2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T4dc,There is growing clinical interest in strategies for improving clinical outcomes in patients with heart failure (HF) and obesity. The development of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and of the dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 RA has expanded therapeutic options for this population. This expert consensus provides a comprehensive and pragmatic framework for the use of GLP-1 RAs and GIP/GLP-1 RA in patients with HF, focusing on clinical integration, patient selection, safety, and tolerability. We review the evidence supporting their use in patients with HF with preserved ejection fraction (HFpEF), where clinical trials have demonstrated meaningful reductions in body weight alongside improvements in health status and exercise capacity. Whether these effects translate into fewer HF events or lower cardiovascular mortality remains uncertain, as current evidence is limited to two small trials with few observed events. In contrast, data regarding the efficacy and safety of these drugs in HF with reduced ejection fraction are scarce, with dedicated outcome trials yet to be launched. Finally, this document highlights knowledge gaps and outlines future research directions in this field.31:T4fb,There is growing clinical interest in strategies for improving clinical outcomes in patients with heart failure (HF) and obesity. The development of glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and of the dual glucose‐dependent insulinotropic polypeptide (GIP)/GLP‐1 RA has expanded therapeutic options for this population. This expert consensus provides a comprehensive and pragmatic framework for the use of GLP‐1 RAs and GIP/GLP‐1 RA in patients with HF, focusing on clinical integration, patient selection, safety, and tolerability. We review the evidence supporting their use in patients with HF with preserved ejection fraction (HFpEF), where clinical trials have demonstrated meaningful reductions in body weight alongside improvements in health status and exercise capacity. Whether these effects translate into fewer HF events or lower cardiovascular mortality remains uncertain, as current evidence is limited to two small trials with few observed events. In contrast, data regarding the efficacy and safety of these drugs in HF with reduced ejection fraction are scarce, with dedicated outcome trials yet to be launched. Finally, this document highlights knowledge gaps and outlines future research directions in this field.32:T79c,Patients with skin of color (SOC) face unique dermatologic challenges that are often underrepresented in research and in dermatological education, creating critical gaps in care. We aimed to identify and explore key gaps in research and clinical management for SOC across four domains: skin diseases, hair disorders, photoprotection, and aesthetic procedures. An international panel reviewed articles retrieved from PubMed using the search terms "skin of color" or "skin of colour" in titles and abstracts from September 2019 to September 2024. Inflammatory skin diseases, including acne, atopic dermatitis, psoriasis, and rosacea, are common in SOC subjects, necessitating tailored diagnostic and therapeutic approaches due to unique clinical presentations and specific challenges such as post-inflammatory hyperpigmentation and erythema detection. Pigmentary disorders such as melasma and acne-induced hyperpigmentation significantly impact quality of life in SOC, requiring cautious treatment to avoid exacerbation, while the unregulated use of skin bleaching agents containing high-potency corticosteroids can pose serious health risks. Skin cancer in SOC often presents at advanced stages with poorer outcomes due to lower awareness and unique clinical manifestations, resulting in delayed diagnosis. Hair disorders in SOC populations require tailored diagnostic and therapeutic approaches due to unique hair properties. Gaps in photoprotection education on SOC exacerbate pigmentary disorders and other dermatologic conditions, with limited research on effective sunscreens for this population. In aesthetic dermatology, misconceptions and knowledge gaps regarding the prevention of complications hinder access to safe and effective procedures for SOC subjects, compounded by inadequate diversity in clinical trials. Inclusive research, improved diagnostic accuracy, and customized procedures are needed to ensure equitable dermatologic care.33:T7ef,ABSTRACT Patients with skin of color (SOC) face unique dermatologic challenges that are often underrepresented in research and in dermatological education, creating critical gaps in care. We aimed to identify and explore key gaps in research and clinical management for SOC across four domains: skin diseases, hair disorders, photoprotection, and aesthetic procedures. An international panel reviewed articles retrieved from PubMed using the search terms “skin of color” or “skin of colour” in titles and abstracts from September 2019 to September 2024. Inflammatory skin diseases, including acne, atopic dermatitis, psoriasis, and rosacea, are common in SOC subjects, necessitating tailored diagnostic and therapeutic approaches due to unique clinical presentations and specific challenges such as post‐inflammatory hyperpigmentation and erythema detection. Pigmentary disorders such as melasma and acne‐induced hyperpigmentation significantly impact quality of life in SOC, requiring cautious treatment to avoid exacerbation, while the unregulated use of skin bleaching agents containing high‐potency corticosteroids can pose serious health risks. Skin cancer in SOC often presents at advanced stages with poorer outcomes due to lower awareness and unique clinical manifestations, resulting in delayed diagnosis. Hair disorders in SOC populations require tailored diagnostic and therapeutic approaches due to unique hair properties. Gaps in photoprotection education on SOC exacerbate pigmentary disorders and other dermatologic conditions, with limited research on effective sunscreens for this population. In aesthetic dermatology, misconceptions and knowledge gaps regarding the prevention of complications hinder access to safe and effective procedures for SOC subjects, compounded by inadequate diversity in clinical trials. Inclusive research, improved diagnostic accuracy, and customized procedures are needed to ensure equitable dermatologic care.25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Expert Consensus: study design Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Expert Consensus (study design). Clinician-written summaries and actionable practice insights. 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Herzzentrum der Charité, Department of Cardiology, Angiology and Intensive Care Medicine, Max Rubner Center for Cardiovascular Metabolic Renal Research (MRC) Berlin Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin Berlin Germany"},{"name":"Translational Approaches in Heart Failure and Cardiometabolic Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) Berlin Germany"},{"name":"Friede Springer Cardiovascular Prevention Center at Charité – Universitätsmedizin Berlin Berlin Germany"},{"name":"Experimental and Clinical Research Center (ECRC), a Cooperation of Charité‐Universitätsmedizin Berlin and Max Delbruck Center for Molecular Medicine (MDC) Berlin Germany"}]},{"given":"Davide","family":"Stolfo","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education, Södersjukhuset; Karolinska Institutet Stockholm Sweden"},{"name":"Cardiology, Cardiothoracic Department, Azienda Sanitaria 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formal consensus methodology is not detailed.","value_numeric":null}],"summaries":{"what_studied":"An international panel reviewed PubMed articles with “skin of color” or “skin of colour” in the title/abstract from September 2019 to September 2024 to map research and clinical care gaps for skin of color across skin diseases, hair disorders, photoprotection, and aesthetic procedures.","key_result":"The panel highlighted consistent gaps: inflammatory diseases in skin of color need tailored diagnosis and treatment due to unique presentations and challenges detecting erythema and managing post‑inflammatory hyperpigmentation; pigmentary disorders strongly affect quality of life and unsafe skin bleaching with high‑potency corticosteroids poses serious risks; skin cancer often presents late with poorer outcomes; and photoprotection and aesthetic care lack inclusive evidence and guidance.","limitations":"The search was limited to PubMed and to papers with “skin of color/colour” in the title or abstract, which may miss relevant studies. No quantitative outcomes or effect estimates are reported, and formal consensus methods are not described.","practice_takeaway":"In patients with skin of color, expect different visual cues and prioritize detection of erythema and post‑inflammatory hyperpigmentation; tailor treatment and counsel on photoprotection and the dangers of unregulated bleaching agents. Be vigilant for late‑presenting skin cancers and proceed cautiously with aesthetic procedures given sparse, non‑inclusive trial data."}},{"doi":"10.2147/ccid.s551492","pmid":null,"title":"Fine-Tuning Treatments with PN HPT Devices to Improve Asian Skin Quality: The ACES Consensus","journal_title":"Clinical, Cosmetic and Investigational Dermatology","journal_issn":"1178-7015","published_at":"2025-11-01T00:00:00.000Z","url":"https://doi.org/10.2147/ccid.s551492","source_score":1,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2025-11-08","doi":"10.2147/ccid.s551492","days":"7","issn":"1178-7015","rank":"8","field":"Clinical 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Board suggestions: Plinest for most areas (mid/lower face 0.5–1 mL per side), Plinest Fast/Eye for periorbital (table lists 1 mL per side); all other proposed PN HPT effects/indications achieved 84.2%–97.0% agreement. Reported combination use: microneedling 73.3%, MFU/HIFU 69.3%, botulinum toxin 66.3%, transdermal RF 52.5%, picosecond lasers 7.2%, and limited use with ablative CO2 lasers (42.6%). Injection‑site erythema typically resolved within 72 h (within 1 h in 30% and ≤12 h in 40%); bruising/hematomas had similar timeframes and were less common with cannulas.","limitations":"No stratification by age, skin aging severity, or sensitivity; self‑reported practice patterns without validated instruments or statistical estimates; limited consideration of intra‑Asian ethnic differences and potential sponsor/author conflicts.","practice_takeaway":"For Asian skin, consider PN HPT in 2–4 sessions spaced 4 weeks apart, using Plinest for most facial/neck areas (e.g., 0.5–1 mL per facial side; 2 mL for neck) and Plinest Fast/Eye for the periocular region, tailoring technique/plane to skin sensitivity and aging. Counsel patients on transient erythema/bruising (usually ≤72 h), avoid UV for 48 h, and hold makeup for at least 6–12 h post‑procedure."}}],"initialOffset":3,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"study_design","value":"Expert Consensus"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Study Designs","href":"/hub/tag/study_design"},{"name":"Expert Consensus"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"study_design","hub_tag_value":"Expert Consensus"}}}]]

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