2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T4ff,Hypocellular bone marrow failure (BMF) may be acquired due to immune-mediated disease, the prototype being immune aplastic anemia (IAA), or inherited, due to germline defects in genes important for hematopoietic stem cells' function and maintenance (inherited bone marrow failure syndromes [IBMFS]). Proper diagnosis of the underlying etiology of hypocellular bone marrow failure, particularly distinguishing immune AA, myelodysplastic syndrome (MDS) (most relevant in this setting, hypoplastic MDS [MDS-h]), and the IBMFS, is important given the differences in clinical management. Clonal hematopoiesis (CH), in this context comprising somatic mutations or chromosomal abnormalities, is incorporated into standard algorithms for classification, risk stratification, and treatment decisions for hematologic malignancies, but the clinical significance in BMF is not well established. Disease-specific clonal signatures have been reported across the BMF spectrum, and here we show how distinct patterns of CH can aid in distinguishing different etiologies of hypocellular BMF. Additionally, detection of somatic alterations in many BMF disorders can estimate risk for secondary myeloid neoplasms, guide surveillance and, in some instances, allow for early therapeutic intervention.31:T510,Hypocellular bone marrow failure (BMF) may be acquired due to immune-mediated disease, the prototype being immune aplastic anemia (IAA), or inherited, due to germline defects in genes important for hematopoietic stem cells' function and maintenance (inherited bone marrow failure syndromes [IBMFS]). Proper diagnosis of the underlying etiology of hypocellular bone marrow failure, particularly distinguishing immune AA, myelodysplastic syndrome (MDS) (most relevant in this setting, hypoplastic MDS [MDS-h]), and the IBMFS, is important given the differences in clinical management. Clonal hematopoiesis (CH), in this context comprising somatic mutations or chromosomal abnormalities, is incorporated into standard algorithms for classification, risk stratification, and treatment decisions for hematologic malignancies, but the clinical significance in BMF is not well established. Disease-specific clonal signatures have been reported across the BMF spectrum, and here we show how distinct patterns of CH can aid in distinguishing different etiologies of hypocellular BMF. Additionally, detection of somatic alterations in many BMF disorders can estimate risk for secondary myeloid neoplasms, guide surveillance and, in some instances, allow for early therapeutic intervention.32:T495,The potential of tools using artificial intelligence (AI) to address the many challenges in delivery of mental health care has been widely discussed. However, the possible negative consequences of AI for such care have received less attention. Integrating AI with mental health care has the potential to expand access and improve quality of care. It may also contribute to improvements in diagnosis, risk stratification, and development of novel therapeutics. At the same time, availability of AI chatbots and stratification algorithms may diminish access to human-delivered care. Reliance on AI tools may have other unanticipated adverse consequences on clinical practice, including diminished human clinician skill. The probabilistic nature of many of these tools, including large language models, makes their capacity to cause harm difficult to determine. The likely benefits of AI for psychiatric care delivery must be balanced against substantial risks. Strategies to mitigate this risk may require regulation to enhance transparency and systematically evaluate the impact of AI in practice, as well as clinician training to make optimal use of these emerging methods.33:T698, Importance The potential of tools using artificial intelligence (AI) to address the many challenges in delivery of mental health care has been widely discussed. However, the possible negative consequences of AI for such care have received less attention. Observations Integrating AI with mental health care has the potential to expand access and improve quality of care. It may also contribute to improvements in diagnosis, risk stratification, and development of novel therapeutics. At the same time, availability of AI chatbots and stratification algorithms may diminish access to human-delivered care. Reliance on AI tools may have other unanticipated adverse consequences on clinical practice, including diminished human clinician skill. The probabilistic nature of many of these tools, including large language models, makes their capacity to cause harm difficult to determine. Conclusions and Relevance The likely benefits of AI for psychiatric care delivery must be balanced against substantial risks. Strategies to mitigate this risk may require regulation to enhance transparency and systematically evaluate the impact of AI in practice, as well as clinician training to make optimal use of these emerging methods. 34:T972,Although most patients with chronic constipation respond to medical therapy, a subset experiences refractory constipation (RC), which poses unique diagnostic and therapeutic challenges. Because RC is relatively rare, clinicians should systematically (1) exclude correctable secondary causes such as medications, neurologic disorders, and defecatory disorders (DDs); (2) confirm the presence of slow colonic transit; and (3) ensure that patients have undergone adequate trials of over-the-counter and Food and Drug Administration-approved medications and nonpharmacologic therapies, including combinations thereof. Surgical treatments, such as colectomy, may be considered in patients who fail available treatments. However, surgical treatment of chronic constipation is associated with increased risk of complications and a not insignificant number of unsatisfactory outcomes. Prior to advising surgery, it is essential to confirm slow colonic transit, exclude concurrent DDs, and evaluate for severe, symptomatic delays in gastric emptying or small bowel dysmotility. Psychological comorbidities may exacerbate symptoms and adversely affect surgical outcomes. Hence, preoperative psychological evaluation is also advisable to assess suitability for surgery. Relative contraindications to surgical treatment of RC include clinically significant upper-gut dysmotility, severe, untreated psychiatric disease, and predominant complaints of bloating and/or abdominal pain. In uncertain cases, a temporary diverting loop ileostomy may help predict the potential response to colectomy. A colectomy with ileorectal anastomosis should only be offered to patients without ongoing DDs. This expert review was commissioned and approved by the American Gastroenterological Association (AGA) Institute Clinical Practice Updates Committee and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership, and underwent internal peer review by the Clinical Practice Updates Committee and external peer review through standard procedures of Clinical Gastroenterology and Hepatology. These Best Practice Advice statements were drawn from a review of the published literature and from expert opinion. Because systematic reviews were not performed, these Best Practice Advice statements do not carry formal ratings of the quality of evidence or strength of the presented considerations.35:T5c2,Founders of quantum mechanics (QM) anticipated that revisions to classical physics due to strange elements of quantum reality, would necessitate similar changes in biology. Complexity theory, systems biology and quantum biology provide possible solutions indicating that subject/object separation is a useful fiction for reductive science. Direct correlates to such QM observational/measurement issues as Complementarity and Uncertainty may justify the introduction of an analog of Heisenberg's uncertainty and the Planck constant for living systems. The phase space of “adjacent possibles” for biological systems from which one “actual” is selected resembles the collapse of the QM wave function. Since biological systems are hierarchical, this occurs across organizational scales resulting in biological coherence. The location of a quantum/classical boundary is unclear due to complexity. Whether biological systems' characteristics arise directly from QM or are of a different origin remains unsettled. To combine non-linear with quantum properties across biological scales we propose the Method of Coherent Structures (MCS), developed for quantum many-body systems. In MCS, a higher-level scale provides a classical envelope for quantum fluctuations at the lower scale. It yields a seamless transition from non-linear classical fields to quantum excitations and accounts for the emergence of complexity by incorporating metabolic energy supply.36:Tb68,Menstrual disturbances are a common yet often overlooked feature of eating disorders, impacting individuals across diagnostic categories and age groups. This Matters Arising piece responds to Porter (2025), a survivor-led qualitative study highlighting that menstruation is often treated as a simple health indicator, with little attention to emotional or psychosocial aspects. Specifically, I discuss broader intersections between eating disorder pathology and menstrual health, including functional hypothalamic amenorrhea, oligomenorrhea and menopause-related changes, illustrating how menstrual irregularities reflect disruptions in hormonal and metabolic regulation and carry psychological and identity-related implications. Current clinical approaches frequently overlook these dimensions, focusing narrowly on the presence or absence of menstruation rather than holistic well-being. Drawing on research evidence and clinical experience, I recommend a patient-centred approach that includes routine assessment of menstrual history and symptoms, integration of menstrual considerations into nutritional, medical and psychological treatment plans and sensitive communication regarding emotional and identity-related experiences. Interdisciplinary collaboration and further research are essential to better understand menstrual experiences across the lifespan. Recognising menstrual health as a meaningful component of overall treatment can enhance recovery and provide more comprehensive, empathetic care. Menstrual health is an important but often overlooked part of care for people with eating disorders. This article responds to a recent survivor-led study by Porter (2025), which found that eating disorder inpatient services often viewed menstruation simply as a sign of physical recovery, with little attention to the emotional or personal meaning of these changes. Building on these findings, this Matters Arising article discusses how eating disorders can affect menstrual cycles in different ways, including missed or irregular periods (amenorrhea and oligomenorrhea respectively) and changes related to menopause. These menstrual disruptions are linked to changes in hormones, metabolism and mental health, and can influence how people feel about their bodies and recovery. Despite this, menstrual health is seemingly rarely discussed in a sensitive or holistic way in treatment. This Matters Arising article recommends that clinicians communicate about menstrual health more openly, assess it regularly and consider it in medical, nutritional and psychological care. A more compassionate and comprehensive approach could improve recovery and overall well-being for people with eating disorders. Collaboration between different health professionals and more research are much needed to better understand how menstrual health is affected by the various types of eating disorders at different stages of life.37:T423,Bronchopulmonary dysplasia (BPD) remains a prevalent and complex complication of preterm birth, yet current definitions fail to capture the heterogeneous and evolving nature of the disease. Longitudinal studies reveal persistent pulmonary disease throughout the lifespan. Despite progress in identifying phenotypes, biomarkers to characterize disease endotypes to guide effective and precise therapies remain elusive. Precision medicine approaches, including multicenter deep phenotyping and integration of multi-omic data, are essential to identify meaningful disease subtypes that inform individualized care. This perspective traces the evolution of BPD definitions, outlines their limitations, and presents a path forward focused on collaborative data networks, enriched trial designs, and longitudinal outcome measures. Recognizing BPD and subsequent cardiopulmonary disease related to prematurity as a lifelong disease, not just a NICU outcome, is critical to improving long-term care and developing targeted interventions for this vulnerable population.38:T5fc,Neuroscience thrives on diversity-not only in the questions it asks but also in the models it uses to explore them. Across the field, different animal models have played pivotal roles in uncovering the principles governing brain function, development, and disease. Yet, the choice of model organisms remains a subject of debate. This editorial highlights the importance of embracing a wide range of animal models in neuroscience research. Each model offers unique strengths aligned with particular experimental approaches and scientific questions, contributing complementary insights that no single species alone can provide. By leveraging this diversity, we can achieve a more comprehensive understanding of the brain across levels of organization, from molecular pathways to behavioral outputs at the organismal level. Beyond the scientific advantages, we also discuss ethical and practical considerations: A diverse approach can promote responsible animal use by tailoring species choice to specific research goals. It can also foster environmental sustainability by avoiding unnecessary duplication of effort and resources. We call on neuroscientists to reflect on the value of integrating insights across species and experimental approaches. By moving beyond entrenched preferences and disciplinary silos, the field can unlock new opportunities for discovery. In championing the use of diverse animal models, we aim to inspire a more inclusive, efficient, and impactful neuroscience that rises to the complexity of its subject.39:T643,ABSTRACT Neuroscience thrives on diversity—not only in the questions it asks but also in the models it uses to explore them. Across the field, different animal models have played pivotal roles in uncovering the principles governing brain function, development, and disease. Yet, the choice of model organisms remains a subject of debate. This editorial highlights the importance of embracing a wide range of animal models in neuroscience research. Each model offers unique strengths aligned with particular experimental approaches and scientific questions, contributing complementary insights that no single species alone can provide. By leveraging this diversity, we can achieve a more comprehensive understanding of the brain across levels of organization, from molecular pathways to behavioral outputs at the organismal level. Beyond the scientific advantages, we also discuss ethical and practical considerations: A diverse approach can promote responsible animal use by tailoring species choice to specific research goals. It can also foster environmental sustainability by avoiding unnecessary duplication of effort and resources. We call on neuroscientists to reflect on the value of integrating insights across species and experimental approaches. By moving beyond entrenched preferences and disciplinary silos, the field can unlock new opportunities for discovery. In championing the use of diverse animal models, we aim to inspire a more inclusive, efficient, and impactful neuroscience that rises to the complexity of its subject.25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Expert Opinion/Editorial: study design Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Expert Opinion/Editorial (study design). Clinician-written summaries and actionable practice insights. 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'Clinical Practice Guidelines'; level of evidence assigned as 5 (expert opinion) accordingly.","value_numeric":null},{"paper_doi":"10.1182/blood.2025029923","tag_type":"warning","value":"The authors explicitly note that clinical significance of clonal hematopoiesis in BMF is 'not well established,' limiting strength of recommendations.","value_numeric":null},{"paper_doi":"10.1182/blood.2025029923","tag_type":"warning","value":"This is a 'How I' expert narrative review, not a primary research study — no original patient cohort or statistical outcomes are reported.","value_numeric":null}],"summaries":{"key_result":"Disease-specific clonal hematopoiesis (CH) signatures differ across hypocellular BMF etiologies and can help distinguish IAA from MDS-h and IBMFS; somatic alterations also estimate risk for secondary myeloid neoplasms and may inform early therapeutic intervention.","what_studied":"A narrative review on how somatic alterations—clonal hematopoiesis from somatic mutations or chromosomal abnormalities—can aid diagnosis, risk stratification, and therapy decisions in hypocellular bone marrow failure, including immune aplastic anemia, hypoplastic MDS, and inherited bone marrow failure syndromes.","limitations":"This is an expert review without reported quantitative outcomes; the abstract does not specify mutation patterns, thresholds, or comparative performance metrics.","practice_takeaway":"In hypocellular marrow failure, incorporate testing for somatic mutations and cytogenetic changes to help distinguish immune AA, MDS-h, and IBMFS, estimate risk for secondary myeloid neoplasms, and guide surveillance; in select cases, results may support earlier therapy."}},{"doi":"10.1038/s43018-025-01110-1","pmid":"41545715","title":"Glucagon-like peptide-1 medicines and cancer","journal_title":"Nature 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GLP-1 medicines acting through weight loss-dependent and weight loss-independent mechanisms hold potential for suppression of tumorigenesis and reduction of rates of obesity-associated cancer. In this Perspective, we summarize data on cancer incidence from trials and registries in individuals with type 2 diabetes, describe the actions of GLP-1 medicines on preclinical cancer models and highlight possible direct and indirect mechanisms linking GLP-1R signaling to cancer development and progression.","keywords":[],"pubmed_id":"41545715","conclusions":"","publication_date":"2026-01-17T00:00:00"},"crossref":{"DOI":"10.1038/s43018-025-01110-1","URL":"https://doi.org/10.1038/s43018-025-01110-1","ISSN":["2662-1347"],"link":[{"URL":"https://www.nature.com/articles/s43018-025-01110-1.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://www.nature.com/articles/s43018-025-01110-1","content-type":"text/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https://www.nature.com/articles/s43018-025-01110-1.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Glucagon-like peptide-1 medicines and cancer"],"author":[{"given":"Julian M.","family":"Yabut","sequence":"first","affiliation":[]},{"given":"Daniel J.","family":"Drucker","sequence":"additional","affiliation":[]}],"issued":{"date-parts":[[2026,1,16]]},"member":"297","prefix":"10.1038","source":"Crossref","volume":null,"created":{"date-time":"2026-01-16T10:02:52Z","timestamp":1768557772000,"date-parts":[[2026,1,16]]},"indexed":{"date-time":"2026-01-16T21:41:51Z","timestamp":1768599711270,"date-parts":[[2026,1,16]]},"license":[{"URL":"https://www.springernature.com/gp/researchers/text-and-data-mining","start":{"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000,"date-parts":[[2026,1,16]]},"delay-in-days":0,"content-version":"tdm"},{"URL":"https://www.springernature.com/gp/researchers/text-and-data-mining","start":{"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000,"date-parts":[[2026,1,16]]},"delay-in-days":0,"content-version":"vor"}],"subject":[],"abstract":null,"language":"en","relation":{},"resource":{"primary":{"URL":"https://www.nature.com/articles/s43018-025-01110-1"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"ArticleHistory","label":"Article History"},"label":"Received","order":1,"value":"21 January 2025"},{"name":"accepted","group":{"name":"ArticleHistory","label":"Article History"},"label":"Accepted","order":2,"value":"9 December 2025"},{"name":"first_online","group":{"name":"ArticleHistory","label":"Article History"},"label":"First Online","order":3,"value":"16 January 2026"},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"},"order":1,"value":"J.M.Y. has no competing interests or conflict of interest. D.J.D. has served as a consultant or speaker within the past 12 months to Alnylam, Amgen, AstraZeneca, Crinetics, Eli Lilly, General Medicines Inc., Kallyope, Metsera, Novo Nordisk, Pfizer Protagonist Therapeutivs Inc and Sanofi. Neither D.J.D. nor his family members hold issued stock directly or indirectly in any of these companies. D.J.D. holds nonexercised options in Kallyope. Mt. Sinai Hospital receives grant support from Amgen, Eli Lilly and Zealand Pharma for preclinical studies in the laboratory of D.J.D."}],"deposited":{"date-time":"2026-01-16T10:02:58Z","timestamp":1768557778000,"date-parts":[[2026,1,16]]},"issn-type":[{"type":"electronic","value":"2662-1347"}],"published":{"date-parts":[[2026,1,16]]},"publisher":"Springer Science and Business Media LLC","reference":[{"DOI":"10.2337/dc20-0204","key":"1110_CR1","year":"2020","issue":null,"author":"S Ling","volume":"43","first-page":"2313","unstructured":"Ling, S. et al. 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Teamwork on the fly n.d.","article-title":null,"journal-title":null,"doi-asserted-by":null}],"short-title":[],"update-policy":"https://doi.org/10.1016/elsevier_cm_policy","alternative-id":["S0300957226000055"],"article-number":"110960","content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resuscitationjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"original-title":[],"container-title":["Resuscitation"],"published-print":{"date-parts":[[2026,1]]},"reference-count":30,"published-online":null,"references-count":30,"short-container-title":["Resuscitation"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1016/j.resuscitation.2026.110960","is_oa":false,"title":"Survival on the Clock: Rethinking Where and How We Deliver ECPR","updated":"2026-01-10T04:46:20+00:00","published_date":"2026-01-01","best_oa_location":null}},"created_at":"2026-01-14T18:30:49.575Z","updated_at":"2026-01-14T18:30:49.575Z","tags":[{"paper_doi":"10.1016/j.resuscitation.2026.110960","tag_type":"category","value":"Emergency Medicine","value_numeric":null},{"paper_doi":"10.1016/j.resuscitation.2026.110960","tag_type":"condition","value":"Refractory Cardiac Arrest","value_numeric":null},{"paper_doi":"10.1016/j.resuscitation.2026.110960","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1016/j.resuscitation.2026.110960","tag_type":"level_of_evidence","value":"7","value_numeric":null},{"paper_doi":"10.1016/j.resuscitation.2026.110960","tag_type":"modality","value":"Extracorporeal Cardiopulmonary Resuscitation","value_numeric":null},{"paper_doi":"10.1016/j.resuscitation.2026.110960","tag_type":"study_design","value":"Expert Opinion/Editorial","value_numeric":null},{"paper_doi":"10.1016/j.resuscitation.2026.110960","tag_type":"warning","value":"Conceptual systems proposal without reported outcomes; classification as editorial/expert opinion is inferred.","value_numeric":null},{"paper_doi":"10.1016/j.resuscitation.2026.110960","tag_type":"warning","value":"No sample size or quantitative results are provided in the abstract.","value_numeric":null}],"summaries":{"what_studied":"A systems model for delivering ECPR that targets achieving ECMO flow within about 45 minutes of collapse. It specifies strike team-style units, parallel activation pathways, and preset deployment and transport plans regardless of cannulation site, with potential AI-enabled dispatch and decision support.","limitations":"This is a proposed model with no patient-level outcomes or comparative evaluation. The AI elements are suggested but not tested.","practice_takeaway":"When building or revising ECPR programs, design workflows to reach ECMO flow in ~45 minutes using organized teams, parallel activation, and predefined deployment/transport pathways independent of cannulation site. Consider AI-enabled dispatch and decision support as emerging tools, not proven standards."}},{"doi":"10.22514/sv.2026.006","pmid":null,"title":"The lethal diamond of AI issue in critical care medicine: Great Power, Great Risk","journal_title":"Signa Vitae","journal_issn":"1334-5605","published_at":"2026-01-08T00:00:00.000Z","url":"https://doi.org/10.22514/sv.2026.006","source_score":1,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-01-09","doi":"10.22514/sv.2026.006","days":"7","issn":"1334-5605","rank":"10","field":"Clinical Medicine","score":"1","category":"Emergency Medicine","categories":["Emergency Medicine"],"_categories":["Emergency Medicine"]},"pubmed":null,"crossref":{"DOI":"10.22514/sv.2026.006","URL":"https://doi.org/10.22514/sv.2026.006","ISSN":["1334-5605","1845-206X"],"page":"141","type":"journal-article","issue":null,"score":1,"title":["The lethal diamond of AI issue in critical care medicine: Great Power, Great Risk"],"author":[{"given":"Elena G.","family":"Bignami","sequence":"first","affiliation":[{"name":"University of Parma"}]},{"given":"Roberto","family":"Lanza","sequence":"additional","affiliation":[{"name":"University of Parma"}]},{"given":"Michele","family":"Russo","sequence":"additional","affiliation":[{"name":"University of Parma"}]},{"given":"Valentina","family":"Bellini","sequence":"additional","affiliation":[{"name":"University of Parma"}]}],"issued":{"date-parts":[[2026,1,8]]},"member":"26027","prefix":"10.22514","source":"Crossref","volume":null,"created":{"date-time":"2026-01-08T05:21:44Z","timestamp":1767849704000,"date-parts":[[2026,1,8]]},"indexed":{"date-time":"2026-01-08T10:49:50Z","timestamp":1767869390699,"date-parts":[[2026,1,8]]},"subject":[],"abstract":"The integration of artificial intelligence (AI) into critical care promises transformative advancements in diagnostics, treatment, and resource allocation. However, the realization of AI’s potential is hampered by critical gaps in data quality, ethical considerations, clinician education, and validation. This article introduces the “Lethal Diamond” framework, expanding on the traditional “Lethal Triad”, to encompass these interconnected challenges that threaten AI’s safe and effective deployment in high-stake critical care settings. It further proposes a shift from the reactive approach of “Garbage In, Garbage Out” (GIGO) to a proactive “Digging In, Diamonds Out” (DIDO) paradigm to cultivate excellence in AI implementation, ensuring AI systems enhance and augment, rather than undermine, healthcare delivery.","relation":{},"resource":{"primary":{"URL":"https://www.signavitae.com/articles/10.22514/sv.2026.006"}},"subtitle":[],"deposited":{"date-time":"2026-01-08T05:21:47Z","timestamp":1767849707000,"date-parts":[[2026,1,8]]},"issn-type":[{"type":"print","value":"1334-5605"},{"type":"electronic","value":"1845-206X"}],"published":{"date-parts":[[2026,1,8]]},"publisher":"MRE Press","reference":null,"short-title":[],"content-domain":{"domain":[],"crossmark-restriction":false},"original-title":[],"container-title":["Signa Vitae"],"published-print":{"date-parts":[[2026,1,8]]},"reference-count":0,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2026,1,8]]},"references-count":0,"short-container-title":[],"is-referenced-by-count":0},"unpaywall":{"doi":"10.22514/sv.2026.006","is_oa":true,"title":"The lethal diamond of AI issue in critical care medicine: Great Power, Great Risk","updated":"2026-01-10T04:46:20+00:00","published_date":"2026-01-08","best_oa_location":{"url":"https://doi.org/10.22514/sv.2026.006","pmh_id":null,"url_for_pdf":null,"url_for_landing_page":"https://doi.org/10.22514/sv.2026.006"}}},"created_at":"2026-01-16T11:56:46.634Z","updated_at":"2026-01-16T11:56:46.634Z","tags":[{"paper_doi":"10.22514/sv.2026.006","tag_type":"category","value":"Emergency Medicine","value_numeric":null},{"paper_doi":"10.22514/sv.2026.006","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.22514/sv.2026.006","tag_type":"level_of_evidence","value":"7","value_numeric":null},{"paper_doi":"10.22514/sv.2026.006","tag_type":"study_design","value":"Expert Opinion/Editorial","value_numeric":null},{"paper_doi":"10.22514/sv.2026.006","tag_type":"warning","value":"Conceptual narrative piece; no primary data or outcomes are reported.","value_numeric":null},{"paper_doi":"10.22514/sv.2026.006","tag_type":"warning","value":"Implementation examples are drawn from other studies and not evaluated within this framework.","value_numeric":null},{"paper_doi":"10.22514/sv.2026.006","tag_type":"warning","value":"Study design labeled as Expert Opinion/Editorial based on content description.","value_numeric":null}],"summaries":{"what_studied":"A conceptual framework (“Lethal Diamond”) for safe AI use in critical care, adding external validation/implementation to the prior triad of data quality, ethics/legal, and clinician education, and proposing a proactive “DIDO” (Digging In, Diamonds Out) approach to guide deployment.","limitations":"This is a viewpoint without new empirical data or quantified outcomes. Examples cited (ECG triage, sepsis prediction, ambient AI scribes) are external and not tested within this framework.","practice_takeaway":"When considering AI in the ICU, require high-quality curated data, ethical and legal guardrails, clinician AI literacy, and rigorous external validation with clear implementation protocols; use DIDO steps to structure adoption."}},{"doi":"10.1038/s41433-025-04197-z","pmid":"41501285","title":"Horizon scanning from panel discussions at the EUGOGO Global TED Forum 2025 London","journal_title":"Eye","journal_issn":"0950-222X","published_at":"2026-01-08T00:00:00.000Z","url":"https://doi.org/10.1038/s41433-025-04197-z","source_score":2,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-01-08","doi":"10.1038/s41433-025-04197-z","days":"7","issn":"0950-222X","rank":"10","field":"Clinical Medicine","score":"2","category":"Ophthalmology","categories":["Ophthalmology"],"_categories":["Ophthalmology"]},"pubmed":{"doi":"10.1038/s41433-025-04197-z","title":"Horizon scanning from panel discussions at the EUGOGO Global TED Forum 2025 London.","journal":"Eye (London, England)","methods":"","results":"","abstract":"","keywords":[],"pubmed_id":"41501285","conclusions":"","publication_date":"2026-01-08T00:00:00"},"crossref":{"DOI":"10.1038/s41433-025-04197-z","URL":"https://doi.org/10.1038/s41433-025-04197-z","ISSN":["0950-222X","1476-5454"],"link":[{"URL":"https://www.nature.com/articles/s41433-025-04197-z.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https://www.nature.com/articles/s41433-025-04197-z","content-type":"text/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https://www.nature.com/articles/s41433-025-04197-z.pdf","content-type":"application/pdf","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":null,"score":1,"title":["Horizon scanning from panel discussions at the EUGOGO Global TED Forum 2025 London"],"author":[{"given":"Vickie","family":"Lee","sequence":"first","affiliation":[]},{"given":"Mario","family":"Salvi","sequence":"additional","affiliation":[]},{"given":"Anja","family":"Eckstein","sequence":"additional","affiliation":[]},{"given":"Colin","family":"Dayan","sequence":"additional","affiliation":[]},{"given":"Karim","family":"Meeran","sequence":"additional","affiliation":[]}],"issued":{"date-parts":[[2026,1,7]]},"member":"297","prefix":"10.1038","source":"Crossref","volume":null,"created":{"date-time":"2026-01-07T07:11:59Z","timestamp":1767769919000,"date-parts":[[2026,1,7]]},"indexed":{"date-time":"2026-01-07T12:40:36Z","timestamp":1767789636026,"date-parts":[[2026,1,7]]},"license":[{"URL":"https://creativecommons.org/licenses/by/4.0","start":{"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000,"date-parts":[[2026,1,7]]},"delay-in-days":0,"content-version":"tdm"},{"URL":"https://creativecommons.org/licenses/by/4.0","start":{"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000,"date-parts":[[2026,1,7]]},"delay-in-days":0,"content-version":"vor"}],"subject":[],"abstract":null,"language":"en","relation":{},"resource":{"primary":{"URL":"https://www.nature.com/articles/s41433-025-04197-z"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"ArticleHistory","label":"Article History"},"label":"Received","order":1,"value":"15 November 2025"},{"name":"revised","group":{"name":"ArticleHistory","label":"Article History"},"label":"Revised","order":2,"value":"1 December 2025"},{"name":"accepted","group":{"name":"ArticleHistory","label":"Article History"},"label":"Accepted","order":3,"value":"15 December 2025"},{"name":"first_online","group":{"name":"ArticleHistory","label":"Article History"},"label":"First Online","order":4,"value":"7 January 2026"},{"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"},"order":1,"value":"Sponsors of the EUGOGO Global TED Forum included. Acelyrin (Alumis). Amgen Inc. Argenx. IMVT Therapeutics. Kriya Therapeutics. Ollin Biosciences. Roche. Shanghai Bayi. Sling Therapeutics. Thyroscope. Viridian Therapeutics.\n Individual Authors COI\n . CD Consultancy advice for Horizon AE received consulting fees from Therapeutics/Amgen, Lassen Therapeutics Roche and Lundbeck A/S. Horizon, Amgen, Viridian Roche and the Aspen Trust; and Honoraria from Horizon, the European Society of Ophthalmic Plastic Reconstructive Surgery, Sanofi, and Henning. MS BSA Institut Biochimie Valenza-Bio Roche -Institutional Funding. Horizon/Amgen Institutional Funding. VL Consultancy Advice for Horizon, Amgen, Viridian Roche Argenx. Institutional funding from Horizon, Amgen, Viridian Argenx Lassen & Sling Therapeutics. AE Consultancy Advice for Horizon, Amgen, Viridian, Roche, Argenx, Institutional funding Argenx, Sling Therapeutics, Sanofi."}],"deposited":{"date-time":"2026-01-07T07:11:59Z","timestamp":1767769919000,"date-parts":[[2026,1,7]]},"issn-type":[{"type":"print","value":"0950-222X"},{"type":"electronic","value":"1476-5454"}],"published":{"date-parts":[[2026,1,7]]},"publisher":"Springer Science and Business Media LLC","reference":null,"short-title":[],"update-policy":"https://doi.org/10.1007/springer_crossmark_policy","alternative-id":["4197"],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"original-title":[],"container-title":["Eye"],"reference-count":0,"published-online":{"date-time":null,"timestamp":null,"date-parts":[[2026,1,7]]},"references-count":0,"short-container-title":["Eye"],"is-referenced-by-count":0},"unpaywall":{"doi":"10.1038/s41433-025-04197-z","is_oa":true,"title":"Horizon scanning from panel discussions at the EUGOGO Global TED Forum 2025 London","updated":"2026-01-10T04:46:20+00:00","published_date":"2026-01-07","best_oa_location":{"url":"https://www.nature.com/articles/s41433-025-04197-z.pdf","pmh_id":null,"url_for_pdf":"https://www.nature.com/articles/s41433-025-04197-z.pdf","url_for_landing_page":"https://doi.org/10.1038/s41433-025-04197-z"}}},"created_at":"2026-01-11T11:19:33.869Z","updated_at":"2026-01-11T11:19:33.869Z","tags":[{"paper_doi":"10.1038/s41433-025-04197-z","tag_type":"age_group","value":"mixed","value_numeric":null},{"paper_doi":"10.1038/s41433-025-04197-z","tag_type":"category","value":"Ophthalmology","value_numeric":null},{"paper_doi":"10.1038/s41433-025-04197-z","tag_type":"condition","value":"Thyroid Eye Disease","value_numeric":null},{"paper_doi":"10.1038/s41433-025-04197-z","tag_type":"generic","value":"belimumab","value_numeric":null},{"paper_doi":"10.1038/s41433-025-04197-z","tag_type":"generic","value":"rituximab","value_numeric":null},{"paper_doi":"10.1038/s41433-025-04197-z","tag_type":"generic","value":"teprotumumab","value_numeric":null},{"paper_doi":"10.1038/s41433-025-04197-z","tag_type":"generic","value":"tocilizumab","value_numeric":null},{"paper_doi":"10.1038/s41433-025-04197-z","tag_type":"impact_flag","value":"safety_signal","value_numeric":null},{"paper_doi":"10.1038/s41433-025-04197-z","tag_type":"level_of_evidence","value":"7","value_numeric":null},{"paper_doi":"10.1038/s41433-025-04197-z","tag_type":"modality","value":"Anti-CD20 Antibody","value_numeric":null},{"paper_doi":"10.1038/s41433-025-04197-z","tag_type":"modality","value":"FcRn Inhibitor","value_numeric":null},{"paper_doi":"10.1038/s41433-025-04197-z","tag_type":"modality","value":"IGF-1R Inhibitor","value_numeric":null},{"paper_doi":"10.1038/s41433-025-04197-z","tag_type":"modality","value":"IL-6 Inhibitor","value_numeric":null},{"paper_doi":"10.1038/s41433-025-04197-z","tag_type":"modality","value":"Orbital Radiotherapy","value_numeric":null},{"paper_doi":"10.1038/s41433-025-04197-z","tag_type":"study_design","value":"Expert Opinion/Editorial","value_numeric":null},{"paper_doi":"10.1038/s41433-025-04197-z","tag_type":"warning","value":"Industry sponsorship and author conflicts were disclosed; interpret therapeutic recommendations with caution.","value_numeric":null},{"paper_doi":"10.1038/s41433-025-04197-z","tag_type":"warning","value":"Many statements lack quantitative estimates and reflect consensus opinion.","value_numeric":null},{"paper_doi":"10.1038/s41433-025-04197-z","tag_type":"warning","value":"This is an editorial summary of expert discussions, not a primary study or guideline.","value_numeric":null}],"summaries":{"what_studied":"Commentary summarizing panel and round‑table discussions from the 2025 EUGOGO Global TED Forum on unmet needs, future directions, and practical strategies in Thyroid Eye Disease.","key_result":"Experts prioritized diplopia as the key patient‑centred outcome and endorsed more objective orthoptic measures over the Gorman score. They highlighted uncommon but clinically important permanent sensorineural hearing loss with IGF‑1R antagonists (often unilateral, high‑frequency) with advice for urgent audiometry and drug cessation if suspected, suggested a 6–12‑month (≈1‑year safer) interval before rehabilitative surgery after teprotumumab, and noted that orbital radiotherapy can be given after teprotumumab.","limitations":"Consensus opinions from a sponsored forum without new comparative or quantitative data; guidance may be influenced by disclosed conflicts of interest.","practice_takeaway":"Counsel patients on IGF‑1R inhibitors about hearing loss, arrange urgent audiometry for symptoms, and stop treatment if detected. Use objective diplopia metrics and, after teprotumumab, plan elective rehabilitative surgery at roughly 6–12 months when feasible; consider orbital radiotherapy where appropriate."}},{"doi":"10.1016/j.cgh.2025.09.031","pmid":"41504675","title":"AGA Clinical Practice Update on Evaluation and Management of Refractory Constipation: Expert Review","journal_title":"Clinical Gastroenterology and Hepatology","journal_issn":"1542-3565","published_at":"2026-01-08T00:00:00.000Z","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12788801/","source_score":101,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-01-09","doi":"10.1016/j.cgh.2025.09.031","days":"14","issn":"1542-3565","rank":"4","field":"Clinical Medicine","score":"101","category":"Gastroenterology & Hepatology","categories":["Gastroenterology & Hepatology"],"_categories":["Gastroenterology & Hepatology"]},"pubmed":{"doi":"10.1016/j.cgh.2025.09.031","title":"AGA Clinical Practice Update on Evaluation and 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Absolute differences were small: angiography cohort AMD 2.1% with AF vs 1.2% without over 5.9 years, and in Taiwan AF incidence 9.85% with AMD vs 8.95% without while AMD was 11.98% with AF vs 10.88% without; dry AMD carried HR 1.09 (95% CI 1.02–1.16) and wet AMD HR 0.94 (0.74–1.19), with an estimated excess of ~1.0–1.1 cases per 1000 patient‑years; after adjustment for CHA2DS2‑VASc components and cardiovascular medications, some associations were no longer significant at 1 or 5 years.","limitations":"Detection bias is likely because AF and AMD patients have more comorbidities and clinic visits; follow‑up (~6.4 years) may be too short to capture dry AMD onset; findings from an East Asian cohort may not generalize, and claims‑based definitions lacked AMD/AF subtyping in places.","practice_takeaway":"For older adults with AF and multiple comorbidities, consider simple vision checks and counsel on early wet AMD symptoms (metamorphopsia, central blur), while prioritizing shared risk‑factor control (smoking, BP, diabetes, lipids). Given the small absolute risk and attenuation after adjustment, routine AMD screening solely due to AF is not supported by current evidence."}}],"initialOffset":60,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"study_design","value":"Expert Opinion/Editorial"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Study Designs","href":"/hub/tag/study_design"},{"name":"Expert Opinion/Editorial"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"study_design","hub_tag_value":"Expert Opinion/Editorial"}}}]]

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