URL":"https://www.nature.com/articles/s41593-026-02290-4.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://www.nature.com/articles/s41593-026-02290-4","content-type":"text/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https://www.nature.com/articles/s41593-026-02290-4.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["A communication subspace relays context-dependent actions from human prefrontal to motor cortex"],"author":[{"given":"Neha","family":"Binish","sequence":"first","affiliation":[]},{"given":"Jonas","family":"Terlau","sequence":"additional","affiliation":[]},{"given":"Jan","family":"Martini","sequence":"additional","affiliation":[]},{"given":"Jack J.","family":"Lin","sequence":"additional","affiliation":[]},{"given":"Robert T.","family":"Knight","sequence":"additional","affiliation":[]},{"given":"Randolph F.","family":"Helfrich","sequence":"additional","affiliation":[]}],"funder":[{"id":[{"id":"10.13039/501100001659","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/501100001659","name":"Deutsche Forschungsgemeinschaft","award":["HE8329/2-1"],"award-info":[{"award-number":["HE8329/2-1"]}],"doi-asserted-by":"publisher"},{"id":[{"id":"10.13039/100000002","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","award":["U19NS107609"],"award-info":[{"award-number":["U19NS107609"]}],"doi-asserted-by":"publisher"},{"id":[{"id":"10.13039/100000002","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/100000002","name":"U.S. Department of Health & Human Services | National Institutes of Health","award":["U19NS107609"],"award-info":[{"award-number":["U19NS107609"]}],"doi-asserted-by":"publisher"},{"id":[{"id":"10.13039/100000065","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/100000065","name":"U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke","award":["2R01NS021135"],"award-info":[{"award-number":["2R01NS021135"]}],"doi-asserted-by":"publisher"}],"issued":{"date-parts":[[2026,5,1]]},"member":"297","prefix":"10.1038","source":"Crossref","volume":null,"created":{"date-time":"2026-05-01T09:02:09Z","timestamp":1777626129000,"date-parts":[[2026,5,1]]},"indexed":{"date-time":"2026-05-04T12:25:23Z","timestamp":1777897523802,"date-parts":[[2026,5,4]]},"license":[{"URL":"https://www.springernature.com/gp/researchers/text-and-data-mining","start":{"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000,"date-parts":[[2026,5,1]]},"delay-in-days":0,"content-version":"tdm"},{"URL":"https://www.springernature.com/gp/researchers/text-and-data-mining","start":{"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000,"date-parts":[[2026,5,1]]},"delay-in-days":0,"content-version":"vor"}],"subject":[],"abstract":null,"language":"en","relation":{},"resource":{"primary":{"URL":"https://www.nature.com/articles/s41593-026-02290-4"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"ArticleHistory","label":"Article History"},"label":"Received","order":1,"value":"8 May 2025"},{"name":"accepted","group":{"name":"ArticleHistory","label":"Article History"},"label":"Accepted","order":2,"value":"1 April 2026"},{"name":"first_online","group":{"name":"ArticleHistory","label":"Article History"},"label":"First Online","order":3,"value":"1 May 2026"},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"},"order":1,"value":"J.M. is currently employed by Springer Nature. However, this employment began after the completion of his contribution to this research and did not influence the study design, data collection, analysis, manuscript preparation or the decision to submit the article for publication. The other authors declare no competing interests."}],"deposited":{"date-time":"2026-05-01T09:02:12Z","timestamp":1777626132000,"date-parts":[[2026,5,1]]},"issn-type":[{"type":"print","value":"1097-6256"},{"type":"electronic","value":"1546-1726"}],"published":{"date-parts":[[2026,5,1]]},"publisher":"Springer Science and Business Media LLC","reference":[{"DOI":"10.1146/annurev.neuro.24.1.167","key":"2290_CR1","year":"2001","issue":null,"author":"EK Miller","volume":"24","first-page":"167","unstructured":"Miller, E. K. et al. An integrative theory of prefrontal cortex function. Annu. Rev. Neurosci. 24, 167–202 (2001).","article-title":null,"journal-title":"Annu. Rev. Neurosci.","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.cobeha.2020.07.002","key":"2290_CR2","year":"2021","issue":null,"author":"D Badre","volume":"38","first-page":"20","unstructured":"Badre, D. et al. The dimensionality of neural representations for control. Curr. Opin. Behav. Sci. 38, 20–28 (2021).","article-title":null,"journal-title":"Curr. Opin. Behav. Sci.","doi-asserted-by":"publisher"},{"DOI":"10.1038/nature12742","key":"2290_CR3","year":"2013","issue":null,"author":"V Mante","volume":"503","first-page":"78","unstructured":"Mante, V. et al. Context-dependent computation by recurrent dynamics in prefrontal cortex. Nature 503, 78–84 (2013).","article-title":null,"journal-title":"Nature","doi-asserted-by":"publisher"},{"DOI":"10.1038/nrn3838","key":"2290_CR4","year":"2014","issue":null,"author":"C Summerfield","volume":"15","first-page":"745","unstructured":"Summerfield, C. et al. Expectation in perceptual decision making: neural and computational mechanisms. Nat. Rev. Neurosci. 15, 745–756 (2014).","article-title":null,"journal-title":"Nat. Rev. Neurosci.","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.tics.2018.06.002","key":"2290_CR5","year":"2018","issue":null,"author":"FP De Lange","volume":"22","first-page":"764","unstructured":"De Lange, F. P. et al. How do expectations shape perception? Trends Cogn. Sci. 22, 764–779 (2018).","article-title":null,"journal-title":"Trends Cogn. Sci.","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.tics.2016.09.007","key":"2290_CR6","year":"2016","issue":null,"author":"RF Helfrich","volume":"20","first-page":"916","unstructured":"Helfrich, R. F. et al. Oscillatory dynamics of prefrontal cognitive control. Trends Cogn. Sci. 20, 916–916 (2016).","article-title":null,"journal-title":"Trends Cogn. Sci.","doi-asserted-by":"publisher"},{"DOI":"10.1146/annurev.ne.11.030188.001033","key":"2290_CR7","year":"1988","issue":null,"author":"PS Goldman-Rakic","volume":"11","first-page":"137","unstructured":"Goldman-Rakic, P. S. Topography of cognition: parallel distributed networks in primate association cortex. Annu. Rev. Neurosci. 11, 137–156 (1988).","article-title":null,"journal-title":"Annu. Rev. Neurosci.","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.tics.2017.11.005","key":"2290_CR8","year":"2018","issue":null,"author":"D Badre","volume":"22","first-page":"170","unstructured":"Badre, D. et al. Frontal cortex and the hierarchical control of behavior. Trends Cogn. Sci. 22, 170–188 (2018).","article-title":null,"journal-title":"Trends Cogn. Sci.","doi-asserted-by":"publisher"},{"DOI":"10.1523/JNEUROSCI.3276-09.2010","key":"2290_CR9","year":"2010","issue":null,"author":"CK Machens","volume":"30","first-page":"350","unstructured":"Machens, C. K. et al. Functional, but not anatomical, separation of ‘what’ and ‘when’ in prefrontal cortex. J. Neurosci. 30, 350–360 (2010).","article-title":null,"journal-title":"J. Neurosci.","doi-asserted-by":"publisher"},{"DOI":"10.1146/annurev-psych-022024-103901","key":"2290_CR10","year":"2025","issue":null,"author":"D Badre","volume":"76","first-page":"167","unstructured":"Badre, D. Cognitive control. Annu. Rev. Psychol. 76, 167–195 (2025).","article-title":null,"journal-title":"Annu. Rev. Psychol.","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41593-017-0003-2","key":"2290_CR11","year":"2017","issue":null,"author":"A Parthasarathy","volume":"20","first-page":"1770","unstructured":"Parthasarathy, A. et al. Mixed selectivity morphs population codes in prefrontal cortex. Nat. Neurosci. 20, 1770–1779 (2017).","article-title":null,"journal-title":"Nat. Neurosci.","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.conb.2016.01.010","key":"2290_CR12","year":"2016","issue":null,"author":"S Fusi","volume":"37","first-page":"66","unstructured":"Fusi, S. et al. Why neurons mix: high dimensionality for higher cognition. Curr. Opin. Neurobiol. 37, 66–74 (2016).","article-title":null,"journal-title":"Curr. Opin. Neurobiol.","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.conb.2022.102606","key":"2290_CR13","year":"2022","issue":null,"author":"CJ MacDowell","volume":"76","first-page":"102606","unstructured":"MacDowell, C. J. et al. A Goldilocks theory of cognitive control: balancing precision and efficiency with low-dimensional control states. Curr. Opin. Neurobiol. 76, 102606 (2022).","article-title":null,"journal-title":"Curr. Opin. Neurobiol.","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41583-020-0262-x","key":"2290_CR14","year":"2020","issue":null,"author":"X-J Wang","volume":"21","first-page":"169","unstructured":"Wang, X.-J. Macroscopic gradients of synaptic excitation and inhibition in the neocortex. Nat. Rev. Neurosci. 21, 169–178 (2020).","article-title":null,"journal-title":"Nat. Rev. Neurosci.","doi-asserted-by":"publisher"},{"DOI":"10.1038/nn.4071","key":"2290_CR15","year":"2015","issue":null,"author":"B Voytek","volume":"18","first-page":"1318","unstructured":"Voytek, B. et al. Oscillatory dynamics coordinating human frontal networks in support of goal maintenance. Nat. Neurosci. 18, 1318–1324 (2015).","article-title":null,"journal-title":"Nat. Neurosci.","doi-asserted-by":"publisher"},{"DOI":"10.1038/nature12160","key":"2290_CR16","year":"2013","issue":null,"author":"M Rigotti","volume":"497","first-page":"585","unstructured":"Rigotti, M. et al. The importance of mixed selectivity in complex cognitive tasks. Nature 497, 585–590 (2013).","article-title":null,"journal-title":"Nature","doi-asserted-by":"publisher"},{"DOI":"10.1038/nature11129","key":"2290_CR17","year":"2012","issue":null,"author":"M Churchland","volume":"487","first-page":"51","unstructured":"Churchland, M. et al. Neural population dynamics during reaching. Nature 487, 51–56 (2012).","article-title":null,"journal-title":"Nature","doi-asserted-by":"publisher"},{"DOI":"10.1146/annurev-neuro-062111-150509","key":"2290_CR18","year":"2013","issue":null,"author":"KV Shenoy","volume":"36","first-page":"337","unstructured":"Shenoy, K. V. et al. Cortical control of arm movements: a dynamical systems perspective. Annu. Rev. Neurosci. 36, 337–359 (2013).","article-title":null,"journal-title":"Annu. Rev. Neurosci.","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.neuron.2017.05.025","key":"2290_CR19","year":"2017","issue":null,"author":"JA Gallego","volume":"94","first-page":"978","unstructured":"Gallego, J. A. et al. Neural manifolds for the control of movement. Neuron 94, 978–984 (2017).","article-title":null,"journal-title":"Neuron","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.neuron.2018.01.004","key":"2290_CR20","year":"2018","issue":null,"author":"AA Russo","volume":"97","first-page":"953","unstructured":"Russo, A. A. et al. Motor cortex embeds muscle-like commands in an untangled population response. Neuron 97, 953–966 (2018).","article-title":null,"journal-title":"Neuron","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41562-017-0267-2","key":"2290_CR21","year":"2018","issue":null,"author":"M Haller","volume":"2","first-page":"80","unstructured":"Haller, M. et al. Persistent neuronal activity in human prefrontal cortex links perception and action. Nat. Hum. Behav. 2, 80–91 (2018).","article-title":null,"journal-title":"Nat. Hum. Behav.","doi-asserted-by":"publisher"},{"DOI":"10.1098/rstb.2020.0524","key":"2290_CR22","year":"2021","issue":null,"author":"JM Fine","volume":"377","first-page":"20200524","unstructured":"Fine, J. M. et al. The whole prefrontal cortex is premotor cortex. Philos. Trans. R. Soc. B Biol. Sci. 377, 20200524 (2021).","article-title":null,"journal-title":"Philos. Trans. R. Soc. B Biol. Sci.","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.tins.2020.07.001","key":"2290_CR23","year":"2020","issue":null,"author":"A Kohn","volume":"43","first-page":"725","unstructured":"Kohn, A. et al. Principles of corticocortical communication: proposed schemes and design considerations. Trends Neurosci. 43, 725–737 (2020).","article-title":null,"journal-title":"Trends Neurosci.","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.neuron.2019.01.026","key":"2290_CR24","year":"2019","issue":null,"author":"AD Joã Semedo","volume":"102","first-page":"249","unstructured":"Joã Semedo, A. D. et al. Cortical areas interact through a communication subspace article cortical areas interact through a communication subspace. Neuron 102, 249–259 (2019).","article-title":null,"journal-title":"Neuron","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.cub.2021.09.076","key":"2290_CR25","year":"2021","issue":null,"author":"R Srinath","volume":"31","first-page":"5299","unstructured":"Srinath, R. et al. Attention improves information flow between neuronal populations without changing the communication subspace. Curr. Biol. 31, 5299–5313 (2021).","article-title":null,"journal-title":"Curr. Biol.","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41467-022-28552-w","key":"2290_CR26","year":"2022","issue":null,"author":"JD Semedo","volume":"13","first-page":null,"unstructured":"Semedo, J. D. et al. Feedforward and feedback interactions between visual cortical areas use different population activity patterns. Nat. Commun. 13, 1099 (2022).","article-title":null,"journal-title":"Nat. Commun.","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.conb.2019.02.002","key":"2290_CR27","year":"2019","issue":null,"author":"S Saxena","volume":"55","first-page":"103","unstructured":"Saxena, S. et al. Towards the neural population doctrine. Curr. Opin. Neurobiol. 55, 103–111 (2019).","article-title":null,"journal-title":"Curr. Opin. Neurobiol.","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.neuron.2021.07.011","key":"2290_CR28","year":"2021","issue":null,"author":"RB Ebitz","volume":"109","first-page":"3055","unstructured":"Ebitz, R. B. et al. The population doctrine in cognitive neuroscience. Neuron 109, 3055–3068 (2021).","article-title":null,"journal-title":"Neuron","doi-asserted-by":"publisher"},{"DOI":"10.1146/annurev-neuro-092619-094115","key":"2290_CR29","year":"2020","issue":null,"author":"S Vyas","volume":"43","first-page":"249","unstructured":"Vyas, S. et al. Computation through neural population dynamics. Annu. Rev. Neurosci. 43, 249–275 (2020).","article-title":null,"journal-title":"Annu. Rev. Neurosci.","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.cub.2024.08.034","key":"2290_CR30","year":"2024","issue":null,"author":"FM Stoll","volume":"34","first-page":"4526","unstructured":"Stoll, F. M. et al. Decision-making shapes dynamic inter-areal communication within macaque ventral frontal cortex. Curr. Biol. 34, 4526–4538 (2024).","article-title":null,"journal-title":"Curr. Biol.","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41467-025-58698-2","key":"2290_CR31","year":"2025","issue":null,"author":"CJ MacDowell","volume":"16","first-page":null,"unstructured":"MacDowell, C. J. et al. Multiplexed subspaces route neural activity across brain-wide networks. Nat. Commun. 16, 3359 (2025).","article-title":null,"journal-title":"Nat. Commun.","doi-asserted-by":"publisher"},{"DOI":"10.1126/science.abm9922","key":"2290_CR32","year":"2022","issue":null,"author":"Z Fu","volume":"376","first-page":null,"unstructured":"Fu, Z. et al. The geometry of domain-general performance monitoring in the human medial frontal cortex. Science 376, eabm9922 (2022).","article-title":null,"journal-title":"Science","doi-asserted-by":"publisher"},{"DOI":"10.1126/science.aba3313","key":"2290_CR33","year":"2020","issue":null,"author":"J Minxha","volume":"368","first-page":null,"unstructured":"Minxha, J. et al. Flexible recruitment of memory-based choice representations by the human medial frontal cortex. Science 368, eaba3313 (2020).","article-title":null,"journal-title":"Science","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41467-023-44571-7","key":"2290_CR34","year":"2024","issue":null,"author":"J Weber","volume":"15","first-page":null,"unstructured":"Weber, J. et al. Ramping dynamics and theta oscillations reflect dissociable signatures during rule-guided human behavior. Nat. Commun. 15, 637 (2024).","article-title":null,"journal-title":"Nat. Commun.","doi-asserted-by":"publisher"},{"DOI":"10.1073/pnas.2220523120","key":"2290_CR35","year":"2023","issue":null,"author":"J Weber","volume":"120","first-page":null,"unstructured":"Weber, J. et al. Subspace partitioning in the human prefrontal cortex resolves cognitive interference. Proc. Natl Acad. Sci. USA 120, e2220523120 (2023).","article-title":null,"journal-title":"Proc. Natl Acad. Sci. USA","doi-asserted-by":"publisher"},{"DOI":"10.1073/pnas.1922166117","key":"2290_CR36","year":"2020","issue":null,"author":"A Kikumoto","volume":"117","first-page":"10603","unstructured":"Kikumoto, A. et al. Conjunctive representations that integrate stimuli, responses, and rules are critical for action selection. Proc. Natl Acad. Sci. USA. 117, 10603–10608 (2020).","article-title":null,"journal-title":"Proc. Natl Acad. Sci. USA.","doi-asserted-by":"publisher"},{"DOI":"10.1126/sciadv.abb0977","key":"2290_CR37","year":"2020","issue":null,"author":"M Leszczyński","volume":"6","first-page":null,"unstructured":"Leszczyński, M. et al. Dissociation of broadband high-frequency activity and neuronal firing in the neocortex. Sci. Adv. 6, eabb0977 (2020).","article-title":null,"journal-title":"Sci. Adv.","doi-asserted-by":"publisher"},{"DOI":"10.1007/978-1-0716-2631-3_10","key":"2290_CR38","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"Helfrich, R. F. in Electrophysiological Recording Techniques, Vol. 192 (eds Vertes, R. P. & Allen, T.) 221–245 (Springer US, 2022).","article-title":null,"journal-title":null,"doi-asserted-by":"crossref"},{"DOI":"10.1038/s41586-023-06839-2","key":"2290_CR39","year":"2024","issue":null,"author":"MK Leonard","volume":"626","first-page":"593","unstructured":"Leonard, M. K. et al. Large-scale single-neuron speech sound encoding across the depth of human cortex. Nature 626, 593–602 (2024).","article-title":null,"journal-title":"Nature","doi-asserted-by":"publisher"},{"DOI":"10.1093/brain/awp230","key":"2290_CR40","year":"2009","issue":null,"author":"N Fogelson","volume":"132","first-page":"3002","unstructured":"Fogelson, N. et al. Prefrontal cortex is critical for contextual processing: evidence from brain lesions. Brain 132, 3002–3010 (2009).","article-title":null,"journal-title":"Brain","doi-asserted-by":"publisher"},{"DOI":"10.1073/pnas.1705965114","key":"2290_CR41","year":"2017","issue":null,"author":"RF Helfrich","volume":"114","first-page":"9457","unstructured":"Helfrich, R. F. et al. Prefrontal cortex modulates posterior alpha oscillations during top-down guided visual perception. Proc. Natl Acad. Sci. USA 114, 9457–9462 (2017).","article-title":null,"journal-title":"Proc. Natl Acad. Sci. USA","doi-asserted-by":"publisher"},{"DOI":"10.1152/jn.90941.2008","key":"2290_CR42","year":"2009","issue":null,"author":"BM Yu","volume":"102","first-page":"614","unstructured":"Yu, B. M. et al. Gaussian-process factor analysis for low-dimensional single-trial analysis of neural population activity. J. Neurophysiol. 102, 614–635 (2009).","article-title":null,"journal-title":"J. Neurophysiol.","doi-asserted-by":"publisher"},{"DOI":"10.1016/0047-259X(75)90042-1","key":"2290_CR43","year":"1975","issue":null,"author":"AJ Izenman","volume":"5","first-page":"248","unstructured":"Izenman, A. J. Reduced-rank regression for the multivariate linear model. J. Multivar. Anal. 5, 248–264 (1975).","article-title":null,"journal-title":"J. Multivar. Anal.","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41467-020-17902-1","key":"2290_CR44","year":"2020","issue":null,"author":"TL Veuthey","volume":"11","first-page":null,"unstructured":"Veuthey, T. L. et al. Single-trial cross-area neural population dynamics during long-term skill learning. Nat. Commun. 11, 4057 (2020).","article-title":null,"journal-title":"Nat. Commun.","doi-asserted-by":"publisher"},{"DOI":"10.7554/eLife.10989","key":"2290_CR45","year":"2016","issue":null,"author":"D Kobak","volume":"5","first-page":null,"unstructured":"Kobak, D. et al. Demixed principal component analysis of neural population data. eLife 5, e10989 (2016).","article-title":null,"journal-title":"eLife","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.neuron.2023.03.017","key":"2290_CR46","year":"2023","issue":null,"author":"IL Hanganu-Opatz","volume":"111","first-page":"1020","unstructured":"Hanganu-Opatz, I. L. et al. Resolving the prefrontal mechanisms of adaptive cognitive behaviors: a cross-species perspective. Neuron 111, 1020–1036 (2023).","article-title":null,"journal-title":"Neuron","doi-asserted-by":"publisher"},{"DOI":"10.1098/rstb.2013.0471","key":"2290_CR47","year":"2014","issue":null,"author":"TJ Buschman","volume":"369","first-page":"20130471","unstructured":"Buschman, T. J. et al. Goal-direction and top-down control. Philos. Trans. R. Soc. B 369, 20130471 (2014).","article-title":null,"journal-title":"Philos. Trans. R. Soc. B","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41586-023-05964-2","key":"2290_CR48","year":"2023","issue":null,"author":"EM Gordon","volume":"617","first-page":"351","unstructured":"Gordon, E. M. et al. A somato-cognitive action network alternates with effector regions in motor cortex. Nature 617, 351–359 (2023).","article-title":null,"journal-title":"Nature","doi-asserted-by":"publisher"},{"DOI":"10.1101/2025.09.07.674717","key":"2290_CR49","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"Amematsro, E. A. et al. Motor cortex flexibly deploys a high-dimensional repertoire of subskills. Preprint at bioRxiv https://doi.org/10.1101/2025.09.07.674717 (2025).","article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1101/2024.03.20.585972","key":"2290_CR50","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"Rajeswaran, P. et al. Assistive sensory-motor perturbations influence learned neural representations. Preprint at bioRxiv https://doi.org/10.1101/2024.03.20.585972 (2024).","article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1101/2024.05.24.595772","key":"2290_CR51","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"Gurnani, H. et al. Feedback control of recurrent circuits imposes dynamical constraints on learning. Preprint at bioRxiv https://doi.org/10.1101/2024.05.24.595772 (2025).","article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.cell.2020.09.031","key":"2290_CR52","year":"2020","issue":null,"author":"S Bernardi","volume":"183","first-page":"954","unstructured":"Bernardi, S. et al. The geometry of abstraction in the hippocampus and prefrontal cortex. Cell 183, 954–967 (2020).","article-title":null,"journal-title":"Cell","doi-asserted-by":"publisher"},{"DOI":"10.1523/JNEUROSCI.1412-21.2022","key":"2290_CR53","year":"2022","issue":null,"author":"S Maggi","volume":"42","first-page":"4131","unstructured":"Maggi, S. et al. Activity subspaces in medial prefrontal cortex distinguish states of the world. J. Neurosci. 42, 4131–4146 (2022).","article-title":null,"journal-title":"J. Neurosci.","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41593-021-00821-9","key":"2290_CR54","year":"2021","issue":null,"author":"A Libby","volume":"24","first-page":"715","unstructured":"Libby, A. et al. Rotational dynamics reduce interference between sensory and memory representations. Nat. Neurosci. 24, 715–726 (2021).","article-title":null,"journal-title":"Nat. Neurosci.","doi-asserted-by":"publisher"},{"DOI":"10.1038/nn.3776","key":"2290_CR55","year":"2014","issue":null,"author":"JP Cunningham","volume":"17","first-page":"1500","unstructured":"Cunningham, J. P. et al. Dimensionality reduction for large-scale neural recordings. Nat. Neurosci. 17, 1500–1500 (2014).","article-title":null,"journal-title":"Nat. Neurosci.","doi-asserted-by":"publisher"},{"DOI":"10.1038/nn.3643","key":"2290_CR56","year":"2014","issue":null,"author":"MT Kaufman","volume":"17","first-page":"440","unstructured":"Kaufman, M. T. et al. Cortical activity in the null space: permitting preparation without movement. Nat. Neurosci. 17, 440–448 (2014).","article-title":null,"journal-title":"Nat. Neurosci.","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.neubiorev.2015.02.016","key":"2290_CR57","year":"2015","issue":null,"author":"N Fogelson","volume":"52","first-page":"207","unstructured":"Fogelson, N. Neural correlates of local contextual processing across stimulus modalities and patient populations. Neurosci. Biobehav. Rev. 52, 207–220 (2015).","article-title":null,"journal-title":"Neurosci. Biobehav. Rev.","doi-asserted-by":"publisher"},{"DOI":"10.1101/2025.05.02.651965","key":"2290_CR58","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"Wentz, P. T. et al. Recycling of prefrontal subspaces dynamically multiplexes information. Preprint at bioRxiv https://doi.org/10.1101/2025.05.02.651965 (2025).","article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1038/nn.3689","key":"2290_CR59","year":"2014","issue":null,"author":"J Fischer","volume":"17","first-page":"738","unstructured":"Fischer, J. et al. Serial dependence in visual perception. Nat. Neurosci. 17, 738–743 (2014).","article-title":null,"journal-title":"Nat. Neurosci.","doi-asserted-by":"publisher"},{"DOI":"10.1073/pnas.2520444122","key":"2290_CR60","year":"2025","issue":null,"author":"J Terlau","volume":"122","first-page":null,"unstructured":"Terlau, J. et al. Conjunctive population coding integrates sensory evidence to guide adaptive behavior. Proc. Natl Acad. Sci. USA 122, e2520444122 (2025).","article-title":null,"journal-title":"Proc. Natl Acad. Sci. USA","doi-asserted-by":"publisher"},{"DOI":"10.7554/eLife.73155","key":"2290_CR61","year":"2022","issue":null,"author":"C Gallego-Carracedo","volume":"11","first-page":null,"unstructured":"Gallego-Carracedo, C. et al. Local field potentials reflect cortical population dynamics in a region-specific and frequency-dependent manner. eLife 11, e73155 (2022).","article-title":null,"journal-title":"eLife","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41467-017-01253-5","key":"2290_CR62","year":"2017","issue":null,"author":"EL Rich","volume":"8","first-page":null,"unstructured":"Rich, E. L. et al. Spatiotemporal dynamics of information encoding revealed in orbitofrontal high-gamma. Nat. Commun. 8, 1139 (2017).","article-title":null,"journal-title":"Nat. Commun.","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.neuron.2015.09.034","key":"2290_CR63","year":"2015","issue":null,"author":"P Fries","volume":"88","first-page":"220","unstructured":"Fries, P. Rhythms for cognition: communication through coherence. Neuron 88, 220–235 (2015).","article-title":null,"journal-title":"Neuron","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41583-022-00606-4","key":"2290_CR64","year":"2022","issue":null,"author":"S Panzeri","volume":"23","first-page":"551","unstructured":"Panzeri, S. et al. The structures and functions of correlations in neural population codes. Nat. Rev. Neurosci. 23, 551–567 (2022).","article-title":null,"journal-title":"Nat. Rev. Neurosci.","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.neuron.2022.05.007","key":"2290_CR65","year":"2022","issue":null,"author":"JE Chung","volume":"110","first-page":"2409","unstructured":"Chung, J. E. et al. High-density single-unit human cortical recordings using the Neuropixels probe. Neuron 110, 2409–2421 (2022).","article-title":null,"journal-title":"Neuron","doi-asserted-by":"publisher"},{"DOI":null,"key":"2290_CR66","year":"2006","issue":null,"author":"X Papademetris","volume":"2006","first-page":"209","unstructured":"Papademetris, X. et al. BioImage Suite: an integrated medical image analysis suite: an update. Insight J. 2006, 209 (2006).","article-title":null,"journal-title":"Insight J.","doi-asserted-by":null},{"DOI":"10.1155/2011/156869","key":"2290_CR67","year":"2011","issue":null,"author":"R Oostenveld","volume":"2011","first-page":"156869","unstructured":"Oostenveld, R. et al. FieldTrip: open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data. Comput. Intell. Neurosci. 2011, 156869 (2011).","article-title":null,"journal-title":"Comput. Intell. Neurosci.","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41596-018-0009-6","key":"2290_CR68","year":"2018","issue":null,"author":"A Stolk","volume":"13","first-page":"1699","unstructured":"Stolk, A. et al. Integrated analysis of anatomical and electrophysiological human intracranial data. Nat. Protoc. 13, 1699–1723 (2018).","article-title":null,"journal-title":"Nat. Protoc.","doi-asserted-by":"publisher"},{"DOI":"10.1006/nimg.1998.0395","key":"2290_CR69","year":"1999","issue":null,"author":"AM Dale","volume":"9","first-page":"179","unstructured":"Dale, A. M. et al. Cortical surface-based analysis. I. Segmentation and surface reconstruction. NeuroImage 9, 179–194 (1999).","article-title":null,"journal-title":"NeuroImage","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.neuroimage.2011.11.046","key":"2290_CR70","year":"2012","issue":null,"author":"AR Dykstra","volume":"59","first-page":"3563","unstructured":"Dykstra, A. R. et al. Individualized localization and cortical surface-based registration of intracranial electrodes. NeuroImage 59, 3563–3570 (2012).","article-title":null,"journal-title":"NeuroImage","doi-asserted-by":"publisher"},{"DOI":null,"key":"2290_CR71","year":"1997","issue":null,"author":"JL Lancaster","volume":"5","first-page":"S633","unstructured":"Lancaster, J. L. et al. The Talairach Daemon a database server for Talairach atlas labels. NeuroImage 5, S633 (1997).","article-title":null,"journal-title":"NeuroImage","doi-asserted-by":null},{"DOI":"10.1371/journal.pone.0065914","key":"2290_CR72","year":"2013","issue":null,"author":"N Fogelson","volume":"8","first-page":"e65914","unstructured":"Fogelson, N. et al. Implicit versus explicit local contextual processing. PLoS ONE 8, e65914 (2013).","article-title":null,"journal-title":"PLoS ONE","doi-asserted-by":"publisher"},{"DOI":"10.1126/science.1128115","key":"2290_CR73","year":"2006","issue":null,"author":"RT Canolty","volume":"313","first-page":"1626","unstructured":"Canolty, R. T. et al. High gamma power is phase-locked to theta oscillations in human neocortex. Science 313, 1626–1628 (2006).","article-title":null,"journal-title":"Science","doi-asserted-by":"publisher"},{"DOI":"10.1371/journal.pbio.1000610","key":"2290_CR74","year":"2011","issue":null,"author":"S Ray","volume":"9","first-page":"e1000610","unstructured":"Ray, S. et al. Different origins of gamma rhythm and high-gamma activity in macaque visual cortex. PLoS Biol. 9, e1000610 (2011).","article-title":null,"journal-title":"PLoS Biol.","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.neuron.2018.07.032","key":"2290_CR75","year":"2018","issue":null,"author":"RF Helfrich","volume":"99","first-page":"854","unstructured":"Helfrich, R. F. et al. Neural mechanisms of sustained attention are rhythmic. Neuron 99, 854–865 (2018).","article-title":null,"journal-title":"Neuron","doi-asserted-by":"publisher"},{"DOI":"10.1101/214262","key":"2290_CR76","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"Gao, P. et al. A theory of multineuronal dimensionality, dynamics and measurement. Preprint at bioRxiv https://doi.org/10.1101/214262 (2017).","article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"2290_CR77","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"Binesh, N. et al. PFC-M1 communication subspace. GitHub https://github.com/nehabinish/pfc-m1-communication-subspace (2026).","article-title":null,"journal-title":null,"doi-asserted-by":null}],"short-title":[],"update-policy":"https://doi.org/10.1007/springer_crossmark_policy","alternative-id":["2290"],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"original-title":[],"container-title":["Nature Neuroscience"],"reference-count":77,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2026,5,1]]},"references-count":77,"short-container-title":["Nat Neurosci"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1038/s41593-026-02290-4","is_oa":false,"title":"A communication subspace relays context-dependent actions from human prefrontal to motor cortex","updated":"2026-05-05T11:59:32+00:00","published_date":"2026-05-01","best_oa_location":null}},"created_at":"2026-05-14T13:22:51.450Z","updated_at":"2026-05-14T15:13:26.918Z","tags":[{"paper_doi":"10.1038/s41593-026-02290-4","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1038/s41593-026-02290-4","tag_type":"category","value":"Neurosciences","value_numeric":null},{"paper_doi":"10.1038/s41593-026-02290-4","tag_type":"condition","value":"Context-Dependent Action Control","value_numeric":null},{"paper_doi":"10.1038/s41593-026-02290-4","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1038/s41593-026-02290-4","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.1038/s41593-026-02290-4","tag_type":"modality","value":"Intracranial EEG (ECoG)","value_numeric":null},{"paper_doi":"10.1038/s41593-026-02290-4","tag_type":"sample_size","value":"n=11","value_numeric":11},{"paper_doi":"10.1038/s41593-026-02290-4","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1038/s41593-026-02290-4","tag_type":"study_design","value":"Cross-Sectional","value_numeric":null},{"paper_doi":"10.1038/s41593-026-02290-4","tag_type":"study_design","value":"Observational Intracranial Electrophysiology Study","value_numeric":null},{"paper_doi":"10.1038/s41593-026-02290-4","tag_type":"warning","value":"Design label is approximate; this is a basic human intracranial neurophysiology study rather than a conventional clinical design.","value_numeric":null},{"paper_doi":"10.1038/s41593-026-02290-4","tag_type":"warning","value":"No drug/therapeutic modality is involved; clinical practice takeaway is not applicable — this is a basic neuroscience study.","value_numeric":null},{"paper_doi":"10.1038/s41593-026-02290-4","tag_type":"warning","value":"No numeric outcomes or effect sizes are provided in the abstract.","value_numeric":null},{"paper_doi":"10.1038/s41593-026-02290-4","tag_type":"warning","value":"Sample size and participant characteristics are not reported in the abstract.","value_numeric":null},{"paper_doi":"10.1038/s41593-026-02290-4","tag_type":"warning","value":"Sample size is very small (n=11, one excluded), so effect size estimates and correlation values should be interpreted cautiously.","value_numeric":null},{"paper_doi":"10.1038/s41593-026-02290-4","tag_type":"warning","value":"Study design is observational/correlational; causal claims about PFC-to-M1 communication direction cannot be confirmed from ECoG alone.","value_numeric":null},{"paper_doi":"10.1038/s41593-026-02290-4","tag_type":"warning","value":"The task paradigm is highly controlled (predictive vs. random contexts only); clinical or real-world generalizability is uncertain.","value_numeric":null}],"summaries":{"limitations":"Small sample (n=11 subjects; one excluded due to artifacts), leaving limited statistical power. The paradigm compares only two conditions (predictive vs. random), so generalizability to naturalistic or more complex contexts is unclear. Correlational intracranial design cannot establish causal directionality of PFC→M1 communication.","what_studied":"Intracranial recordings from human prefrontal (PFC) and primary motor (M1) cortices were used to test whether a low-dimensional “communication subspace” within high-dimensional PFC population activity relays context-dependent action information on single trials.","key_result":"A communication subspace embedded in PFC activity selectively relayed behaviorally relevant information, and activity in this subspace predicted context-dependent actions more strongly than signals from either PFC or M1 alone."}},{"doi":"10.1111/pde.70226","pmid":"42056722","title":"Social Media and Direct‐to‐Consumer Treatments in Pediatric and Young‐Adult Patients With Alopecia: Variable Use and Mixed Perceptions","journal_title":"Pediatric Dermatology","journal_issn":"0736-8046","published_at":"2026-04-30T00:00:00.000Z","url":"https://doi.org/10.1111/pde.70226","source_score":7,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2026-05-08","doi":"10.1111/pde.70226","days":"7","issn":"0736-8046","rank":"5","field":"Clinical Medicine","score":"7","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1111/pde.70226","title":"Social Media and Direct-to-Consumer Treatments in Pediatric and Young-Adult Patients With Alopecia: Variable Use and Mixed Perceptions.","journal":"Pediatric dermatology","methods":"","results":"Of 115 respondents, 65% reported social media use, with higher use reported in older age groups (90% ≥ 18 years, 72% 12-17 years, 34% < 12 years; p < 0.001). Among users, 59% encountered hair loss-related content, most often on TikTok, Instagram, and YouTube. Many reported uncertainty regarding the qualifications of content creators, and nearly one-quarter rarely or never questioned the accuracy of information presented. Among respondents exposed to hair loss-related content, 28% reported trying a treatment seen online. These treatments were associated with low satisfaction, variable costs ($0-$500+), and side effects including dryness, itching, and increased shedding. Across all respondents, 60% reported ever using at least one DTC treatment, though only 30% were current users. Perceived effectiveness was inconsistent.","abstract":"$36","keywords":["adolescent","alopecia","direct‐to‐consumer","pediatrics","social media"],"pubmed_id":"42056722","conclusions":"","publication_date":"2026-04-30T00:00:00"},"crossref":{"DOI":"10.1111/pde.70226","URL":"https://doi.org/10.1111/pde.70226","ISSN":["0736-8046","1525-1470"],"link":[{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/pde.70226","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/pde.70226","content-type":"application/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/pde.70226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Social Media and Direct‐to‐Consumer Treatments in Pediatric and Young‐Adult Patients With Alopecia: Variable Use and Mixed Perceptions"],"author":[{"given":"Sarah","family":"Lee","sequence":"first","affiliation":[{"name":"Harvard Medical School Boston Massachusetts USA"}]},{"given":"Adrienne","family":"Conza","sequence":"additional","affiliation":[{"name":"UMass Chan Medical School Worcester Massachusetts USA"}]},{"given":"Itohan","family":"Aigbekaen","sequence":"additional","affiliation":[{"name":"Dermatology Section, Division of Immunology Boston Children's Hospital Boston Massachusetts USA"}]},{"given":"Jasmine","family":"Chang","sequence":"additional","affiliation":[{"name":"Dermatology Section, Division of Immunology Boston Children's Hospital Boston Massachusetts USA"}]},{"given":"Yasin","family":"Damji","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston Massachusetts USA"},{"name":"Dermatology Section, Division of Immunology Boston Children's Hospital Boston Massachusetts USA"}]}],"issued":{"date-parts":[[2026,4,29]]},"member":"311","prefix":"10.1111","source":"Crossref","volume":null,"archive":["Portico"],"created":{"date-time":"2026-04-30T03:21:37Z","timestamp":1777519297000,"date-parts":[[2026,4,30]]},"indexed":{"date-time":"2026-05-04T02:20:40Z","timestamp":1777861240944,"date-parts":[[2026,5,4]]},"license":[{"URL":"http://onlinelibrary.wiley.com/termsAndConditions#vor","start":{"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000,"date-parts":[[2026,4,29]]},"delay-in-days":0,"content-version":"vor"},{"URL":"http://doi.wiley.com/10.1002/tdm_license_1.1","start":{"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000,"date-parts":[[2026,4,29]]},"delay-in-days":0,"content-version":"tdm"}],"subject":[],"abstract":"$37","language":"en","relation":{},"resource":{"primary":{"URL":"https://onlinelibrary.wiley.com/doi/10.1111/pde.70226"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"publication_history","label":"Publication History"},"label":"Received","order":0,"value":"2025-09-24"},{"name":"accepted","group":{"name":"publication_history","label":"Publication History"},"label":"Accepted","order":2,"value":"2026-03-24"},{"name":"published","group":{"name":"publication_history","label":"Publication History"},"label":"Published","order":3,"value":"2026-04-29"}],"deposited":{"date-time":"2026-04-30T03:21:44Z","timestamp":1777519304000,"date-parts":[[2026,4,30]]},"issn-type":[{"type":"print","value":"0736-8046"},{"type":"electronic","value":"1525-1470"}],"published":{"date-parts":[[2026,4,29]]},"publisher":"Wiley","reference":[{"DOI":"10.1016/j.pedhc.2021.05.001","key":"e_1_2_11_2_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.jaad.2020.06.047","key":"e_1_2_11_3_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1159/000466704","key":"e_1_2_11_4_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1159/000492035","key":"e_1_2_11_5_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s13671‐021‐00343‐4","key":"e_1_2_11_6_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.7759/cureus.39111","key":"e_1_2_11_7_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.5826/dpc.1403a156","key":"e_1_2_11_8_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.jaad.2020.05.039","key":"e_1_2_11_9_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.36849/JDD.7990","key":"e_1_2_11_10_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/jdv.18500","key":"e_1_2_11_11_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/pde.15285","key":"e_1_2_11_12_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/ced/llae127","key":"e_1_2_11_13_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/jocd.15605","key":"e_1_2_11_14_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1159/000542880","key":"e_1_2_11_15_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.jaad.2020.12.028","key":"e_1_2_11_16_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/ijd.17666","key":"e_1_2_11_17_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.2196/34935","key":"e_1_2_11_18_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.clindermatol.2025.02.009","key":"e_1_2_11_19_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/pde.15796","key":"e_1_2_11_20_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1126/science.aap9559","key":"e_1_2_11_21_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.2471/BLT.20.276782","key":"e_1_2_11_22_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/ijd.15254","key":"e_1_2_11_23_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/j.1365‐4632.2010.04705.x","key":"e_1_2_11_24_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.7759/cureus.58656","key":"e_1_2_11_25_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"}],"short-title":[],"update-policy":"https://doi.org/10.1002/crossmark_policy","alternative-id":["10.1111/pde.70226"],"article-number":"pde.70226","content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"original-title":[],"container-title":["Pediatric Dermatology"],"reference-count":24,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2026,4,29]]},"references-count":24,"short-container-title":["Pediatric Dermatology"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1111/pde.70226","is_oa":false,"title":"Social Media and Direct‐to‐Consumer Treatments in Pediatric and Young‐Adult Patients With Alopecia: Variable Use and Mixed Perceptions","updated":"2026-05-05T11:59:32+00:00","published_date":"2026-04-29","best_oa_location":null}},"created_at":"2026-05-14T13:22:53.974Z","updated_at":"2026-05-14T15:13:26.918Z","tags":[{"paper_doi":"10.1111/pde.70226","tag_type":"age_group","value":"adolescent","value_numeric":null},{"paper_doi":"10.1111/pde.70226","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1111/pde.70226","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1111/pde.70226","tag_type":"age_group","value":"pediatric","value_numeric":null},{"paper_doi":"10.1111/pde.70226","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1111/pde.70226","tag_type":"condition","value":"Alopecia","value_numeric":null},{"paper_doi":"10.1111/pde.70226","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1111/pde.70226","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.1111/pde.70226","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1111/pde.70226","tag_type":"sample_size","value":"n=115","value_numeric":115},{"paper_doi":"10.1111/pde.70226","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1111/pde.70226","tag_type":"study_design","value":"Cross-Sectional","value_numeric":null},{"paper_doi":"10.1111/pde.70226","tag_type":"study_design","value":"Cross-Sectional Survey","value_numeric":null},{"paper_doi":"10.1111/pde.70226","tag_type":"warning","value":"Alopecia subtype(s) and specific DTC products were not specified.","value_numeric":null},{"paper_doi":"10.1111/pde.70226","tag_type":"warning","value":"Generalizability may be limited to a single tertiary pediatric dermatology clinic.","value_numeric":null},{"paper_doi":"10.1111/pde.70226","tag_type":"warning","value":"No specific alopecia subtypes (e.g., alopecia areata vs. androgenetic) are broken out in the abstract, limiting condition-specific interpretation.","value_numeric":null},{"paper_doi":"10.1111/pde.70226","tag_type":"warning","value":"Self-reported satisfaction and side effects may be subject to recall and reporting bias.","value_numeric":null},{"paper_doi":"10.1111/pde.70226","tag_type":"warning","value":"Survey data are self-reported from a single academic center, which may not reflect community or non-English-speaking populations.","value_numeric":null},{"paper_doi":"10.1111/pde.70226","tag_type":"warning","value":"The study includes patients up to age 25, so a subset are adults; findings are not exclusively pediatric despite the pediatric clinic setting.","value_numeric":null}],"summaries":{"what_studied":"A cross-sectional survey at a tertiary pediatric dermatology clinic (Nov 2024–Sep 2025) of patients ≤25 years with physician-diagnosed alopecia examined social media engagement and use/perceived effectiveness of direct-to-consumer (DTC) treatments.","key_result":"Of 115 respondents, 65% used social media (90% ≥18 years, 72% 12–17 years, 34% <12 years; p<0.001); among users, 59% encountered hair loss content and 28% of those tried a treatment seen online. Across all respondents, 60% had ever used a DTC product but only 30% were current users; satisfaction was low, costs ranged $0–$500+, and side effects included dryness, itching, and increased shedding.","limitations":"Single-center, cross-sectional survey with self-reported behaviors and perceptions. Specific DTC products and objective effectiveness measures were not detailed.","practice_takeaway":"Ask pediatric and young-adult patients with alopecia about social media exposure and DTC product use, including costs and side effects, and guide families toward evidence-based management."}},{"doi":"10.1097/xcs.0000000000001759","pmid":"41810795","title":"Evaluating Factors Associated with Advanced-Stage Breast Cancer Presentation in Rural Patients in the National Cancer Database","journal_title":"Journal of the American College of Surgeons","journal_issn":"1072-7515","published_at":"2026-03-11T00:00:00.000Z","url":"https://doi.org/10.1097/xcs.0000000000001759","source_score":38,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2026-04-17","doi":"10.1097/xcs.0000000000001759","days":"30","issn":"1072-7515","rank":"8","field":"Clinical Medicine","score":"38","category":"Surgery","categories":["Surgery"],"_categories":["Surgery"]},"pubmed":{"doi":"10.1097/XCS.0000000000001759","title":"Evaluating Factors Associated with Advanced-Stage Breast Cancer Presentation in Rural Patients in the National Cancer Database.","journal":"Journal of the American College of Surgeons","methods":"","results":"$38","abstract":"$39","keywords":[],"pubmed_id":"41810795","conclusions":"","publication_date":"2026-03-11T00:00:00"},"crossref":{"DOI":"10.1097/xcs.0000000000001759","URL":"https://doi.org/10.1097/xcs.0000000000001759","ISSN":["1072-7515","1879-1190"],"link":[{"URL":"https://journals.lww.com/10.1097/XCS.0000000000001759","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":"1138-1146","type":"journal-article","issue":"4","score":1,"title":["Evaluating Factors Associated with Advanced-Stage Breast Cancer Presentation in Rural Patients in the National Cancer Database"],"author":[{"given":"Omolade O","family":"Sogade","sequence":"first","affiliation":[{"name":"From the Section of Surgical Oncology, Department of Surgery, Washington University in St Louis School of Medicine, St Louis, MO."}]},{"given":"Julie A","family":"Margenthaler","sequence":"additional","affiliation":[{"name":"From the Section of Surgical Oncology, Department of Surgery, Washington University in St Louis School of Medicine, St Louis, MO."}]}],"issued":{"date-parts":[[2026,3,26]]},"member":"276","prefix":"10.1097","source":"Crossref","volume":"242","created":{"date-time":"2026-03-11T12:04:14Z","timestamp":1773230654000,"date-parts":[[2026,3,11]]},"indexed":{"date-time":"2026-03-26T12:56:32Z","timestamp":1774529792935,"date-parts":[[2026,3,26]]},"subject":[],"abstract":"$3a","language":"en","relation":{},"resource":{"primary":{"URL":"https://journals.lww.com/10.1097/XCS.0000000000001759"}},"subtitle":[],"deposited":{"date-time":"2026-03-26T12:03:22Z","timestamp":1774526602000,"date-parts":[[2026,3,26]]},"issn-type":[{"type":"print","value":"1072-7515"},{"type":"electronic","value":"1879-1190"}],"published":{"date-parts":[[2026,3,26]]},"publisher":"Ovid Technologies (Wolters Kluwer Health)","reference":[{"DOI":"10.1093/jnci/djac030","key":"R2-20260326","year":"2022","issue":null,"author":"Bhatia","volume":"114","first-page":"940","unstructured":null,"article-title":"Rural-urban disparities in cancer outcomes: opportunities for future research.","journal-title":"J Natl Cancer Inst","doi-asserted-by":"crossref"},{"DOI":"10.1111/jrh.70063","key":"R3-20260326","year":"2025","issue":null,"author":"Golden","volume":"41","first-page":"e70063","unstructured":null,"article-title":"Route and efficiency analysis of cancer health care (REACH): investigating sociodemographic and rurality of metastatic breast cancer patients at an NCI-designated facility.","journal-title":"J Rural Health","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.ypmed.2021.106741","key":"R4-20260326","year":"2021","issue":"Pt 2","author":"Sprague","volume":"152","first-page":"106741","unstructured":null,"article-title":"Identifying key barriers to effective breast cancer control in rural settings.","journal-title":"Prev Med","doi-asserted-by":"crossref"},{"DOI":"10.1136/bmjopen-2014-006960","key":"R5-20260326","year":"2015","issue":null,"author":"Drake","volume":"5","first-page":"e006960","unstructured":null,"article-title":"Mammograms on-the-go-predictors of repeat visits to mobile mammography vans in St Louis, Missouri, USA: a case-control study.","journal-title":"BMJ Open","doi-asserted-by":"crossref"},{"DOI":"10.1006/pmed.1997.0110","key":"R6-20260326","year":"1997","issue":null,"author":"Flynn","volume":"26","first-page":"102","unstructured":null,"article-title":"Community education programs to promote mammography participation in rural New York State.","journal-title":"Prev Med","doi-asserted-by":"crossref"},{"DOI":"10.2214/AJR.16.17670","key":"R7-20260326","year":"2017","issue":null,"author":"Stanley","volume":"209","first-page":"1426","unstructured":null,"article-title":"Effectiveness of a mobile mammography program.","journal-title":"AJR Am J Roentgenol","doi-asserted-by":"crossref"},{"DOI":"10.1007/s10900-011-9494-z","key":"R8-20260326","year":"2012","issue":null,"author":"Vyas","volume":"37","first-page":"632","unstructured":null,"article-title":"Factors influencing adherence to mammography screening guidelines in Appalachian women participating in a mobile mammography program.","journal-title":"J Community Health","doi-asserted-by":"crossref"},{"DOI":"10.3390/cancers14102550","key":"R9-20260326","year":"2022","issue":null,"author":"Drake","volume":"14","first-page":"2550","unstructured":null,"article-title":"Strategies to achieve breast health equity in the St. Louis region and beyond over 15+ years.","journal-title":"Cancers (Basel)","doi-asserted-by":"crossref"},{"DOI":"10.2196/47851","key":"R10-20260326","year":"2023","issue":null,"author":"Roh","volume":"7","first-page":"e47851","unstructured":null,"article-title":"Mobile web app intervention to promote breast cancer screening among American Indian women in the northern plains: feasibility and efficacy study.","journal-title":"JMIR Form Res","doi-asserted-by":"crossref"},{"DOI":null,"key":"R11-20260326","year":"1998","issue":null,"author":"Frank-Stromborg","volume":"13","first-page":"231","unstructured":null,"article-title":"A study of rural Latino women seeking cancer-detection examinations.","journal-title":"J Cancer Educ","doi-asserted-by":null},{"DOI":"10.1001/jamanetworkopen.2024.61021","key":"R12-20260326","year":"2025","issue":null,"author":"Moen","volume":"8","first-page":"e2461021","unstructured":null,"article-title":"Cross-state travel for cancer care and implications for telehealth reciprocity.","journal-title":"JAMA Netw Open","doi-asserted-by":"crossref"},{"DOI":"10.1097/SLA.0000000000006710","key":"R13-20260326","year":"2025","issue":null,"author":"Reddy","volume":null,"first-page":null,"unstructured":null,"article-title":"The effect of rurality on time to surgery and overall survival among women with breast cancer.","journal-title":"Ann Surg","doi-asserted-by":"crossref"},{"DOI":"10.1245/s10434-020-08376-y","key":"R14-20260326","year":"2020","issue":null,"author":"Obeng-Gyasi","volume":"27","first-page":"1805","unstructured":null,"article-title":"Breast cancer presentation, surgical management and mortality across the rural-urban continuum in the national cancer database.","journal-title":"Ann Surg Oncol","doi-asserted-by":"crossref"},{"DOI":"10.1158/1940-6207.CAPR-24-0587","key":"R15-20260326","year":"2025","issue":null,"author":"Fairfield","volume":"18","first-page":"465","unstructured":null,"article-title":"Stage at diagnosis for common cancers according to rurality, area deprivation, and insurance, 2017 to 2021.","journal-title":"Cancer Prev Res (Phila)","doi-asserted-by":"crossref"},{"DOI":"10.1111/j.1748-0361.1997.tb00939.x","key":"R18-20260326","year":"1997","issue":null,"author":"Amey","volume":"13","first-page":"99","unstructured":null,"article-title":"The role of race and residence in determining stage at diagnosis of breast cancer.","journal-title":"J Rural Health","doi-asserted-by":"crossref"},{"DOI":"10.1111/1475-6773.12096","key":"R19-20260326","year":"2014","issue":null,"author":"Markossian","volume":"49","first-page":"481","unstructured":null,"article-title":"Geographic and racial disparities in breast cancer-related outcomes in Georgia.","journal-title":"Health Serv Res","doi-asserted-by":"crossref"},{"DOI":"10.1080/03630242.2012.674091","key":"R20-20260326","year":"2012","issue":null,"author":"Markossian","volume":"52","first-page":"317","unstructured":null,"article-title":"Disparities in late stage diagnosis, treatment, and breast cancer-related death by race, age, and rural residence among women in Georgia.","journal-title":"Women Health","doi-asserted-by":"crossref"},{"DOI":null,"key":"R21-20260326","year":"2015","issue":null,"author":"Williams","volume":"15","first-page":"3063","unstructured":null,"article-title":"Rural-urban difference in female breast cancer diagnosis in Missouri.","journal-title":"Rural Remote Health","doi-asserted-by":null},{"DOI":"10.1007/s40615-015-0132-9","key":"R22-20260326","year":"2016","issue":null,"author":"Williams","volume":"3","first-page":"233","unstructured":null,"article-title":"Disparity in breast cancer late stage at diagnosis in missouri: does rural versus urban residence matter?","journal-title":"J Racial Ethn Health Disparities","doi-asserted-by":"crossref"},{"DOI":"10.1186/1471-2458-12-520","key":"R23-20260326","year":"2012","issue":null,"author":"Peipins","volume":"12","first-page":"520","unstructured":null,"article-title":"The lack of paid sick leave as a barrier to cancer screening and medical care-seeking: results from the National Health Interview Survey.","journal-title":"BMC Public Health","doi-asserted-by":"crossref"},{"DOI":"10.1056/NEJMsa2209197","key":"R24-20260326","year":"2023","issue":null,"author":"Callison","volume":"388","first-page":"824","unstructured":null,"article-title":"Cancer screening after the adoption of paid-sick-leave mandates.","journal-title":"N Engl J Med","doi-asserted-by":"crossref"},{"DOI":"10.1097/SLA.0b013e31824b194b","key":"R25-20260326","year":"2012","issue":null,"author":"Polk","volume":"255","first-page":"611","unstructured":null,"article-title":"A proposal for enhancing the general surgical workforce and access to surgical care.","journal-title":"Ann Surg","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.cpsurg.2022.101173","key":"R26-20260326","year":"2022","issue":null,"author":"Borgstrom","volume":"59","first-page":"101173","unstructured":null,"article-title":"Rural surgery.","journal-title":"Curr Probl Surg","doi-asserted-by":"crossref"}],"short-title":[],"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026]]}},"update-policy":"https://doi.org/10.1097/lww.0000000000001000","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"original-title":[],"container-title":["Journal of the American College of Surgeons"],"published-print":{"date-parts":[[2026,4]]},"reference-count":23,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2026,3,26]]},"references-count":23,"short-container-title":[],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1097/xcs.0000000000001759","is_oa":false,"title":"Evaluating Factors Associated with Advanced-Stage Breast Cancer Presentation in Rural Patients in the National Cancer Database","updated":"2026-03-12T12:36:34+00:00","published_date":"2026-03-11","best_oa_location":null}},"created_at":"2026-05-14T13:22:52.984Z","updated_at":"2026-05-14T15:13:26.918Z","tags":[{"paper_doi":"10.1097/xcs.0000000000001759","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1097/xcs.0000000000001759","tag_type":"category","value":"Surgery","value_numeric":null},{"paper_doi":"10.1097/xcs.0000000000001759","tag_type":"condition","value":"Breast Cancer","value_numeric":null},{"paper_doi":"10.1097/xcs.0000000000001759","tag_type":"impact_flag","value":"safety_signal","value_numeric":null},{"paper_doi":"10.1097/xcs.0000000000001759","tag_type":"level_of_evidence","value":"3","value_numeric":null},{"paper_doi":"10.1097/xcs.0000000000001759","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1097/xcs.0000000000001759","tag_type":"modality","value":"Cancer Screening","value_numeric":null},{"paper_doi":"10.1097/xcs.0000000000001759","tag_type":"sample_size","value":"n=52287","value_numeric":52287},{"paper_doi":"10.1097/xcs.0000000000001759","tag_type":"sample_size","value":"n=52,287","value_numeric":52287},{"paper_doi":"10.1097/xcs.0000000000001759","tag_type":"sex","value":"female","value_numeric":null},{"paper_doi":"10.1097/xcs.0000000000001759","tag_type":"study_design","value":"Cross-Sectional","value_numeric":null},{"paper_doi":"10.1097/xcs.0000000000001759","tag_type":"study_design","value":"Retrospective Cohort Study","value_numeric":null},{"paper_doi":"10.1097/xcs.0000000000001759","tag_type":"warning","value":"Design classification is inferred from a registry analysis and may be considered retrospective cross-sectional.","value_numeric":null},{"paper_doi":"10.1097/xcs.0000000000001759","tag_type":"warning","value":"Only abstract-level details were provided; full methods and limitations were not available in the excerpt.","value_numeric":null},{"paper_doi":"10.1097/xcs.0000000000001759","tag_type":"warning","value":"Sex was not explicitly stated in the abstract as female-only, but breast cancer population in NCDB is overwhelmingly female; tagged accordingly with a note of minor uncertainty.","value_numeric":null},{"paper_doi":"10.1097/xcs.0000000000001759","tag_type":"warning","value":"Study design is labeled retrospective cohort based on NCDB methodology; the paper does not use this exact label explicitly.","value_numeric":null},{"paper_doi":"10.1097/xcs.0000000000001759","tag_type":"warning","value":"The definition of “rural” and covariates adjusted for in the models were not specified in the provided text.","value_numeric":null},{"paper_doi":"10.1097/xcs.0000000000001759","tag_type":"warning","value":"The paper is listed as published 2026-03-26 but today's date is May 14, 2026 — treated as a recently published study with no additional concerns.","value_numeric":null}],"summaries":{"limitations":"- Retrospective database study; causality cannot be established.\n- The National Cancer Database captures only facility-reported cases (~70% of U.S. cancers), which may introduce selection bias.\n- Insurance status and rurality are broad categories that may not capture nuanced access-to-care barriers.","what_studied":"Registry analysis of rural breast cancer cases in the National Cancer Database (2004–2021) assessing clinicopathologic and demographic factors associated with stage at diagnosis using multinomial logistic regression.","key_result":"Among 52,287 rural patients, 7,111 (13.6%) were diagnosed at advanced stages. Later-stage diagnosis was more likely for Non-Hispanic Black vs Non-Hispanic White patients (stage 2 OR 1.4 [95% CI 1.26–1.55]; stage 3 OR 1.58 [1.38–1.82]; stage 4 OR 1.29 [1.07–1.54]); for Hispanic patients at stage 3 (OR 1.5 [1.03–2.20]); for uninsured vs insured patients (stage 2 OR 1.37 [1.12–1.68]; stage 3 OR 2.06 [1.61–2.64]; stage 4 OR 3.88 [2.94–5.11]); and for those in East South Central (OR 1.28 [1.07–1.52]) and West South Central (OR 1.33 [1.03–1.70]) vs West North Central at stage 4.","practice_takeaway":"In rural settings, expect higher odds of advanced-stage breast cancer at diagnosis among Non-Hispanic Black and uninsured patients and in East/West South Central regions; use this to focus timely screening and diagnostic access."}},{"doi":"10.1182/blood.2025030872","pmid":"41543441","title":"Global access to commercial CAR T cells: A cross-sectional study of health technology assessment in the G20","journal_title":"Blood Journal","journal_issn":"0006-4971","published_at":"2026-01-16T00:00:00.000Z","url":"https://doi.org/10.1182/blood.2025030872","source_score":19,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2026-01-17","doi":"10.1182/blood.2025030872","days":"7","issn":"0006-4971","rank":"5","field":"Clinical Medicine","score":"19","category":"Hematology","categories":["Hematology"],"_categories":["Hematology"]},"pubmed":{"doi":"10.1182/blood.2025030872","title":"Global access to commercial CAR T cells: A cross-sectional study of health technology assessment in the G20.","journal":"Blood","methods":"","results":"","abstract":"$3b","keywords":[],"pubmed_id":"41543441","conclusions":"","publication_date":"2026-01-16T00:00:00"},"crossref":{"DOI":"10.1182/blood.2025030872","URL":"https://doi.org/10.1182/blood.2025030872","ISSN":["0006-4971","1528-0020"],"link":[{"URL":"https://ashpublications.org/blood/article-pdf/doi/10.1182/blood.2025030872/2498479/blood.2025030872.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https://ashpublications.org/blood/article-pdf/doi/10.1182/blood.2025030872/2498479/blood.2025030872.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Global access to commercial CAR T cells: A cross-sectional study of health technology assessment in the G20"],"author":[{"given":"Alex Y","family":"Ge","sequence":"first","affiliation":[{"name":"UMass Chan Medical School, Worcester, Massachusetts, United States"}]},{"given":"William B","family":"Feldman","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital, Boston, Massachusetts, United States"}]},{"given":"Martin F","family":"Kaiser","sequence":"additional","affiliation":[{"name":"The Institute of Cancer Research, London, United Kingdom"}]},{"given":"Kai","family":"Rejeski","sequence":"additional","affiliation":[{"name":"LMU Munich, Germany"}]},{"given":"Gloria","family":"Iacoboni","sequence":"additional","affiliation":[{"name":"Department of Hematology, Vall d'Hebron University Hospital, Experimental Hematology, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain, Barcelona, Spain"}]},{"given":"Gaurav","family":"Narula","sequence":"additional","affiliation":[{"name":"Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India"}]},{"given":"Jason Yongsheng","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore"}]},{"given":"Michael","family":"Dickinson","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre, Royal Melbourne Hospital and The University of Melbourne, Melbourne, Australia"}]},{"given":"Aaron S","family":"Kesselheim","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital, Boston, Massachusetts, United States"}]},{"given":"Edward Robert Scheffer","family":"Cliff","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre, Melbourne, Australia"}]}],"issued":{"date-parts":[[2026,1,16]]},"member":"234","prefix":"10.1182","source":"Crossref","volume":null,"created":{"date-time":"2026-01-16T15:04:02Z","timestamp":1768575842000,"date-parts":[[2026,1,16]]},"indexed":{"date-time":"2026-01-17T00:31:14Z","timestamp":1768609874356,"date-parts":[[2026,1,17]]},"subject":[],"abstract":"$3c","language":"en","relation":{},"resource":{"primary":{"URL":"https://ashpublications.org/blood/article/doi/10.1182/blood.2025030872/566028/Global-access-to-commercial-CAR-T-cells-A-cross"}},"subtitle":[],"deposited":{"date-time":"2026-01-16T15:04:02Z","timestamp":1768575842000,"date-parts":[[2026,1,16]]},"issn-type":[{"type":"print","value":"0006-4971"},{"type":"electronic","value":"1528-0020"}],"published":{"date-parts":[[2026,1,16]]},"publisher":"American Society of Hematology","reference":null,"short-title":[],"update-policy":"https://doi.org/10.1182/blood.2019cm0000","article-number":"blood.2025030872","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"original-title":[],"container-title":["Blood Journal"],"reference-count":0,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2026,1,16]]},"references-count":0,"short-container-title":[],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1182/blood.2025030872","is_oa":false,"title":"Global access to commercial CAR T cells: A cross-sectional study of health technology assessment in the G20","updated":"2026-01-18T01:04:10+00:00","published_date":"2026-01-16","best_oa_location":null}},"created_at":"2026-01-21T12:05:26.220Z","updated_at":"2026-01-21T12:05:26.220Z","tags":[{"paper_doi":"10.1182/blood.2025030872","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1182/blood.2025030872","tag_type":"category","value":"Hematology","value_numeric":null},{"paper_doi":"10.1182/blood.2025030872","tag_type":"condition","value":"Hematologic Malignancies","value_numeric":null},{"paper_doi":"10.1182/blood.2025030872","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1182/blood.2025030872","tag_type":"modality","value":"CAR T-Cell Therapy","value_numeric":null},{"paper_doi":"10.1182/blood.2025030872","tag_type":"sample_size","value":"n=252","value_numeric":252},{"paper_doi":"10.1182/blood.2025030872","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1182/blood.2025030872","tag_type":"study_design","value":"Cross-Sectional","value_numeric":null},{"paper_doi":"10.1182/blood.2025030872","tag_type":"warning","value":"Only the abstract was available; country-level details and methods may be expanded in the full text.","value_numeric":null},{"paper_doi":"10.1182/blood.2025030872","tag_type":"warning","value":"Sample size refers to country–indication assessments (252), not patients.","value_numeric":null}],"summaries":{"what_studied":"A cross-sectional analysis of health technology assessments (HTAs) for commercial CAR T therapies across G20 countries plus Spain, Singapore, and Switzerland through 1 August 2025. It examined timing and rationale of HTA reimbursement decisions for 18 FDA-approved CAR T product–indication pairs, including 14 countries with public HTA data.","key_result":"Across 252 country–indication evaluations, 48% (122/252) were recommended for public reimbursement. The median time from FDA approval to HTA decision was 1.54 years (IQR 1.15–2.59), and HTA-cited barriers to cost-effectiveness included single-arm trial designs, small study populations, and immature data on survival, safety, and quality of life.","limitations":"Only 14 countries with public HTA data were included. Findings reflect HTA review documentation up to 1 August 2025.","practice_takeaway":"Expect wide variation and delays in reimbursement for CAR T across high- and upper middle-income countries, with about half of country–indication evaluations supported and a typical HTA timeline of ~1.5 years. More mature survival, safety, and quality-of-life data and stronger comparative evidence may help address HTA cost-effectiveness concerns."}},{"doi":"10.1038/s41590-025-02387-1","pmid":"41535626","title":"A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID","journal_title":"Nature Immunology","journal_issn":"1529-2908","published_at":"2026-01-15T00:00:00.000Z","url":"https://doi.org/10.1038/s41590-025-02387-1","source_score":166,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-01-15","doi":"10.1038/s41590-025-02387-1","days":"7","issn":"1529-2908","rank":"1","field":"Clinical Medicine","score":"166","category":"Immunology","categories":["Immunology"],"_categories":["Immunology"]},"pubmed":{"doi":"10.1038/s41590-025-02387-1","title":"A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID.","journal":"Nature immunology","methods":"","results":"","abstract":"$3d","keywords":[],"pubmed_id":"41535626","conclusions":"","publication_date":"2026-01-15T00:00:00"},"crossref":{"DOI":"10.1038/s41590-025-02387-1","URL":"https://doi.org/10.1038/s41590-025-02387-1","ISSN":["1529-2908","1529-2916"],"link":[{"URL":"https://www.nature.com/articles/s41590-025-02387-1.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://www.nature.com/articles/s41590-025-02387-1","content-type":"text/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https://www.nature.com/articles/s41590-025-02387-1.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID"],"author":[{"given":"Saumya","family":"Kumar","sequence":"first","affiliation":[]},{"given":"Chaofan","family":"Li","sequence":"additional","affiliation":[]},{"given":"Liang","family":"Zhou","sequence":"additional","affiliation":[]},{"given":"Qiuyao","family":"Zhan","sequence":"additional","affiliation":[]},{"given":"Ahmed","family":"Alaswad","sequence":"additional","affiliation":[]},{"given":"Sonja","family":"Volland","sequence":"additional","affiliation":[]},{"given":"Bibiana","family":"Costa","sequence":"additional","affiliation":[]},{"given":"Simon Alexander","family":"Krooss","sequence":"additional","affiliation":[]},{"given":"Isabel","family":"Klefenz","sequence":"additional","affiliation":[]},{"given":"Hagen","family":"Schmaus","sequence":"additional","affiliation":[]},{"given":"Antonia","family":"Zeuzem","sequence":"additional","affiliation":[]},{"given":"Dorothee","family":"von Witzendorff","sequence":"additional","affiliation":[]},{"given":"Helena","family":"Lickei","sequence":"additional","affiliation":[]},{"given":"Lea","family":"Pueschel","sequence":"additional","affiliation":[]},{"given":"Anke R. M.","family":"Kraft","sequence":"additional","affiliation":[]},{"given":"Markus","family":"Cornberg","sequence":"additional","affiliation":[]},{"given":"Andreas Rembert","family":"Koczulla","sequence":"additional","affiliation":[]},{"given":"Isabell","family":"Pink","sequence":"additional","affiliation":[]},{"given":"Marius M.","family":"Hoeper","sequence":"additional","affiliation":[]},{"given":"Cheng-Jian","family":"Xu","sequence":"additional","affiliation":[]},{"given":"Susanne","family":"Häussler","sequence":"additional","affiliation":[]},{"given":"Miriam","family":"Wiestler","sequence":"additional","affiliation":[]},{"given":"Mihai G.","family":"Netea","sequence":"additional","affiliation":[]},{"given":"Thomas","family":"Illig","sequence":"additional","affiliation":[]},{"given":"Jie","family":"Sun","sequence":"additional","affiliation":[]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[]}],"issued":{"date-parts":[[2026,1,14]]},"member":"297","prefix":"10.1038","source":"Crossref","volume":null,"created":{"date-time":"2026-01-14T10:02:04Z","timestamp":1768384924000,"date-parts":[[2026,1,14]]},"indexed":{"date-time":"2026-01-14T16:27:09Z","timestamp":1768408029396,"date-parts":[[2026,1,14]]},"license":[{"URL":"https://creativecommons.org/licenses/by/4.0","start":{"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000,"date-parts":[[2026,1,14]]},"delay-in-days":0,"content-version":"tdm"},{"URL":"https://creativecommons.org/licenses/by/4.0","start":{"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000,"date-parts":[[2026,1,14]]},"delay-in-days":0,"content-version":"vor"}],"subject":[],"abstract":"$3e","language":"en","relation":{},"resource":{"primary":{"URL":"https://www.nature.com/articles/s41590-025-02387-1"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"ArticleHistory","label":"Article History"},"label":"Received","order":1,"value":"17 March 2025"},{"name":"accepted","group":{"name":"ArticleHistory","label":"Article History"},"label":"Accepted","order":2,"value":"3 December 2025"},{"name":"first_online","group":{"name":"ArticleHistory","label":"Article History"},"label":"First Online","order":3,"value":"14 January 2026"},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"},"order":1,"value":"M.G.N. is the scientific founder of Biotrip, Salvina, TTxD and Lemba. MHH has received fees for consultations or lectures from 35Pharma, Acceleron, Actelion, Aerovate, AOP Health, Bayer, Ferrer, Gossamer, Inhibikase, Janssen, Keros, MSD and Novartis. The other authors declare no competing interests."}],"deposited":{"date-time":"2026-01-14T10:02:06Z","timestamp":1768384926000,"date-parts":[[2026,1,14]]},"issn-type":[{"type":"print","value":"1529-2908"},{"type":"electronic","value":"1529-2916"}],"published":{"date-parts":[[2026,1,14]]},"publisher":"Springer Science and Business Media LLC","reference":[{"DOI":"10.1016/j.eclinm.2021.101019","key":"2387_CR1","year":"2021","issue":null,"author":"HE Davis","volume":"38","first-page":"101019","unstructured":"Davis, H. E. et al. Characterizing long COVID in an international cohort: 7 months of symptoms and their impact. eClinicalMedicine 38, 101019 (2021).","article-title":null,"journal-title":"eClinicalMedicine","doi-asserted-by":"publisher"},{"DOI":"10.1097/PR9.0000000000000913","key":"2387_CR2","year":"2021","issue":null,"author":"L McCorkell","volume":"6","first-page":null,"unstructured":"McCorkell, L. et al. Patient-led research collaborative: embedding patients in the long COVID narrative. Pain Rep. 6, e913 (2021).","article-title":null,"journal-title":"Pain Rep.","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41467-023-43661-w","key":"2387_CR3","year":"2023","issue":null,"author":"CE Hastie","volume":"14","first-page":null,"unstructured":"Hastie, C. E. et al. True prevalence of long-COVID in a nationwide, population cohort study. Nat. Commun. 14, 7892 (2023).","article-title":null,"journal-title":"Nat. Commun.","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41591-021-01283-z","key":"2387_CR4","year":"2021","issue":null,"author":"A Nalbandian","volume":"27","first-page":"601","unstructured":"Nalbandian, A. et al. Post-acute COVID-19 syndrome. Nat. Med. 27, 601–615 (2021).","article-title":null,"journal-title":"Nat. Med.","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41467-024-52404-4","key":"2387_CR5","year":"2024","issue":null,"author":"PM Archambault","volume":"15","first-page":null,"unstructured":"Archambault, P. M. et al. Post-COVID-19 condition symptoms among emergency department patients tested for SARS-CoV-2 infection. Nat. Commun. 15, 8449 (2024).","article-title":null,"journal-title":"Nat. Commun.","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41586-023-06651-y","key":"2387_CR6","year":"2023","issue":null,"author":"J Klein","volume":"623","first-page":"139","unstructured":"Klein, J. et al. Distinguishing features of long COVID identified through immune profiling. Nature 623, 139–148 (2023).","article-title":null,"journal-title":"Nature","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.cell.2022.01.014","key":"2387_CR7","year":"2022","issue":null,"author":"Y Su","volume":"185","first-page":"881","unstructured":"Su, Y. et al. Multiple early factors anticipate post-acute COVID-19 sequelae. Cell 185, 881–895 (2022).","article-title":null,"journal-title":"Cell","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.xcrm.2022.100663","key":"2387_CR8","year":"2022","issue":null,"author":"C Schultheiß","volume":"3","first-page":null,"unstructured":"Schultheiß, C. et al. The IL-1β, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19. Cell Rep. Med. 3, 100663 (2022).","article-title":null,"journal-title":"Cell Rep. Med.","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41467-024-51893-7","key":"2387_CR9","year":"2024","issue":null,"author":"S Lu","volume":"15","first-page":null,"unstructured":"Lu, S. et al. Early biological markers of post-acute sequelae of SARS-CoV-2 infection. Nat. Commun. 15, 7466 (2024).","article-title":null,"journal-title":"Nat. Commun.","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41590-021-01113-x","key":"2387_CR10","year":"2022","issue":null,"author":"C Phetsouphanh","volume":"23","first-page":"210","unstructured":"Phetsouphanh, C. et al. Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection. Nat. Immunol. 23, 210–216 (2022).","article-title":null,"journal-title":"Nat. Immunol.","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.cell.2023.09.013","key":"2387_CR11","year":"2023","issue":null,"author":"AC Wong","volume":"186","first-page":"4851","unstructured":"Wong, A. C. et al. Serotonin reduction in post-acute sequelae of viral infection. Cell 186, 4851–4867 (2023).","article-title":null,"journal-title":"Cell","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41577-023-00904-7","key":"2387_CR12","year":"2023","issue":null,"author":"DM Altmann","volume":"23","first-page":"618","unstructured":"Altmann, D. M., Whettlock, E. M., Liu, S., Arachchillage, D. J. & Boyton, R. J. The immunology of long COVID. Nat. Rev. Immunol. 23, 618–634 (2023).","article-title":null,"journal-title":"Nat. Rev. Immunol.","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41579-022-00846-2","key":"2387_CR13","year":"2023","issue":null,"author":"HE Davis","volume":"21","first-page":"133","unstructured":"Davis, H. E., McCorkell, L., Vogel, J. M. & Topol, E. J. Long COVID: major findings, mechanisms and recommendations. Nat. Rev. Microbiol. 21, 133–146 (2023).","article-title":null,"journal-title":"Nat. Rev. Microbiol.","doi-asserted-by":"publisher"},{"DOI":"10.1016/S0140-6736(24)01136-X","key":"2387_CR14","year":"2024","issue":null,"author":"T Greenhalgh","volume":"404","first-page":"707","unstructured":"Greenhalgh, T., Sivan, M., Perlowski, A. & Nikolich, J. Ž. Long COVID: a clinical update. Lancet 404, 707–724 (2024).","article-title":null,"journal-title":"Lancet","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.cell.2024.07.054","key":"2387_CR15","year":"2024","issue":null,"author":"MJ Peluso","volume":"187","first-page":"5500","unstructured":"Peluso, M. J. & Deeks, S. G. Mechanisms of long COVID and the path toward therapeutics. Cell 187, 5500–5529 (2024).","article-title":null,"journal-title":"Cell","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41590-024-01778-0","key":"2387_CR16","year":"2024","issue":null,"author":"F Liew","volume":"25","first-page":"607","unstructured":"Liew, F. et al. Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease. Nat. Immunol. 25, 607–621 (2024).","article-title":null,"journal-title":"Nat. Immunol.","doi-asserted-by":"publisher"},{"DOI":"10.1126/science.adg7942","key":"2387_CR17","year":"2024","issue":null,"author":"C Cervia-Hasler","volume":"383","first-page":null,"unstructured":"Cervia-Hasler, C. et al. Persistent complement dysregulation with signs of thromboinflammation in active long COVID. Science 383, eadg7942 (2024).","article-title":null,"journal-title":"Science","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41591-024-03173-6","key":"2387_CR18","year":"2024","issue":null,"author":"Z Al-Aly","volume":"30","first-page":"2148","unstructured":"Al-Aly, Z. et al. Long COVID science, research and policy. Nat. Med. 30, 2148–2164 (2024).","article-title":null,"journal-title":"Nat. Med.","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41590-024-01754-8","key":"2387_CR19","year":"2024","issue":null,"author":"AL Hanson","volume":"25","first-page":"471","unstructured":"Hanson, A. L. et al. Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19. Nat. Immunol. 25, 471–482 (2024).","article-title":null,"journal-title":"Nat. Immunol.","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41590-023-01724-6","key":"2387_CR20","year":"2024","issue":null,"author":"K Yin","volume":"25","first-page":"218","unstructured":"Yin, K. et al. Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2. Nat. Immunol. 25, 218–225 (2024).","article-title":null,"journal-title":"Nat. Immunol.","doi-asserted-by":"publisher"},{"DOI":null,"key":"2387_CR21","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"A Clinical Case Definition of Post COVID-19 Condition by a Delphi Consensus (World Health Organization, 2021); https://www.who.int/publications/i/item/WHO-2019-nCoV-Post_COVID-19_condition-Clinical_case_definition-2021.1","article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.1055/a-1551-9734","key":"2387_CR22","year":"2021","issue":null,"author":"AR Koczulla","volume":"75","first-page":"869","unstructured":"Koczulla, A. R. et al. S1 guideline post-COVID/long-COVID. Pneumologie 75, 869–900 (2021).","article-title":null,"journal-title":"Pneumologie","doi-asserted-by":"publisher"},{"DOI":"10.1126/scitranslmed.adn0136","key":"2387_CR23","year":"2024","issue":null,"author":"C Li","volume":"16","first-page":null,"unstructured":"Li, C. et al. Comparative single-cell analysis reveals IFN-γ as a driver of respiratory sequelae after acute COVID-19. Sci. Transl. Med. 16, eadn0136 (2024).","article-title":null,"journal-title":"Sci. Transl. Med.","doi-asserted-by":"publisher"},{"DOI":"10.1348/1359107041557048","key":"2387_CR24","year":"2004","issue":null,"author":"J De Vries","volume":"9","first-page":"279","unstructured":"De Vries, J., Michielsen, H., Van Heck, G. L. & Drent, M. Measuring fatigue in sarcoidosis: the Fatigue Assessment Scale (FAS). Br. J. Health Psychol. 9, 279–291 (2004).","article-title":null,"journal-title":"Br. J. Health Psychol.","doi-asserted-by":"publisher"},{"DOI":"10.1183/09031936.00002512","key":"2387_CR25","year":"2012","issue":null,"author":"M Drent","volume":"40","first-page":"255","unstructured":"Drent, M., Lower, E. E. & De Vries, J. Sarcoidosis-associated fatigue. Eur. Respir. J. 40, 255–263 (2012).","article-title":null,"journal-title":"Eur. Respir. J.","doi-asserted-by":"publisher"},{"DOI":"10.1097/MCP.0000000000000496","key":"2387_CR26","year":"2018","issue":null,"author":"C Hendriks","volume":"24","first-page":"495","unstructured":"Hendriks, C., Drent, M., Elfferich, M. & De Vries, J. The Fatigue Assessment Scale: quality and availability in sarcoidosis and other diseases. Curr. Opin. Pulm. Med. 24, 495–503 (2018).","article-title":null,"journal-title":"Curr. Opin. Pulm. Med.","doi-asserted-by":"publisher"},{"DOI":"10.1183/13993003.01494-2020","key":"2387_CR27","year":"2020","issue":null,"author":"FA Klok","volume":"56","first-page":"2001494","unstructured":"Klok, F. A. et al. The post-COVID-19 functional status scale: a tool to measure functional status over time after COVID-19. Eur. Respir. J. 56, 2001494 (2020).","article-title":null,"journal-title":"Eur. Respir. J.","doi-asserted-by":"publisher"},{"DOI":"10.1126/scitranslmed.abo0686","key":"2387_CR28","year":"2022","issue":null,"author":"AH Jonsson","volume":"14","first-page":null,"unstructured":"Jonsson, A. H. et al. Granzyme K+ CD8 T cells form a core population in inflamed human tissue. Sci. Transl. Med. 14, eabo0686 (2022).","article-title":null,"journal-title":"Sci. Transl. Med.","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.immuni.2023.10.013","key":"2387_CR29","year":"2023","issue":null,"author":"M Terekhova","volume":"56","first-page":"2836","unstructured":"Terekhova, M. et al. Single-cell atlas of healthy human blood unveils age-related loss of NKG2C+GZMB−CD8+ memory T cells and accumulation of type 2 memory T cells. Immunity 56, 2836–2854 (2023).","article-title":null,"journal-title":"Immunity","doi-asserted-by":"publisher"},{"DOI":"10.1126/sciimmunol.abg5021","key":"2387_CR30","year":"2021","issue":null,"author":"S Notarbartolo","volume":"6","first-page":null,"unstructured":"Notarbartolo, S. et al. Integrated longitudinal immunophenotypic, transcriptional and repertoire analyses delineate immune responses in COVID-19 patients. Sci. Immunol. 6, eabg5021 (2021).","article-title":null,"journal-title":"Sci. Immunol.","doi-asserted-by":"publisher"},{"DOI":"10.1159/000540297","key":"2387_CR31","year":"2024","issue":null,"author":"SA Krooss","volume":"103","first-page":"622","unstructured":"Krooss, S. A. et al. Bronchodilator response in post-COVID-19 patients undergoing pulmonary rehabilitation. Respiration 103, 622–629 (2024).","article-title":null,"journal-title":"Respiration","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41590-024-01975-x","key":"2387_CR32","year":"2024","issue":null,"author":"JI Bailey","volume":"25","first-page":"2097","unstructured":"Bailey, J. I. et al. Profibrotic monocyte-derived alveolar macrophages are expanded in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19. Nat. Immunol. 25, 2097–2109 (2024).","article-title":null,"journal-title":"Nat. Immunol.","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.cell.2021.11.033","key":"2387_CR33","year":"2021","issue":null,"author":"D Wendisch","volume":"184","first-page":"6243","unstructured":"Wendisch, D. et al. SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis. Cell 184, 6243–6261 (2021).","article-title":null,"journal-title":"Cell","doi-asserted-by":"publisher"},{"DOI":"10.1002/eji.201545802","key":"2387_CR34","year":"2016","issue":null,"author":"J Däbritz","volume":"46","first-page":"1997","unstructured":"Däbritz, J. et al. Activation-dependent cell death of human monocytes is a novel mechanism of fine-tuning inflammation and autoimmunity. Eur. J. Immunol. 46, 1997–2007 (2016).","article-title":null,"journal-title":"Eur. J. Immunol.","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41419-018-0520-2","key":"2387_CR35","year":"2018","issue":null,"author":"M Monguió-Tortajada","volume":"9","first-page":null,"unstructured":"Monguió-Tortajada, M., Franquesa, M., Sarrias, M.-R. & Borràs, F. E. Low doses of LPS exacerbate the inflammatory response and trigger death on TLR3-primed human monocytes. Cell Death Dis. 9, 499 (2018).","article-title":null,"journal-title":"Cell Death Dis.","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.cell.2020.08.001","key":"2387_CR36","year":"2020","issue":null,"author":"J Schulte-Schrepping","volume":"182","first-page":"1419","unstructured":"Schulte-Schrepping, J. et al. Severe COVID-19 is marked by a dysregulated myeloid cell compartment. Cell 182, 1419–1440 (2020).","article-title":null,"journal-title":"Cell","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.xgen.2022.100232","key":"2387_CR37","year":"2023","issue":null,"author":"B Zhang","volume":"3","first-page":null,"unstructured":"Zhang, B. et al. Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19. Cell Genom. 3, 100232 (2023).","article-title":null,"journal-title":"Cell Genom.","doi-asserted-by":"publisher"},{"DOI":"10.3390/ijms24076142","key":"2387_CR38","year":"2023","issue":null,"author":"Z Mohd Zawawi","volume":"24","first-page":"6142","unstructured":"Mohd Zawawi, Z. et al. Prospective roles of tumor necrosis factor-α (TNF-α) in COVID-19: prognosis, therapeutic and management. Int. J. Mol. Sci. 24, 6142 (2023).","article-title":null,"journal-title":"Int. J. Mol. Sci.","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41586-024-08395-9","key":"2387_CR39","year":"2025","issue":null,"author":"F Lan","volume":"638","first-page":"490","unstructured":"Lan, F. et al. GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases. Nature 638, 490–498 (2025).","article-title":null,"journal-title":"Nature","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.molimm.2024.07.003","key":"2387_CR40","year":"2024","issue":null,"author":"L Zhao","volume":"173","first-page":"40","unstructured":"Zhao, L. et al. Characteristics and functions of an atypical inflammation-associated GZMK+GZMB+CD8+ T subset in people living with HIV-1. Mol. Immunol. 173, 40–52 (2024).","article-title":null,"journal-title":"Mol. Immunol.","doi-asserted-by":"publisher"},{"DOI":"10.1074/jbc.M115.702571","key":"2387_CR41","year":"2016","issue":null,"author":"Y Qiao","volume":"291","first-page":"5068","unstructured":"Qiao, Y. et al. AP-1 is a key regulator of proinflammatory cytokine TNFα-mediated triple-negative breast cancer progression. J. Biol. Chem. 291, 5068–5079 (2016).","article-title":null,"journal-title":"J. Biol. Chem.","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41467-023-38682-4","key":"2387_CR42","year":"2023","issue":null,"author":"A Talla","volume":"14","first-page":null,"unstructured":"Talla, A. et al. Persistent serum protein signatures define an inflammatory subcategory of long COVID. Nat. Commun. 14, 3417 (2023).","article-title":null,"journal-title":"Nat. Commun.","doi-asserted-by":"publisher"},{"DOI":"10.1002/jmv.28364","key":"2387_CR43","year":"2023","issue":null,"author":"C Schultheiß","volume":"95","first-page":null,"unstructured":"Schultheiß, C. et al. Liquid biomarkers of macrophage dysregulation and circulating spike protein illustrate the biological heterogeneity in patients with post-acute sequelae of COVID-19. J. Med. Virol. 95, e28364 (2023).","article-title":null,"journal-title":"J. Med. Virol.","doi-asserted-by":"publisher"},{"DOI":"10.1212/NXI.0000000000200003","key":"2387_CR44","year":"2022","issue":null,"author":"MJ Peluso","volume":"9","first-page":null,"unstructured":"Peluso, M. J. et al. Plasma markers of neurologic injury and inflammation in people with self-reported neurologic postacute sequelae of SARS-CoV-2 infection. Neurol. Neuroimmunol. Neuroinflamm. 9, e200003 (2022).","article-title":null,"journal-title":"Neurol. Neuroimmunol. Neuroinflamm.","doi-asserted-by":"publisher"},{"DOI":"10.1002/prca.202200031","key":"2387_CR45","year":"2022","issue":null,"author":"J Zhao","volume":"16","first-page":null,"unstructured":"Zhao, J. et al. Plasma biomarkers for systemic inflammation in COVID-19 survivors. Proteomics Clin. Appl. 16, e2200031 (2022).","article-title":null,"journal-title":"Proteomics Clin. Appl.","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.immuni.2013.11.022","key":"2387_CR46","year":"2014","issue":null,"author":"Y Yoshida","volume":"40","first-page":"187","unstructured":"Yoshida, Y. et al. The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation. Immunity 40, 187–198 (2014).","article-title":null,"journal-title":"Immunity","doi-asserted-by":"publisher"},{"DOI":"10.1007/s12079-011-0145-z","key":"2387_CR47","year":"2011","issue":null,"author":"A Leask","volume":"5","first-page":"325","unstructured":"Leask, A. Eureka! ETS a target for fibrosis! J. Cell Commun. Signal. 5, 325–326 (2011).","article-title":null,"journal-title":"J. Cell Commun. Signal.","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.yjmcc.2014.10.010","key":"2387_CR48","year":"2014","issue":null,"author":"G Ende","volume":"77","first-page":"125","unstructured":"Ende, G. et al. TNF-α-mediated adhesion of monocytes to endothelial cells—the role of ephrinA1. J. Mol. Cell. Cardiol. 77, 125–135 (2014).","article-title":null,"journal-title":"J. Mol. Cell. Cardiol.","doi-asserted-by":"publisher"},{"DOI":"10.5334/ojb.70","key":"2387_CR49","year":"2021","issue":null,"author":"V Kopfnagel","volume":"8","first-page":"2","unstructured":"Kopfnagel, V. et al. The Hannover Unified Biobank (HUB)—centralized standardised biobanking at Hannover Medical School. Open J. Bioresour. 8, 2 (2021).","article-title":null,"journal-title":"Open J. Bioresour.","doi-asserted-by":"publisher"},{"DOI":"10.1086/519795","key":"2387_CR50","year":"2007","issue":null,"author":"S Purcell","volume":"81","first-page":"559","unstructured":"Purcell, S. et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559–575 (2007).","article-title":null,"journal-title":"Am. J. Hum. Genet.","doi-asserted-by":"publisher"},{"DOI":"10.1093/bioinformatics/btu704","key":"2387_CR51","year":"2015","issue":null,"author":"C Fuchsberger","volume":"31","first-page":"782","unstructured":"Fuchsberger, C., Abecasis, G. R. & Hinds, D. A. minimac2: faster genotype imputation. Bioinformatics 31, 782–784 (2015).","article-title":null,"journal-title":"Bioinformatics","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41586-021-03205-y","key":"2387_CR52","year":"2021","issue":null,"author":"D Taliun","volume":"590","first-page":"290","unstructured":"Taliun, D. et al. Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program. Nature 590, 290–299 (2021).","article-title":null,"journal-title":"Nature","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41592-020-0820-1","key":"2387_CR53","year":"2020","issue":null,"author":"H Heaton","volume":"17","first-page":"615","unstructured":"Heaton, H. et al. Souporcell: robust clustering of single-cell RNA-seq data by genotype without reference genotypes. Nat. Methods 17, 615–620 (2020).","article-title":null,"journal-title":"Nat. Methods","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41587-023-01767-y","key":"2387_CR54","year":"2024","issue":null,"author":"Y Hao","volume":"42","first-page":"293","unstructured":"Hao, Y. et al. Dictionary learning for integrative, multimodal and scalable single-cell analysis. Nat. Biotechnol. 42, 293–304 (2024).","article-title":null,"journal-title":"Nat. Biotechnol.","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41592-021-01282-5","key":"2387_CR55","year":"2021","issue":null,"author":"T Stuart","volume":"18","first-page":"1333","unstructured":"Stuart, T., Srivastava, A., Madad, S., Lareau, C. A. & Satija, R. Single-cell chromatin state analysis with Signac. Nat. Methods 18, 1333–1341 (2021).","article-title":null,"journal-title":"Nat. Methods","doi-asserted-by":"publisher"},{"DOI":"10.1038/s41587-021-01033-z","key":"2387_CR56","year":"2022","issue":null,"author":"E Dann","volume":"40","first-page":"245","unstructured":"Dann, E., Henderson, N. C., Teichmann, S. A., Morgan, M. D. & Marioni, J. C. Differential abundance testing on single-cell data using k-nearest neighbor graphs. Nat. Biotechnol. 40, 245–253 (2022).","article-title":null,"journal-title":"Nat. Biotechnol.","doi-asserted-by":"publisher"},{"DOI":"10.1093/bioinformatics/btv715","key":"2387_CR57","year":"2016","issue":null,"author":"P Angerer","volume":"32","first-page":"1241","unstructured":"Angerer, P. et al. destiny: diffusion maps for large-scale single-cell data in R. Bioinformatics 32, 1241–1243 (2016).","article-title":null,"journal-title":"Bioinformatics","doi-asserted-by":"publisher"},{"DOI":"10.1186/s12864-018-4772-0","key":"2387_CR58","year":"2018","issue":null,"author":"K Street","volume":"19","first-page":null,"unstructured":"Street, K. et al. Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics. BMC Genomics 19, 477 (2018).","article-title":null,"journal-title":"BMC Genomics","doi-asserted-by":"publisher"}],"short-title":[],"update-policy":"https://doi.org/10.1007/springer_crossmark_policy","alternative-id":["2387"],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"original-title":[],"container-title":["Nature Immunology"],"reference-count":58,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2026,1,14]]},"references-count":58,"short-container-title":["Nat Immunol"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1038/s41590-025-02387-1","is_oa":true,"title":"A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID","updated":"2026-01-15T02:17:35+00:00","published_date":"2026-01-14","best_oa_location":{"url":"https://doi.org/10.1038/s41590-025-02387-1","pmh_id":null,"url_for_pdf":null,"url_for_landing_page":"https://doi.org/10.1038/s41590-025-02387-1"}}},"created_at":"2026-01-17T09:03:27.421Z","updated_at":"2026-01-21T12:05:26.220Z","tags":[{"paper_doi":"10.1038/s41590-025-02387-1","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1038/s41590-025-02387-1","tag_type":"category","value":"Immunology","value_numeric":null},{"paper_doi":"10.1038/s41590-025-02387-1","tag_type":"condition","value":"Long COVID","value_numeric":null},{"paper_doi":"10.1038/s41590-025-02387-1","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1038/s41590-025-02387-1","tag_type":"study_design","value":"Cross-Sectional","value_numeric":null},{"paper_doi":"10.1038/s41590-025-02387-1","tag_type":"warning","value":"Abstract does not provide absolute effect sizes or rates; subgroup numbers are small for some respiratory PASC analyses.","value_numeric":null},{"paper_doi":"10.1038/s41590-025-02387-1","tag_type":"warning","value":"Study design label is approximate; this is an integrative, multi-cohort mechanistic analysis rather than a single-design study.","value_numeric":null}],"summaries":{"what_studied":"Integrated single-cell multiome data, immunologic profiling, and functional assays across multiple cohorts to map immune changes in long COVID, comparing non-infected, acute infection, recovered, and long COVID groups (including respiratory PASC).","key_result":"A distinct circulating monocyte transcriptional state (LC-Mo) was enriched after mild–moderate acute infection, accompanied by persistent plasma CCL2, CXCL11, and TNF elevations; LC-Mo showed TGFβ and WNT–β-catenin signaling and correlated with fatigue severity. Protein markers of LC-Mo were higher with pronounced fatigue or dyspnea, severe respiratory symptoms showed higher LC-Mo expression, bronchoalveolar LC-Mo–like macrophages were profibrotic, and individuals with high LC-Mo states had impaired interferon responses after stimulation.","limitations":"Findings are observational and correlative across multi-cohort datasets, limiting causal inference. Some subgroups were small (e.g., respiratory PASC n=5; bronchial hyper-responsiveness n=3; bronchoalveolar lavage samples from those with severe respiratory symptoms), which may affect generalizability."}},{"doi":"10.1016/j.cmet.2025.12.008","pmid":"41534526","title":"Cytoarchitectural multi-depot profiling reveals immune-metabolic crosstalk in human colon-associated adipose tissue","journal_title":"Cell Metabolism","journal_issn":"1550-4131","published_at":"2026-01-15T00:00:00.000Z","url":"https://doi.org/10.1016/j.cmet.2025.12.008","source_score":171,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-01-15","doi":"10.1016/j.cmet.2025.12.008","days":"7","issn":"1550-4131","rank":"1","field":"Clinical Medicine","score":"171","category":"Endocrinology & Metabolism","categories":["Endocrinology & Metabolism"],"_categories":["Endocrinology & Metabolism"]},"pubmed":{"doi":"10.1016/j.cmet.2025.12.008","title":"Cytoarchitectural multi-depot profiling reveals immune-metabolic crosstalk in human colon-associated adipose tissue.","journal":"Cell metabolism","methods":"","results":"","abstract":"$3f","keywords":["adipocyte subtypes","adipose depots","cell-cell communication","cellular heterogeneity","inflammation","insulin resistance","microbiome","obesity","transcriptomics"],"pubmed_id":"41534526","conclusions":"","publication_date":"2026-01-15T00:00:00"},"crossref":{"DOI":"10.1016/j.cmet.2025.12.008","URL":"https://doi.org/10.1016/j.cmet.2025.12.008","ISSN":["1550-4131"],"link":[{"URL":"https://api.elsevier.com/content/article/PII:S155041312500539X?httpAccept=text/xml","content-type":"text/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https://api.elsevier.com/content/article/PII:S155041312500539X?httpAccept=text/plain","content-type":"text/plain","content-version":"vor","intended-application":"text-mining"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Cytoarchitectural multi-depot profiling reveals immune-metabolic crosstalk in human colon-associated adipose tissue"],"author":[{"given":"Jutta","family":"Jalkanen","sequence":"first","affiliation":[]},{"given":"Jiawei","family":"Zhong","sequence":"additional","affiliation":[]},{"given":"Pamela A.","family":"Nono Nankam","sequence":"additional","affiliation":[]},{"given":"Nayanika","family":"Bhalla","sequence":"additional","affiliation":[]},{"given":"Merve","family":"Elmastas","sequence":"additional","affiliation":[]},{"given":"Jiaxin","family":"Luo","sequence":"additional","affiliation":[]},{"given":"Sophie","family":"Weinbrenner","sequence":"additional","affiliation":[]},{"given":"Scott","family":"Frendo-Cumbo","sequence":"additional","affiliation":[]},{"given":"Benedek","family":"Pesti","sequence":"additional","affiliation":[]},{"given":"William","family":"Gourash","sequence":"additional","affiliation":[]},{"given":"Anita","family":"Courcoulas","sequence":"additional","affiliation":[]},{"given":"Zinger","family":"Yang Loureiro","sequence":"additional","affiliation":[]},{"given":"Arne","family":"Dietrich","sequence":"additional","affiliation":[]},{"given":"Jesper","family":"Bäckdahl","sequence":"additional","affiliation":[]},{"given":"Anders","family":"Thorell","sequence":"additional","affiliation":[]},{"given":"Marcus","family":"Buggert","sequence":"additional","affiliation":[]},{"given":"Joanna","family":"Kalucka","sequence":"additional","affiliation":[]},{"given":"Margo P.","family":"Emont","sequence":"additional","affiliation":[]},{"given":"Evan D.","family":"Rosen","sequence":"additional","affiliation":[]},{"given":"Matthias","family":"Blüher","sequence":"additional","affiliation":[]},{"given":"Peter","family":"Kovacs","sequence":"additional","affiliation":[]},{"given":"Patrik L.","family":"Ståhl","sequence":"additional","affiliation":[]},{"given":"Lucas","family":"Massier","sequence":"additional","affiliation":[]},{"given":"Mikael","family":"Rydén","sequence":"additional","affiliation":[]},{"given":"Niklas","family":"Mejhert","sequence":"additional","affiliation":[]}],"funder":[{"id":[{"id":"10.13039/501100018713","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/501100018713","name":"Centrum for innovativ medicin","doi-asserted-by":"publisher"},{"id":[{"id":"10.13039/501100001648","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher"},{"id":[{"id":"10.13039/501100006129","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/501100006129","name":"King Gustaf V and Queen Victoria's Masonic Foundation","doi-asserted-by":"publisher"},{"id":[{"id":"10.13039/501100000781","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/501100000781","name":"European Research Council","doi-asserted-by":"publisher"},{"id":[{"id":"10.13039/501100004348","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/501100004348","name":"Region Stockholm","doi-asserted-by":"publisher"},{"id":[{"id":"10.13039/501100004063","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/501100004063","name":"Knut and Alice Wallenberg Foundation","doi-asserted-by":"publisher"},{"id":[{"id":"10.13039/501100009804","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/501100009804","name":"Swedish Diabetes Foundation","doi-asserted-by":"publisher"},{"id":[{"id":"10.13039/501100009708","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher"},{"id":[{"id":"10.13039/501100004359","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher"},{"id":[{"id":"10.13039/100015326","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/100015326","name":"National Institutes of Health Common Fund","doi-asserted-by":"publisher"}],"issued":{"date-parts":[[2026,1]]},"member":"78","prefix":"10.1016","source":"Crossref","volume":null,"created":{"date-time":"2026-01-13T15:55:26Z","timestamp":1768319726000,"date-parts":[[2026,1,13]]},"indexed":{"date-time":"2026-01-14T18:42:42Z","timestamp":1768416162001,"date-parts":[[2026,1,14]]},"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","start":{"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000,"date-parts":[[2026,1,1]]},"delay-in-days":0,"content-version":"tdm"},{"URL":"https://www.elsevier.com/legal/tdmrep-license","start":{"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000,"date-parts":[[2026,1,1]]},"delay-in-days":0,"content-version":"tdm"},{"URL":"http://creativecommons.org/licenses/by/4.0/","start":{"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000,"date-parts":[[2025,12,15]]},"delay-in-days":0,"content-version":"vor"}],"subject":[],"abstract":null,"language":"en","relation":{},"resource":{"primary":{"URL":"https://linkinghub.elsevier.com/retrieve/pii/S155041312500539X"}},"subtitle":[],"assertion":[{"name":"publisher","label":"This article is maintained by","value":"Elsevier"},{"name":"articletitle","label":"Article Title","value":"Cytoarchitectural multi-depot profiling reveals immune-metabolic crosstalk in human colon-associated adipose tissue"},{"name":"journaltitle","label":"Journal Title","value":"Cell Metabolism"},{"name":"articlelink","label":"CrossRef DOI link to publisher maintained version","value":"https://doi.org/10.1016/j.cmet.2025.12.008"},{"name":"content_type","label":"Content Type","value":"article"},{"name":"copyright","label":"Copyright","value":"© 2025 The Authors. Published by Elsevier Inc."}],"deposited":{"date-time":"2026-01-14T10:38:31Z","timestamp":1768387111000,"date-parts":[[2026,1,14]]},"issn-type":[{"type":"print","value":"1550-4131"}],"published":{"date-parts":[[2026,1]]},"publisher":"Elsevier BV","reference":[{"DOI":"10.1016/j.cell.2021.12.016","key":"10.1016/j.cmet.2025.12.008_bib1","year":"2022","issue":null,"author":"Sakers","volume":"185","first-page":"419","unstructured":null,"article-title":"Adipose-tissue plasticity in health and disease","journal-title":"Cell","doi-asserted-by":"crossref"},{"DOI":"10.1038/s41586-022-04518-2","key":"10.1016/j.cmet.2025.12.008_bib2","year":"2022","issue":null,"author":"Emont","volume":"7903","first-page":"926","unstructured":null,"article-title":"A single-cell atlas of human and mouse white adipose tissue","journal-title":"Nature","doi-asserted-by":"crossref"},{"DOI":"10.1038/s41598-019-47719-y","key":"10.1016/j.cmet.2025.12.008_bib3","year":"2019","issue":null,"author":"Belligoli","volume":"9","first-page":null,"unstructured":null,"article-title":"Characterization of subcutaneous and omental adipose tissue in patients with obesity and with different degrees of glucose impairment","journal-title":"Sci. Rep.","doi-asserted-by":"crossref"},{"DOI":"10.1038/s42255-019-0152-6","key":"10.1016/j.cmet.2025.12.008_bib4","year":"2019","issue":null,"author":"Vijay","volume":"2","first-page":"97","unstructured":null,"article-title":"Single-cell analysis of human adipose tissue identifies depot- and disease-specific cell types","journal-title":"Nat. Metab.","doi-asserted-by":"crossref"},{"DOI":"10.1152/ajpgi.00256.2021","key":"10.1016/j.cmet.2025.12.008_bib5","year":"2022","issue":null,"author":"Zhang","volume":"322","first-page":"G310","unstructured":null,"article-title":"Characteristics of mesenteric adipose tissue attached to different intestinal segments and their roles in immune regulation","journal-title":"Am. J. Physiol., Gastrointest. Liver Physiol.","doi-asserted-by":"crossref"},{"DOI":"10.1152/ajpgi.00079.2018","key":"10.1016/j.cmet.2025.12.008_bib6","year":"2018","issue":null,"author":"Wu","volume":"315","first-page":"G659","unstructured":null,"article-title":"Mesenteric adipose tissue contributes to intestinal barrier integrity and protects against nonalcoholic fatty liver disease in mice","journal-title":"Am. J. Physiol., Gastrointest. Liver Physiol.","doi-asserted-by":"crossref"},{"DOI":"10.1136/gutjnl-2021-324603","key":"10.1016/j.cmet.2025.12.008_bib7","year":"2022","issue":null,"author":"Krieg","volume":"71","first-page":"2179","unstructured":null,"article-title":"Multiomics reveal unique signatures of human epiploic adipose tissue related to systemic insulin resistance","journal-title":"Gut","doi-asserted-by":"crossref"},{"DOI":"10.1038/s41467-022-30587-y","key":"10.1016/j.cmet.2025.12.008_bib8","year":"2022","issue":null,"author":"Ni","volume":"13","first-page":null,"unstructured":null,"article-title":"SpotClean adjusts for spot swapping in spatial transcriptomics data","journal-title":"Nat. Commun.","doi-asserted-by":"crossref"},{"DOI":"10.1038/s41592-019-0619-0","key":"10.1016/j.cmet.2025.12.008_bib9","year":"2019","issue":null,"author":"Korsunsky","volume":"16","first-page":"1289","unstructured":null,"article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","journal-title":"Nat. Methods","doi-asserted-by":"crossref"},{"DOI":"10.1038/s41592-018-0229-2","key":"10.1016/j.cmet.2025.12.008_bib10","year":"2018","issue":null,"author":"Lopez","volume":"15","first-page":"1053","unstructured":null,"article-title":"Deep generative modeling for single-cell transcriptomics","journal-title":"Nat. Methods","doi-asserted-by":"crossref"},{"DOI":"10.1038/s41592-021-01336-8","key":"10.1016/j.cmet.2025.12.008_bib11","year":"2021","issue":null,"author":"Luecken","volume":"19","first-page":"41","unstructured":null,"article-title":"Benchmarking atlas-level data integration in single-cell genomics","journal-title":"Nat. Methods","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.cmet.2021.07.018","key":"10.1016/j.cmet.2025.12.008_bib12","year":"2021","issue":null,"author":"Bäckdahl","volume":"33","first-page":"1869","unstructured":null,"article-title":"Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin","journal-title":"Cell Metab.","doi-asserted-by":"crossref"},{"DOI":"10.1038/s41467-023-36983-2","key":"10.1016/j.cmet.2025.12.008_bib13","year":"2023","issue":null,"author":"Massier","volume":"14","first-page":null,"unstructured":null,"article-title":"An integrated single cell and spatial transcriptomic map of human white adipose tissue","journal-title":"Nat. Commun.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.cmet.2024.04.017","key":"10.1016/j.cmet.2025.12.008_bib14","year":"2024","issue":null,"author":"Ferrero","volume":"36","first-page":"1566","unstructured":null,"article-title":"A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion","journal-title":"Cell Metab.","doi-asserted-by":"crossref"},{"DOI":"10.1186/s13287-017-0701-4","key":"10.1016/j.cmet.2025.12.008_bib15","year":"2017","issue":null,"author":"Acosta","volume":"8","first-page":"1","unstructured":null,"article-title":"Single cell transcriptomics suggest that human adipocyte progenitor cells constitute a homogeneous cell population","journal-title":"Stem Cell Res. Ther.","doi-asserted-by":"crossref"},{"DOI":"10.2337/db16-0631","key":"10.1016/j.cmet.2025.12.008_bib16","year":"2017","issue":null,"author":"Ehrlund","volume":"66","first-page":"218","unstructured":null,"article-title":"Transcriptional dynamics during human adipogenesis and its link to adipose morphology and distribution","journal-title":"Diabetes","doi-asserted-by":"crossref"},{"DOI":"10.1038/sdata.2017.112","key":"10.1016/j.cmet.2025.12.008_bib17","year":"2017","issue":null,"author":"Noguchi","volume":"4","first-page":null,"unstructured":null,"article-title":"FANTOM5 CAGE profiles of human and mouse samples","journal-title":"Sci. Data","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.cmet.2025.01.012","key":"10.1016/j.cmet.2025.12.008_bib18","year":"2025","issue":null,"author":"Zhong","volume":"37","first-page":"566","unstructured":null,"article-title":"adiposetissue.org: A knowledge portal integrating clinical and experimental data from human adipose tissue","journal-title":"Cell Metab.","doi-asserted-by":"crossref"},{"DOI":"10.1038/s41587-021-01139-4","key":"10.1016/j.cmet.2025.12.008_bib19","year":"2022","issue":null,"author":"Kleshchevnikov","volume":"40","first-page":"661","unstructured":null,"article-title":"Cell2location maps fine-grained cell types in spatial transcriptomics","journal-title":"Nat. Biotechnol.","doi-asserted-by":"crossref"},{"DOI":"10.1126/science.aav2501","key":"10.1016/j.cmet.2025.12.008_bib21","year":"2019","issue":null,"author":"Merrick","volume":"364","first-page":null,"unstructured":null,"article-title":"Identification of a mesenchymal progenitor cell hierarchy in adipose tissue","journal-title":"Science","doi-asserted-by":"crossref"},{"DOI":null,"key":"10.1016/j.cmet.2025.12.008_bib22","year":"2018","issue":null,"author":"Benias","volume":"8","first-page":null,"unstructured":null,"article-title":"Structure and distribution of an unrecognized interstitium in human tissues","journal-title":"Sci. Rep.","doi-asserted-by":null},{"DOI":"10.1038/s41467-024-51867-9","key":"10.1016/j.cmet.2025.12.008_bib23","year":"2024","issue":null,"author":"Uhrbom","volume":"15","first-page":null,"unstructured":null,"article-title":"Adipose stem cells are sexually dimorphic cells with dual roles as preadipocytes and resident fibroblasts","journal-title":"Nat. Commun.","doi-asserted-by":"crossref"},{"DOI":"10.1038/s42255-024-01025-8","key":"10.1016/j.cmet.2025.12.008_bib20","year":"2024","issue":null,"author":"Klingelhuber","volume":"6","first-page":"861","unstructured":null,"article-title":"A spatiotemporal proteomic map of human adipogenesis","journal-title":"Nat. Metab.","doi-asserted-by":"crossref"},{"DOI":"10.1038/s41592-024-02303-9","key":"10.1016/j.cmet.2025.12.008_bib24","year":"2024","issue":null,"author":"Weiler","volume":"21","first-page":"1196","unstructured":null,"article-title":"CellRank 2: unified fate mapping in multiview single-cell data","journal-title":"Nat. Methods","doi-asserted-by":"crossref"},{"DOI":"10.1038/s41596-024-01045-4","key":"10.1016/j.cmet.2025.12.008_bib25","year":"2024","issue":null,"author":"Jin","volume":"20","first-page":"180","unstructured":null,"article-title":"CellChat for systematic analysis of cell–cell communication from single-cell transcriptomics","journal-title":"Nat. Protoc.","doi-asserted-by":"crossref"},{"DOI":"10.1126/science.abf9232","key":"10.1016/j.cmet.2025.12.008_bib26","year":"2021","issue":null,"author":"Bang","volume":"373","first-page":null,"unstructured":null,"article-title":"Serum amyloid a delivers retinol to intestinal myeloid cells to promote adaptive immunity","journal-title":"Science","doi-asserted-by":"crossref"},{"DOI":"10.4049/jimmunol.181.1.22","key":"10.1016/j.cmet.2025.12.008_bib27","year":"2008","issue":null,"author":"Cheng","volume":"181","first-page":"22","unstructured":null,"article-title":"Cutting Edge: TLR2 is a functional receptor for acute-phase serum amyloid A","journal-title":"J. Immunol.","doi-asserted-by":"crossref"},{"DOI":"10.1084/jem.189.2.395","key":"10.1016/j.cmet.2025.12.008_bib28","year":"1999","issue":null,"author":"Su","volume":"189","first-page":"395","unstructured":null,"article-title":"A seven-transmembrane, G protein–coupled receptor, FPRL1, mediates the chemotactic activity of serum amyloid A for human phagocytic cells","journal-title":"J. Exp. Med.","doi-asserted-by":"crossref"},{"DOI":"10.1111/imm.13295","key":"10.1016/j.cmet.2025.12.008_bib29","year":"2021","issue":null,"author":"Abouelasrar Salama","volume":"163","first-page":"115","unstructured":null,"article-title":"The turning away of serum amyloid A biological activities and receptor usage","journal-title":"Immunology","doi-asserted-by":"crossref"},{"DOI":"10.1136/gutjnl-2019-320118","key":"10.1016/j.cmet.2025.12.008_bib30","year":"2020","issue":null,"author":"Massier","volume":"69","first-page":"1796","unstructured":null,"article-title":"Adipose tissue derived bacteria are associated with inflammation in obesity and type 2 diabetes","journal-title":"Gut","doi-asserted-by":"crossref"},{"DOI":"10.2337/db06-1491","key":"10.1016/j.cmet.2025.12.008_bib31","year":"2007","issue":null,"author":"Cani","volume":"56","first-page":"1761","unstructured":null,"article-title":"Metabolic endotoxemia initiates obesity and insulin resistance","journal-title":"Diabetes","doi-asserted-by":"crossref"},{"DOI":null,"key":"10.1016/j.cmet.2025.12.008_bib32","year":"2010","issue":null,"author":"Schnedl","volume":"1","first-page":"45","unstructured":null,"article-title":"Insights into epiploic appendagitis","journal-title":"Nat. Rev. Gastroenterol. Hepatol.","doi-asserted-by":null},{"DOI":"10.1038/mi.2012.33","key":"10.1016/j.cmet.2025.12.008_bib33","year":"2012","issue":null,"author":"Batra","volume":"5","first-page":"580","unstructured":null,"article-title":"Mesenteric fat—control site for bacterial translocation in colitis?","journal-title":"Mucosal Immunol.","doi-asserted-by":"crossref"},{"DOI":"10.1177/1753425910393370","key":"10.1016/j.cmet.2025.12.008_bib34","year":"2012","issue":null,"author":"Nakarai","volume":"18","first-page":"164","unstructured":null,"article-title":"Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation: Potential link with metabolic complications","journal-title":"Innate Immun.","doi-asserted-by":"crossref"},{"DOI":"10.1038/s41588-025-02300-4","key":"10.1016/j.cmet.2025.12.008_bib35","year":"2025","issue":null,"author":"Chen","volume":"57","first-page":"2238","unstructured":null,"article-title":"Single-cell DNA methylome and 3D genome atlas of human subcutaneous adipose tissue","journal-title":"Nat. Genet.","doi-asserted-by":"crossref"},{"DOI":"10.7554/eLife.51317","key":"10.1016/j.cmet.2025.12.008_bib36","year":"2020","issue":null,"author":"Zhang","volume":"9","first-page":null,"unstructured":null,"article-title":"Reversible promoter methylation determines fluctuating expression of acute phase proteins","journal-title":"eLife","doi-asserted-by":"crossref"},{"DOI":"10.1074/jbc.M202524200","key":"10.1016/j.cmet.2025.12.008_bib37","year":"2002","issue":null,"author":"Han","volume":"277","first-page":"44715","unstructured":null,"article-title":"Molecular mechanisms for lipopolysaccharide-induced biphasic activation of nuclear factor-κB (NF-κB)","journal-title":"J. Biol. Chem.","doi-asserted-by":"crossref"},{"DOI":"10.3892/etm.2014.2023","key":"10.1016/j.cmet.2025.12.008_bib38","year":"2014","issue":null,"author":"Meng","volume":"8","first-page":"1772","unstructured":null,"article-title":"Role of p38 MAPK and STAT3 in lipopolysaccharide-stimulated mouse alveolar macrophages","journal-title":"Exp. Ther. Med.","doi-asserted-by":"crossref"},{"DOI":"10.1038/embor.2009.243","key":"10.1016/j.cmet.2025.12.008_bib39","year":"2009","issue":null,"author":"Bollrath","volume":"10","first-page":"1314","unstructured":null,"article-title":"IKK/NF-B and STAT3 pathways: Central signalling hubs in inflammation-mediated tumour promotion and metastasis","journal-title":"EMBO Rep.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.ccr.2009.02.015","key":"10.1016/j.cmet.2025.12.008_bib40","year":"2009","issue":null,"author":"Lee","volume":"15","first-page":"283","unstructured":null,"article-title":"Persistently activated Stat3 maintains constitutive NF-κB activity in tumors","journal-title":"Cancer Cell","doi-asserted-by":"crossref"},{"DOI":"10.3390/ijms21207675","key":"10.1016/j.cmet.2025.12.008_bib41","year":"2020","issue":null,"author":"Ahuja","volume":"21","first-page":null,"unstructured":null,"article-title":"STAT3 differentially regulates TLR4-mediated inflammatory responses in early or late phases","journal-title":"Int. J. Mol. Sci.","doi-asserted-by":"crossref"},{"DOI":"10.1038/s41593-020-00787-0","key":"10.1016/j.cmet.2025.12.008_bib42","year":"2021","issue":null,"author":"Maynard","volume":"24","first-page":"425","unstructured":null,"article-title":"Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex","journal-title":"Nat. Neurosci.","doi-asserted-by":"crossref"},{"DOI":null,"key":"10.1016/j.cmet.2025.12.008_bib43","year":"2025","issue":null,"author":"Chang","volume":"26","first-page":null,"unstructured":null,"article-title":"Recent advances in studies of serum amyloid A: implications in inflammation, immunity and tumor metastasis","journal-title":"Int. J. Mol. Sci.","doi-asserted-by":null},{"DOI":"10.1038/s41420-023-01455-5","key":"10.1016/j.cmet.2025.12.008_bib44","year":"2023","issue":null,"author":"Chen","volume":"9","first-page":null,"unstructured":null,"article-title":"Serum amyloid protein A in inflammatory bowel disease: from bench to bedside","journal-title":"Cell Death Discov.","doi-asserted-by":"crossref"},{"DOI":"10.1186/s10020-018-0047-0","key":"10.1016/j.cmet.2025.12.008_bib45","year":"2018","issue":null,"author":"Sack","volume":"24","first-page":null,"unstructured":null,"article-title":"Serum amyloid A – a review","journal-title":"Mol. Med.","doi-asserted-by":"crossref"},{"DOI":"10.1210/jc.2008-2040","key":"10.1016/j.cmet.2025.12.008_bib46","year":"2009","issue":null,"author":"Poitou","volume":"94","first-page":"1810","unstructured":null,"article-title":"Role of serum amyloid A in adipocyte-macrophage cross talk and adipocyte cholesterol efflux","journal-title":"J. Clin. Endocrinol. Metab.","doi-asserted-by":"crossref"},{"DOI":"10.3945/ajcn.116.131110","key":"10.1016/j.cmet.2025.12.008_bib47","year":"2017","issue":null,"author":"Damms-Machado","volume":"105","first-page":"127","unstructured":null,"article-title":"Gut permeability is related to body weight, fatty liver disease, and insulin resistance in obese individuals undergoing weight reduction","journal-title":"Am. J. Clin. Nutr.","doi-asserted-by":"crossref"},{"DOI":"10.1177/0148607111413772","key":"10.1016/j.cmet.2025.12.008_bib48","year":"2011","issue":null,"author":"Frazier","volume":"35","first-page":"14S","unstructured":null,"article-title":"Gut microbiota, intestinal permeability, obesity-induced inflammation, and liver injury","journal-title":"JPEN J. Parenter. Enteral Nutr.","doi-asserted-by":"crossref"},{"DOI":"10.3389/fcell.2022.1003118","key":"10.1016/j.cmet.2025.12.008_bib49","year":"2022","issue":null,"author":"Börgeson","volume":"10","first-page":null,"unstructured":null,"article-title":"Of mice and men: Pinpointing species differences in adipose tissue biology","journal-title":"Front. Cell Dev. Biol.","doi-asserted-by":"crossref"},{"DOI":"10.1093/gigascience/giaa151","key":"10.1016/j.cmet.2025.12.008_bib52","year":"2020","issue":null,"author":"Young","volume":"9","first-page":null,"unstructured":null,"article-title":"SoupX removes ambient RNA contamination from droplet-based single-cell RNA sequencing data","journal-title":"GigaScience","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.cels.2019.03.003","key":"10.1016/j.cmet.2025.12.008_bib53","year":"2019","issue":null,"author":"McGinnis","volume":"8","first-page":"329","unstructured":null,"article-title":"DoubletFinder: doublet detection in single-cell RNA sequencing data using artificial nearest neighbors","journal-title":"Cell Syst.","doi-asserted-by":"crossref"},{"DOI":"10.14806/ej.17.1.200","key":"10.1016/j.cmet.2025.12.008_bib50","year":"2011","issue":null,"author":"Martin","volume":"17","first-page":"10","unstructured":null,"article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","journal-title":"EMBnet J.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.cell.2021.04.048","key":"10.1016/j.cmet.2025.12.008_bib51","year":"2021","issue":null,"author":"Hao","volume":"184","first-page":"3573","unstructured":null,"article-title":"Integrated analysis of multimodal single-cell data","journal-title":"Cell","doi-asserted-by":"crossref"},{"DOI":"10.1038/s41467-019-10756-2","key":"10.1016/j.cmet.2025.12.008_bib55","year":"2019","issue":null,"author":"Gaublomme","volume":"10","first-page":null,"unstructured":null,"article-title":"Nuclei multiplexing with barcoded antibodies for single-nucleus genomics","journal-title":"Nat. Commun.","doi-asserted-by":"crossref"},{"DOI":"10.1038/s41592-023-01943-7","key":"10.1016/j.cmet.2025.12.008_bib56","year":"2023","issue":null,"author":"Fleming","volume":"20","first-page":"1323","unstructured":null,"article-title":"Unsupervised removal of systematic background noise from droplet-based single-cell experiments using CellBender","journal-title":"Nat. Methods","doi-asserted-by":"crossref"},{"DOI":"10.1093/bioinformatics/btz698","key":"10.1016/j.cmet.2025.12.008_bib58","year":"2020","issue":null,"author":"Bais","volume":"36","first-page":"1150","unstructured":null,"article-title":"scds: computational annotation of doublets in single-cell RNA sequencing data","journal-title":"Bioinformatics","doi-asserted-by":"crossref"},{"DOI":"10.12688/f1000research.73600.2","key":"10.1016/j.cmet.2025.12.008_bib57","year":"2022","issue":null,"author":"Germain","volume":"10","first-page":null,"unstructured":null,"article-title":"Doublet identification in single-cell sequencing data using scDblFinder","journal-title":"F1000Research","doi-asserted-by":"crossref"},{"DOI":null,"key":"10.1016/j.cmet.2025.12.008_bib59","year":"2020","issue":null,"author":"Jew","volume":"11","first-page":null,"unstructured":null,"article-title":"Accurate estimation of cell composition in bulk expression through robust integration of single-cell information","journal-title":"Nat. Commun.","doi-asserted-by":null},{"DOI":"10.1093/bioinformatics/bts635","key":"10.1016/j.cmet.2025.12.008_bib64","year":"2013","issue":null,"author":"Dobin","volume":"29","first-page":"15","unstructured":null,"article-title":"STAR: ultrafast universal RNA-seq aligner","journal-title":"Bioinformatics","doi-asserted-by":"crossref"},{"DOI":"10.1093/bioinformatics/btu638","key":"10.1016/j.cmet.2025.12.008_bib65","year":"2015","issue":null,"author":"Anders","volume":"31","first-page":"166","unstructured":null,"article-title":"HTSeq—a Python framework to work with high-throughput sequencing data","journal-title":"Bioinformatics","doi-asserted-by":"crossref"},{"DOI":"10.1093/nar/gkae1078","key":"10.1016/j.cmet.2025.12.008_bib66","year":"2025","issue":null,"author":"Mudge","volume":"53","first-page":"D966","unstructured":null,"article-title":"GENCODE 2025: reference gene annotation for human and mouse","journal-title":"Nucleic Acids Res.","doi-asserted-by":"crossref"},{"DOI":"10.1089/omi.2011.0118","key":"10.1016/j.cmet.2025.12.008_bib68","year":"2012","issue":null,"author":"Yu","volume":"16","first-page":"284","unstructured":null,"article-title":"ClusterProfiler: An R package for comparing biological themes among gene clusters","journal-title":"Omics","doi-asserted-by":"crossref"},{"DOI":"10.1186/s13059-014-0550-8","key":"10.1016/j.cmet.2025.12.008_bib67","year":"2014","issue":null,"author":"Love","volume":"15","first-page":"1","unstructured":null,"article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","journal-title":"Genome Biol.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.xpro.2024.102893","key":"10.1016/j.cmet.2025.12.008_bib54","year":"2024","issue":null,"author":"Gulko","volume":"5","first-page":null,"unstructured":null,"article-title":"Protocol for flow cytometry-assisted single-nucleus RNA sequencing of human and mouse adipose tissue with sample multiplexing","journal-title":"Star Protoc.","doi-asserted-by":"crossref"},{"DOI":"10.1080/21623945.2023.2283213","key":"10.1016/j.cmet.2025.12.008_bib60","year":"2025","issue":null,"author":"Couchet","volume":"14","first-page":null,"unstructured":null,"article-title":"Adipogenic characterization of immortalized CD55+ progenitor cells from human white adipose tissue","journal-title":"Adipocyte","doi-asserted-by":"crossref"},{"DOI":"10.1007/978-1-0716-2059-5_18","key":"10.1016/j.cmet.2025.12.008_bib61","year":"2022","issue":null,"author":"Herold","volume":"2441","first-page":"235","unstructured":null,"article-title":"A rapid adaptable method for isolation of endothelial cells from human adipose tissue","journal-title":"Methods Mol. Biol.","doi-asserted-by":"crossref"},{"DOI":"10.1006/meth.2001.1262","key":"10.1016/j.cmet.2025.12.008_bib62","year":"2001","issue":null,"author":"Livak","volume":"25","first-page":"402","unstructured":null,"article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method","journal-title":"Methods","doi-asserted-by":"crossref"},{"DOI":null,"key":"10.1016/j.cmet.2025.12.008_bib63","year":"2005","issue":null,"author":"van Harmelen","volume":"107","first-page":"125","unstructured":null,"article-title":"Primary culture and differentiation of human adipocyte precursor cells","journal-title":"Methods Mol. Med.","doi-asserted-by":null}],"short-title":[],"update-policy":"https://doi.org/10.1016/elsevier_cm_policy","alternative-id":["S155041312500539X"],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"original-title":[],"container-title":["Cell Metabolism"],"published-print":{"date-parts":[[2026,1]]},"reference-count":68,"published-online":null,"references-count":68,"short-container-title":["Cell Metabolism"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1016/j.cmet.2025.12.008","is_oa":true,"title":"Cytoarchitectural multi-depot profiling reveals immune-metabolic crosstalk in human colon-associated adipose tissue","updated":"2026-01-15T02:17:35+00:00","published_date":"2026-01-01","best_oa_location":{"url":"https://doi.org/10.1016/j.cmet.2025.12.008","pmh_id":null,"url_for_pdf":null,"url_for_landing_page":"https://doi.org/10.1016/j.cmet.2025.12.008"}}},"created_at":"2026-01-16T11:56:46.634Z","updated_at":"2026-01-21T12:05:26.220Z","tags":[{"paper_doi":"10.1016/j.cmet.2025.12.008","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1016/j.cmet.2025.12.008","tag_type":"category","value":"Endocrinology & Metabolism","value_numeric":null},{"paper_doi":"10.1016/j.cmet.2025.12.008","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1016/j.cmet.2025.12.008","tag_type":"study_design","value":"Cross-Sectional","value_numeric":null},{"paper_doi":"10.1016/j.cmet.2025.12.008","tag_type":"warning","value":"Design mixes tissue profiling with mechanistic in vitro assays; the chosen design label is approximate.","value_numeric":null},{"paper_doi":"10.1016/j.cmet.2025.12.008","tag_type":"warning","value":"No quantitative effect sizes or counts are provided in the abstract.","value_numeric":null},{"paper_doi":"10.1016/j.cmet.2025.12.008","tag_type":"warning","value":"Sample size, inclusion criteria, and timeframe are not reported in the abstract.","value_numeric":null}],"summaries":{"what_studied":"Spatial and single-nucleus RNA sequencing were used to map the cellular architecture of human subcutaneous and visceral white adipose tissue (omental, mesenteric, mesocolic, and epiploic) in men and women. Mechanistic experiments tested how inflammatory cues induce adipocyte SAA (SAA1/SAA2) and how SAA1 affects adipose-resident myeloid cells.","key_result":"Visceral depots had distinct cell-type enrichments and communication routes; epiploic fat contained high proportions of SAA1/SAA2-expressing adipocytes and several leukocyte populations. In mechanistic assays, inflammatory signals including lipopolysaccharide induced adipocyte SAA1/SAA2 expression, and SAA1 activated immune responses in adipose-resident myeloid cells."}},{"doi":"10.1111/hdi.70052","pmid":"41532601","title":"Volume Overload Assessed by Vector Impedance Analysis and Physical Function in Hemodialysis Patients","journal_title":"Hemodialysis International","journal_issn":"1492-7535","published_at":"2026-01-14T00:00:00.000Z","url":"https://doi.org/10.1111/hdi.70052","source_score":8,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-01-15","doi":"10.1111/hdi.70052","days":"7","issn":"1492-7535","rank":"8","field":"Clinical Medicine","score":"8","category":"Urology & Nephrology","categories":["Urology & Nephrology"],"_categories":["Urology & Nephrology"]},"pubmed":{"doi":"10.1111/hdi.70052","title":"Volume Overload Assessed by Vector Impedance Analysis and Physical Function in Hemodialysis Patients.","journal":"Hemodialysis international. International Symposium on Home Hemodialysis","methods":"","results":"","abstract":"$40","keywords":["hemodialysis","muscle strength","physical functionality","volume overload"],"pubmed_id":"41532601","conclusions":"","publication_date":"2026-01-14T00:00:00"},"crossref":{"DOI":"10.1111/hdi.70052","URL":"https://doi.org/10.1111/hdi.70052","ISSN":["1492-7535","1542-4758"],"link":[{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/hdi.70052","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/hdi.70052","content-type":"application/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/hdi.70052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Volume Overload Assessed by Vector Impedance Analysis and Physical Function in Hemodialysis Patients"],"author":[{"given":"Geovana","family":"Martin‐Alemañy","sequence":"first","affiliation":[{"name":"School of Nutritional Science and Wellness The University of Arizona Tucson Arizona USA"}]},{"given":"Monserrat","family":"Pérez‐Navarro","sequence":"additional","affiliation":[{"name":"Servicio de Nefrología, Hospital General de México “Dr. Eduardo Liceaga” Mexico City Mexico"}]},{"given":"Paola","family":"Miranda‐Alatriste","sequence":"additional","affiliation":[{"name":"Departamento de Nefrología y Metabolismo Mineral Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Mexico City Mexico"}]},{"given":"Eloísa","family":"Colin‐Ramirez","sequence":"additional","affiliation":[{"name":"Departamento de Vigilancia Epidemiológica Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Mexico City Mexico"}]},{"given":"Milad","family":"Hasankhani","sequence":"additional","affiliation":[{"name":"School of Nutritional Science and Wellness The University of Arizona Tucson Arizona USA"}]},{"given":"Samuel","family":"Ramos‐Acevedo","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Department of Medicine McMaster University Hamilton Ontario Canada"}]},{"given":"Rafael","family":"Valdez‐Ortiz","sequence":"additional","affiliation":[{"name":"Servicio de Nefrología, Hospital General de México “Dr. Eduardo Liceaga” Mexico City Mexico"}]},{"given":"Ángeles","family":"Espinosa‐Cuevas","sequence":"additional","affiliation":[{"name":"Departamento de Nefrología y Metabolismo Mineral Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Mexico City Mexico"}]},{"given":"Kenneth R.","family":"Wilund","sequence":"additional","affiliation":[{"name":"School of Nutritional Science and Wellness The University of Arizona Tucson Arizona USA"}]}],"issued":{"date-parts":[[2026,1,14]]},"member":"311","prefix":"10.1111","source":"Crossref","volume":null,"archive":["Portico"],"created":{"date-time":"2026-01-14T12:19:36Z","timestamp":1768393176000,"date-parts":[[2026,1,14]]},"indexed":{"date-time":"2026-01-14T20:48:34Z","timestamp":1768423714181,"date-parts":[[2026,1,14]]},"license":[{"URL":"http://onlinelibrary.wiley.com/termsAndConditions#vor","start":{"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000,"date-parts":[[2026,1,14]]},"delay-in-days":0,"content-version":"vor"},{"URL":"http://doi.wiley.com/10.1002/tdm_license_1.1","start":{"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000,"date-parts":[[2026,1,14]]},"delay-in-days":0,"content-version":"tdm"}],"subject":[],"abstract":"$41","language":"en","relation":{},"resource":{"primary":{"URL":"https://onlinelibrary.wiley.com/doi/10.1111/hdi.70052"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"publication_history","label":"Publication History"},"label":"Received","order":0,"value":"2025-07-18"},{"name":"accepted","group":{"name":"publication_history","label":"Publication History"},"label":"Accepted","order":2,"value":"2025-12-12"},{"name":"published","group":{"name":"publication_history","label":"Publication History"},"label":"Published","order":3,"value":"2026-01-14"}],"deposited":{"date-time":"2026-01-14T12:19:37Z","timestamp":1768393177000,"date-parts":[[2026,1,14]]},"issn-type":[{"type":"print","value":"1492-7535"},{"type":"electronic","value":"1542-4758"}],"published":{"date-parts":[[2026,1,14]]},"publisher":"Wiley","reference":[{"DOI":"10.1093/ndt/gfv122","key":"e_1_2_9_2_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3390/ijms23116047","key":"e_1_2_9_3_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3390/ijms25105117","key":"e_1_2_9_4_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/aje/kwr384","key":"e_1_2_9_5_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s00223‐021‐00898‐1","key":"e_1_2_9_6_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3389/fnut.2021.686245","key":"e_1_2_9_7_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1681/ASN.2016121341","key":"e_1_2_9_8_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/ndt/gfz272","key":"e_1_2_9_9_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1053/j.ajkd.2020.05.028","key":"e_1_2_9_10_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_2_9_11_1","year":"2010","issue":"4","author":"Espinosa Cuevas M. A.","volume":"73","first-page":"300","unstructured":null,"article-title":"Body Fluid Volume Overloadlume and Nutritional Status in Hemodialysis: Vector Bioelectric Impedance Analysis","journal-title":"Clinical Nephrology","doi-asserted-by":null},{"DOI":"10.20960/nh.03970","key":"e_1_2_9_12_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1053/j.ajkd.2018.03.030","key":"e_1_2_9_13_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/j.1523‐1755.2004.00467.x","key":"e_1_2_9_14_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/geronj/49.2.m85","key":"e_1_2_9_15_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.4235/agmr.23.0164","key":"e_1_2_9_16_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/ageing/afr051","key":"e_1_2_9_17_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/ageing/afq034","key":"e_1_2_9_18_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_2_9_19_1","year":"2007","issue":"1","author":"Espinosa‐Cuevas M. Á.","volume":"59","first-page":"11","unstructured":null,"article-title":"Vectores de Impedancia Bioeléctrica Para la Composición Corporal En Población Mexicana","journal-title":"Revista de Investigación Clínica","doi-asserted-by":null},{"DOI":null,"key":"e_1_2_9_20_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"A.PiccoliandG.Pastori “Bioelectrical Impedance Vector Analysis Software 2002: A Guide to Bioelectrical Impedance Vector Analysis ” 2002 http://www.renalgate.it/formule_calcolatori/BIOELECTRICALIMPEDANCEVECTORANALYSISguide.pdf.","article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.1016/j.clnu.2013.08.007","key":"e_1_2_9_21_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/sdi.12649","key":"e_1_2_9_22_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/hemodialysisi.13022","key":"e_1_2_9_23_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3390/diagnostics15010075","key":"e_1_2_9_24_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"}],"short-title":[],"update-policy":"https://doi.org/10.1002/crossmark_policy","alternative-id":["10.1111/hdi.70052"],"article-number":"hdi.70052","content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"original-title":[],"container-title":["Hemodialysis International"],"reference-count":23,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2026,1,14]]},"references-count":23,"short-container-title":["Hemodialysis International"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1111/hdi.70052","is_oa":true,"title":"Volume Overload Assessed by Vector Impedance Analysis and Physical Function in Hemodialysis Patients","updated":"2026-01-17T01:14:18+00:00","published_date":"2026-01-14","best_oa_location":{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hdi.70052","pmh_id":null,"url_for_pdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hdi.70052","url_for_landing_page":"https://doi.org/10.1111/hdi.70052"}}},"created_at":"2026-01-19T09:31:36.873Z","updated_at":"2026-01-21T12:05:26.220Z","tags":[{"paper_doi":"10.1111/hdi.70052","tag_type":"category","value":"Urology & Nephrology","value_numeric":null},{"paper_doi":"10.1111/hdi.70052","tag_type":"condition","value":"End-Stage Kidney Disease","value_numeric":null},{"paper_doi":"10.1111/hdi.70052","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1111/hdi.70052","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1111/hdi.70052","tag_type":"sample_size","value":"n=52","value_numeric":52},{"paper_doi":"10.1111/hdi.70052","tag_type":"study_design","value":"Cross-Sectional","value_numeric":null},{"paper_doi":"10.1111/hdi.70052","tag_type":"warning","value":"Abstract does not provide effect sizes or covariate details for the regression models.","value_numeric":null},{"paper_doi":"10.1111/hdi.70052","tag_type":"warning","value":"Group differences by Hotelling’s T are reported without numeric statistics beyond p-values.","value_numeric":null},{"paper_doi":"10.1111/hdi.70052","tag_type":"warning","value":"Study design not explicitly stated; classified as cross-sectional based on single-timepoint assessments.","value_numeric":null}],"summaries":{"what_studied":"In 52 hemodialysis patients, the study tested whether volume overload assessed by bioelectrical impedance vector analysis (BIVA) z-scores relates to physical function (Short Physical Performance Battery ≤8) and to handgrip-defined dynapenia (<20 kg women, <30 kg men).","key_result":"Patients with reduced physical function plotted outside the 95th percentile major axis on BIVA, indicating volume overload, while those with normal function showed adequate hydration (p<0.0001). In multivariable logistic regression, volume overload was associated with low physical function (Model 1), and no independent variable was associated with muscle strength (Model 2).","limitations":"Small sample size (n=52); the abstract reports associations without effect sizes or adjustment details, limiting interpretability.","practice_takeaway":"In hemodialysis patients with low SPPB scores, assess for volume overload; handgrip strength alone may not reflect fluid excess."}},{"doi":"10.1080/02791072.2026.2614506","pmid":"41533430","title":"The Exploration of Cannabis Beverage Substitution for Alcohol: A Novel Harm Reduction Strategy","journal_title":"Journal of Psychoactive Drugs","journal_issn":"0279-1072","published_at":"2026-01-14T00:00:00.000Z","url":"https://doi.org/10.1080/02791072.2026.2614506","source_score":26,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2026-01-18","doi":"10.1080/02791072.2026.2614506","days":"7","issn":"0279-1072","rank":"2","field":"Clinical Medicine","score":"26","category":"Psychology, Clinical","categories":["Psychology, Clinical"],"_categories":["Psychology, Clinical"]},"pubmed":{"doi":"10.1080/02791072.2026.2614506","title":"The Exploration of Cannabis Beverage Substitution for Alcohol: A Novel Harm Reduction Strategy.","journal":"Journal of psychoactive drugs","methods":"","results":"","abstract":"Alcohol consumption is associated with nearly 200 health conditions. As cannabis-infused beverages emerge in the legal market, their potential as a substitute for alcohol is of growing interest. This study investigates whether cannabis beverages may reduce alcohol use.A total of 438 anonymous adults who used cannabis in the past year completed a survey including cannabis use and alcohol consumption items from the Behavioral Risk Factor Surveillance System (BRFSS). Chi-square and t-tests compared alcohol use between cannabis beverage users and non-users, and before vs. after cannabis beverage initiation.About one-third (33.6%) of respondents used cannabis beverages, typically consuming one per session. Users were more likely to report substituting cannabis for alcohol (58.6%) than non-users (47.2%). They also reported fewer weekly alcoholic drinks after starting cannabis beverages (","keywords":["Cannabis","alcohol","harm reduction"],"pubmed_id":"41533430","conclusions":"","publication_date":"2026-01-14T00:00:00"},"crossref":{"DOI":"10.1080/02791072.2026.2614506","URL":"https://doi.org/10.1080/02791072.2026.2614506","ISSN":["0279-1072","2159-9777"],"link":[{"URL":"https://www.tandfonline.com/doi/pdf/10.1080/02791072.2026.2614506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":"1-7","type":"journal-article","issue":null,"score":1,"title":["The Exploration of Cannabis Beverage Substitution for Alcohol: A Novel Harm Reduction Strategy"],"author":[{"given":"Jessica S","family":"Kruger","sequence":"first","affiliation":[{"name":"University at Buffalo - The State University of New York"}]},{"given":"Nicholas","family":"Felicione","sequence":"additional","affiliation":[{"name":"University at Buffalo"}]},{"given":"Daniel J","family":"Kruger","sequence":"additional","affiliation":[{"name":"University at Buffalo"}]}],"issued":{"date-parts":[[2026,1,14]]},"member":"301","prefix":"10.1080","source":"Crossref","volume":null,"created":{"date-time":"2026-01-14T16:42:02Z","timestamp":1768408922000,"date-parts":[[2026,1,14]]},"indexed":{"date-time":"2026-01-15T03:09:48Z","timestamp":1768446588931,"date-parts":[[2026,1,15]]},"subject":[],"abstract":null,"language":"en","relation":{},"resource":{"primary":{"URL":"https://www.tandfonline.com/doi/full/10.1080/02791072.2026.2614506"}},"subtitle":[],"assertion":[{"name":"peerreview_statement","label":"Peer Review Statement","order":1,"value":"The publishing and review policy for this title is described in its Aims & Scope."},{"URL":"http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=ujpd20","name":"aims_and_scope_url","label":"Aim & Scope","order":2,"value":"http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=ujpd20"},{"name":"received","group":{"name":"publication_history","label":"Publication History"},"label":"Received","order":0,"value":"2025-07-01"},{"name":"revised","group":{"name":"publication_history","label":"Publication History"},"label":"Revised","order":1,"value":"2025-10-18"},{"name":"accepted","group":{"name":"publication_history","label":"Publication History"},"label":"Accepted","order":2,"value":"2025-11-05"},{"name":"published","group":{"name":"publication_history","label":"Publication History"},"label":"Published","order":3,"value":"2026-01-14"}],"deposited":{"date-time":"2026-01-14T16:42:04Z","timestamp":1768408924000,"date-parts":[[2026,1,14]]},"issn-type":[{"type":"print","value":"0279-1072"},{"type":"electronic","value":"2159-9777"}],"published":{"date-parts":[[2026,1,14]]},"publisher":"Informa UK Limited","reference":[{"DOI":"10.1080/00952990.2019.1680683","key":"e_1_3_2_2_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_3_2_3_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"2025. Alcohol and cancer risk. www.hhs.gov/surgeongeneral/priorities/alcohol-cancer/index.html.","article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.1016/j.neubiorev.2015.06.012","key":"e_1_3_2_4_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.drugalcdep.2017.03.006","key":"e_1_3_2_5_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3390/nu14091954","key":"e_1_3_2_6_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1002/phar.1187","key":"e_1_3_2_7_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1136/bmj.h4238","key":"e_1_3_2_8_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.tifs.2019.12.025","key":"e_1_3_2_9_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1038/nrcardio.2015.91","key":"e_1_3_2_10_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.drugpo.2021.103381","key":"e_1_3_2_11_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.2105/ajph.2017.303818","key":"e_1_3_2_12_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.26828/cannabis/2024/000271","key":"e_1_3_2_13_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_3_2_14_1","year":"2020","issue":null,"author":"Gabrys R.","volume":null,"first-page":null,"unstructured":"Gabrys, R. 2020. Clearing the smoke on cannabis: Edible cannabis products, cannabis extracts and cannabis topicals. Canadian Centre on Substance Use and Addiction.","article-title":"Clearing the smoke on cannabis: Edible cannabis products, cannabis extracts and cannabis topicals","journal-title":"Canadian Centre on Substance Use and Addiction","doi-asserted-by":null},{"DOI":"10.1001/jamaoto.2024.2419","key":"e_1_3_2_15_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1001/jamanetworkopen.2019.16318","key":"e_1_3_2_16_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1080/10826084.2017.1343353","key":"e_1_3_2_17_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.2165/00003088-200342040-00003","key":"e_1_3_2_18_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1176/appi.ajp.2015.15030358","key":"e_1_3_2_19_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/dar.12275","key":"e_1_3_2_20_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.eclinm.2020.100697","key":"e_1_3_2_21_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.drugalcdep.2014.02.370","key":"e_1_3_2_22_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1021/tx700275p","key":"e_1_3_2_23_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1089/can.2021.0229","key":"e_1_3_2_24_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.7326/M18-2809","key":"e_1_3_2_25_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/S2468-2667(24)00223-8","key":"e_1_3_2_26_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_3_2_27_1","year":"2017","issue":null,"author":"National Academies of Sciences, E. & Medicine","volume":null,"first-page":null,"unstructured":"National Academies of Sciences, E. & Medicine. 2017. The health effects of cannabis and cannabinoids: the current state of evidence and recommendations for research.","article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.1016/s0140-6736(10)61462-6","key":"e_1_3_2_28_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1097/01.NAJ.0000471234.77585.9e","key":"e_1_3_2_29_1","year":"2015","issue":"9","author":"Potera C.","volume":"115","first-page":"15","unstructured":"Potera, C. 2015. Kids and marijuana edibles: A worrisome trend emerges. AJN, American Journal of Nursing 115 (9):15. https://journals.lww.com/ajnonline/fulltext/2015/09000/kids_and_marijuana_edibles__a_worrisome_trend.10.aspx.","article-title":"Kids and marijuana edibles: A worrisome trend emerges","journal-title":"AJN, American Journal of Nursing","doi-asserted-by":"crossref"},{"DOI":"10.1111/j.1360-0443.2010.02899.x","key":"e_1_3_2_30_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1186/s42238-020-00056-8","key":"e_1_3_2_31_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_3_2_32_1","year":"2021","issue":null,"author":"Renard J.","volume":null,"first-page":null,"unstructured":"Renard, J. 2021. Clearing the smoke on cannabis: Respiratory and cardiovascular effects of cannabis smoking. Canadian Centre on Substance Use and Addiction.","article-title":"Clearing the smoke on cannabis: Respiratory and cardiovascular effects of cannabis smoking","journal-title":"Canadian Centre on Substance Use and Addiction","doi-asserted-by":null},{"DOI":"10.1007/s11469-020-00244-w","key":"e_1_3_2_33_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3109/15412555.2012.671868","key":"e_1_3_2_34_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1177/0269881115581980","key":"e_1_3_2_35_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1161/JAHA.116.003858","key":"e_1_3_2_36_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1186/s12954-024-01111-w","key":"e_1_3_2_37_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.drugpo.2014.11.007","key":"e_1_3_2_38_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s40429-017-0149-8","key":"e_1_3_2_39_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"}],"short-title":[],"update-policy":"https://doi.org/10.1080/tandf_crossmark_01","alternative-id":["10.1080/02791072.2026.2614506"],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"original-title":[],"container-title":["Journal of Psychoactive Drugs"],"reference-count":38,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2026,1,14]]},"references-count":38,"short-container-title":["Journal of Psychoactive Drugs"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1080/02791072.2026.2614506","is_oa":false,"title":"The Exploration of Cannabis Beverage Substitution for Alcohol: A Novel Harm Reduction Strategy","updated":"2026-01-16T01:10:40+00:00","published_date":"2026-01-14","best_oa_location":null}},"created_at":"2026-01-19T09:31:36.873Z","updated_at":"2026-01-21T12:05:26.220Z","tags":[{"paper_doi":"10.1080/02791072.2026.2614506","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1080/02791072.2026.2614506","tag_type":"category","value":"Psychology, Clinical","value_numeric":null},{"paper_doi":"10.1080/02791072.2026.2614506","tag_type":"condition","value":"Alcohol Use","value_numeric":null},{"paper_doi":"10.1080/02791072.2026.2614506","tag_type":"condition","value":"Cannabis Use","value_numeric":null},{"paper_doi":"10.1080/02791072.2026.2614506","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1080/02791072.2026.2614506","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1080/02791072.2026.2614506","tag_type":"sample_size","value":"n=438","value_numeric":438},{"paper_doi":"10.1080/02791072.2026.2614506","tag_type":"study_design","value":"Cross-Sectional","value_numeric":null},{"paper_doi":"10.1080/02791072.2026.2614506","tag_type":"warning","value":"Design appears to be a self‑reported cross‑sectional survey with retrospective before/after recall; causality cannot be inferred.","value_numeric":null},{"paper_doi":"10.1080/02791072.2026.2614506","tag_type":"warning","value":"Only an abstract excerpt was provided; the sentence on reduced weekly drinks is truncated and no magnitude is available.","value_numeric":null}],"summaries":{"what_studied":"An anonymous survey of 438 adults who used cannabis in the past year examined alcohol consumption and cannabis beverage use with BRFSS items, comparing beverage users with non‑users and self‑reported alcohol use before vs after starting cannabis beverages.","key_result":"33.6% reported using cannabis beverages, typically one per session. Beverage users more often reported substituting cannabis for alcohol (58.6%) than non‑users (47.2%), and users reported fewer weekly alcoholic drinks after starting cannabis beverages (magnitude not stated in the abstract).","limitations":"Findings rely on self‑reported survey data with retrospective before/after recall rather than prospective measurement. The abstract does not report the size of the reduction in weekly alcoholic drinks.","practice_takeaway":"Adults who use cannabis beverages more often report substituting them for alcohol and report fewer weekly drinks after starting them. When counseling on alcohol harm reduction, ask about cannabis beverage use while noting these are self‑reports, not causal data."}},{"doi":"10.1002/ppul.71453","pmid":"41532159","title":"School Health Staff Perspectives on the Implementation of Single Maintenance and Reliever Therapy (SMART) for Children with Asthma","journal_title":"Pediatric Pulmonology","journal_issn":"8755-6863","published_at":"2026-01-14T00:00:00.000Z","url":"https://doi.org/10.1002/ppul.71453","source_score":2,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2026-01-16","doi":"10.1002/ppul.71453","days":"7","issn":"8755-6863","rank":"10","field":"Clinical Medicine","score":"2","category":"Respiratory System","categories":["Respiratory System"],"_categories":["Respiratory System"]},"pubmed":{"doi":"10.1002/ppul.71453","title":"School Health Staff Perspectives on the Implementation of Single Maintenance and Reliever Therapy (SMART) for Children with Asthma.","journal":"Pediatric pulmonology","methods":"","results":"A total of 11 SHS completed an interview and 22 completed a survey. Nearly all participants were familiar with SMART and 45% reported experience administering SMART. Most participants (59%) believed that SMART would be simpler for their students. In interviews, many participants highlighted that having one inhaler would also be simpler for them to manage. To support SMART implementation, communication with prescribing providers was highlighted as a primary need; 64% wanted a brief phone call with a provider, 59% wanted an email, and 82% wanted to receive a SMART-specific Asthma Action Plan.","abstract":"$42","keywords":["implementation","mixed methods research","pediatric asthma","school health staff","school‐based interventions"],"pubmed_id":"41532159","conclusions":"","publication_date":"2026-01-14T00:00:00"},"crossref":{"DOI":"10.1002/ppul.71453","URL":"https://doi.org/10.1002/ppul.71453","ISSN":["8755-6863","1099-0496"],"link":[{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/ppul.71453","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ppul.71453","content-type":"application/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/ppul.71453","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":"1","score":1,"title":["School Health Staff Perspectives on the Implementation of Single Maintenance and Reliever Therapy (SMART) for Children with Asthma"],"author":[{"given":"Melissa","family":"Goulding","sequence":"first","affiliation":[{"name":"Department of Population and Quantitative Health Sciences UMass Chan Medical School Worcester Massachusetts USA"}]},{"given":"Grace","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Population and Quantitative Health Sciences UMass Chan Medical School Worcester Massachusetts USA"}]},{"given":"Deicy","family":"Mejia","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Pediatrics UMass Chan Medical School, UMass Memorial Children's Medical Center Worcester Massachusetts USA"}]},{"given":"Stephanie","family":"Simms","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Pediatrics UMass Chan Medical School, UMass Memorial Children's Medical Center Worcester Massachusetts USA"}]},{"given":"Michelle","family":"Spano","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Pediatrics UMass Chan Medical School, UMass Memorial Children's Medical Center Worcester Massachusetts USA"}]},{"given":"Elika","family":"Eshghi","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Pediatrics UMass Chan Medical School, UMass Memorial Children's Medical Center Worcester Massachusetts USA"}]},{"given":"Christine","family":"Frisard","sequence":"additional","affiliation":[{"name":"Department of Population and Quantitative Health Sciences UMass Chan Medical School Worcester Massachusetts USA"}]},{"given":"Sybil","family":"Crawford","sequence":"additional","affiliation":[{"name":"Tan Chingfen Graduate School of Nursing UMass Chan Medical School Worcester Massachusetts USA"}]},{"given":"Nancy","family":"Byatt","sequence":"additional","affiliation":[{"name":"Lifeline for Families Center, Department of Psychiatry UMass Chan School of Medicine Worcester Massachusetts USA"},{"name":"Department of Obstetrics and Gynecology UMass Chan Medical School Worcester Massachusetts USA"}]},{"given":"Stephenie C.","family":"Lemon","sequence":"additional","affiliation":[{"name":"Department of Population and Quantitative Health Sciences UMass Chan Medical School Worcester Massachusetts USA"}]},{"given":"Thomas","family":"Mackie","sequence":"additional","affiliation":[{"name":"School of Public Health & Health Sciences University of Massachusetts Amherst Worcester Massachusetts USA"}]},{"given":"Lori","family":"Pbert","sequence":"additional","affiliation":[{"name":"Department of Population and Quantitative Health Sciences UMass Chan Medical School Worcester Massachusetts USA"}]},{"given":"Michelle","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Department of Population and Quantitative Health Sciences UMass Chan Medical School Worcester Massachusetts USA"},{"name":"Division of Pulmonary Medicine, Department of Pediatrics UMass Chan Medical School, UMass Memorial Children's Medical Center Worcester Massachusetts USA"},{"name":"Child Health Equity Center, Department of Pediatrics UMass Chan Medical School, UMass Memorial Children's Medical Center Worcester Massachusetts USA"}]}],"issued":{"date-parts":[[2026,1]]},"member":"311","prefix":"10.1002","source":"Crossref","volume":"61","archive":["Portico"],"created":{"date-time":"2026-01-14T09:05:58Z","timestamp":1768381558000,"date-parts":[[2026,1,14]]},"indexed":{"date-time":"2026-01-14T15:13:45Z","timestamp":1768403625110,"date-parts":[[2026,1,14]]},"license":[{"URL":"http://onlinelibrary.wiley.com/termsAndConditions#vor","start":{"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000,"date-parts":[[2026,1,14]]},"delay-in-days":13,"content-version":"vor"},{"URL":"http://doi.wiley.com/10.1002/tdm_license_1.1","start":{"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000,"date-parts":[[2026,1,1]]},"delay-in-days":0,"content-version":"tdm"}],"subject":[],"abstract":"$43","language":"en","relation":{},"resource":{"primary":{"URL":"https://onlinelibrary.wiley.com/doi/10.1002/ppul.71453"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"publication_history","label":"Publication History"},"label":"Received","order":0,"value":"2025-09-05"},{"name":"accepted","group":{"name":"publication_history","label":"Publication History"},"label":"Accepted","order":2,"value":"2025-12-19"},{"name":"published","group":{"name":"publication_history","label":"Publication History"},"label":"Published","order":3,"value":"2026-01-14"}],"deposited":{"date-time":"2026-01-14T09:06:02Z","timestamp":1768381562000,"date-parts":[[2026,1,14]]},"issn-type":[{"type":"print","value":"8755-6863"},{"type":"electronic","value":"1099-0496"}],"published":{"date-parts":[[2026,1]]},"publisher":"Wiley","reference":[{"DOI":null,"key":"e_1_2_11_2_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"CDC. Most Recent National Asthma Data https://www.cdc.gov/asthma/most_recent_national_asthma_data.htm. Published 2023 accessed July 30 2025.","article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.5888/pcd16.190074","key":"e_1_2_11_3_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1080/02770903.2017.1350972","key":"e_1_2_11_4_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.5888/pcd21.230449","key":"e_1_2_11_5_1","year":"2024","issue":null,"author":"Wang N.","volume":"21","first-page":null,"unstructured":null,"article-title":"Sociodemographic Factors of Asthma Prevalence and Costs Among Children and Adolescents in the United States, 2016–2021","journal-title":"Preventing chronic disease","doi-asserted-by":"crossref"},{"DOI":"10.1186/s13223-020-00472-8","key":"e_1_2_11_6_1","year":"2020","issue":"1","author":"Papi A.","volume":"16","first-page":"75","unstructured":null,"article-title":"Treatment Strategies for Asthma: Reshaping the Concept of Asthma Management","journal-title":"Allergy, asthma, and clinical immunology: official journal of the Canadian Society of Allergy and Clinical Immunology","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.jaip.2021.10.032","key":"e_1_2_11_7_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.jaci.2020.10.003","key":"e_1_2_11_8_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1056/NEJMoa1715275","key":"e_1_2_11_9_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1056/NEJMoa1715274","key":"e_1_2_11_10_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1186/s13063-016-1731-4","key":"e_1_2_11_11_1","year":"2017","issue":"1","author":"O'byrne P. M.","volume":"18","first-page":"12","unstructured":null,"article-title":"The Sygma Programme of Phase 3 Trials to Evaluate the Efficacy and Safety of Budesonide/Formoterol Given ‘As Needed'in Mild Asthma: Study Protocols for Two Randomised Controlled Trials","journal-title":"Trials","doi-asserted-by":"crossref"},{"DOI":"10.1001/jama.2018.2769","key":"e_1_2_11_12_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.jaip.2025.05.004","key":"e_1_2_11_13_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1080/02770903.2019.1568455","key":"e_1_2_11_14_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1177/1942602X211037260","key":"e_1_2_11_15_1","year":"2022","issue":"1","author":"Russell A. F.","volume":"37","first-page":"8","unstructured":null,"article-title":"The Vital Role of the School Nurse in Managing Asthma","journal-title":"NASN School Nurse","doi-asserted-by":"crossref"},{"DOI":"10.1089/ped.2022.0022","key":"e_1_2_11_16_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_2_11_17_1","year":"2025","issue":null,"author":"Trivedi M.","volume":"13","first-page":"2980","unstructured":null,"article-title":"A Pilot Pragmatic Cluster Randomized Trial of School‐Supervised Therapy to Improve Pediatric Asthma Control","journal-title":"Journal of Allergy and Clinical Immunology: In Practice","doi-asserted-by":null},{"DOI":"10.1016/j.jaip.2024.10.008","key":"e_1_2_11_18_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_2_11_19_1","year":"1995","issue":null,"author":"Morse J. M.","volume":null,"first-page":"147","unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.1186/s13012-022-01245-0","key":"e_1_2_11_20_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.psychres.2019.112516","key":"e_1_2_11_21_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1186/s13012-021-01111-5","key":"e_1_2_11_22_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.nurpra.2023.104641","key":"e_1_2_11_23_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_2_11_24_1","year":"2022","issue":"1","author":"Reddel H. K.","volume":"10","first-page":"S31","unstructured":null,"article-title":"A Practical Guide to Implementing SMART in Asthma Management","journal-title":"Journal of Allergy and Clinical Immunology: In Practice","doi-asserted-by":null},{"DOI":"10.1177/10598405211045693","key":"e_1_2_11_25_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.jaip.2023.05.023","key":"e_1_2_11_26_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.jaci.2014.10.014","key":"e_1_2_11_27_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1186/s43058-022-00283-5","key":"e_1_2_11_28_1","year":"2022","issue":"1","author":"Trivedi M.","volume":"3","first-page":"33","unstructured":null,"article-title":"CENTER‐IT: A Novel Methodology for Adapting Multi‐Level Interventions Using the Consolidated Framework for Implementation Research—A Case Example of a School‐Supervised Asthma Intervention","journal-title":"Implementation Science Communications","doi-asserted-by":"crossref"}],"short-title":[],"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"update-policy":"https://doi.org/10.1002/crossmark_policy","alternative-id":["10.1002/ppul.71453"],"article-number":"e71453","content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"original-title":[],"container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2026,1]]},"reference-count":27,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2026,1,14]]},"references-count":27,"short-container-title":["Pediatric Pulmonology"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1002/ppul.71453","is_oa":false,"title":"School Health Staff Perspectives on the Implementation of Single Maintenance and Reliever Therapy (SMART) for Children with Asthma","updated":"2026-01-15T02:17:35+00:00","published_date":"2026-01-01","best_oa_location":null}},"created_at":"2026-01-20T15:55:50.695Z","updated_at":"2026-01-20T15:55:50.695Z","tags":[{"paper_doi":"10.1002/ppul.71453","tag_type":"age_group","value":"pediatric","value_numeric":null},{"paper_doi":"10.1002/ppul.71453","tag_type":"category","value":"Respiratory System","value_numeric":null},{"paper_doi":"10.1002/ppul.71453","tag_type":"condition","value":"Asthma","value_numeric":null},{"paper_doi":"10.1002/ppul.71453","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1002/ppul.71453","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1002/ppul.71453","tag_type":"study_design","value":"Cross-Sectional","value_numeric":null},{"paper_doi":"10.1002/ppul.71453","tag_type":"warning","value":"Descriptive convergent mixed methods; design classification is approximate.","value_numeric":null},{"paper_doi":"10.1002/ppul.71453","tag_type":"warning","value":"Unclear whether interview and survey participants overlap, so a total sample size cannot be confirmed from the abstract.","value_numeric":null}],"summaries":{"what_studied":"A descriptive convergent mixed-methods study surveyed (n=22) and interviewed (n=11) school health staff to assess their perspectives on implementing Single Maintenance and Reliever Therapy (SMART) for children with asthma in schools.","key_result":"Nearly all staff were familiar with SMART and 45% had administered it; 59% believed it would be simpler for students, and interviewees noted one inhaler would be simpler for staff. To support implementation, 64% preferred a brief phone call, 59% an email, and 82% a SMART-specific Asthma Action Plan from prescribing providers.","limitations":"Small sample (11 interviews; 22 surveys) and findings reflect only school health staff perspectives; providers and families were not included. No clinical outcomes were reported.","practice_takeaway":"When initiating SMART for schoolchildren, proactively notify school health staff and provide a SMART-specific Asthma Action Plan; many prefer a brief phone call or email. Expect school staff to be familiar with SMART and view one inhaler as simpler for students and school management."}},{"doi":"10.1001/jama.2025.24407","pmid":"41533386","title":"Trends in County-Level Childhood Vaccination Exemptions in the US","journal_title":"JAMA","journal_issn":"0098-7484","published_at":"2026-01-14T00:00:00.000Z","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12805488/","source_score":626,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-01-17","doi":"10.1001/jama.2025.24407","days":"7","issn":"0098-7484","rank":"5","field":"Clinical Medicine","score":"626","category":"Medicine, General & Internal","categories":["Medicine, General & Internal"],"_categories":["Medicine, General & Internal"]},"pubmed":{"doi":"10.1001/jama.2025.24407","title":"Trends in County-Level Childhood Vaccination Exemptions in the US.","journal":"JAMA","methods":"","results":"","abstract":"This study examines US county-level trends in nonmedical and medical exemptions to childhood vaccination requirements.","keywords":[],"pubmed_id":"41533386","conclusions":"","publication_date":"2026-01-14T00:00:00"},"crossref":{"DOI":"10.1001/jama.2025.24407","URL":"https://doi.org/10.1001/jama.2025.24407","ISSN":["0098-7484"],"link":[{"URL":"https://jamanetwork.com/journals/jama/articlepdf/2843870/jama_fattah_2026_ld_250083_1767805073.7032.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Trends in County-Level Childhood Vaccination Exemptions in the US"],"author":[{"given":"Mustafa","family":"Fattah","sequence":"first","affiliation":[{"name":"Vagelos College of Physicians and Surgeons, Columbia University, New York, New York"}]},{"given":"Lauren A.","family":"Stoffel","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, California"}]},{"given":"Kate M.","family":"Bubar","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, California"}]},{"given":"Samantha J.","family":"Bents","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, California"}]},{"given":"Yvonne","family":"Maldonado","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Epidemiology and Population Health, Stanford University, Stanford, California"}]},{"given":"Peter J.","family":"Hotez","sequence":"additional","affiliation":[{"name":"Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics and Molecular Virology and Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston"}]},{"given":"Mathew V.","family":"Kiang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health, Stanford University, Stanford, California"}]},{"given":"Nathan C.","family":"Lo","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, California"}]}],"issued":{"date-parts":[[2026,1,14]]},"member":"10","prefix":"10.1001","source":"Crossref","volume":null,"created":{"date-time":"2026-01-14T16:01:05Z","timestamp":1768406465000,"date-parts":[[2026,1,14]]},"indexed":{"date-time":"2026-01-15T02:17:08Z","timestamp":1768443428608,"date-parts":[[2026,1,15]]},"subject":[],"abstract":"This study examines US county-level trends in nonmedical and medical exemptions to childhood vaccination requirements.","language":"en","relation":{},"resource":{"primary":{"URL":"https://jamanetwork.com/journals/jama/fullarticle/2843870"}},"subtitle":[],"deposited":{"date-time":"2026-01-14T16:01:06Z","timestamp":1768406466000,"date-parts":[[2026,1,14]]},"issn-type":[{"type":"print","value":"0098-7484"}],"published":{"date-parts":[[2026,1,14]]},"publisher":"American Medical Association (AMA)","reference":[{"DOI":"10.1001/jama.2025.8952","key":"jld250083r1","year":"2025","issue":"8","author":"Dong","volume":"334","first-page":"730","unstructured":null,"article-title":"Trends in county-level MMR vaccination coverage in children in the United States.","journal-title":"JAMA","doi-asserted-by":"publisher"},{"DOI":"10.1001/jama.2025.6495","key":"jld250083r2","year":"2025","issue":"24","author":"Kiang","volume":"333","first-page":"2176","unstructured":null,"article-title":"Modeling reemergence of vaccine-eliminated infectious diseases under declining vaccination in the US.","journal-title":"JAMA","doi-asserted-by":"publisher"},{"DOI":"10.1001/jama.2023.16995","key":"jld250083r3","year":"2023","issue":"16","author":"Delamater","volume":"330","first-page":"1585","unstructured":null,"article-title":"Kindergarten vaccination status in California after changes to medical exemption policy.","journal-title":"JAMA","doi-asserted-by":"publisher"},{"DOI":"10.1542/peds.2025-072714","key":"jld250083r4","year":"2025","issue":"2","author":"Hackell","volume":"156","first-page":null,"unstructured":null,"article-title":"Medical vs nonmedical immunization exemptions for child care and school attendance: policy statement.","journal-title":"Pediatrics","doi-asserted-by":"publisher"},{"DOI":"10.1001/jamapediatrics.2025.4185","key":"jld250083r5","year":"2025","issue":null,"author":"Bald","volume":null,"first-page":null,"unstructured":null,"article-title":"State repeal of nonmedical vaccine exemptions and kindergarten vaccination rates.","journal-title":"JAMA Pediatr","doi-asserted-by":"publisher"},{"DOI":"10.1073/pnas.2011529117","key":"jld250083r6","year":"2020","issue":"45","author":"Masters","volume":"117","first-page":"28506","unstructured":null,"article-title":"Fine-scale spatial clustering of measles nonvaccination that increases outbreak potential is obscured by aggregated reporting data.","journal-title":"Proc Natl Acad Sci U S A","doi-asserted-by":"publisher"}],"short-title":[],"content-domain":{"domain":[],"crossmark-restriction":false},"original-title":[],"container-title":["JAMA"],"reference-count":6,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2026,1,14]]},"references-count":6,"short-container-title":["JAMA"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1001/jama.2025.24407","is_oa":true,"title":"Trends in County-Level Childhood Vaccination Exemptions in the US","updated":"2026-01-18T01:04:10+00:00","published_date":"2026-01-14","best_oa_location":{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12805488/","pmh_id":"oai:pubmedcentral.nih.gov:12805488","url_for_pdf":null,"url_for_landing_page":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12805488/"}}},"created_at":"2026-01-20T15:55:50.695Z","updated_at":"2026-01-21T12:05:26.220Z","tags":[{"paper_doi":"10.1001/jama.2025.24407","tag_type":"age_group","value":"pediatric","value_numeric":null},{"paper_doi":"10.1001/jama.2025.24407","tag_type":"category","value":"Medicine, General & Internal","value_numeric":null},{"paper_doi":"10.1001/jama.2025.24407","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1001/jama.2025.24407","tag_type":"study_design","value":"Cross-Sectional","value_numeric":null},{"paper_doi":"10.1001/jama.2025.24407","tag_type":"warning","value":"Only the study aim was provided; no results, timeframe, or sample size were included in the supplied text.","value_numeric":null},{"paper_doi":"10.1001/jama.2025.24407","tag_type":"warning","value":"Study design classification is approximate based on an ecological, county-level trend description.","value_numeric":null},{"paper_doi":"10.1001/jama.2025.24407","tag_type":"warning","value":"Without reported outcomes, no practice takeaway can be given.","value_numeric":null}],"summaries":{"what_studied":"US county-level trends in medical and nonmedical exemptions to childhood vaccination requirements."}},{"doi":"10.3322/caac.70043","pmid":"41528114","title":"Cancer statistics, 2026","journal_title":"CA: A Cancer Journal for Clinicians","journal_issn":"0007-9235","published_at":"2026-01-13T00:00:00.000Z","url":"https://doi.org/10.3322/caac.70043","source_score":810,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-01-17","doi":"10.3322/caac.70043","days":"7","issn":"0007-9235","rank":"2","field":"Clinical Medicine","score":"810","category":"Oncology","categories":["Oncology"],"_categories":["Oncology"]},"pubmed":{"doi":"10.3322/caac.70043","title":"Cancer statistics, 2026.","journal":"CA: a cancer journal for clinicians","methods":"","results":"","abstract":"$44","keywords":["cancer cases","cancer mortality","cancer statistics","incidence","survival"],"pubmed_id":"41528114","conclusions":"","publication_date":"2026-01-13T00:00:00"},"crossref":{"DOI":"10.3322/caac.70043","URL":"https://doi.org/10.3322/caac.70043","ISSN":["0007-9235","1542-4863"],"link":[{"URL":"https://acsjournals.onlinelibrary.wiley.com/doi/pdf/10.3322/caac.70043","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://acsjournals.onlinelibrary.wiley.com/doi/full-xml/10.3322/caac.70043","content-type":"application/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https://acsjournals.onlinelibrary.wiley.com/doi/pdf/10.3322/caac.70043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":"1","score":1,"title":["Cancer statistics, 2026"],"author":[{"given":"Rebecca L.","family":"Siegel","sequence":"first","affiliation":[{"name":"Surveillance, Prevention, and Health Services Research (SPHeRe) American Cancer Society Atlanta Georgia USA"}]},{"given":"Tyler B.","family":"Kratzer","sequence":"additional","affiliation":[{"name":"Surveillance, Prevention, and Health Services Research (SPHeRe) American Cancer Society Atlanta Georgia USA"}]},{"given":"Nikita Sandeep","family":"Wagle","sequence":"additional","affiliation":[{"name":"Surveillance, Prevention, and Health Services Research (SPHeRe) American Cancer Society Atlanta Georgia USA"}]},{"given":"Hyuna","family":"Sung","sequence":"additional","affiliation":[{"name":"Surveillance, Prevention, and Health Services Research (SPHeRe) American Cancer Society Atlanta Georgia USA"}]},{"given":"Ahmedin","family":"Jemal","sequence":"additional","affiliation":[{"name":"Surveillance, Prevention, and Health Services Research (SPHeRe) American Cancer Society Atlanta Georgia USA"}]}],"issued":{"date-parts":[[2026,1]]},"member":"311","prefix":"10.3322","source":"Crossref","volume":"76","archive":["Portico"],"created":{"date-time":"2026-01-13T13:54:34Z","timestamp":1768312474000,"date-parts":[[2026,1,13]]},"indexed":{"date-time":"2026-01-13T20:26:37Z","timestamp":1768335997348,"date-parts":[[2026,1,13]]},"license":[{"URL":"http://creativecommons.org/licenses/by-nc-nd/4.0/","start":{"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000,"date-parts":[[2026,1,13]]},"delay-in-days":12,"content-version":"vor"},{"URL":"http://doi.wiley.com/10.1002/tdm_license_1.1","start":{"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000,"date-parts":[[2026,1,1]]},"delay-in-days":0,"content-version":"tdm"}],"subject":[],"abstract":"$45","language":"en","relation":{},"resource":{"primary":{"URL":"https://acsjournals.onlinelibrary.wiley.com/doi/10.3322/caac.70043"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"publication_history","label":"Publication History"},"label":"Received","order":0,"value":"2025-10-17"},{"name":"accepted","group":{"name":"publication_history","label":"Publication History"},"label":"Accepted","order":2,"value":"2025-10-20"},{"name":"published","group":{"name":"publication_history","label":"Publication History"},"label":"Published","order":3,"value":"2026-01-13"}],"deposited":{"date-time":"2026-01-13T13:54:40Z","timestamp":1768312480000,"date-parts":[[2026,1,13]]},"issn-type":[{"type":"print","value":"0007-9235"},{"type":"electronic","value":"1542-4863"}],"published":{"date-parts":[[2026,1]]},"publisher":"Wiley","reference":[{"DOI":"10.1158/1055‐9965.Epi‐22‐0544","key":"e_1_2_7_2_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1158/1055‐9965.EPI‐23‐0114","key":"e_1_2_7_3_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/jnci/djac172","key":"e_1_2_7_4_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_2_7_5_1","year":"2025","issue":null,"author":"Surveillance, Epidemiology, and End Results (SEER) Program","volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":null,"key":"e_1_2_7_6_1","year":"2021","issue":null,"author":"Surveillance, Epidemiology, and End Results (SEER) Program","volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":null,"key":"e_1_2_7_7_1","year":"2025","issue":null,"author":"Surveillance, Epidemiology, and End Results (SEER) Program","volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":null,"key":"e_1_2_7_8_1","year":"2025","issue":null,"author":"Surveillance, Epidemiology, and End Results (SEER) Program","volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":null,"key":"e_1_2_7_9_1","year":"2025","issue":null,"author":"Surveillance, Epidemiology, and End Results (SEER) Program","volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":null,"key":"e_1_2_7_10_1","year":"2025","issue":null,"author":"Surveillance, Epidemiology, and End Results (SEER) Program","volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.1002/cncr.11380","key":"e_1_2_7_11_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_2_7_12_1","year":"2015","issue":"9","author":"Murphy SL","volume":"63","first-page":"1","unstructured":null,"article-title":"Deaths: final data for 2012","journal-title":"Natl Vital Stat Rep","doi-asserted-by":null},{"DOI":"10.1002/cncr.20910","key":"e_1_2_7_13_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_2_7_14_1","year":"2000","issue":null,"author":"Fritz A","volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.1016/S1470‐2045(17)30186‐9","key":"e_1_2_7_15_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_2_7_16_1","year":"2011","issue":null,"author":"World Health Organization","volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.1093/jnci/djad086","key":"e_1_2_7_17_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_2_7_18_1","year":"2021","issue":"12","author":"Arias E","volume":"70","first-page":"1","unstructured":null,"article-title":"Mortality profile of the non‐Hispanic American Indian or Alaska Native population, 2019","journal-title":"Natl Vital Stat Rep","doi-asserted-by":null},{"DOI":"10.1093/jnci/94.20.1537","key":"e_1_2_7_19_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_2_7_20_1","year":"2018","issue":null,"author":"Centers for Disease Control and Prevention (CDC)","volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.1371/journal.pone.0201034","key":"e_1_2_7_21_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/jncimonographs/lgu024","key":"e_1_2_7_22_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_2_7_23_1","year":"2021","issue":null,"author":"Cho H","volume":null,"first-page":null,"unstructured":null,"article-title":"Estimating relative survival for cancer patients from the SEER program using expected rates based on Ederer I versus Ederer II method","journal-title":"Surveillance Research Program, NCI, Technical Report #2011‐01","doi-asserted-by":null},{"DOI":"10.1158/1055‐9965.EPI‐20‐1727","key":"e_1_2_7_24_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1158/1055‐9965.EPI‐20‐1780","key":"e_1_2_7_25_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3322/canjclin.57.1.30","key":"e_1_2_7_26_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3322/caac.21858","key":"e_1_2_7_27_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1158/1055‐9965.EPI‐24‐1835","key":"e_1_2_7_28_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1002/cncr.35026","key":"e_1_2_7_29_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1001/jamanetworkopen.2024.32288","key":"e_1_2_7_30_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/jnci/djae180","key":"e_1_2_7_31_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1001/jama.1995.03520310046028","key":"e_1_2_7_32_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1038/s41416‐018‐0371‐8","key":"e_1_2_7_33_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/S1470‐2045(11)70154‐1","key":"e_1_2_7_34_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1038/nri.2016.90","key":"e_1_2_7_35_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1002/cncr.34390","key":"e_1_2_7_36_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1001/jama.2015.14905","key":"e_1_2_7_37_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.7326/0003‐4819‐157‐2‐201207170‐00459","key":"e_1_2_7_38_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3322/caac.70028","key":"e_1_2_7_39_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.urolonc.2024.05.009","key":"e_1_2_7_40_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1001/jama.2018.3710","key":"e_1_2_7_41_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3322/caac.20066","key":"e_1_2_7_42_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1001/jamaoncol.2024.4397","key":"e_1_2_7_43_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/jnci/djaf271","key":"e_1_2_7_44_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3322/caac.21863","key":"e_1_2_7_45_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1158/1055‐9965.EPI‐18‐0098","key":"e_1_2_7_46_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1001/jamaoncol.2018.1771","key":"e_1_2_7_47_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_2_7_48_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"U.S. Census Bureau.Current Population Survey June 1976–2024. Technical Documentation: Methodology (for information on confidentiality protection sampling error nonsampling error and definitions). Accessed September 24 2025.http://www.census.gov/programs‐surveys/cps/technical‐documentation/methodology.html","article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.1093/jnci/djn514","key":"e_1_2_7_49_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/acer.14082","key":"e_1_2_7_50_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.drugalcdep.2020.108026","key":"e_1_2_7_51_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/add.16262","key":"e_1_2_7_52_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1200/jco.24.00418","key":"e_1_2_7_53_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1200/JCO.19.00151","key":"e_1_2_7_54_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_2_7_55_1","year":"1983","issue":"3","author":"Harris JE","volume":"71","first-page":"473","unstructured":null,"article-title":"Cigarette smoking among successive birth cohorts of men and women in the United States during 1900–80","journal-title":"J Natl Cancer Inst","doi-asserted-by":null},{"DOI":"10.1056/NEJMoa1715907","key":"e_1_2_7_56_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1002/cncr.35128","key":"e_1_2_7_57_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.5888/pcd20.220375","key":"e_1_2_7_58_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1001/jamaoncol.2025.0247","key":"e_1_2_7_59_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1001/jama.2025.0902","key":"e_1_2_7_60_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1001/jama.2025.9147","key":"e_1_2_7_61_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1158/1055‐9965.Epi‐19‐1052","key":"e_1_2_7_62_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1053/j.seminoncol.2010.05.006","key":"e_1_2_7_63_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1002/ijc.29634","key":"e_1_2_7_64_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1001/jamaoncol.2017.0589","key":"e_1_2_7_65_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.anndiagpath.2015.01.001","key":"e_1_2_7_66_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1056/NEJMoa0912217","key":"e_1_2_7_67_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_2_7_68_1","year":"2025","issue":null,"author":"Surveillance, Epidemiology, and End Results (SEER) Program","volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":null,"key":"e_1_2_7_69_1","year":"2025","issue":null,"author":"Surveillance, Epidemiology, and End Results (SEER) Program","volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.1016/S2352‐3026(15)00048‐4","key":"e_1_2_7_70_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3322/caac.70018","key":"e_1_2_7_71_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1053/j.gastro.2025.03.047","key":"e_1_2_7_72_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1001/jamasurg.2022.7989","key":"e_1_2_7_73_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1056/EVIDoa2100070","key":"e_1_2_7_74_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1056/NEJMoa1915745","key":"e_1_2_7_75_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/s0140‐6736(18)30207‐1","key":"e_1_2_7_76_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1056/NEJMe2507130","key":"e_1_2_7_77_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1002/cncr.35353","key":"e_1_2_7_78_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1056/NEJMoa1916623","key":"e_1_2_7_79_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1056/NEJMra2034861","key":"e_1_2_7_80_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1177/1758834017714997","key":"e_1_2_7_81_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1002/cncr.35976","key":"e_1_2_7_82_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1001/jama.283.22.2975","key":"e_1_2_7_83_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/jnci/djaf192","key":"e_1_2_7_84_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/jnci/djad256","key":"e_1_2_7_85_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1002/cncr.70004","key":"e_1_2_7_86_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1056/NEJMoa1911793","key":"e_1_2_7_87_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1002/cncr.28326","key":"e_1_2_7_88_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1148/radiol.231988","key":"e_1_2_7_89_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1001/jamainternmed.2024.1655","key":"e_1_2_7_90_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1001/jamanetworkopen.2025.15798","key":"e_1_2_7_91_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1001/jama.2023.25881","key":"e_1_2_7_92_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s10552‐007‐9083‐8","key":"e_1_2_7_93_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.7326/M16‐2586","key":"e_1_2_7_94_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_2_7_95_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"American Cancer Society.Cancer Facts & Figures for Asian American Native Hawaiian & other Pacific Islander People 2024. American Cancer Society; 2024.Accessed September 24 2025.https://www.cancer.org/research/cancer‐facts‐statistics/acs‐aanhpi‐cancer‐facts‐figures‐2024.html","article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.1001/jamainternmed.2024.6487","key":"e_1_2_7_96_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/jnci/djac038","key":"e_1_2_7_97_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1200/jco.2017.73.7932","key":"e_1_2_7_98_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/jnci/djad027","key":"e_1_2_7_99_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1002/cncr.34632","key":"e_1_2_7_100_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1001/jamaoncol.2022.1990","key":"e_1_2_7_101_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/jnci/djae140","key":"e_1_2_7_102_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.7326/m23‐1341","key":"e_1_2_7_103_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1001/jama.2023.9526","key":"e_1_2_7_104_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1200/JCO.22.00754","key":"e_1_2_7_105_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/S0140‐6736(17)30569‐X","key":"e_1_2_7_106_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/jnci/djaf105","key":"e_1_2_7_107_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1200/JCO.21.00112","key":"e_1_2_7_108_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/jnci/djad034","key":"e_1_2_7_109_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1158/1055‐9965.EPI‐20‐1038","key":"e_1_2_7_110_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/aje/kwaa045","key":"e_1_2_7_111_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.ssmph.2021.100793","key":"e_1_2_7_112_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3322/canjclin.54.2.78","key":"e_1_2_7_113_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1001/jama.287.16.2106","key":"e_1_2_7_114_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.2105/ajph.2015.302777","key":"e_1_2_7_115_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1001/jamanetworkopen.2025.16740","key":"e_1_2_7_116_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/jnci/djae001","key":"e_1_2_7_117_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1001/jamainternmed.2023.0276","key":"e_1_2_7_118_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1155/2017/2819372","key":"e_1_2_7_119_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3322/caac.21703","key":"e_1_2_7_120_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1158/1055‐9965.EPI‐24‐0450","key":"e_1_2_7_121_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1200/JCO.23.02780","key":"e_1_2_7_122_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.ypmed.2016.08.015","key":"e_1_2_7_123_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1056/NEJMsb1706645","key":"e_1_2_7_124_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_2_7_125_1","year":"2025","issue":null,"author":"American Cancer Society","volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":null,"key":"e_1_2_7_126_1","year":"2024","issue":null,"author":"American Cancer Society","volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.1016/S0140‐6736(21)02178‐4","key":"e_1_2_7_127_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1002/cncr.31669","key":"e_1_2_7_128_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1001/jamapediatrics.2015.4689","key":"e_1_2_7_129_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/S1470‐2045(24)00157‐8","key":"e_1_2_7_130_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1200/jco‐25‐00385","key":"e_1_2_7_131_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1001/jamaoncol.2025.0236","key":"e_1_2_7_132_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1002/cncr.35355","key":"e_1_2_7_133_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"}],"short-title":[],"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"update-policy":"https://doi.org/10.1002/crossmark_policy","alternative-id":["10.3322/caac.70043"],"article-number":"e70043","content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"original-title":[],"container-title":["CA: A Cancer Journal for Clinicians"],"published-print":{"date-parts":[[2026,1]]},"reference-count":132,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2026,1,13]]},"references-count":132,"short-container-title":["CA A Cancer J Clinicians"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.3322/caac.70043","is_oa":true,"title":"Cancer statistics, 2026","updated":"2026-01-17T01:14:18+00:00","published_date":"2026-01-01","best_oa_location":{"url":"https://doi.org/10.3322/caac.70043","pmh_id":null,"url_for_pdf":null,"url_for_landing_page":"https://doi.org/10.3322/caac.70043"}}},"created_at":"2026-01-18T22:40:12.285Z","updated_at":"2026-01-21T12:05:26.220Z","tags":[{"paper_doi":"10.3322/caac.70043","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.3322/caac.70043","tag_type":"category","value":"Oncology","value_numeric":null},{"paper_doi":"10.3322/caac.70043","tag_type":"condition","value":"Cancer","value_numeric":null},{"paper_doi":"10.3322/caac.70043","tag_type":"impact_flag","value":"confirms_prior","value_numeric":null},{"paper_doi":"10.3322/caac.70043","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.3322/caac.70043","tag_type":"study_design","value":"Cross-Sectional","value_numeric":null},{"paper_doi":"10.3322/caac.70043","tag_type":"warning","value":"Only abstract details were available for review; full methods and stratifications were not assessed.","value_numeric":null},{"paper_doi":"10.3322/caac.70043","tag_type":"warning","value":"Study design classification is approximate; this is a descriptive, registry-based surveillance report with projections.","value_numeric":null}],"summaries":{"what_studied":"Annual U.S. cancer burden using incidence data through 2022 and mortality data through 2023, with projections for 2026 (2,114,850 new cases; 626,140 deaths).","key_result":"The cancer mortality rate continued to fall through 2023, averting 4.8 million deaths since 1991. Five-year relative survival reached 70% for 2015–2021 diagnoses overall (regional 69%, distant 35%), up from 63%, 54%, and 17% in the mid‑1990s; large gains include myeloma 32%→62%, liver 7%→22%, metastatic melanoma 16%→35%, metastatic rectal 8%→18%, regional lung 20%→37%, and metastatic lung 2%→10%; lung cancer will cause more deaths in 2026 than colorectal and pancreatic cancers combined.","practice_takeaway":"Reinforce smoking cessation, guideline-based early detection, and timely treatment—these are linked to falling mortality and rising survival. Prioritize vigilance for lung cancer, which is projected to cause more deaths in 2026 than colorectal and pancreatic cancers combined."}},{"doi":"10.1016/j.biopsych.2026.01.004","pmid":"41525818","title":"Reduced ATP-to-phosphocreatine ratios in neuropsychiatric post-COVID condition: Evidence from 31P magnetic resonance spectroscopy","journal_title":"Biological Psychiatry","journal_issn":"0006-3223","published_at":"2026-01-13T00:00:00.000Z","url":"https://doi.org/10.1016/j.biopsych.2026.01.004","source_score":282,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-01-11","doi":"10.1016/j.biopsych.2026.01.004","days":"30","issn":"0006-3223","rank":"3","field":"Clinical Medicine","score":"282","category":"Neurosciences","categories":["Neurosciences","Psychiatry"],"_categories":["Neurosciences","Psychiatry"]},"pubmed":{"doi":"10.1016/j.biopsych.2026.01.004","title":"Reduced ATP-to-phosphocreatine ratios in neuropsychiatric post-COVID condition: Evidence from ","journal":"Biological psychiatry","methods":"","results":"PCCo patients showed a significant cluster of reduced ATP/PCr ratios centered on the cingulate cortex. Regional analysis revealed consistent reductions across anterior (ACC), mid- (MCC), and posterior (PCC) cingulate cortices. Lower ATP/PCr ratios in the ACC specifically correlated with poorer cognitive performance. Exploratory analyses revealed a trend toward higher intracellular pH in the MCC with significant negative correlation between pH and ATP/PCr observed only in patients, suggesting disease-specific alterations in pH regulation and bioenergetic homeostasis. Subgroup analysis showed similar metabolic alterations in PCCo patients meeting ME/CFS criteria.","abstract":"$46","keywords":["(6): 31P-MRS","ATP","brain energy metabolism","cingulate cortex","mitochondrial dysfunction","post-COVID condition"],"pubmed_id":"41525818","conclusions":"","publication_date":"2026-01-13T00:00:00"},"crossref":{"DOI":"10.1016/j.biopsych.2026.01.004","URL":"https://doi.org/10.1016/j.biopsych.2026.01.004","ISSN":["0006-3223"],"link":[{"URL":"https://api.elsevier.com/content/article/PII:S0006322326000211?httpAccept=text/xml","content-type":"text/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https://api.elsevier.com/content/article/PII:S0006322326000211?httpAccept=text/plain","content-type":"text/plain","content-version":"vor","intended-application":"text-mining"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Reduced ATP-to-phosphocreatine ratios in neuropsychiatric post-COVID condition: Evidence from 31P magnetic resonance spectroscopy"],"author":[{"given":"Wolfgang","family":"Weber-Fahr","sequence":"first","affiliation":[]},{"given":"Sandra","family":"Dommke","sequence":"additional","affiliation":[]},{"given":"Markus","family":"Sack","sequence":"additional","affiliation":[]},{"given":"Nabil","family":"Alzein","sequence":"additional","affiliation":[]},{"given":"Robert","family":"Becker","sequence":"additional","affiliation":[]},{"given":"Traute","family":"Demirakca","sequence":"additional","affiliation":[]},{"given":"Gabriele","family":"Ende","sequence":"additional","affiliation":[]},{"given":"Claudia","family":"Schilling","sequence":"additional","affiliation":[]}],"issued":{"date-parts":[[2026,1]]},"member":"78","prefix":"10.1016","source":"Crossref","volume":null,"created":{"date-time":"2026-01-10T23:26:24Z","timestamp":1768087584000,"date-parts":[[2026,1,10]]},"indexed":{"date-time":"2026-01-17T20:44:47Z","timestamp":1768682687751,"date-parts":[[2026,1,17]]},"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","start":{"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000,"date-parts":[[2026,1,1]]},"delay-in-days":0,"content-version":"tdm"},{"URL":"https://www.elsevier.com/legal/tdmrep-license","start":{"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000,"date-parts":[[2026,1,1]]},"delay-in-days":0,"content-version":"tdm"},{"URL":"http://creativecommons.org/licenses/by/4.0/","start":{"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000,"date-parts":[[2026,1,14]]},"delay-in-days":13,"content-version":"vor"}],"subject":[],"abstract":null,"language":"en","relation":{},"resource":{"primary":{"URL":"https://linkinghub.elsevier.com/retrieve/pii/S0006322326000211"}},"subtitle":[],"assertion":[{"name":"publisher","label":"This article is maintained by","value":"Elsevier"},{"name":"articletitle","label":"Article Title","value":"Reduced ATP-to-phosphocreatine ratios in neuropsychiatric post-COVID condition: Evidence from 31P magnetic resonance spectroscopy"},{"name":"journaltitle","label":"Journal Title","value":"Biological Psychiatry"},{"name":"articlelink","label":"CrossRef DOI link to publisher maintained version","value":"https://doi.org/10.1016/j.biopsych.2026.01.004"},{"name":"content_type","label":"Content Type","value":"article"},{"name":"copyright","label":"Copyright","value":"© 2026 Published by Elsevier Inc on behalf of Society of Biological Psychiatry."}],"deposited":{"date-time":"2026-01-17T10:28:54Z","timestamp":1768645734000,"date-parts":[[2026,1,17]]},"issn-type":[{"type":"print","value":"0006-3223"}],"published":{"date-parts":[[2026,1]]},"publisher":"Elsevier BV","reference":[{"DOI":"10.1016/S1473-3099(21)00703-9","key":"10.1016/j.biopsych.2026.01.004_bib1","year":"2022","issue":null,"author":"Soriano","volume":"22","first-page":"e102","unstructured":null,"article-title":"A clinical case definition of post-COVID-19 condition by a Delphi consensus","journal-title":"The Lancet Infectious Diseases","doi-asserted-by":"crossref"},{"DOI":"10.1136/bmj-2022-071050","key":"10.1016/j.biopsych.2026.01.004_bib2","year":"2022","issue":null,"author":"Peter","volume":"379","first-page":null,"unstructured":null,"article-title":"Post-acute sequelae of covid-19 six to 12 months after infection: population based study","journal-title":"BMJ","doi-asserted-by":"crossref"},{"DOI":"10.1016/S0140-6736(22)01214-4","key":"10.1016/j.biopsych.2026.01.004_bib3","year":"2022","issue":null,"author":"Ballering","volume":"400","first-page":"452","unstructured":null,"article-title":"Persistence of somatic symptoms after COVID-19 in the Netherlands: an observational cohort study","journal-title":"Lancet","doi-asserted-by":"crossref"},{"DOI":"10.1056/NEJMoa2403211","key":"10.1016/j.biopsych.2026.01.004_bib4","year":"2024","issue":null,"author":"Xie","volume":"391","first-page":"515","unstructured":null,"article-title":"Postacute Sequelae of SARS-CoV-2 Infection in the Pre-Delta, Delta, and Omicron Eras","journal-title":"N Engl J Med","doi-asserted-by":"crossref"},{"DOI":"10.1001/jamanetworkopen.2021.30645","key":"10.1016/j.biopsych.2026.01.004_bib5","year":"2021","issue":null,"author":"Becker","volume":"4","first-page":null,"unstructured":null,"article-title":"Assessment of Cognitive Function in Patients After COVID-19 Infection","journal-title":"JAMA Network Open","doi-asserted-by":"crossref"},{"DOI":"10.1371/journal.pmed.1004511","key":"10.1016/j.biopsych.2026.01.004_bib6","year":"2025","issue":null,"author":"Peter","volume":"22","first-page":null,"unstructured":null,"article-title":"Persistent symptoms and clinical findings in adults with post-acute sequelae of COVID-19/post-COVID-19 syndrome in the second year after acute infection: A population-based, nested case-control study","journal-title":"PLoS Med","doi-asserted-by":"crossref"},{"DOI":"10.1126/science.abm2052","key":"10.1016/j.biopsych.2026.01.004_bib7","year":"2022","issue":null,"author":"Spudich","volume":"375","first-page":"267","unstructured":null,"article-title":"Nervous system consequences of COVID-19","journal-title":"Science","doi-asserted-by":"crossref"},{"DOI":"10.1042/BCJ20220016","key":"10.1016/j.biopsych.2026.01.004_bib8","year":"2022","issue":null,"author":"Kell","volume":"479","first-page":"537","unstructured":null,"article-title":"A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications","journal-title":"Biochem J","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.cell.2024.07.054","key":"10.1016/j.biopsych.2026.01.004_bib9","year":"2024","issue":null,"author":"Peluso","volume":"187","first-page":"5500","unstructured":null,"article-title":"Mechanisms of long COVID and the path toward therapeutics","journal-title":"Cell","doi-asserted-by":"crossref"},{"DOI":"10.1186/s12933-021-01359-7","key":"10.1016/j.biopsych.2026.01.004_bib10","year":"2021","issue":null,"author":"Pretorius","volume":"20","first-page":"172","unstructured":null,"article-title":"Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin","journal-title":"Cardiovasc Diabetol","doi-asserted-by":"crossref"},{"DOI":"10.1002/jcsm.13669","key":"10.1016/j.biopsych.2026.01.004_bib11","year":"2025","issue":null,"author":"Scheibenbogen","volume":"16","first-page":null,"unstructured":null,"article-title":"Key Pathophysiological Role of Skeletal Muscle Disturbance in Post COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Accumulated Evidence","journal-title":"J Cachexia Sarcopenia Muscle","doi-asserted-by":"crossref"},{"DOI":"10.3390/medicina60020194","key":"10.1016/j.biopsych.2026.01.004_bib12","year":"2024","issue":null,"author":"Wirth","volume":"60","first-page":"194","unstructured":null,"article-title":"Microvascular Capillary and Precapillary Cardiovascular Disturbances Strongly Interact to Severely Affect Tissue Perfusion and Mitochondrial Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Evolving from the Post COVID-19 Syndrome","journal-title":"Medicina","doi-asserted-by":"crossref"},{"DOI":"10.1038/s41593-024-01576-9","key":"10.1016/j.biopsych.2026.01.004_bib13","year":"2024","issue":null,"author":"Greene","volume":"27","first-page":"421","unstructured":null,"article-title":"Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment","journal-title":"Nat Neurosci","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.bbi.2024.04.015","key":"10.1016/j.biopsych.2026.01.004_bib14","year":"2024","issue":null,"author":"VanElzakker","volume":"119","first-page":"713","unstructured":null,"article-title":"Neuroinflammation in post-acute sequelae of COVID-19 (PASC) as assessed by [(11)C]PBR28 PET correlates with vascular disease measures","journal-title":"Brain Behav Immun","doi-asserted-by":"crossref"},{"DOI":"10.1126/scitranslmed.abq1533","key":"10.1016/j.biopsych.2026.01.004_bib15","year":"2023","issue":null,"author":"Guarnieri","volume":"15","first-page":null,"unstructured":null,"article-title":"Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts","journal-title":"Sci Transl Med","doi-asserted-by":"crossref"},{"DOI":"10.1164/rccm.202108-1903LE","key":"10.1016/j.biopsych.2026.01.004_bib16","year":"2022","issue":null,"author":"de Boer","volume":"205","first-page":"126","unstructured":null,"article-title":"Decreased Fatty Acid Oxidation and Altered Lactate Production during Exercise in Patients with Post-acute COVID-19 Syndrome","journal-title":"Am J Respir Crit Care Med","doi-asserted-by":"crossref"},{"DOI":"10.3390/metabo12111026","key":"10.1016/j.biopsych.2026.01.004_bib17","year":"2022","issue":null,"author":"Guntur","volume":"12","first-page":null,"unstructured":null,"article-title":"Signatures of Mitochondrial Dysfunction and Impaired Fatty Acid Metabolism in Plasma of Patients with Post-Acute Sequelae of COVID-19 (PASC)","journal-title":"Metabolites","doi-asserted-by":"crossref"},{"DOI":"10.1007/s15010-024-02386-8","key":"10.1016/j.biopsych.2026.01.004_bib18","year":"2025","issue":null,"author":"Haunhorst","volume":"53","first-page":"1","unstructured":null,"article-title":"Towards an understanding of physical activity-induced post-exertional malaise: Insights into microvascular alterations and immunometabolic interactions in post-COVID condition and myalgic encephalomyelitis/chronic fatigue syndrome","journal-title":"Infection","doi-asserted-by":"crossref"},{"DOI":"10.21037/qims.2017.11.03","key":"10.1016/j.biopsych.2026.01.004_bib19","year":"2017","issue":null,"author":"Liu","volume":"7","first-page":"707","unstructured":null,"article-title":"Assessing tissue metabolism by phosphorous-31 magnetic resonance spectroscopy and imaging: a methodology review","journal-title":"Quant Imaging Med Surg","doi-asserted-by":"crossref"},{"DOI":"10.1300/J092v11n01_02","key":"10.1016/j.biopsych.2026.01.004_bib20","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"Carruthers BM, Kumar JA, L. DMK, L. PD, G. KN, Martin LA, et al. (2003): Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Journal Of Chronic Fatigue Syndrome. 11:7-115.","article-title":null,"journal-title":null,"doi-asserted-by":"crossref"},{"DOI":"10.1016/j.eclinm.2023.102146","key":"10.1016/j.biopsych.2026.01.004_bib21","year":"2023","issue":null,"author":"Legler","volume":"63","first-page":null,"unstructured":null,"article-title":"Long-term symptom severity and clinical biomarkers in post-COVID-19/chronic fatigue syndrome: results from a prospective observational cohort","journal-title":"EClinicalMedicine","doi-asserted-by":"crossref"},{"DOI":null,"key":"10.1016/j.biopsych.2026.01.004_bib22","year":"2023","issue":null,"author":"Komaroff","volume":"10","first-page":null,"unstructured":null,"article-title":"ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature","journal-title":"Front Med (Lausanne)","doi-asserted-by":null},{"DOI":"10.1111/j.1532-5415.2005.53221.x","key":"10.1016/j.biopsych.2026.01.004_bib23","year":"2005","issue":null,"author":"Nasreddine","volume":"53","first-page":"695","unstructured":null,"article-title":"The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment","journal-title":"J Am Geriatr Soc","doi-asserted-by":"crossref"},{"DOI":"10.2466/pms.1958.8.3.271","key":"10.1016/j.biopsych.2026.01.004_bib24","year":"1958","issue":null,"author":"Reitan","volume":"8","first-page":"271","unstructured":null,"article-title":"Validity of the Trail Making Test as an Indicator of Organic Brain Damage","journal-title":"Percept Mot Skills","doi-asserted-by":"crossref"},{"DOI":null,"key":"10.1016/j.biopsych.2026.01.004_bib25","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"Helmstaedter C, Lendt, M., Lux, Silke, (2001): Verbaler Lern- und Merkfähigkeitstest (VLMT). BELTZ TEST GmbH, .","article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.17116/neiro2019830215","key":"10.1016/j.biopsych.2026.01.004_bib26","year":"2019","issue":null,"author":"Pronin","volume":"83","first-page":"5","unstructured":null,"article-title":"[Phosphorus (P) magnetic resonance spectroscopy for evaluation of brain tissue metabolism and measuring non-invasive pH. A study involving 23 volunteers. Part I]","journal-title":"Zh Vopr Neirokhir Im N N Burdenko","doi-asserted-by":"crossref"},{"DOI":null,"key":"10.1016/j.biopsych.2026.01.004_bib27","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"Zimmermann P, Fimm, B. (n.d.): TAP – Testbatterie zur Aufmerksamkeitsprüfung.","article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.1002/nbm.4169","key":"10.1016/j.biopsych.2026.01.004_bib28","year":"2021","issue":null,"author":"Peeters","volume":"34","first-page":null,"unstructured":null,"article-title":"3D (31) P MR spectroscopic imaging of the human brain at 3 T with a (31) P receive array: An assessment of (1) H decoupling, T(1) relaxation times, (1) H-(31) P nuclear Overhauser effects and NAD","journal-title":"NMR Biomed","doi-asserted-by":"crossref"},{"DOI":"10.1088/0957-0233/20/10/104035","key":"10.1016/j.biopsych.2026.01.004_bib29","year":"2009","issue":null,"author":"Stefan","volume":"20","first-page":null,"unstructured":null,"article-title":"Quantitation of magnetic resonance spectroscopy signals: the jMRUI software package","journal-title":"Measurement Science and Technology","doi-asserted-by":"crossref"},{"DOI":"10.1006/jmre.1997.1244","key":"10.1016/j.biopsych.2026.01.004_bib30","year":"1997","issue":null,"author":"Vanhamme","volume":"129","first-page":"35","unstructured":null,"article-title":"Improved method for accurate and efficient quantification of MRS data with use of prior knowledge","journal-title":"J Magn Reson","doi-asserted-by":"crossref"},{"DOI":"10.1002/9780470512968","key":"10.1016/j.biopsych.2026.01.004_bib31","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"de Graaf RA (2007): In Vivo NMR Spectroscopy: Principles and Techniques. 2. vollst. überarb. ed. Hoboken, NJ: Wiley.","article-title":null,"journal-title":null,"doi-asserted-by":"crossref"},{"DOI":"10.1016/j.neurad.2021.11.006","key":"10.1016/j.biopsych.2026.01.004_bib32","year":"2022","issue":null,"author":"Rietzler","volume":"49","first-page":"370","unstructured":null,"article-title":"Energy metabolism measured by 31P magnetic resonance spectroscopy in the healthy human brain","journal-title":"J Neuroradiol","doi-asserted-by":"crossref"},{"DOI":"10.1038/jcbfm.2010.48","key":"10.1016/j.biopsych.2026.01.004_bib33","year":"2010","issue":null,"author":"Schmoller","volume":"30","first-page":"1403","unstructured":null,"article-title":"Evidence for a relationship between body mass and energy metabolism in the human brain","journal-title":"J Cereb Blood Flow Metab","doi-asserted-by":"crossref"},{"DOI":"10.3389/fnagi.2023.1183228","key":"10.1016/j.biopsych.2026.01.004_bib34","year":"2023","issue":null,"author":"Jett","volume":"15","first-page":null,"unstructured":null,"article-title":"Systematic review of (31)P-magnetic resonance spectroscopy studies of brain high energy phosphates and membrane phospholipids in aging and Alzheimer's disease","journal-title":"Front Aging Neurosci","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.jphysparis.2014.06.004","key":"10.1016/j.biopsych.2026.01.004_bib35","year":"2015","issue":null,"author":"Newman","volume":"109","first-page":"95","unstructured":null,"article-title":"Cognitive control and the anterior cingulate cortex: how conflicting stimuli affect attentional control in the rat","journal-title":"J Physiol Paris","doi-asserted-by":"crossref"},{"DOI":"10.1097/WNP.0000000000000970","key":"10.1016/j.biopsych.2026.01.004_bib36","year":"2023","issue":null,"author":"Oane","volume":"40","first-page":"482","unstructured":null,"article-title":"Cingulate Cortex: Anatomy, Structural and Functional Connectivity","journal-title":"J Clin Neurophysiol","doi-asserted-by":"crossref"},{"DOI":"10.1002/1097-0193(200007)10:3<120::AID-HBM30>3.0.CO;2-8","key":"10.1016/j.biopsych.2026.01.004_bib37","year":"2000","issue":null,"author":"Lancaster","volume":"10","first-page":"120","unstructured":null,"article-title":"Automated Talairach atlas labels for functional brain mapping","journal-title":"Hum Brain Mapp","doi-asserted-by":"crossref"},{"DOI":"10.1016/0022-3999(93)90081-P","key":"10.1016/j.biopsych.2026.01.004_bib38","year":"1993","issue":"2","author":"Chalder","volume":"37","first-page":"147","unstructured":null,"article-title":"Development of a fatigue scale","journal-title":"J Psychosom Res","doi-asserted-by":"crossref"},{"DOI":"10.1006/nimg.2002.1057","key":"10.1016/j.biopsych.2026.01.004_bib39","year":"2002","issue":null,"author":"Weber-Fahr","volume":"16","first-page":"49","unstructured":null,"article-title":"A fully automated method for tissue segmentation and CSF-correction of proton MRSI metabolites corroborates abnormal hippocampal NAA in schizophrenia","journal-title":"Neuroimage","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.neuron.2013.07.007","key":"10.1016/j.biopsych.2026.01.004_bib40","year":"2013","issue":null,"author":"Shenhav","volume":"79","first-page":"217","unstructured":null,"article-title":"The Expected Value of Control: An Integrative Theory of Anterior Cingulate Cortex Function","journal-title":"Neuron","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.jchemneu.2016.01.010","key":"10.1016/j.biopsych.2026.01.004_bib41","year":"2016","issue":null,"author":"Vogt","volume":"74","first-page":"28","unstructured":null,"article-title":"Midcingulate cortex: Structure, connections, homologies, functions and diseases","journal-title":"J Chem Neuroanat","doi-asserted-by":"crossref"},{"DOI":"10.1038/s41583-022-00661-x","key":"10.1016/j.biopsych.2026.01.004_bib42","year":"2023","issue":null,"author":"Foster","volume":"24","first-page":"173","unstructured":null,"article-title":"A tripartite view of the posterior cingulate cortex","journal-title":"Nature Reviews Neuroscience","doi-asserted-by":"crossref"},{"DOI":"10.1002/nbm.1444","key":"10.1016/j.biopsych.2026.01.004_bib43","year":"2010","issue":null,"author":"Forester","volume":"23","first-page":"242","unstructured":null,"article-title":"Age-related changes in brain energetics and phospholipid metabolism","journal-title":"NMR Biomed","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.nicl.2018.01.031","key":"10.1016/j.biopsych.2026.01.004_bib44","year":"2018","issue":null,"author":"Rijpma","volume":"18","first-page":"254","unstructured":null,"article-title":"Altered brain high-energy phosphate metabolism in mild Alzheimer's disease: A 3-dimensional (31)P MR spectroscopic imaging study","journal-title":"Neuroimage Clin","doi-asserted-by":"crossref"},{"DOI":"10.1007/s00726-011-0877-3","key":"10.1016/j.biopsych.2026.01.004_bib45","year":"2011","issue":null,"author":"Wallimann","volume":"40","first-page":"1271","unstructured":null,"article-title":"The creatine kinase system and pleiotropic effects of creatine","journal-title":"Amino Acids","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.bbadis.2005.09.004","key":"10.1016/j.biopsych.2026.01.004_bib46","year":"2006","issue":null,"author":"Schlattner","volume":"1762","first-page":"164","unstructured":null,"article-title":"Mitochondrial creatine kinase in human health and disease","journal-title":"Biochim Biophys Acta","doi-asserted-by":"crossref"},{"DOI":"10.1152/japplphysiol.00715.2016","key":"10.1016/j.biopsych.2026.01.004_bib47","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"Wilson DF (2017): Oxidative phosphorylation: unique regulatory mechanism and role in metabolic homeostasis. J Appl Physiol (1985). 122:611-619.","article-title":null,"journal-title":null,"doi-asserted-by":"crossref"},{"DOI":"10.1515/REVNEURO.1999.10.1.49","key":"10.1016/j.biopsych.2026.01.004_bib48","year":"1999","issue":null,"author":"Carter","volume":"10","first-page":"49","unstructured":null,"article-title":"The Contribution of the Anterior Cingulate Cortex to Executive Processes in Cognition","journal-title":"Rev Neurosci","doi-asserted-by":"crossref"},{"DOI":"10.1016/S1364-6613(00)01483-2","key":"10.1016/j.biopsych.2026.01.004_bib49","year":"2000","issue":null,"author":"Bush","volume":"4","first-page":"215","unstructured":null,"article-title":"Cognitive and emotional influences in anterior cingulate cortex","journal-title":"Trends Cogn Sci","doi-asserted-by":"crossref"},{"DOI":"10.1038/s41467-023-44432-3","key":"10.1016/j.biopsych.2026.01.004_bib50","year":"2024","issue":null,"author":"Appelman","volume":"15","first-page":"17","unstructured":null,"article-title":"Muscle abnormalities worsen after post-exertional malaise in long COVID","journal-title":"Nat Commun","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.cell.2023.09.013","key":"10.1016/j.biopsych.2026.01.004_bib51","year":"2023","issue":null,"author":"Wong","volume":"186","first-page":"4851","unstructured":null,"article-title":"Serotonin reduction in post-acute sequelae of viral infection","journal-title":"Cell","doi-asserted-by":"crossref"},{"DOI":"10.1038/nature09663","key":"10.1016/j.biopsych.2026.01.004_bib52","year":"2011","issue":null,"author":"Zhou","volume":"469","first-page":"221","unstructured":null,"article-title":"A role for mitochondria in NLRP3 inflammasome activation","journal-title":"Nature","doi-asserted-by":"crossref"},{"DOI":"10.18103/mra.v10i9.3050","key":"10.1016/j.biopsych.2026.01.004_bib53","year":"2022","issue":null,"author":"Walker","volume":"10","first-page":null,"unstructured":null,"article-title":"The significance of oxidative stress in the pathophysiology of Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)","journal-title":"Medical Research Archives","doi-asserted-by":"crossref"},{"DOI":"10.1073/pnas.2024358118","key":"10.1016/j.biopsych.2026.01.004_bib54","year":"2021","issue":null,"author":"Paul","volume":"118","first-page":null,"unstructured":null,"article-title":"Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome","journal-title":"Proc Natl Acad Sci U S A","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.neuron.2012.08.019","key":"10.1016/j.biopsych.2026.01.004_bib55","year":"2012","issue":null,"author":"Harris","volume":"75","first-page":"762","unstructured":null,"article-title":"Synaptic energy use and supply","journal-title":"Neuron","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.cmet.2011.08.016","key":"10.1016/j.biopsych.2026.01.004_bib56","year":"2011","issue":null,"author":"Bélanger","volume":"14","first-page":"724","unstructured":null,"article-title":"Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation","journal-title":"Cell Metab","doi-asserted-by":"crossref"},{"DOI":"10.1111/jnc.14829","key":"10.1016/j.biopsych.2026.01.004_bib57","year":"2019","issue":null,"author":"Bordone","volume":"151","first-page":"139","unstructured":null,"article-title":"The energetic brain - A review from students to students","journal-title":"J Neurochem","doi-asserted-by":"crossref"}],"short-title":[],"update-policy":"https://doi.org/10.1016/elsevier_cm_policy","alternative-id":["S0006322326000211"],"content-domain":{"domain":["biologicalpsychiatryjournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"original-title":[],"container-title":["Biological Psychiatry"],"published-print":{"date-parts":[[2026,1]]},"reference-count":57,"published-online":null,"references-count":57,"short-container-title":["Biological Psychiatry"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1016/j.biopsych.2026.01.004","is_oa":true,"title":"Reduced ATP-to-phosphocreatine ratios in neuropsychiatric post-COVID condition: Evidence from 31P magnetic resonance spectroscopy","updated":"2026-01-17T01:14:18+00:00","published_date":"2026-01-01","best_oa_location":{"url":"https://doi.org/10.1016/j.biopsych.2026.01.004","pmh_id":null,"url_for_pdf":null,"url_for_landing_page":"https://doi.org/10.1016/j.biopsych.2026.01.004"}}},"created_at":"2026-01-15T20:51:27.064Z","updated_at":"2026-01-21T12:05:26.220Z","tags":[{"paper_doi":"10.1016/j.biopsych.2026.01.004","tag_type":"category","value":"Neurosciences","value_numeric":null},{"paper_doi":"10.1016/j.biopsych.2026.01.004","tag_type":"category","value":"Psychiatry","value_numeric":null},{"paper_doi":"10.1016/j.biopsych.2026.01.004","tag_type":"condition","value":"Myalgic Encephalomyelitis/Chronic Fatigue Syndrome","value_numeric":null},{"paper_doi":"10.1016/j.biopsych.2026.01.004","tag_type":"condition","value":"Post-COVID Condition","value_numeric":null},{"paper_doi":"10.1016/j.biopsych.2026.01.004","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1016/j.biopsych.2026.01.004","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1016/j.biopsych.2026.01.004","tag_type":"sample_size","value":"n=50","value_numeric":50},{"paper_doi":"10.1016/j.biopsych.2026.01.004","tag_type":"study_design","value":"Cross-Sectional","value_numeric":null},{"paper_doi":"10.1016/j.biopsych.2026.01.004","tag_type":"warning","value":"Correlation coefficients, effect sizes, and exact p values were not reported in the abstract.","value_numeric":null},{"paper_doi":"10.1016/j.biopsych.2026.01.004","tag_type":"warning","value":"Design could also be described as a case–control imaging comparison; classified here as cross‑sectional.","value_numeric":null},{"paper_doi":"10.1016/j.biopsych.2026.01.004","tag_type":"warning","value":"Methods details are abstract-only; imaging acquisition, preprocessing, and cognitive measures are not fully described.","value_numeric":null}],"summaries":{"what_studied":"Whole-brain 31P magnetic resonance spectroscopy compared cerebral high‑energy phosphate metabolism in 27 patients with neuropsychiatric post‑COVID condition versus 23 fully recovered controls. It examined ATP/PCr ratios across cingulate subregions and their links to cognition and intracellular pH.","key_result":"Patients showed a cluster of reduced ATP/PCr centered on the cingulate cortex, with consistent reductions in the ACC, MCC, and PCC. Lower ACC ATP/PCr correlated with poorer cognitive performance; only patients showed a negative pH–ATP/PCr relationship, and those meeting ME/CFS criteria had similar metabolic changes.","limitations":"Small sample (27 patients; 23 controls) and cross‑sectional imaging limit causal inference. pH findings were exploratory and lacked reported effect sizes."}},{"doi":"10.1007/s10508-025-03288-y","pmid":"41528652","title":"The Associations That Sociosexual Orientation and Personality Traits Have with Men’s Preferences for Different Genres of Pornography","journal_title":"Archives of Sexual Behavior","journal_issn":"0004-0002","published_at":"2026-01-13T00:00:00.000Z","url":"https://doi.org/10.1007/s10508-025-03288-y","source_score":7,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2026-01-17","doi":"10.1007/s10508-025-03288-y","days":"7","issn":"0004-0002","rank":"10","field":"Clinical Medicine","score":"7","category":"Psychology, Clinical","categories":["Psychology, Clinical"],"_categories":["Psychology, Clinical"]},"pubmed":{"doi":"10.1007/s10508-025-03288-y","title":"The Associations That Sociosexual Orientation and Personality Traits Have with Men's Preferences for Different Genres of Pornography.","journal":"Archives of sexual behavior","methods":"","results":"","abstract":"$47","keywords":["Evolutionary psychology","Personality","Pornography","Sociosexual orientation"],"pubmed_id":"41528652","conclusions":"","publication_date":"2026-01-13T00:00:00"},"crossref":{"DOI":"10.1007/s10508-025-03288-y","URL":"https://doi.org/10.1007/s10508-025-03288-y","ISSN":["0004-0002","1573-2800"],"link":[{"URL":"https://link.springer.com/content/pdf/10.1007/s10508-025-03288-y.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://link.springer.com/article/10.1007/s10508-025-03288-y","content-type":"text/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https://link.springer.com/content/pdf/10.1007/s10508-025-03288-y.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["The Associations That Sociosexual Orientation and Personality Traits Have with Men’s Preferences for Different Genres of Pornography"],"author":[{"given":"Gavin S.","family":"Vance","sequence":"first","affiliation":[]},{"given":"Virgil","family":"Zeigler-Hill","sequence":"additional","affiliation":[]},{"given":"Madeleine K.","family":"Meehan","sequence":"additional","affiliation":[]},{"given":"Todd K.","family":"Shackelford","sequence":"additional","affiliation":[]}],"issued":{"date-parts":[[2026,1,13]]},"member":"297","prefix":"10.1007","source":"Crossref","volume":null,"created":{"date-time":"2026-01-13T15:49:50Z","timestamp":1768319390000,"date-parts":[[2026,1,13]]},"indexed":{"date-time":"2026-01-13T22:25:52Z","timestamp":1768343152904,"date-parts":[[2026,1,13]]},"license":[{"URL":"https://www.springernature.com/gp/researchers/text-and-data-mining","start":{"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000,"date-parts":[[2026,1,13]]},"delay-in-days":0,"content-version":"tdm"},{"URL":"https://www.springernature.com/gp/researchers/text-and-data-mining","start":{"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000,"date-parts":[[2026,1,13]]},"delay-in-days":0,"content-version":"vor"}],"subject":[],"abstract":null,"language":"en","relation":{},"resource":{"primary":{"URL":"https://link.springer.com/10.1007/s10508-025-03288-y"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"ArticleHistory","label":"Article History"},"label":"Received","order":1,"value":"20 June 2024"},{"name":"revised","group":{"name":"ArticleHistory","label":"Article History"},"label":"Revised","order":2,"value":"12 July 2025"},{"name":"accepted","group":{"name":"ArticleHistory","label":"Article History"},"label":"Accepted","order":3,"value":"23 August 2025"},{"name":"first_online","group":{"name":"ArticleHistory","label":"Article History"},"label":"First Online","order":4,"value":"13 January 2026"},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"},"order":1},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"},"order":2,"value":"The authors declare that they have no conflict of interest."}],"deposited":{"date-time":"2026-01-13T15:49:53Z","timestamp":1768319393000,"date-parts":[[2026,1,13]]},"issn-type":[{"type":"print","value":"0004-0002"},{"type":"electronic","value":"1573-2800"}],"published":{"date-parts":[[2026,1,13]]},"publisher":"Springer Science and Business Media LLC","reference":[{"DOI":"10.1177/00936502241287834","key":"3288_CR1","year":"2024","issue":null,"author":"M Akbari","volume":null,"first-page":null,"unstructured":"Akbari, M., Jamshidi, S., Hosseini, Z. S., Sheikhi, S., Asadi Asadabad, R., Zamani, M., & Wright, P. J. (2024). Personality, attachment, and pornography: A meta-analysis. Communication Research. https://doi.org/10.1177/00936502241287834","article-title":null,"journal-title":"Communication Research","doi-asserted-by":"publisher"},{"DOI":"10.1080/00224490801987481","key":"3288_CR2","year":"2008","issue":"2","author":"JM Albright","volume":"45","first-page":"175","unstructured":"Albright, J. M. (2008). Sex in America online: An exploration of sex, marital status, and sexual identity in internet sex seeking and its impacts. Journal of Sex Research, 45(2), 175–186. https://doi.org/10.1080/00224490801987481","article-title":null,"journal-title":"Journal of Sex Research","doi-asserted-by":"publisher"},{"DOI":"10.1080/00223890902935878","key":"3288_CR3","year":"2009","issue":null,"author":"MC Ashton","volume":"91","first-page":"340","unstructured":"Ashton, M. C., & Lee, K. (2009). The HEXACO-60: A short measure of the major dimensions of personality. Journal of Personality Assessment, 91, 340–345.","article-title":null,"journal-title":"Journal of Personality Assessment","doi-asserted-by":"publisher"},{"DOI":"10.1080/19317611.2011.611220","key":"3288_CR4","year":"2011","issue":"4","author":"V Baćak a","volume":"23","first-page":"248","unstructured":"Baćaka, V., & Štulhofer, A. (2011). Masturbation among sexually active young women in Croatia: Associations with religiosity and pornography use. International Journal of Sexual Health, 23(4), 248–257. https://doi.org/10.1080/19317611.2011.611220","article-title":null,"journal-title":"International Journal of Sexual Health","doi-asserted-by":"publisher"},{"DOI":"10.1007/s13178-022-00720-z","key":"3288_CR5","year":"2023","issue":"2","author":"R Ballester-Arnal","volume":"20","first-page":"766","unstructured":"Ballester-Arnal, R., García-Barba, M., Castro-Calvo, J., Giménez-García, C., & Gil-Llario, M. D. (2023). Pornography consumption in people of different age groups: An analysis based on gender, contents, and consequences. Sexuality Research & Social Policy, 20(2), 766–779. https://doi.org/10.1007/s13178-022-00720-z","article-title":null,"journal-title":"Sexuality Research & Social Policy","doi-asserted-by":"publisher"},{"DOI":"10.1177/1474704915618411","key":"3288_CR6","year":"2015","issue":"4","author":"N Barbaro","volume":"13","first-page":"1","unstructured":"Barbaro, N., Pham, M. N., & Shackelford, T. K. (2015). Sperm competition risk and sexual coercion predict copulatory duration in humans. Evolutionary Psychology, 13(4), 1–8. https://doi.org/10.1177/1474704915618411","article-title":null,"journal-title":"Evolutionary Psychology","doi-asserted-by":"publisher"},{"DOI":"10.1093/jsxmed/qdae101","key":"3288_CR7","year":"2024","issue":"10","author":"S Bocci Benucci","volume":"21","first-page":"922","unstructured":"Bocci Benucci, S., Di Gesto, C., Ghinassi, S., Casale, S., & Fioravanti, G. (2024). Pornography use, problematic pornography use, impulsivity, and sensation seeking: A meta-analysis. Journal of Sexual Medicine, 21(10), 922–939. https://doi.org/10.1093/jsxmed/qdae101","article-title":null,"journal-title":"The Journal of Sexual Medicine","doi-asserted-by":"publisher"},{"DOI":"10.1023/A:1026416723291","key":"3288_CR8","year":"2001","issue":"1","author":"AF Bogaert","volume":"30","first-page":"29","unstructured":"Bogaert, A. F. (2001). Personality, individual differences, and preferences for the sexual media. Archives of Sexual Behavior, 30(1), 29–53. https://doi.org/10.1023/A:1026416723291","article-title":null,"journal-title":"Archives of Sexual Behavior","doi-asserted-by":"publisher"},{"DOI":"10.1037/adb0000603","key":"3288_CR9","year":"2021","issue":"2","author":"B Bőthe","volume":"35","first-page":"172","unstructured":"Bőthe, B., Tóth-Király, I., Bella, N., Potenza, M. N., Demetrovics, Z., & Orosz, G. (2021). Why do people watch pornography? The motivational basis of pornography use. Psychology of Addictive Behaviors, 35(2), 172–186. https://doi.org/10.1037/adb0000603","article-title":null,"journal-title":"Psychology of Addictive Behaviors","doi-asserted-by":"publisher"},{"DOI":"10.1080/00224499.2021.1893261","key":"3288_CR11","year":"2022","issue":"4","author":"B Bőthe","volume":"59","first-page":"457","unstructured":"Bőthe, B., Vaillancourt-Morel, M. P., & Bergeron, S. (2022). Associations between pornography use frequency, pornography use motivations, and sexual wellbeing in couples. Journal of Sex Research, 59(4), 457–471. https://doi.org/10.1080/00224499.2021.1893261","article-title":null,"journal-title":"The Journal of Sex Research","doi-asserted-by":"publisher"},{"DOI":"10.1037/ebs0000307","key":"3288_CR12","year":"2024","issue":"1","author":"KJ Brazil","volume":"18","first-page":"11","unstructured":"Brazil, K. J. (2024). HEXACO personality and mating in young adults: Links to sociosexual dimensions and sexual debut. Evolutionary Behavioral Sciences, 18(1), 11–25. https://doi.org/10.1037/ebs0000307","article-title":null,"journal-title":"Evolutionary Behavioral Sciences","doi-asserted-by":"publisher"},{"DOI":"10.1037/ebs0000165","key":"3288_CR13","year":"2019","issue":"4","author":"RL Burch","volume":"13","first-page":"376","unstructured":"Burch, R. L., & Gallup, G. G., Jr. (2019). The other man: Knowledge of sexual rivals and changes in sexual behavior. Evolutionary Behavioral Sciences, 13(4), 376–386. https://doi.org/10.1037/ebs0000165","article-title":null,"journal-title":"Evolutionary Behavioral Sciences","doi-asserted-by":"publisher"},{"DOI":"10.1177/14747049211028798","key":"3288_CR14","year":"2021","issue":"2","author":"V Burtăverde","volume":"19","first-page":"1","unstructured":"Burtăverde, V., Jonason, P. K., Giosan, C., & Ene, C. (2021). Why do people watch porn? An evolutionary perspective on the reasons for pornography consumption. Evolutionary Psychology, 19(2), 1–15. https://doi.org/10.1177/14747049211028798","article-title":null,"journal-title":"Evolutionary Psychology","doi-asserted-by":"publisher"},{"DOI":"10.1007/BF02908761","key":"3288_CR15","year":"2005","issue":"1","author":"T Buzzell","volume":"9","first-page":"28","unstructured":"Buzzell, T. (2005). Demographic characteristics of persons using pornography in three technological contexts. Sexuality & Culture, 9(1), 28–48. https://doi.org/10.1007/BF02908761","article-title":null,"journal-title":"Sexuality & Culture","doi-asserted-by":"publisher"},{"DOI":"10.1177/0743558407306348","key":"3288_CR16","year":"2008","issue":"1","author":"JS Carroll","volume":"23","first-page":"6","unstructured":"Carroll, J. S., Padilla-Walker, L. M., Nelson, L. J., Olson, C. D., McNamara B. C., & Madsen, S. D. (2008). Generation XXX: Pornography acceptance and use among emerging adults. Journal of Adolescent Research, 23(1), 6–30. https://doi.org/10.1177/0743558407306348","article-title":null,"journal-title":"Journal of Adolescent Research","doi-asserted-by":"publisher"},{"DOI":"10.1080/0092623X.2014.958790","key":"3288_CR17","year":"2015","issue":"6","author":"A Carvalheira","volume":"41","first-page":"626","unstructured":"Carvalheira, A., Træen, B., & Štulhofer, A. (2015). Masturbation and pornography use among coupled heterosexual men with decreased sexual desire: How many roles of masturbation? Journal of Sex & Marital Therapy, 41(6), 626–635. https://doi.org/10.1080/0092623X.2014.958790","article-title":null,"journal-title":"Journal of Sex & Marital Therapy","doi-asserted-by":"publisher"},{"DOI":"10.1038/ijir.2012.47","key":"3288_CR18","year":"2013","issue":"4","author":"WS Chung","volume":"25","first-page":"138","unstructured":"Chung, W. S., Lim, S. M., Yoo, J. H., & Yoon, H. (2013). Gender difference in brain activation to audio-visual sexual stimulation; Do women and men experience the same level of arousal in response to the same video clip? International Journal of Impotence Research, 25(4), 138–142. https://doi.org/10.1038/ijir.2012.47","article-title":null,"journal-title":"International Journal of Impotence Research","doi-asserted-by":"publisher"},{"DOI":null,"key":"3288_CR77","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"Cohen, J. (1988). Statistical power analysis for the behavioral sciences (2nd ed.). Erlbaum.","article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.1016/j.jesp.2015.07.006","key":"3288_CR19","year":"2016","issue":null,"author":"PG Curran","volume":"66","first-page":"4","unstructured":"Curran, P. G. (2016). Methods for the detection of carelessly invalid responses in survey data. Journal of Experimental Social Psychology, 66, 4–19.","article-title":null,"journal-title":"Journal of Experimental Social Psychology","doi-asserted-by":"publisher"},{"DOI":null,"key":"3288_CR21","year":"2017","issue":null,"author":"RB Darlington","volume":null,"first-page":null,"unstructured":"Darlington, R. B., & Hayes, A. F. (2017). Regression analysis and linear models: Concepts, applications, and implementation. The Guilford Press.","article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.1007/s12119-017-9452-8","key":"3288_CR23","year":"2018","issue":"1","author":"TM Emmers-Sommer","volume":"22","first-page":"48","unstructured":"Emmers-Sommer, T. M. (2018). Reasons for pornography consumption: Associations with gender, psychological and physical sexual satisfaction, and attitudinal impacts. Sexuality & Culture, 22(1), 48–62. https://doi.org/10.1007/s12119-017-9452-8","article-title":null,"journal-title":"Sexuality & Culture","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.sbspro.2014.04.408","key":"3288_CR24","year":"2014","issue":null,"author":"K Franczyk","volume":"140","first-page":"192","unstructured":"Franczyk, K., Cielecka, E., & Tuszyńska-Bogucka, W. (2014). Porn on desktop. Procedia-Social and Behavioral Sciences, 140, 192–196. https://doi.org/10.1016/j.sbspro.2014.04.408","article-title":null,"journal-title":"Procedia-Social and Behavioral Sciences","doi-asserted-by":"publisher"},{"DOI":null,"key":"3288_CR25","year":"2017","issue":"3","author":"R Gerymski","volume":"15","first-page":"10","unstructured":"Gerymski, R. (2017). Are personality traits a good predictors of the type of watched pornography? Analysis of the relationship between personality traits and the preference of a chosen pornographic categories. Przegląd Seksuologiczny, 15(3), 10–16.","article-title":null,"journal-title":"Przegląd Seksuologiczny","doi-asserted-by":null},{"DOI":"10.1007/s12110-006-1009-8","key":"3288_CR26","year":"2006","issue":"3","author":"AT Goetz","volume":"17","first-page":"265","unstructured":"Goetz, A. T., & Shackelford, T. K. (2006). Sexual coercion and forced in-pair copulation as sperm competition tactics in humans. Human Nature, 17(3), 265–282. https://doi.org/10.1007/s12110-006-1009-8","article-title":null,"journal-title":"Human Nature","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.jrp.2023.104419","key":"3288_CR27","year":"2023","issue":null,"author":"JB Grubbs","volume":"107","first-page":"104419","unstructured":"Grubbs, J. B., Tahk, R., Fernandez, D. P., Fernandez, E. F., & Ley, D. (2023). Pornography and pride: Antagonism drives links between narcissism and perceived addiction to pornography. Journal of Research in Personality, 107, 104419. https://doi.org/10.1016/j.jrp.2023.104419","article-title":null,"journal-title":"Journal of Research in Personality","doi-asserted-by":"publisher"},{"DOI":"10.1111/add.14007","key":"3288_CR28","year":"2018","issue":"3","author":"JB Grubbs","volume":"113","first-page":"496","unstructured":"Grubbs, J. B., Wilt, J. A., Exline, J. J., Pargament, K. I., & Kraus, S. W. (2018). Moral disapproval and perceived addiction to internet pornography: A longitudinal examination. Addiction, 113(3), 496–506. https://doi.org/10.1111/add.14007","article-title":null,"journal-title":"Addiction","doi-asserted-by":"publisher"},{"DOI":"10.1007/s10508-006-9064-0","key":"3288_CR29","year":"2006","issue":"5","author":"GM Hald","volume":"35","first-page":"577","unstructured":"Hald, G. M. (2006). Gender differences in pornography consumption among young heterosexual Danish adults. Archives of Sexual Behavior, 35(5), 577–585. https://doi.org/10.1007/s10508-006-9064-0","article-title":null,"journal-title":"Archives of Sexual Behavior","doi-asserted-by":"publisher"},{"DOI":"10.1080/00224499.2015.1065953","key":"3288_CR30","year":"2016","issue":"7","author":"GM Hald","volume":"53","first-page":"849","unstructured":"Hald, G. M., & Štulhofer, A. (2016). What types of pornography do people use and do they cluster? Assessing types and categories of pornography consumption in a large-scale online sample. Journal of Sex Research, 53(7), 849–859. https://doi.org/10.1080/00224499.2015.1065953","article-title":null,"journal-title":"The Journal of Sex Research","doi-asserted-by":"publisher"},{"DOI":"10.1007/s10869-011-9231-8","key":"3288_CR32","year":"2012","issue":"1","author":"JL Huang","volume":"27","first-page":"99","unstructured":"Huang, J. L., Curran, P. G., Keeney, J., Poposki, E. M., & DeShon, R. P. (2012). Detecting and deterring insufficient effort responding to surveys. Journal of Business and Psychology, 27(1), 99–114.","article-title":null,"journal-title":"Journal of Business and Psychology","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.evolhumbehav.2012.01.001","key":"3288_CR33","year":"2012","issue":"5","author":"LEO Kennair","volume":"33","first-page":"479","unstructured":"Kennair, L. E. O., & Bendixen, M. (2012). Sociosexuality as predictor of sexual harassment and coercion in female and male high school students. Evolution and Human Behavior, 33(5), 479–490. https://doi.org/10.1016/j.evolhumbehav.2012.01.001","article-title":null,"journal-title":"Evolution and Human Behavior","doi-asserted-by":"publisher"},{"DOI":"10.1080/00224499.2015.1023427","key":"3288_CR34","year":"2016","issue":"1","author":"T Kohut","volume":"53","first-page":"1","unstructured":"Kohut, T., Baer, J. L., & Watts, B. (2016). Is pornography really about “making hate to women”? Pornography users hold more gender egalitarian attitudes than nonusers in a representative American sample. Journal of Sex Research, 53(1), 1–11. https://doi.org/10.1080/00224499.2015.1023427","article-title":null,"journal-title":"The Journal of Sex Research","doi-asserted-by":"publisher"},{"DOI":"10.1007/s10508-016-0783-6","key":"3288_CR36","year":"2017","issue":"2","author":"T Kohut","volume":"46","first-page":"585","unstructured":"Kohut, T., Fisher, W. A., & Campbell, L. (2017). Perceived effects of pornography on the couple relationship: Initial findings of open-ended, participant-informed, “bottom-up” research. Archives of Sexual Behavior, 46(2), 585–602. https://doi.org/10.1007/s10508-016-0783-6","article-title":null,"journal-title":"Archives of Sexual Behavior","doi-asserted-by":"publisher"},{"DOI":"10.1080/00224499.2024.2359641","key":"3288_CR37","year":"2025","issue":"6","author":"M Koós","volume":"62","first-page":"1049","unstructured":"Koós, M., Nagy, L., Kraus, S. W., Demetrovics, Z., Potenza, M. N., Gaudet, É., Ballester-Arnal, R., Batthyány, D., Bergeron, S., Billieux, J., Briken, P., Burkauskas, J., Cárdenas-López, G., Carvalho, J., Castro-Calvo, J., Chang, Y.-H., Chen, L., Ciocca, G., Corazza, O., … Bőthe, B. (2025). Why do people watch pornography? Cross-cultural validation of the Pornography Use Motivations Scale (PUMS) and its short form (PUMS-8). Journal of Sex Research, 62(6), 1049–1065. https://doi.org/10.1080/00224499.2024.2359641","article-title":null,"journal-title":"The Journal of Sex Research","doi-asserted-by":"publisher"},{"DOI":"10.1016/S0169-7439(99)00047-7","key":"3288_CR42","year":"2000","issue":"1","author":"R Maesschalck","volume":"50","first-page":"1","unstructured":"Maesschalck, R., Jouan-Rimbaud, D., & Massart, D. L. (2000). The Mahalanobis distance. Chemometrics and Intelligent Laboratory Systems, 50(1), 1–18.","article-title":null,"journal-title":"Chemometrics and Intelligent Laboratory Systems","doi-asserted-by":"publisher"},{"DOI":"10.1177/009365088015006005","key":"3288_CR43","year":"1988","issue":"6","author":"NM Malamuth","volume":"15","first-page":"753","unstructured":"Malamuth, N. M., & McIlwraith, R. D. (1988). Fantasies and exposure to sexually explicit magazines. Communication Research, 15(6), 753–771. https://doi.org/10.1177/009365088015006005","article-title":null,"journal-title":"Communication Research","doi-asserted-by":"publisher"},{"DOI":"10.1300/J514v19n01_05","key":"3288_CR45","year":"2007","issue":"1","author":"A McKee","volume":"19","first-page":"31","unstructured":"McKee, A. (2007). The relationship between attitudes towards women, consumption of pornography, and other demographic variables in a survey of 1,023 consumers of pornography. International Journal of Sexual Health, 19(1), 31–45. https://doi.org/10.1300/J514v19n01_05","article-title":null,"journal-title":"International Journal of Sexual Health","doi-asserted-by":"publisher"},{"DOI":"10.1093/beheco/art031","key":"3288_CR46","year":"2013","issue":"4","author":"WF McKibbin","volume":"24","first-page":"819","unstructured":"McKibbin, W. F., Pham, M. N., & Shackelford, T. K. (2013). Human sperm competition in postindustrial ecologies: Sperm competition cues predict adult DVD sales. Behavioral Ecology, 24(4), 819–823. https://doi.org/10.1093/beheco/art031","article-title":null,"journal-title":"Behavioral Ecology","doi-asserted-by":"publisher"},{"DOI":"10.1037/a0028085","key":"3288_CR47","year":"2012","issue":"3","author":"AW Meade","volume":"17","first-page":"437","unstructured":"Meade, A. W., & Craig, S. B. (2012). Identifying careless responses in survey data. Psychological Methods, 17(3), 437–457.","article-title":null,"journal-title":"Psychological Methods","doi-asserted-by":"publisher"},{"DOI":"10.1111/pere.12267","key":"3288_CR48","year":"2019","issue":"1","author":"DJ Miller","volume":"26","first-page":"93","unstructured":"Miller, D. J., McBain, K. A., Li, W. W., & Raggatt, P. T. (2019). Pornography, preference for porn-like sex, masturbation, and men’s sexual and relationship satisfaction. Personal Relationships, 26(1), 93–113. https://doi.org/10.1111/pere.12267","article-title":null,"journal-title":"Personal Relationships","doi-asserted-by":"publisher"},{"DOI":"10.1037/a0019127","key":"3288_CR50","year":"2010","issue":"3","author":"LJ Nelson","volume":"2","first-page":"136","unstructured":"Nelson, L. J., Padilla-Walker, L. M., & Carroll, J. S. (2010). “I believe it is wrong but I still do it”: A comparison of religious young men who do versus do not use pornography. Psychology of Religion and Spirituality, 2(3), 136–147.","article-title":null,"journal-title":"Psychology of Religion and Spirituality","doi-asserted-by":"publisher"},{"DOI":"10.1037/0022-3514.95.5.1113","key":"3288_CR52","year":"2008","issue":null,"author":"L Penke","volume":"95","first-page":"1113","unstructured":"Penke, L., & Asendorpf, J. B. (2008). Beyond global sociosexual orientations: A more differentiated look at sociosexuality and its effects on courtship and romantic relationships. Journal of Personality and Social Psychology, 95, 1113–1135.","article-title":null,"journal-title":"Journal of Personality and Social Psychology","doi-asserted-by":"publisher"},{"DOI":"10.1007/s10508-020-01793-w","key":"3288_CR53","year":"2020","issue":"8","author":"SL Perry","volume":"49","first-page":"3013","unstructured":"Perry, S. L. (2020). Does low-cost sexual gratification make men less eager to marry? Pornography use, masturbation, hookup sex, and desire to be married among single men. Archives of Sexual Behavior, 49(8), 3013–3026. https://doi.org/10.1007/s10508-020-01793-w","article-title":null,"journal-title":"Archives of Sexual Behavior","doi-asserted-by":"publisher"},{"DOI":"10.1080/00224499.2017.1317709","key":"3288_CR54","year":"2018","issue":"3","author":"SL Perry","volume":"55","first-page":"284","unstructured":"Perry, S. L., & Schleifer, C. (2018). Till porn do us part? A longitudinal examination of pornography use and divorce. Journal of Sex Research, 55(3), 284–296. https://doi.org/10.1080/00224499.2017.1317709","article-title":null,"journal-title":"The Journal of Sex Research","doi-asserted-by":"publisher"},{"DOI":"10.1080/00224499.2017.1423017","key":"3288_CR55","year":"2019","issue":"1","author":"SL Perry","volume":"56","first-page":"50","unstructured":"Perry, S. L., & Whitehead, A. L. (2019). Only bad for believers? Religion, pornography use, and sexual satisfaction among American men. Journal of Sex Research, 56(1), 50–61. https://doi.org/10.1080/00224499.2017.1423017","article-title":null,"journal-title":"The Journal of Sex Research","doi-asserted-by":"publisher"},{"DOI":"10.1007/s12110-013-9181-0","key":"3288_CR56","year":"2013","issue":"4","author":"MN Pham","volume":"24","first-page":"476","unstructured":"Pham, M. N., & Shackelford, T. K. (2013). The relationship between objective sperm competition risk and men’s copulatory interest is moderated by partner’s time spent with other men. Human Nature, 24(4), 476–485. https://doi.org/10.1007/s12110-013-9181-0","article-title":null,"journal-title":"Human Nature","doi-asserted-by":"publisher"},{"DOI":"10.4018/IJT.2017010103","key":"3288_CR57","year":"2017","issue":"1","author":"A Pina","volume":"8","first-page":"30","unstructured":"Pina, A., Holland, J., & James, M. (2017). The malevolent side of revenge porn proclivity: Dark personality traits and sexist ideology. International Journal of Technoethics, 8(1), 30–43. https://doi.org/10.4018/IJT.2017010103","article-title":null,"journal-title":"International Journal of Technoethics","doi-asserted-by":"publisher"},{"DOI":null,"key":"3288_CR58","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"Pornhub 2018 Year in Review. (2018). Pornhub insights. Retrieved from https://www.pornhub.com/insights/2018-year-in-review.","article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":null,"key":"3288_CR59","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"Pornhub 2024 Year in Review. (2024). Pornhub insights. Retrieved from https://www.pornhub.com/insights/2024-year-in-review.","article-title":null,"journal-title":null,"doi-asserted-by":null},{"DOI":"10.1002/ab.21505","key":"3288_CR61","year":"2014","issue":"1","author":"CA Robertson","volume":"40","first-page":"12","unstructured":"Robertson, C. A., & Knight, R. A. (2014). Relating sexual sadism and psychopathy to one another, non-sexual violence, and sexual crime behaviors. Aggressive Behavior, 40(1), 12–23. https://doi.org/10.1002/ab.21505","article-title":null,"journal-title":"Aggressive Behavior","doi-asserted-by":"publisher"},{"DOI":"10.1089/cpb.2007.0179","key":"3288_CR62","year":"2008","issue":"6","author":"C Sabina","volume":"11","first-page":"691","unstructured":"Sabina, C., Wolak, J., & Finkelhor, D. (2008). The nature and dynamics of internet pornography exposure for youth. Cyberpsychology & Behavior, 11(6), 691–693. https://doi.org/10.1089/cpb.2007.0179","article-title":null,"journal-title":"Cyberpsychology & Behavior","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.paid.2019.05.030","key":"3288_CR63","year":"2019","issue":null,"author":"C Salmon","volume":"148","first-page":"45","unstructured":"Salmon, C., Fisher, M. L., & Burch, R. L. (2019). Evolutionary approaches: Integrating pornography preferences, short-term mating, and infidelity. Personality and Individual Differences, 148, 45–49. https://doi.org/10.1016/j.paid.2019.05.030","article-title":null,"journal-title":"Personality and Individual Differences","doi-asserted-by":"publisher"},{"DOI":"10.3389/fpsyg.2012.00111","key":"3288_CR78","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":"Selya, A. S., Rose, J. S., Dierker, L. C., Hedeker, D., & Mermelstein, R. J. (2012). A practical guide to calculating Cohen’sf 2, a measure of local effect size, from PROC MIXED. Frontiers in Psychology, 3, 111. https://doi.org/10.3389/fpsyg.2012.00111","article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1037/0735-7036.121.2.214","key":"3288_CR64","year":"2007","issue":"2","author":"TK Shackelford","volume":"121","first-page":"214","unstructured":"Shackelford, T. K., Goetz, A. T., McKibbin, W. F., & Starratt, V. G. (2007). Absence makes the adaptations grow fonder: Proportion of time apart from partner, male sexual psychology, and sperm competition in humans (Homo sapiens). Journal of Comparative Psychology, 121(2), 214–220. https://doi.org/10.1037/0735-7036.121.2.214","article-title":null,"journal-title":"Journal of Comparative Psychology","doi-asserted-by":"publisher"},{"DOI":"10.1016/S1090-5138(01)00090-3","key":"3288_CR65","year":"2002","issue":"2","author":"TK Shackelford","volume":"23","first-page":"123","unstructured":"Shackelford, T. K., LeBlanc, G. J., Weekes-Shackelford, V. A., Bleske-Rechek, A. L., Euler, H. A., & Hoier, S. (2002). Psychological adaptation to human sperm competition. Evolution and Human Behavior, 23(2), 123–138. https://doi.org/10.1016/S1090-5138(01)00090-3","article-title":null,"journal-title":"Evolution and Human Behavior","doi-asserted-by":"publisher"},{"DOI":"10.1530/REP-12-0285","key":"3288_CR66","year":"2012","issue":"5","author":"LW Simmons","volume":"144","first-page":"519","unstructured":"Simmons, L. W., & Fitzpatrick, J. L. (2012). Sperm wars and the evolution of male fertility. Reproduction, 144(5), 519–534. https://doi.org/10.1530/REP-12-0285","article-title":null,"journal-title":"Reproduction","doi-asserted-by":"publisher"},{"DOI":"10.1080/00224499.2012.681403","key":"3288_CR67","year":"2013","issue":"7","author":"M Sinković","volume":"50","first-page":"633","unstructured":"Sinković, M., Štulhofer, A., & Božić, J. (2013). Revisiting the association between pornography use and risky sexual behaviors: The role of early exposure to pornography and sexual sensation seeking. Journal of Sex Research, 50(7), 633–641. https://doi.org/10.1080/00224499.2012.681403","article-title":null,"journal-title":"Journal of Sex Research","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.paid.2016.03.047","key":"3288_CR68","year":"2017","issue":null,"author":"PH Strouts","volume":"115","first-page":"128","unstructured":"Strouts, P. H., Brase, G. L., & Dillon, H. M. (2017). Personality and evolutionary strategies: The relationships between HEXACO traits, mate value, life history strategy, and sociosexuality. Personality and Individual Differences, 115, 128–132. https://doi.org/10.1016/j.paid.2016.03.047","article-title":null,"journal-title":"Personality and Individual Differences","doi-asserted-by":"publisher"},{"DOI":"10.1186/1471-2148-11-12","key":"3288_CR69","year":"2011","issue":"1","author":"M Tourmente","volume":"11","first-page":"1","unstructured":"Tourmente, M., Gomendio, M., & Roldan, E. R. S. (2011). Sperm competition and the evolution of sperm design in mammals. BMC Evolutionary Biology, 11(1). https://doi.org/10.1186/1471-2148-11-12","article-title":null,"journal-title":"BMC Evolutionary Biology","doi-asserted-by":"publisher"},{"DOI":"10.1007/s10508-022-02300-z","key":"3288_CR70","year":"2022","issue":"6","author":"G Vance","volume":"51","first-page":"2781","unstructured":"Vance, G., Zeigler-Hill, V., & Shackelford, T. K. (2022). Erectile dysfunction and sexual coercion: The role of sperm competition risk. Archives of Sexual Behavior, 51(6), 2781–2790. https://doi.org/10.1007/s10508-022-02300-z","article-title":null,"journal-title":"Archives of Sexual Behavior","doi-asserted-by":"publisher"},{"DOI":null,"key":"3288_CR71","year":"2004","issue":"154","author":"RS Weisskirch","volume":"39","first-page":"189","unstructured":"Weisskirch, R. S., & Murphy, L. C. (2004). Friends, porn, and punk: Sensation seeking in personal relationships, internet activities, and music preference among college students. Adolescence, 39(154), 189–201.","article-title":null,"journal-title":"Adolescence","doi-asserted-by":null},{"DOI":"10.1007/BF01542157","key":"3288_CR72","year":"1980","issue":"6","author":"JP Wincze","volume":"9","first-page":"533","unstructured":"Wincze, J. P., Venditti, E., Barlow, D., & Mavissakalian, M. (1980). The effects of a subjective monitoring task in the physiological measure of genital response to erotic stimulation. Archives of Sexual Behavior, 9(6), 533–545. https://doi.org/10.1007/BF01542157","article-title":null,"journal-title":"Archives of Sexual Behavior","doi-asserted-by":"publisher"},{"DOI":"10.3390/sexes2020017","key":"3288_CR74","year":"2021","issue":"2","author":"V Zeigler-Hill","volume":"2","first-page":"189","unstructured":"Zeigler-Hill, V., & Andrews, D. (2021). Narcissism and subjective arousal in response to sexual aggression: The mediating role of perceived power. Sexes, 2(2), 189–201. https://doi.org/10.3390/sexes2020017","article-title":null,"journal-title":"Sexes","doi-asserted-by":"publisher"},{"DOI":"10.1016/j.chb.2014.03.062","key":"3288_CR76","year":"2014","issue":null,"author":"L Zheng","volume":"36","first-page":"323","unstructured":"Zheng, L., & Zheng, Y. (2014). Online sexual activity in mainland China: Relationship to sexual sensation seeking and sociosexuality. Computers in Human Behavior, 36, 323–329. https://doi.org/10.1016/j.chb.2014.03.062","article-title":null,"journal-title":"Computers in Human Behavior","doi-asserted-by":"publisher"}],"short-title":[],"update-policy":"https://doi.org/10.1007/springer_crossmark_policy","alternative-id":["3288"],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"original-title":[],"container-title":["Archives of Sexual Behavior"],"reference-count":63,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2026,1,13]]},"references-count":63,"short-container-title":["Arch Sex Behav"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1007/s10508-025-03288-y","is_oa":false,"title":"The Associations That Sociosexual Orientation and Personality Traits Have with Men’s Preferences for Different Genres of Pornography","updated":"2026-01-15T02:17:35+00:00","published_date":"2026-01-13","best_oa_location":null}},"created_at":"2026-01-21T12:05:26.220Z","updated_at":"2026-01-21T12:05:26.220Z","tags":[{"paper_doi":"10.1007/s10508-025-03288-y","tag_type":"category","value":"Psychology, Clinical","value_numeric":null},{"paper_doi":"10.1007/s10508-025-03288-y","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1007/s10508-025-03288-y","tag_type":"sex","value":"male","value_numeric":null},{"paper_doi":"10.1007/s10508-025-03288-y","tag_type":"study_design","value":"Cross-Sectional","value_numeric":null},{"paper_doi":"10.1007/s10508-025-03288-y","tag_type":"warning","value":"Design classification is inferred from the abstract summarizing three separate survey studies.","value_numeric":null},{"paper_doi":"10.1007/s10508-025-03288-y","tag_type":"warning","value":"Genre definitions (e.g., “female-specific,” “paraphilic”) are based on thumbnails or brief descriptions and may vary across studies.","value_numeric":null},{"paper_doi":"10.1007/s10508-025-03288-y","tag_type":"warning","value":"Only the abstract was available; no numeric effect sizes or coefficients were reported.","value_numeric":null}],"summaries":{"what_studied":"Across three survey studies of men (n=126, n=166, n=169), researchers measured self-reported frequency or interest in four pornography genres and tested associations with sociosexual orientation and personality traits using correlations and regression.","key_result":"Sociosexual orientation and personality were correlated with men’s use of different genres; in regression models, these traits uniquely predicted use of group sex pornography (cues to high sperm competition), as well as female-specific and paraphilic pornography."}},{"doi":"10.1111/jocd.70670","pmid":"41521763","title":"Rising Public Interest in Weight Loss Medications and Growing Awareness of Their Aesthetic Sequelae: An Infodemiologic Google Trends Analysis and Clinical Diagnostic Patterning","journal_title":"Journal of Cosmetic Dermatology","journal_issn":"1473-2130","published_at":"2026-01-12T00:00:00.000Z","url":"https://doi.org/10.1111/jocd.70670","source_score":11,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-01-15","doi":"10.1111/jocd.70670","days":"7","issn":"1473-2130","rank":"8","field":"Clinical Medicine","score":"11","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1111/jocd.70670","title":"Rising Public Interest in Weight Loss Medications and Growing Awareness of Their Aesthetic Sequelae: An Infodemiologic Google Trends Analysis and Clinical Diagnostic Patterning.","journal":"Journal of cosmetic dermatology","methods":"","results":"RSV for \"Ozempic\" showed a steady upward trajectory over the study period. Queries related to facial aesthetic consequences exhibited substantial proportional increases. Notably, \"Ozempic face\" demonstrated a 4600% rise in RSV, and searches for \"plastic surgeons Ozempic face\" similarly grew markedly.","abstract":"$48","keywords":["Google trends","Ozempic face","biostimulators","glucagon‐like peptide‐1 receptor agonists","public interest"],"pubmed_id":"41521763","conclusions":"","publication_date":"2026-01-12T00:00:00"},"crossref":{"DOI":"10.1111/jocd.70670","URL":"https://doi.org/10.1111/jocd.70670","ISSN":["1473-2130","1473-2165"],"link":[{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/jocd.70670","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jocd.70670","content-type":"application/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/jocd.70670","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":"1","score":1,"title":["Rising Public Interest in Weight Loss Medications and Growing Awareness of Their Aesthetic Sequelae: An Infodemiologic Google Trends Analysis and Clinical Diagnostic Patterning"],"author":[{"given":"Alec D.","family":"McCarthy","sequence":"first","affiliation":[{"name":"Global Medical Affairs Merz Aesthetics Raleigh North Carolina USA"}]},{"given":"Kay","family":"Durairaj","sequence":"additional","affiliation":[{"name":"K. Kay Durairaj, M.D., A Medical Corp Pasadena California USA"}]},{"given":"Jacob","family":"Linneman‐Heath","sequence":"additional","affiliation":[{"name":"Global Medical Affairs Merz Aesthetics Raleigh North Carolina USA"},{"name":"K. Kay Durairaj, M.D., A Medical Corp Pasadena California USA"}]},{"given":"Dusan","family":"Sajic","sequence":"additional","affiliation":[{"name":"Derma Skin Institute Guelph Ontario Canada"},{"name":"McMaster University Hamilton Ontario Canada"}]},{"given":"Mara","family":"Dacso","sequence":"additional","affiliation":[{"name":"Innovative Dermatology Plano Texas USA"}]},{"given":"Alan","family":"Durkin","sequence":"additional","affiliation":[{"name":"Ocean Drive Plastic Surgery, Dermatology, and MedSpa Vero Beach Florida USA"},{"name":"Florida State University College of Medicine Tallahassee Florida USA"}]}],"issued":{"date-parts":[[2026,1]]},"member":"311","prefix":"10.1111","source":"Crossref","volume":"25","archive":["Portico"],"created":{"date-time":"2026-01-12T08:13:36Z","timestamp":1768205616000,"date-parts":[[2026,1,12]]},"indexed":{"date-time":"2026-01-12T11:09:59Z","timestamp":1768216199163,"date-parts":[[2026,1,12]]},"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","start":{"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000,"date-parts":[[2026,1,12]]},"delay-in-days":11,"content-version":"vor"},{"URL":"http://doi.wiley.com/10.1002/tdm_license_1.1","start":{"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000,"date-parts":[[2026,1,1]]},"delay-in-days":0,"content-version":"tdm"}],"subject":[],"abstract":"$49","language":"en","relation":{},"resource":{"primary":{"URL":"https://onlinelibrary.wiley.com/doi/10.1111/jocd.70670"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"publication_history","label":"Publication History"},"label":"Received","order":0,"value":"2025-06-25"},{"name":"accepted","group":{"name":"publication_history","label":"Publication History"},"label":"Accepted","order":2,"value":"2025-12-18"},{"name":"published","group":{"name":"publication_history","label":"Publication History"},"label":"Published","order":3,"value":"2026-01-12"}],"deposited":{"date-time":"2026-01-12T08:13:38Z","timestamp":1768205618000,"date-parts":[[2026,1,12]]},"issn-type":[{"type":"print","value":"1473-2130"},{"type":"electronic","value":"1473-2165"}],"published":{"date-parts":[[2026,1]]},"publisher":"Wiley","reference":[{"DOI":"10.1016/j.japh.2023.10.002","key":"e_1_2_13_2_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.jval.2024.03.2316","key":"e_1_2_13_3_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s11154‐021‐09699‐1","key":"e_1_2_13_4_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1002/der2.70003","key":"e_1_2_13_5_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/asj/sjae132","key":"e_1_2_13_6_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3389/fdata.2023.1132764","key":"e_1_2_13_7_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1016/j.envint.2018.05.016","key":"e_1_2_13_8_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/asj/sjab084","key":"e_1_2_13_9_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.7759/cureus.52011","key":"e_1_2_13_10_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1101/2024.01.18.24301500","key":"e_1_2_13_11_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1177/0145445516673998","key":"e_1_2_13_12_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.2196/47620","key":"e_1_2_13_13_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/jocd.16216","key":"e_1_2_13_14_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/asj/sjad173","key":"e_1_2_13_15_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1177/1090820X13515270","key":"e_1_2_13_16_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1080/147641704100003048","key":"e_1_2_13_17_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.2147/CCID.S72878","key":"e_1_2_13_18_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1002/ohn.1209","key":"e_1_2_13_19_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1093/asjof/ojaf088","key":"e_1_2_13_20_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1097/DSS.0000000000004659","key":"e_1_2_13_21_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/jocd.70094","key":"e_1_2_13_22_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"}],"short-title":[],"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"update-policy":"https://doi.org/10.1002/crossmark_policy","alternative-id":["10.1111/jocd.70670"],"article-number":"e70670","content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"original-title":[],"container-title":["Journal of Cosmetic Dermatology"],"published-print":{"date-parts":[[2026,1]]},"reference-count":21,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2026,1,12]]},"references-count":21,"short-container-title":["J of Cosmetic Dermatology"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1111/jocd.70670","is_oa":true,"title":"Rising Public Interest in Weight Loss Medications and Growing Awareness of Their Aesthetic Sequelae: An Infodemiologic Google Trends Analysis and Clinical Diagnostic Patterning","updated":"2026-01-16T01:10:40+00:00","published_date":"2026-01-01","best_oa_location":{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jocd.70670","pmh_id":null,"url_for_pdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jocd.70670","url_for_landing_page":"https://doi.org/10.1111/jocd.70670"}}},"created_at":"2026-01-21T12:05:26.220Z","updated_at":"2026-01-21T12:05:26.220Z","tags":[{"paper_doi":"10.1111/jocd.70670","tag_type":"brand","value":"Ozempic","value_numeric":null},{"paper_doi":"10.1111/jocd.70670","tag_type":"category","value":"Dermatology","value_numeric":null},{"paper_doi":"10.1111/jocd.70670","tag_type":"generic","value":"semaglutide","value_numeric":null},{"paper_doi":"10.1111/jocd.70670","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1111/jocd.70670","tag_type":"modality","value":"GLP-1 Receptor Agonist","value_numeric":null},{"paper_doi":"10.1111/jocd.70670","tag_type":"study_design","value":"Cross-Sectional","value_numeric":null},{"paper_doi":"10.1111/jocd.70670","tag_type":"warning","value":"Findings reflect public interest and awareness, not clinical incidence or outcomes.","value_numeric":null},{"paper_doi":"10.1111/jocd.70670","tag_type":"warning","value":"Google Trends provides relative, not absolute, search volumes.","value_numeric":null},{"paper_doi":"10.1111/jocd.70670","tag_type":"warning","value":"Study design classification is approximate for an infodemiologic time-series analysis.","value_numeric":null}],"summaries":{"what_studied":"An infodemiologic analysis of Google Trends data (Nov 2021–Dec 2024) assessed relative search volume (RSV) for “Ozempic” and co-searched terms tied to facial aesthetics, including “Ozempic face” and “plastic surgeons Ozempic face.” The aim was to track public interest in GLP-1 receptor agonists and awareness of their cosmetic facial sequelae over time.","key_result":"RSV for “Ozempic” rose steadily across the study period. “Ozempic face” showed a 4600% increase in RSV, and searches for “plastic surgeons Ozempic face” also grew markedly.","practice_takeaway":"Expect more patient inquiries about GLP-1–related facial changes; integrate counseling and corrective options into aesthetic consultations."}},{"doi":"10.1053/j.gastro.2025.10.011","pmid":"41524686","title":"Mutational Landscape of Colorectal Tumors From Individuals With Unexplained Adenomatous or Serrated Colorectal Polyposis","journal_title":"Gastroenterology","journal_issn":"0016-5085","published_at":"2026-01-12T00:00:00.000Z","url":"https://doi.org/10.1053/j.gastro.2025.10.011","source_score":103,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-01-17","doi":"10.1053/j.gastro.2025.10.011","days":"7","issn":"0016-5085","rank":"3","field":"Clinical Medicine","score":"103","category":"Gastroenterology & Hepatology","categories":["Gastroenterology & Hepatology"],"_categories":["Gastroenterology & Hepatology"]},"pubmed":{"doi":"10.1053/j.gastro.2025.10.011","title":"Mutational Landscape of Colorectal Tumors From Individuals With Unexplained Adenomatous or Serrated Colorectal Polyposis.","journal":"Gastroenterology","methods":"","results":"Somatic mutations in APC/CTNNB1 and BRAF were significantly more frequent in adenomatous and serrated polyps, respectively. APC mosaicism was identified in 19% of individuals with adenomatous polyposis. In 9% of serrated polyps, a CpG island methylator phenotypes high methylation status was detected. Almost all polyps presented with a low tumor mutational burden and the majority were microsatellite stable. In APC/CTNNB1- and BRAF-mutated polyps, we identified a significantly lower contribution of the clock-like signature SBS1 and a significantly higher contribution of the normal colon tissue signature SBS89, respectively, compared with sporadic colorectal tumors.","abstract":"$4a","keywords":["APC Mutational Mosaicism","Colorectal Polyposis","Molecular Tumor Profiling","Mutational Signatures","Solve-RD","Somatic Mutations"],"pubmed_id":"41524686","conclusions":"","publication_date":"2026-01-12T00:00:00"},"crossref":{"DOI":"10.1053/j.gastro.2025.10.011","URL":"https://doi.org/10.1053/j.gastro.2025.10.011","ISSN":["0016-5085"],"link":[{"URL":"https://api.elsevier.com/content/article/PII:S0016508525061347?httpAccept=text/xml","content-type":"text/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https://api.elsevier.com/content/article/PII:S0016508525061347?httpAccept=text/plain","content-type":"text/plain","content-version":"vor","intended-application":"text-mining"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Mutational Landscape of Colorectal Tumors From Individuals With Unexplained Adenomatous or Serrated Colorectal Polyposis"],"author":[{"given":"Anna K.","family":"Sommer","sequence":"first","affiliation":[]},{"given":"Iris B.A.W.","family":"te Paske","sequence":"additional","affiliation":[]},{"given":"Erik A.M.","family":"Jansen","sequence":"additional","affiliation":[]},{"given":"Axel","family":"Gschwind","sequence":"additional","affiliation":[]},{"given":"German","family":"Demidov","sequence":"additional","affiliation":[]},{"given":"Verena","family":"Steinke-Lange","sequence":"additional","affiliation":[]},{"given":"Isabel","family":"Spier","sequence":"additional","affiliation":[]},{"given":"Wouter","family":"Steyaert","sequence":"additional","affiliation":[]},{"given":"Burcu","family":"Yaldiz","sequence":"additional","affiliation":[]},{"given":"Marloes","family":"Steehouwer","sequence":"additional","affiliation":[]},{"given":"Oliver","family":"Hommerding","sequence":"additional","affiliation":[]},{"given":"Dimo","family":"Dietrich","sequence":"additional","affiliation":[]},{"given":"Sophia","family":"Peters","sequence":"additional","affiliation":[]},{"given":"José","family":"Garcia-Pelaez","sequence":"additional","affiliation":[]},{"given":"Andreas","family":"Laner","sequence":"additional","affiliation":[]},{"given":"Carla","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Gabriel","family":"Capellá","sequence":"additional","affiliation":[]},{"given":"Iris D.","family":"Nagtegaal","sequence":"additional","affiliation":[]},{"given":"Hendrik","family":"Bläker","sequence":"additional","affiliation":[]},{"given":"Kornelia","family":"Ellwanger","sequence":"additional","affiliation":[]},{"given":"Alexander","family":"Hoischen","sequence":"additional","affiliation":[]},{"given":"Christian","family":"Gilissen","sequence":"additional","affiliation":[]},{"given":"Rachel S.","family":"van der Post","sequence":"additional","affiliation":[]},{"given":"Glen","family":"Kristiansen","sequence":"additional","affiliation":[]},{"given":"Nicoline","family":"Hoogerbrugge","sequence":"additional","affiliation":[]},{"given":"Stephan","family":"Ossowski","sequence":"additional","affiliation":[]},{"given":"Laura","family":"Valle","sequence":"additional","affiliation":[]},{"given":"Elke","family":"Holinski-Feder","sequence":"additional","affiliation":[]},{"given":"Marjolijn J.L.","family":"Ligtenberg","sequence":"additional","affiliation":[]},{"given":"Stefan","family":"Aretz","sequence":"additional","affiliation":[]},{"given":"Richarda M.","family":"de Voer","sequence":"additional","affiliation":[]}],"funder":[{"id":[{"id":"10.13039/100011102","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/100011102","name":"Seventh Framework Programme","award":["305444"],"award-info":[{"award-number":["305444"]}],"doi-asserted-by":"publisher"},{"id":[{"id":"10.13039/100011102","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/100011102","name":"Seventh Framework Programme","award":["101155809"],"award-info":[{"award-number":["101155809"]}],"doi-asserted-by":"publisher"},{"id":[{"id":"10.13039/501100000780","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/501100000780","name":"European Commission","doi-asserted-by":"publisher"},{"id":[{"id":"10.13039/100010661","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/100010661","name":"Horizon 2020 Framework Programme","award":["779257"],"award-info":[{"award-number":["779257"]}],"doi-asserted-by":"publisher"}],"issued":{"date-parts":[[2026,1]]},"member":"78","prefix":"10.1053","source":"Crossref","volume":null,"created":{"date-time":"2026-01-12T09:16:45Z","timestamp":1768209405000,"date-parts":[[2026,1,12]]},"indexed":{"date-time":"2026-01-19T03:57:35Z","timestamp":1768795055114,"date-parts":[[2026,1,19]]},"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","start":{"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000,"date-parts":[[2026,1,1]]},"delay-in-days":0,"content-version":"tdm"},{"URL":"https://www.elsevier.com/legal/tdmrep-license","start":{"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000,"date-parts":[[2026,1,1]]},"delay-in-days":0,"content-version":"tdm"},{"URL":"http://creativecommons.org/licenses/by/4.0/","start":{"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000,"date-parts":[[2025,10,16]]},"delay-in-days":0,"content-version":"vor"}],"subject":[],"abstract":null,"language":"en","relation":{},"resource":{"primary":{"URL":"https://linkinghub.elsevier.com/retrieve/pii/S0016508525061347"}},"subtitle":[],"assertion":[{"name":"publisher","label":"This article is maintained by","value":"Elsevier"},{"name":"articletitle","label":"Article Title","value":"Mutational Landscape of Colorectal Tumors From Individuals With Unexplained Adenomatous or Serrated Colorectal Polyposis"},{"name":"journaltitle","label":"Journal Title","value":"Gastroenterology"},{"name":"articlelink","label":"CrossRef DOI link to publisher maintained version","value":"https://doi.org/10.1053/j.gastro.2025.10.011"},{"name":"content_type","label":"Content Type","value":"article"},{"name":"copyright","label":"Copyright","value":"© 2025 The Author(s). Published by Elsevier Inc. on behalf of the AGA Institute."}],"deposited":{"date-time":"2026-01-17T23:47:20Z","timestamp":1768693640000,"date-parts":[[2026,1,17]]},"issn-type":[{"type":"print","value":"0016-5085"}],"published":{"date-parts":[[2026,1]]},"publisher":"Elsevier BV","reference":[{"DOI":"10.1007/s10689-020-00170-9","key":"10.1053/j.gastro.2025.10.011_bib1","year":"2020","issue":null,"author":"Heald","volume":"19","first-page":"223","unstructured":null,"article-title":"Collaborative Group of the Americas on Inherited Gastrointestinal Cancer Position statement on multigene panel testing for patients with colorectal cancer and/or polyposis","journal-title":"Fam Cancer","doi-asserted-by":"crossref"},{"DOI":"10.1016/0016-5085(79)90164-1","key":"10.1053/j.gastro.2025.10.011_bib2","year":"1979","issue":null,"author":"Maskens","volume":"77","first-page":"1245","unstructured":null,"article-title":"Histogenesis of adenomatous polyps in the human large intestine","journal-title":"Gastroenterology","doi-asserted-by":"crossref"},{"DOI":"10.1053/j.gastro.2019.06.041","key":"10.1053/j.gastro.2025.10.011_bib3","year":"2019","issue":null,"author":"Crockett","volume":"157","first-page":"949","unstructured":null,"article-title":"Terminology, molecular features, epidemiology, and management of serrated colorectal neoplasia","journal-title":"Gastroenterology","doi-asserted-by":"crossref"},{"DOI":"10.1038/s41379-019-0280-2","key":"10.1053/j.gastro.2025.10.011_bib4","year":"2019","issue":null,"author":"Pai","volume":"32","first-page":"1390","unstructured":null,"article-title":"An update on the morphology and molecular pathology of serrated colorectal polyps and associated carcinomas","journal-title":"Mod Pathol","doi-asserted-by":"crossref"},{"DOI":"10.1016/S2468-1253(23)00240-6","key":"10.1053/j.gastro.2025.10.011_bib5","year":"2024","issue":null,"author":"Valle","volume":"9","first-page":"68","unstructured":null,"article-title":"Genetic predisposition to gastrointestinal polyposis: syndromes, tumour features, genetic testing, and clinical management","journal-title":"Lancet Gastroenterol Hepatol","doi-asserted-by":"crossref"},{"DOI":"10.1038/s41586-020-1943-3","key":"10.1053/j.gastro.2025.10.011_bib6","year":"2020","issue":null,"author":"Alexandrov","volume":"578","first-page":"94","unstructured":null,"article-title":"The repertoire of mutational signatures in human cancer","journal-title":"Nature","doi-asserted-by":"crossref"},{"DOI":"10.1093/annonc/mdq632","key":"10.1053/j.gastro.2025.10.011_bib7","year":"2011","issue":null,"author":"Bokemeyer","volume":"22","first-page":"1535","unstructured":null,"article-title":"Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study","journal-title":"Ann Oncol","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.ejca.2015.03.026","key":"10.1053/j.gastro.2025.10.011_bib8","year":"2015","issue":null,"author":"Douillard","volume":"51","first-page":"1231","unstructured":null,"article-title":"Impact of early tumour shrinkage and resection on outcomes in patients with wild-type RAS metastatic colorectal cancer","journal-title":"Eur J Cancer","doi-asserted-by":"crossref"},{"DOI":"10.1038/s41598-022-06498-9","key":"10.1053/j.gastro.2025.10.011_bib9","year":"2022","issue":null,"author":"Jungwirth","volume":"12","first-page":"2570","unstructured":null,"article-title":"Mutational analysis of driver genes defines the colorectal adenoma: in situ carcinoma transition","journal-title":"Sci Rep","doi-asserted-by":"crossref"},{"DOI":"10.1136/gutjnl-2016-313573","key":"10.1053/j.gastro.2025.10.011_bib10","year":"2018","issue":null,"author":"Lin","volume":"67","first-page":"1299","unstructured":null,"article-title":"The somatic mutation landscape of premalignant colorectal adenoma","journal-title":"Gut","doi-asserted-by":"crossref"},{"DOI":"10.3389/fonc.2021.668466","key":"10.1053/j.gastro.2025.10.011_bib11","year":"2021","issue":null,"author":"Tornillo","volume":"11","first-page":null,"unstructured":null,"article-title":"The genomic landscape of serrated lesion of the colorectum: similarities and differences with tubular and tubulovillous adenomas","journal-title":"Front Oncol","doi-asserted-by":"crossref"},{"DOI":"10.1038/s41431-021-00859-0","key":"10.1053/j.gastro.2025.10.011_bib12","year":"2021","issue":null,"author":"Zurek","volume":"29","first-page":"1325","unstructured":null,"article-title":"Solve-RD: systematic pan-European data sharing and collaborative analysis to solve rare diseases","journal-title":"Eur J Hum Genet","doi-asserted-by":"crossref"},{"DOI":"10.1038/s41591-024-03420-w","key":"10.1053/j.gastro.2025.10.011_bib13","year":"2025","issue":null,"author":"Laurie","volume":"31","first-page":"478","unstructured":null,"article-title":"Genomic reanalysis of a pan-European rare-disease resource yields new diagnoses","journal-title":"Nat Med","doi-asserted-by":"crossref"},{"DOI":null,"key":"10.1053/j.gastro.2025.10.011_bib14","year":"2022","issue":null,"author":"Laurie","volume":"43","first-page":"717","unstructured":null,"article-title":"The RD-Connect Genome-Phenome Analysis Platform: accelerating diagnosis, research, and gene discovery for rare diseases","journal-title":"Hum Mutat","doi-asserted-by":null},{"DOI":"10.1038/s41431-021-00852-7","key":"10.1053/j.gastro.2025.10.011_bib15","year":"2021","issue":null,"author":"Matalonga","volume":"29","first-page":"1337","unstructured":null,"article-title":"Solving patients with rare diseases through programmatic reanalysis of genome-phenome data","journal-title":"Eur J Hum Genet","doi-asserted-by":"crossref"},{"DOI":"10.1038/nn.4352","key":"10.1053/j.gastro.2025.10.011_bib16","year":"2016","issue":null,"author":"Lelieveld","volume":"19","first-page":"1194","unstructured":null,"article-title":"Meta-analysis of 2,104 trios provides support for 10 new genes for intellectual disability","journal-title":"Nat Neurosci","doi-asserted-by":"crossref"},{"DOI":"10.2353/jmoldx.2007.060170","key":"10.1053/j.gastro.2025.10.011_bib17","year":"2007","issue":null,"author":"Ogino","volume":"9","first-page":"305","unstructured":null,"article-title":"Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample","journal-title":"J Mol Diagn","doi-asserted-by":"crossref"},{"DOI":null,"key":"10.1053/j.gastro.2025.10.011_bib18","year":"2022","issue":null,"author":"Islam","volume":"2","first-page":null,"unstructured":null,"article-title":"Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor","journal-title":"Cell Genom","doi-asserted-by":null},{"DOI":"10.1093/nar/gky1015","key":"10.1053/j.gastro.2025.10.011_bib19","year":"2019","issue":null,"author":"Tate","volume":"47","first-page":"D941","unstructured":null,"article-title":"COSMIC: the Catalogue Of Somatic Mutations In Cancer","journal-title":"Nucleic Acids Res","doi-asserted-by":"crossref"},{"DOI":"10.1038/ng.2764","key":"10.1053/j.gastro.2025.10.011_bib20","year":"2013","issue":null,"author":"Weinstein","volume":"45","first-page":"1113","unstructured":null,"article-title":"The Cancer Genome Atlas Pan-Cancer analysis project","journal-title":"Nat Genet","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.ajhg.2022.03.018","key":"10.1053/j.gastro.2025.10.011_bib21","year":"2022","issue":null,"author":"Palles","volume":"109","first-page":"953","unstructured":null,"article-title":"Germline MBD4 deficiency causes a multi-tumor predisposition syndrome","journal-title":"Am J Hum Genet","doi-asserted-by":"crossref"},{"DOI":"10.1097/PAS.0b013e318205df20","key":"10.1053/j.gastro.2025.10.011_bib22","year":"2011","issue":null,"author":"Ishii","volume":"35","first-page":"212","unstructured":null,"article-title":"Tubular adenomas with minor villous changes show molecular features characteristic of tubulovillous adenomas","journal-title":"Am J Surg Pathol","doi-asserted-by":"crossref"},{"DOI":"10.1016/S1470-2045(20)30445-9","key":"10.1053/j.gastro.2025.10.011_bib23","year":"2020","issue":null,"author":"Marabelle","volume":"21","first-page":"1353","unstructured":null,"article-title":"Association of tumour mutational burden with outcomes in patients with advanced solid tumours treated with pembrolizumab: prospective biomarker analysis of the multicohort, open-label, phase 2 KEYNOTE-158 study","journal-title":"Lancet Oncol","doi-asserted-by":"crossref"},{"DOI":"10.1186/s12864-022-08357-3","key":"10.1053/j.gastro.2025.10.011_bib24","year":"2022","issue":null,"author":"Manders","volume":"23","first-page":"134","unstructured":null,"article-title":"MutationalPatterns: the one stop shop for the analysis of mutational processes","journal-title":"BMC Genomics","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.cell.2012.04.024","key":"10.1053/j.gastro.2025.10.011_bib25","year":"2012","issue":null,"author":"Nik-Zainal","volume":"149","first-page":"979","unstructured":null,"article-title":"Mutational processes molding the genomes of 21 breast cancers","journal-title":"Cell","doi-asserted-by":"crossref"},{"DOI":"10.1038/ng.3441","key":"10.1053/j.gastro.2025.10.011_bib26","year":"2015","issue":null,"author":"Alexandrov","volume":"47","first-page":"1402","unstructured":null,"article-title":"Clock-like mutational processes in human somatic cells","journal-title":"Nat Genet","doi-asserted-by":"crossref"},{"DOI":"10.1038/s41586-019-1672-7","key":"10.1053/j.gastro.2025.10.011_bib27","year":"2019","issue":null,"author":"Lee-Six","volume":"574","first-page":"532","unstructured":null,"article-title":"The landscape of somatic mutation in normal colorectal epithelial cells","journal-title":"Nature","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.ccell.2018.12.011","key":"10.1053/j.gastro.2025.10.011_bib28","year":"2019","issue":null,"author":"Grolleman","volume":"35","first-page":"256","unstructured":null,"article-title":"Mutational signature analysis reveals NTHL1 deficiency to cause a multi-tumor phenotype","journal-title":"Cancer Cell","doi-asserted-by":"crossref"},{"DOI":"10.1038/s41467-022-32041-5","key":"10.1053/j.gastro.2025.10.011_bib29","year":"2022","issue":null,"author":"Guo","volume":"13","first-page":"4487","unstructured":null,"article-title":"The mutational signatures of formalin fixation on the human genome","journal-title":"Nat Commun","doi-asserted-by":"crossref"},{"DOI":"10.1371/journal.pone.0088367","key":"10.1053/j.gastro.2025.10.011_bib30","year":"2014","issue":null,"author":"Delker","volume":"9","first-page":null,"unstructured":null,"article-title":"RNA sequencing of sessile serrated colon polyps identifies differentially expressed genes and immunohistochemical markers","journal-title":"PLoS One","doi-asserted-by":"crossref"},{"DOI":"10.1158/1940-6207.CAPR-15-0363","key":"10.1053/j.gastro.2025.10.011_bib31","year":"2016","issue":null,"author":"Kanth","volume":"9","first-page":"456","unstructured":null,"article-title":"Gene signature in sessile serrated polyps identifies colon cancer subtype","journal-title":"Cancer Prev Res (Phila)","doi-asserted-by":"crossref"},{"DOI":"10.1038/modpathol.2017.150","key":"10.1053/j.gastro.2025.10.011_bib32","year":"2018","issue":null,"author":"Borowsky","volume":"31","first-page":"495","unstructured":null,"article-title":"The role of APC in WNT pathway activation in serrated neoplasia","journal-title":"Mod Pathol","doi-asserted-by":"crossref"},{"DOI":"10.1097/PAS.0000000000001502","key":"10.1053/j.gastro.2025.10.011_bib33","year":"2020","issue":null,"author":"Okamura","volume":"44","first-page":"1282","unstructured":null,"article-title":"Clinicopathologic and molecular characteristics of familial adenomatous polyposis-associated traditional serrated adenoma","journal-title":"Am J Surg Pathol","doi-asserted-by":"crossref"},{"DOI":"10.1038/modpathol.2014.122","key":"10.1053/j.gastro.2025.10.011_bib34","year":"2015","issue":null,"author":"Bettington","volume":"28","first-page":"414","unstructured":null,"article-title":"A clinicopathological and molecular analysis of 200 traditional serrated adenomas","journal-title":"Mod Pathol","doi-asserted-by":"crossref"},{"DOI":"10.1056/NEJM198809013190901","key":"10.1053/j.gastro.2025.10.011_bib35","year":"1988","issue":null,"author":"Vogelstein","volume":"319","first-page":"525","unstructured":null,"article-title":"Genetic alterations during colorectal-tumor development","journal-title":"N Engl J Med","doi-asserted-by":"crossref"},{"DOI":"10.1038/418934a","key":"10.1053/j.gastro.2025.10.011_bib36","year":"2002","issue":null,"author":"Rajagopalan","volume":"418","first-page":"934","unstructured":null,"article-title":"Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status","journal-title":"Nature","doi-asserted-by":"crossref"},{"DOI":"10.1111/j.1572-0241.2004.40131.x","key":"10.1053/j.gastro.2025.10.011_bib37","year":"2004","issue":null,"author":"Huang","volume":"99","first-page":"2242","unstructured":null,"article-title":"Hyperplastic polyps, serrated adenomas, and the serrated polyp neoplasia pathway","journal-title":"Am J Gastroenterol","doi-asserted-by":"crossref"},{"DOI":"10.1136/gutjnl-2016-311849","key":"10.1053/j.gastro.2025.10.011_bib38","year":"2017","issue":null,"author":"Yan","volume":"66","first-page":"1645","unstructured":null,"article-title":"RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation","journal-title":"Gut","doi-asserted-by":"crossref"},{"DOI":"10.1111/his.14286","key":"10.1053/j.gastro.2025.10.011_bib39","year":"2021","issue":null,"author":"van Herwaarden","volume":"78","first-page":"749","unstructured":null,"article-title":"RNF43 mutation analysis in serrated polyposis, sporadic serrated polyps and Lynch syndrome polyps","journal-title":"Histopathology","doi-asserted-by":"crossref"},{"DOI":"10.1002/path.5881","key":"10.1053/j.gastro.2025.10.011_bib40","year":"2022","issue":null,"author":"Bleijenberg","volume":"257","first-page":"239","unstructured":null,"article-title":"The earliest events in BRAF-mutant colorectal cancer: exome sequencing of sessile serrated lesions with a tiny focus dysplasia or cancer reveals recurring mutations in two distinct progression pathways","journal-title":"J Pathol","doi-asserted-by":"crossref"},{"DOI":"10.1186/s12885-020-07537-2","key":"10.1053/j.gastro.2025.10.011_bib41","year":"2020","issue":null,"author":"Arnold","volume":"20","first-page":"1038","unstructured":null,"article-title":"The majority of β-catenin mutations in colorectal cancer is homozygous","journal-title":"BMC Cancer","doi-asserted-by":"crossref"},{"DOI":"10.15252/embj.201591739","key":"10.1053/j.gastro.2025.10.011_bib42","year":"2015","issue":null,"author":"Huels","volume":"34","first-page":"2321","unstructured":null,"article-title":"E-cadherin can limit the transforming properties of activating β-catenin mutations","journal-title":"EMBO J","doi-asserted-by":"crossref"},{"DOI":"10.1038/sj.ejhg.5200853","key":"10.1053/j.gastro.2025.10.011_bib43","year":"2002","issue":null,"author":"Ripa","volume":"10","first-page":"631","unstructured":null,"article-title":"De novo mutations in familial adenomatous polyposis (FAP)","journal-title":"Eur J Hum Genet","doi-asserted-by":"crossref"},{"DOI":"10.1136/jmedgenet-2015-103468","key":"10.1053/j.gastro.2025.10.011_bib44","year":"2016","issue":null,"author":"Spier","volume":"53","first-page":"172","unstructured":null,"article-title":"Low-level APC mutational mosaicism is the underlying cause in a substantial fraction of unexplained colorectal adenomatous polyposis cases","journal-title":"J Med Genet","doi-asserted-by":"crossref"},{"DOI":"10.1038/s41586-020-2080-8","key":"10.1053/j.gastro.2025.10.011_bib45","year":"2020","issue":null,"author":"Pleguezuelos-Manzano","volume":"580","first-page":"269","unstructured":null,"article-title":"Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli","journal-title":"Nature","doi-asserted-by":"crossref"},{"DOI":"10.1053/j.gastro.2020.06.055","key":"10.1053/j.gastro.2025.10.011_bib46","year":"2020","issue":null,"author":"Terlouw","volume":"159","first-page":"1612","unstructured":null,"article-title":"Recurrent APC splice variant c.835-8AG in patients with unexplained colorectal polyposis fulfilling the Colibactin Mutational Signature","journal-title":"Gastroenterology","doi-asserted-by":"crossref"},{"DOI":"10.1097/01.pas.0000213313.36306.85","key":"10.1053/j.gastro.2025.10.011_bib47","year":"2006","issue":null,"author":"O'Brien","volume":"30","first-page":"1491","unstructured":null,"article-title":"Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate pathways to distinct colorectal carcinoma end points","journal-title":"Am J Surg Pathol","doi-asserted-by":"crossref"},{"DOI":"10.1126/science.1235122","key":"10.1053/j.gastro.2025.10.011_bib48","year":"2013","issue":null,"author":"Vogelstein","volume":"339","first-page":"1546","unstructured":null,"article-title":"Cancer genome landscapes","journal-title":"Science","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.yexcr.2017.04.010","key":"10.1053/j.gastro.2025.10.011_bib49","year":"2017","issue":null,"author":"Wang","volume":"357","first-page":"1","unstructured":null,"article-title":"Down-regulation of LRP1B in colon cancer promoted the growth and migration of cancer cells","journal-title":"Exp Cell Res","doi-asserted-by":"crossref"},{"DOI":"10.1158/1078-0432.CCR-15-0159","key":"10.1053/j.gastro.2025.10.011_bib50","year":"2015","issue":null,"author":"Sanz-Pamplona","volume":"21","first-page":"4709","unstructured":null,"article-title":"Exome sequencing reveals AMER1 as a frequently mutated gene in colorectal cancer","journal-title":"Clin Cancer Res","doi-asserted-by":"crossref"},{"DOI":"10.1093/narcan/zcac023","key":"10.1053/j.gastro.2025.10.011_bib51","year":"2022","issue":null,"author":"Hu","volume":"4","first-page":null,"unstructured":null,"article-title":"KMT2C-deficient tumors have elevated APOBEC mutagenesis and genomic instability in multiple cancers","journal-title":"NAR Cancer","doi-asserted-by":"crossref"},{"DOI":"10.1593/neo.08312","key":"10.1053/j.gastro.2025.10.011_bib52","year":"2008","issue":null,"author":"Ahlquist","volume":"10","first-page":"680","unstructured":null,"article-title":"RAS signaling in colorectal carcinomas through alteration of RAS, RAF, NF1, and/or RASSF1A","journal-title":"Neoplasia","doi-asserted-by":"crossref"},{"DOI":null,"key":"10.1053/j.gastro.2025.10.011_bib53","year":"2022","issue":null,"author":"Cannon","volume":"32","first-page":null,"unstructured":null,"article-title":"Concurrent BRAFV600E and BRCA mutations in MSS metastatic colorectal cancer: prevalence and case series of mCRC patients with prolonged OS","journal-title":"Cancer Treat Res Commun","doi-asserted-by":null},{"DOI":"10.18632/oncotarget.18098","key":"10.1053/j.gastro.2025.10.011_bib54","year":"2017","issue":null,"author":"Deihimi","volume":"8","first-page":"39945","unstructured":null,"article-title":"BRCA2, EGFR, and NTRK mutations in mismatch repair-deficient colorectal cancers with MSH2 or MLH1 mutations","journal-title":"Oncotarget","doi-asserted-by":"crossref"},{"DOI":"10.1002/1878-0261.12467","key":"10.1053/j.gastro.2025.10.011_bib55","year":"2019","issue":null,"author":"Reilly","volume":"13","first-page":"681","unstructured":null,"article-title":"Exploiting DNA repair defects in colorectal cancer","journal-title":"Mol Oncol","doi-asserted-by":"crossref"}],"short-title":[],"update-policy":"https://doi.org/10.1016/elsevier_cm_policy","alternative-id":["S0016508525061347"],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"original-title":[],"container-title":["Gastroenterology"],"published-print":{"date-parts":[[2026,1]]},"reference-count":55,"published-online":null,"references-count":55,"short-container-title":["Gastroenterology"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1053/j.gastro.2025.10.011","is_oa":true,"title":"Mutational Landscape of Colorectal Tumors From Individuals With Unexplained Adenomatous or Serrated Colorectal Polyposis","updated":"2026-01-14T02:41:26+00:00","published_date":"2026-01-01","best_oa_location":{"url":"https://www.gastrojournal.org/article/S0016-5085(25)06134-7/pdf","pmh_id":null,"url_for_pdf":"https://www.gastrojournal.org/article/S0016-5085(25)06134-7/pdf","url_for_landing_page":"https://doi.org/10.1053/j.gastro.2025.10.011"}}},"created_at":"2026-01-19T09:31:36.873Z","updated_at":"2026-01-21T12:05:26.220Z","tags":[{"paper_doi":"10.1053/j.gastro.2025.10.011","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1053/j.gastro.2025.10.011","tag_type":"category","value":"Gastroenterology & Hepatology","value_numeric":null},{"paper_doi":"10.1053/j.gastro.2025.10.011","tag_type":"condition","value":"Adenomatous Polyposis","value_numeric":null},{"paper_doi":"10.1053/j.gastro.2025.10.011","tag_type":"condition","value":"Colorectal Cancer","value_numeric":null},{"paper_doi":"10.1053/j.gastro.2025.10.011","tag_type":"condition","value":"Serrated Polyposis","value_numeric":null},{"paper_doi":"10.1053/j.gastro.2025.10.011","tag_type":"level_of_evidence","value":"5","value_numeric":null},{"paper_doi":"10.1053/j.gastro.2025.10.011","tag_type":"sample_size","value":"n=299","value_numeric":299},{"paper_doi":"10.1053/j.gastro.2025.10.011","tag_type":"study_design","value":"Cross-Sectional","value_numeric":null},{"paper_doi":"10.1053/j.gastro.2025.10.011","tag_type":"warning","value":"Abstract lacks demographic details and exact mutation frequencies beyond the percentages reported.","value_numeric":null},{"paper_doi":"10.1053/j.gastro.2025.10.011","tag_type":"warning","value":"Comparisons rely on publicly available datasets, which may differ in methods and platforms.","value_numeric":null},{"paper_doi":"10.1053/j.gastro.2025.10.011","tag_type":"warning","value":"Design classification is approximate (genomic cross-sectional profiling without clinical outcomes).","value_numeric":null}],"summaries":{"what_studied":"Whole-exome sequencing of 299 colorectal tumors from 153 individuals with adenomatous or serrated polyposis and 16 with early-onset colorectal cancer lacking known pathogenic germline variants; somatic drivers, CpG island methylator phenotype, tumor mutational burden, microsatellite instability, and mutational signatures were compared with public datasets.","key_result":"APC/CTNNB1 mutations were enriched in adenomatous polyps and BRAF in serrated polyps; APC mosaicism was identified in 19% of individuals with adenomatous polyposis, 9% of serrated polyps were CIMP-high, most polyps had low tumor mutational burden and were microsatellite stable, and APC/CTNNB1- and BRAF-mutated polyps showed lower SBS1 and higher SBS89 contributions, respectively, versus sporadic tumors.","practice_takeaway":"For unexplained adenomatous polyposis, consider testing for somatic APC mosaicism; molecular tumor profiling can help distinguish adenomatous (APC/CTNNB1) from serrated (BRAF) pathways and shows most lesions are low TMB and MSS."}},{"doi":"10.1016/j.rmed.2026.108636","pmid":"41520899","title":"Relationships between bronchodilator responsiveness, a COPD polygenic risk score, and COPD progression","journal_title":"Respiratory Medicine","journal_issn":"0954-6111","published_at":"2026-01-12T00:00:00.000Z","url":"https://doi.org/10.1016/j.rmed.2026.108636","source_score":15,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2026-01-13","doi":"10.1016/j.rmed.2026.108636","days":"14","issn":"0954-6111","rank":"3","field":"Clinical Medicine","score":"15","category":"Respiratory System","categories":["Respiratory System"],"_categories":["Respiratory System"]},"pubmed":{"doi":"10.1016/j.rmed.2026.108636","title":"Relationships between bronchodilator responsiveness, a COPD polygenic risk score, and COPD progression.","journal":"Respiratory medicine","methods":"","results":"PRS did not correlate with 2005-BDR-FEV","abstract":"Bronchodilator responsiveness (BDR) is associated with progression to COPD. Genetic risk for COPD, summarized by polygenic risk scores (PRS), predicts low lung function and COPD. However, it remains unclear whether genetic predisposition to COPD is related to BDR and whether PRS and BDR together influence lung function decline in individuals at risk for the disease.\nWe analyzed data from COPDGene participants with a smoking history and normal spirometry at study enrollment. We cross-sectionally examined the association of a PRS with 2005-BDR-FEV\nPRS did not correlate with 2005-BDR-FEV\nBDR is more strongly associated with progression to COPD and FEV","keywords":["Bronchodilators responsiveness","COPD","Polygenic risk score","Pulmonary function test"],"pubmed_id":"41520899","conclusions":"","publication_date":"2026-01-12T00:00:00"},"crossref":{"DOI":"10.1016/j.rmed.2026.108636","URL":"https://doi.org/10.1016/j.rmed.2026.108636","ISSN":["0954-6111"],"link":[{"URL":"https://api.elsevier.com/content/article/PII:S0954611126000041?httpAccept=text/xml","content-type":"text/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https://api.elsevier.com/content/article/PII:S0954611126000041?httpAccept=text/plain","content-type":"text/plain","content-version":"vor","intended-application":"text-mining"}],"page":"108636","type":"journal-article","issue":null,"score":1,"title":["Relationships between bronchodilator responsiveness, a COPD polygenic risk score, and COPD progression"],"author":[{"given":"Spyridon","family":"Fortis","sequence":"first","affiliation":[]},{"given":"Alejandro P.","family":"Comellas","sequence":"additional","affiliation":[]},{"given":"Russell P.","family":"Bowler","sequence":"additional","affiliation":[]},{"given":"Surya P.","family":"Bhatt","sequence":"additional","affiliation":[]},{"given":"Craig P.","family":"Hersh","sequence":"additional","affiliation":[]},{"given":"Dawn L.","family":"Demeo","sequence":"additional","affiliation":[]},{"given":"Gregory","family":"Kinney","sequence":"additional","affiliation":[]},{"given":"Edwin K.","family":"Silverman","sequence":"additional","affiliation":[]},{"given":"Michael H.","family":"Cho","sequence":"additional","affiliation":[]},{"given":"Matthew","family":"Moll","sequence":"additional","affiliation":[]}],"funder":[{"id":[{"id":"10.13039/100000050","id-type":"DOI","asserted-by":"publisher"}],"DOI":"10.13039/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher"}],"issued":{"date-parts":[[2026,2]]},"member":"78","prefix":"10.1016","source":"Crossref","volume":"252","created":{"date-time":"2026-01-10T00:24:23Z","timestamp":1768004663000,"date-parts":[[2026,1,10]]},"indexed":{"date-time":"2026-01-19T13:32:08Z","timestamp":1768829528960,"date-parts":[[2026,1,19]]},"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","start":{"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000,"date-parts":[[2026,2,1]]},"delay-in-days":0,"content-version":"tdm"},{"URL":"https://www.elsevier.com/legal/tdmrep-license","start":{"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000,"date-parts":[[2026,2,1]]},"delay-in-days":0,"content-version":"tdm"},{"URL":"http://www.elsevier.com/open-access/userlicense/1.0/","start":{"date-time":"2027-01-12T00:00:00Z","timestamp":1799712000000,"date-parts":[[2027,1,12]]},"delay-in-days":345,"content-version":"am"}],"subject":[],"abstract":null,"language":"en","relation":{},"resource":{"primary":{"URL":"https://linkinghub.elsevier.com/retrieve/pii/S0954611126000041"}},"subtitle":[],"assertion":[{"name":"publisher","label":"This article is maintained by","value":"Elsevier"},{"name":"articletitle","label":"Article Title","value":"Relationships between bronchodilator responsiveness, a COPD polygenic risk score, and COPD progression"},{"name":"journaltitle","label":"Journal Title","value":"Respiratory Medicine"},{"name":"articlelink","label":"CrossRef DOI link to publisher maintained version","value":"https://doi.org/10.1016/j.rmed.2026.108636"},{"name":"content_type","label":"Content Type","value":"article"},{"name":"copyright","label":"Copyright","value":"Published by Elsevier Ltd."}],"deposited":{"date-time":"2026-01-18T22:33:08Z","timestamp":1768775588000,"date-parts":[[2026,1,18]]},"issn-type":[{"type":"print","value":"0954-6111"}],"published":{"date-parts":[[2026,2]]},"publisher":"Elsevier BV","reference":[{"DOI":"10.1016/S2213-2600(13)70086-9","key":"10.1016/j.rmed.2026.108636_bib1","year":"2013","issue":"7","author":"Calverley","volume":"1","first-page":"564","unstructured":null,"article-title":"Bronchodilator reversibility in chronic obstructive pulmonary disease: use and limitations","journal-title":"Lancet Respir. Med.","doi-asserted-by":"crossref"},{"DOI":"10.1186/1465-9921-12-6","key":"10.1016/j.rmed.2026.108636_bib2","year":"2011","issue":null,"author":"Hanania","volume":"12","first-page":"6","unstructured":null,"article-title":"Acute bronchodilator responsiveness and health outcomes in COPD patients in the UPLIFT trial","journal-title":"Respir. Res.","doi-asserted-by":"crossref"},{"DOI":"10.1136/thoraxjnl-2011-201458","key":"10.1016/j.rmed.2026.108636_bib3","year":"2012","issue":"8","author":"Albert","volume":"67","first-page":"701","unstructured":null,"article-title":"Bronchodilator responsiveness as a phenotypic characteristic of established chronic obstructive pulmonary disease","journal-title":"Thorax","doi-asserted-by":"crossref"},{"DOI":"10.1136/thorax.58.8.659","key":"10.1016/j.rmed.2026.108636_bib4","year":"2003","issue":"8","author":"Calverley","volume":"58","first-page":"659","unstructured":null,"article-title":"Bronchodilator reversibility testing in chronic obstructive pulmonary disease","journal-title":"Thorax","doi-asserted-by":"crossref"},{"DOI":"10.2147/COPD.S220164","key":"10.1016/j.rmed.2026.108636_bib5","year":"2019","issue":null,"author":"Barjaktarevic","volume":"14","first-page":"2927","unstructured":null,"article-title":"Clinical significance of bronchodilator responsiveness evaluated by forced vital capacity in COPD: SPIROMICS cohort analysis","journal-title":"Int. J. Chronic Obstr. Pulm. Dis.","doi-asserted-by":"crossref"},{"DOI":"10.1513/AnnalsATS.201901-030OC","key":"10.1016/j.rmed.2026.108636_bib6","year":"2019","issue":"12","author":"Hansen","volume":"16","first-page":"1504","unstructured":null,"article-title":"A new bronchodilator response grading strategy identifies distinct patient populations","journal-title":"Ann. Am. Thorac. Soc.","doi-asserted-by":"crossref"},{"DOI":null,"key":"10.1016/j.rmed.2026.108636_bib7","year":"2019","issue":null,"author":"Fortis","volume":null,"first-page":null,"unstructured":null,"article-title":"Combined FEV1 and FVC bronchodilator response, exacerbations, and mortality in COPD","journal-title":"Ann. Am. Thorac. Soc.","doi-asserted-by":null},{"DOI":"10.1056/NEJMoa1105482","key":"10.1016/j.rmed.2026.108636_bib8","year":"2011","issue":"13","author":"Vestbo","volume":"365","first-page":"1184","unstructured":null,"article-title":"Changes in forced expiratory volume in 1 second over time in COPD","journal-title":"N. Engl. J. Med.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.chest.2022.11.009","key":"10.1016/j.rmed.2026.108636_bib9","year":"2023","issue":"3","author":"Fortis","volume":"163","first-page":"502","unstructured":null,"article-title":"Bronchodilator responsiveness in tobacco-exposed people with or without COPD","journal-title":"Chest","doi-asserted-by":"crossref"},{"DOI":"10.1038/tpj.2015.65","key":"10.1016/j.rmed.2026.108636_bib10","year":"2016","issue":"4","author":"Hardin","volume":"16","first-page":"326","unstructured":null,"article-title":"A genome-wide analysis of the response to inhaled beta2-agonists in chronic obstructive pulmonary disease","journal-title":"Pharmacogenomics J.","doi-asserted-by":"crossref"},{"DOI":"10.1183/23120541.00484-2021","key":"10.1016/j.rmed.2026.108636_bib11","year":"2022","issue":"2","author":"Gereige","volume":"8","first-page":null,"unstructured":null,"article-title":"A genome-wide association study of bronchodilator response in participants of European and African ancestry from six independent cohorts","journal-title":"ERJ Open Res","doi-asserted-by":"crossref"},{"DOI":"10.1007/s11882-021-01023-w","key":"10.1016/j.rmed.2026.108636_bib12","year":"2021","issue":"12","author":"Sordillo","volume":"21","first-page":"47","unstructured":null,"article-title":"Pharmacogenetics of bronchodilator response: future directions","journal-title":"Curr. Allergy Asthma Rep.","doi-asserted-by":"crossref"},{"DOI":"10.1002/1098-2272(200007)19:1<81::AID-GEPI6>3.0.CO;2-8","key":"10.1016/j.rmed.2026.108636_bib13","year":"2000","issue":"1","author":"Wilk","volume":"19","first-page":"81","unstructured":null,"article-title":"Evidence for major genes influencing pulmonary function in the NHLBI family heart study","journal-title":"Genet. Epidemiol.","doi-asserted-by":"crossref"},{"DOI":"10.1183/09031936.01.17406960","key":"10.1016/j.rmed.2026.108636_bib14","year":"2001","issue":"4","author":"Palmer","volume":"17","first-page":"696","unstructured":null,"article-title":"Familial aggregation and heritability of adult lung function: results from the Busselton health study","journal-title":"Eur. Respir. J.","doi-asserted-by":"crossref"},{"DOI":"10.1164/rccm.201302-0263OC","key":"10.1016/j.rmed.2026.108636_bib15","year":"2013","issue":"8","author":"Zhou","volume":"188","first-page":"941","unstructured":null,"article-title":"Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers","journal-title":"Am. J. Respir. Crit. Care Med.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.jaci.2013.10.040","key":"10.1016/j.rmed.2026.108636_bib16","year":"2014","issue":"1","author":"Ortega","volume":"133","first-page":"16","unstructured":null,"article-title":"Pharmacogenetics: implications of race and ethnicity on defining genetic profiles for personalized medicine","journal-title":"J. Allergy Clin. Immunol.","doi-asserted-by":"crossref"},{"DOI":"10.1097/FPC.0b013e3283607acf","key":"10.1016/j.rmed.2026.108636_bib17","year":"2013","issue":"6","author":"McGeachie","volume":"23","first-page":"324","unstructured":null,"article-title":"Polygenic heritability estimates in pharmacogenetics: focus on asthma and related phenotypes","journal-title":"Pharmacogenet. Genom.","doi-asserted-by":"crossref"},{"DOI":"10.1016/S2213-2600(21)00510-5","key":"10.1016/j.rmed.2026.108636_bib18","year":"2022","issue":"5","author":"Cho","volume":"10","first-page":"485","unstructured":null,"article-title":"Genetics of chronic obstructive pulmonary disease: understanding the pathobiology and heterogeneity of a complex disorder","journal-title":"Lancet Respir. Med.","doi-asserted-by":"crossref"},{"DOI":"10.1038/s41588-023-01314-0","key":"10.1016/j.rmed.2026.108636_bib19","year":"2023","issue":"3","author":"Shrine","volume":"55","first-page":"410","unstructured":null,"article-title":"Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk","journal-title":"Nat. Genet.","doi-asserted-by":"crossref"},{"DOI":"10.1016/S2213-2600(20)30101-6","key":"10.1016/j.rmed.2026.108636_bib20","year":"2020","issue":"7","author":"Moll","volume":"8","first-page":"696","unstructured":null,"article-title":"Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts","journal-title":"Lancet Respir. Med.","doi-asserted-by":"crossref"},{"DOI":"10.1165/rcmb.2016-0331OC","key":"10.1016/j.rmed.2026.108636_bib21","year":"2017","issue":"1","author":"Busch","volume":"57","first-page":"35","unstructured":null,"article-title":"Genetic association and risk scores in a chronic obstructive pulmonary disease meta-analysis of 16,707 subjects","journal-title":"Am. J. Respir. Cell Mol. Biol.","doi-asserted-by":"crossref"},{"DOI":"10.1183/13993003.01954-2021","key":"10.1016/j.rmed.2026.108636_bib22","year":"2022","issue":"3","author":"Zhang","volume":"60","first-page":null,"unstructured":null,"article-title":"A polygenic risk score and age of diagnosis of COPD","journal-title":"Eur. Respir. J.","doi-asserted-by":"crossref"},{"DOI":null,"key":"10.1016/j.rmed.2026.108636_bib23","year":"2010","issue":"1","author":"Regan","volume":"7","first-page":"32","unstructured":null,"article-title":"Genetic epidemiology of COPD (COPDGene) study design","journal-title":"COPD J. Chronic Obstr. Pulm. Dis.","doi-asserted-by":null},{"DOI":"10.1183/09031936.05.00034505","key":"10.1016/j.rmed.2026.108636_bib24","year":"2005","issue":"1","author":"Miller","volume":"26","first-page":"153","unstructured":null,"article-title":"General considerations for lung function testing","journal-title":"Eur. Respir. J.","doi-asserted-by":"crossref"},{"DOI":"10.1038/s41588-018-0342-2","key":"10.1016/j.rmed.2026.108636_bib25","year":"2019","issue":"3","author":"Sakornsakolpat","volume":"51","first-page":"494","unstructured":null,"article-title":"Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations","journal-title":"Nat. Genet.","doi-asserted-by":"crossref"},{"DOI":"10.1164/rccm.202205-0963OC","key":"10.1016/j.rmed.2026.108636_bib26","year":"2023","issue":"6","author":"Bowerman","volume":"207","first-page":"768","unstructured":null,"article-title":"A race-neutral approach to the interpretation of lung function measurements","journal-title":"Am. J. Respir. Crit. Care Med.","doi-asserted-by":"crossref"},{"DOI":"10.1183/09031936.00080312","key":"10.1016/j.rmed.2026.108636_bib27","year":"2012","issue":"6","author":"Quanjer","volume":"40","first-page":"1324","unstructured":null,"article-title":"Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations","journal-title":"Eur. Respir. J.","doi-asserted-by":"crossref"},{"DOI":"10.1183/09031936.05.00035205","key":"10.1016/j.rmed.2026.108636_bib28","year":"2005","issue":"5","author":"Pellegrino","volume":"26","first-page":"948","unstructured":null,"article-title":"Interpretative strategies for lung function tests","journal-title":"Eur. Respir. J.","doi-asserted-by":"crossref"},{"DOI":null,"key":"10.1016/j.rmed.2026.108636_bib29","year":"2021","issue":null,"author":"Stanojevic","volume":null,"first-page":null,"unstructured":null,"article-title":"ERS/ATS technical standard on interpretive strategies for routine lung function tests","journal-title":"Eur. Respir. J.","doi-asserted-by":null},{"DOI":"10.1038/s41588-018-0321-7","key":"10.1016/j.rmed.2026.108636_bib30","year":"2019","issue":"3","author":"Shrine","volume":"51","first-page":"481","unstructured":null,"article-title":"New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries","journal-title":"Nat. Genet.","doi-asserted-by":"crossref"},{"DOI":"10.1001/jamaoncol.2017.4298","key":"10.1016/j.rmed.2026.108636_bib31","year":"2018","issue":"2","author":"Weiss","volume":"4","first-page":"203","unstructured":null,"article-title":"Validation study of the American joint committee on cancer eighth edition prognostic stage compared with the anatomic stage in breast cancer","journal-title":"JAMA Oncol.","doi-asserted-by":"crossref"},{"DOI":"10.1136/bmjresp-2017-000213","key":"10.1016/j.rmed.2026.108636_bib32","year":"2017","issue":"1","author":"Fortis","volume":"4","first-page":null,"unstructured":null,"article-title":"Predictive value of prebronchodilator and postbronchodilator spirometry for COPD features and outcomes","journal-title":"BMJ Open Respir Res","doi-asserted-by":"crossref"},{"DOI":"10.4187/respcare.01537","key":"10.1016/j.rmed.2026.108636_bib33","year":"2012","issue":"10","author":"Hegewald","volume":"57","first-page":"1564","unstructured":null,"article-title":"Bronchodilator response in patients with normal baseline spirometry","journal-title":"Respir. Care","doi-asserted-by":"crossref"},{"DOI":"10.4187/respcare.11603","key":"10.1016/j.rmed.2026.108636_bib34","year":"2024","issue":null,"author":"de la Serna","volume":null,"first-page":null,"unstructured":null,"article-title":"Prevalence of bronchodilator responsiveness: a comparison of old versus new criteria","journal-title":"Respir. Care","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.ccm.2012.05.002","key":"10.1016/j.rmed.2026.108636_bib35","year":"2012","issue":"3","author":"Black","volume":"33","first-page":"543","unstructured":null,"article-title":"Airway smooth muscle in asthma: just a target for bronchodilation?","journal-title":"Clin. Chest Med.","doi-asserted-by":"crossref"},{"DOI":"10.1513/pats.200504-028SR","key":"10.1016/j.rmed.2026.108636_bib36","year":"2005","issue":"4","author":"Chung","volume":"2","first-page":"347","unstructured":null,"article-title":"The role of airway smooth muscle in the pathogenesis of airway wall remodeling in chronic obstructive pulmonary disease","journal-title":"Proc. Am. Thorac. Soc.","doi-asserted-by":"crossref"},{"DOI":"10.1126/science.adk2758","key":"10.1016/j.rmed.2026.108636_bib37","year":"2024","issue":"6691","author":"Bagley","volume":"384","first-page":"66","unstructured":null,"article-title":"Bronchoconstriction damages airway epithelia by crowding-induced excess cell extrusion","journal-title":"Science","doi-asserted-by":"crossref"},{"DOI":"10.1081/JAS-200062992","key":"10.1016/j.rmed.2026.108636_bib38","year":"2005","issue":"5","author":"Chhabra","volume":"42","first-page":"367","unstructured":null,"article-title":"Acute bronchodilator response has limited value in differentiating bronchial asthma from COPD","journal-title":"J. Asthma","doi-asserted-by":"crossref"},{"DOI":null,"key":"10.1016/j.rmed.2026.108636_bib39","year":"2008","issue":"4","author":"Richter","volume":"3","first-page":"693","unstructured":null,"article-title":"Diagnostic value of post-bronchodilator pulmonary function testing to distinguish between stable, moderate to severe COPD and asthma","journal-title":"Int. J. Chronic Obstr. Pulm. Dis.","doi-asserted-by":null},{"DOI":"10.1378/chest.105.4.1042","key":"10.1016/j.rmed.2026.108636_bib40","year":"1994","issue":"4","author":"Kesten","volume":"105","first-page":"1042","unstructured":null,"article-title":"Is the short-term response to inhaled beta-adrenergic agonist sensitive or specific for distinguishing between asthma and COPD?","journal-title":"Chest","doi-asserted-by":"crossref"},{"DOI":"10.1183/09031936.93.02060497","key":"10.1016/j.rmed.2026.108636_bib41","year":"1989","issue":"6","author":"Meslier","volume":"2","first-page":"497","unstructured":null,"article-title":"Diagnostic value of reversibility of chronic airway obstruction to separate asthma from chronic bronchitis: a statistical approach","journal-title":"Eur. Respir. J.","doi-asserted-by":"crossref"},{"DOI":"10.3389/fmed.2024.1375457","key":"10.1016/j.rmed.2026.108636_bib42","year":"2024","issue":null,"author":"Fortis","volume":"11","first-page":null,"unstructured":null,"article-title":"Chronic obstructive pulmonary disease (COPD) and COPD-Like phenotypes","journal-title":"Front. Med.","doi-asserted-by":"crossref"},{"DOI":"10.2147/COPD.S220164","key":"10.1016/j.rmed.2026.108636_bib43","year":"2019","issue":null,"author":"Barjaktarevic","volume":"14","first-page":"2927","unstructured":null,"article-title":"Clinical significance of bronchodilator responsiveness evaluated by forced vital capacity in COPD: SPIROMICS cohort analysis","journal-title":"Int. J. Chronic Obstr. Pulm. Dis.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.chest.2022.11.009","key":"10.1016/j.rmed.2026.108636_bib44","year":"2023","issue":"3","author":"Fortis","volume":"163","first-page":"502","unstructured":null,"article-title":"Bronchodilator responsiveness in tobacco-exposed people with or without COPD","journal-title":"Chest","doi-asserted-by":"crossref"},{"DOI":"10.1164/rccm.201408-1426OC","key":"10.1016/j.rmed.2026.108636_bib45","year":"2015","issue":"5","author":"Israel","volume":"191","first-page":"530","unstructured":null,"article-title":"Genome-wide association study of short-acting beta2-agonists. A novel genome-wide significant locus on chromosome 2 near ASB3","journal-title":"Am. J. Respir. Crit. Care Med.","doi-asserted-by":"crossref"},{"DOI":"10.1016/j.jaci.2013.06.043","key":"10.1016/j.rmed.2026.108636_bib46","year":"2014","issue":"2","author":"Drake","volume":"133","first-page":"370","unstructured":null,"article-title":"A genome-wide association study of bronchodilator response in latinos implicates rare variants","journal-title":"J. Allergy Clin. Immunol.","doi-asserted-by":"crossref"},{"DOI":"10.1038/tpj.2013.5","key":"10.1016/j.rmed.2026.108636_bib47","year":"2014","issue":"1","author":"Duan","volume":"14","first-page":"41","unstructured":null,"article-title":"A genome-wide association study of bronchodilator response in asthmatics","journal-title":"Pharmacogenomics J.","doi-asserted-by":"crossref"},{"DOI":"10.1164/rccm.201712-2529OC","key":"10.1016/j.rmed.2026.108636_bib48","year":"2018","issue":"12","author":"Mak","volume":"197","first-page":"1552","unstructured":null,"article-title":"Whole-genome sequencing of pharmacogenetic drug response in racially diverse children with asthma","journal-title":"Am. J. Respir. Crit. Care Med.","doi-asserted-by":"crossref"},{"DOI":"10.1016/S2213-2600(14)70185-7","key":"10.1016/j.rmed.2026.108636_bib49","year":"2014","issue":"11","author":"Bhatt","volume":"2","first-page":"911","unstructured":null,"article-title":"Radiological correlates and clinical implications of the paradoxical lung function response to beta(2) agonists: an observational study","journal-title":"Lancet Respir. Med.","doi-asserted-by":"crossref"},{"DOI":"10.1056/NEJMoa1513737","key":"10.1016/j.rmed.2026.108636_bib50","year":"2016","issue":"19","author":"McGeachie","volume":"374","first-page":"1842","unstructured":null,"article-title":"Patterns of growth and decline in lung function in persistent childhood asthma","journal-title":"N. Engl. J. Med.","doi-asserted-by":"crossref"},{"DOI":"10.1056/NEJMoa2401389","key":"10.1016/j.rmed.2026.108636_bib51","year":"2024","issue":"22","author":"Aaron","volume":"390","first-page":"2061","unstructured":null,"article-title":"Early diagnosis and treatment of COPD and asthma - a randomized, controlled trial","journal-title":"N. Engl. J. Med.","doi-asserted-by":"crossref"},{"DOI":"10.1513/AnnalsATS.201809-601OC","key":"10.1016/j.rmed.2026.108636_bib52","year":"2019","issue":"7","author":"Fortis","volume":"16","first-page":"826","unstructured":null,"article-title":"Combined forced expiratory volume in 1 second and forced vital capacity bronchodilator response, exacerbations, and mortality in chronic obstructive pulmonary disease","journal-title":"Ann. Am. Thorac. Soc.","doi-asserted-by":"crossref"},{"DOI":"10.1016/S0140-6736(22)00470-6","key":"10.1016/j.rmed.2026.108636_bib53","year":"2022","issue":"10342","author":"Christenson","volume":"399","first-page":"2227","unstructured":null,"article-title":"Chronic obstructive pulmonary disease","journal-title":"Lancet","doi-asserted-by":"crossref"},{"DOI":"10.1001/jama.2024.24212","key":"10.1016/j.rmed.2026.108636_bib54","year":"2025","issue":"9","author":"Zhang","volume":"333","first-page":"784","unstructured":null,"article-title":"Polygenic risk score added to conventional case finding to identify undiagnosed chronic obstructive pulmonary disease","journal-title":"JAMA","doi-asserted-by":"crossref"}],"short-title":[],"update-policy":"https://doi.org/10.1016/elsevier_cm_policy","alternative-id":["S0954611126000041"],"article-number":"108636","content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"original-title":[],"container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2026,2]]},"reference-count":54,"published-online":null,"references-count":54,"special_numbering":"C","short-container-title":["Respiratory Medicine"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1016/j.rmed.2026.108636","is_oa":false,"title":"Relationships between bronchodilator responsiveness, a COPD polygenic risk score, and COPD progression","updated":"2026-01-14T02:41:26+00:00","published_date":"2026-01-10","best_oa_location":null}},"created_at":"2026-01-17T09:03:27.421Z","updated_at":"2026-01-21T12:05:26.220Z","tags":[{"paper_doi":"10.1016/j.rmed.2026.108636","tag_type":"category","value":"Respiratory System","value_numeric":null},{"paper_doi":"10.1016/j.rmed.2026.108636","tag_type":"condition","value":"Chronic Obstructive Pulmonary Disease","value_numeric":null},{"paper_doi":"10.1016/j.rmed.2026.108636","tag_type":"study_design","value":"Cross-Sectional","value_numeric":null},{"paper_doi":"10.1016/j.rmed.2026.108636","tag_type":"warning","value":"Abstract text appears truncated; key variables (e.g., '2005-BDR-FEV') and outcomes are unclear.","value_numeric":null},{"paper_doi":"10.1016/j.rmed.2026.108636","tag_type":"warning","value":"No sample size or numeric effect estimates are provided in the excerpt.","value_numeric":null},{"paper_doi":"10.1016/j.rmed.2026.108636","tag_type":"warning","value":"Study may include longitudinal analyses of COPD progression, but only a cross-sectional association is explicitly described.","value_numeric":null}],"summaries":{"what_studied":"Among COPDGene participants with a smoking history and normal spirometry at enrollment, investigators tested whether a COPD polygenic risk score (PRS) is associated with bronchodilator responsiveness (BDR) and whether PRS and BDR relate to COPD progression.","key_result":"PRS did not correlate with 2005-BDR-FEV.","practice_takeaway":"In smokers with normal spirometry, a COPD PRS did not correlate with BDR; do not assume current PRS predicts acute bronchodilator response."}}],"initialOffset":60,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"study_design","value":"Cross-Sectional"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Study Designs","href":"/hub/tag/study_design"},{"name":"Cross-Sectional"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"study_design","hub_tag_value":"Cross-Sectional"}}}]]

Papers