2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T7bf,Providing lethal means counseling to caregivers is an underutilized component of emergency department (ED)-based suicide prevention. We assessed the feasibility and acceptability of Lock and Protect, a web-based lethal means counseling decision aid, among caregivers of adolescents who presented to the ED for self-injurious and/or suicidal thoughts and behaviors. We conducted a pilot feasibility study of caregiver-adolescent dyads in a pediatric ED. Adolescents were 13-17 years old with current suicidal ideation, suicide attempt, or non-suicidal self-injury. Caregivers received the Lock and Protect intervention plus usual care while their child was in the ED. Feasibility was measured via enrollment rates, duration of time caregivers interacted with Lock and Protect, and tool completion rates. Caregiver acceptability was measured with the Ottawa Acceptability Scale. Follow-up assessments measured changes in home storage at 2- and 4-weeks after enrollment. Of 47 caregivers screened and eligible, 40 enrolled (85.1%), of whom 39/40 and 1/40 reported home access to medications and firearms, respectively. Caregivers found Lock and Protect respectful of their family values about medications (100%) and firearms (97.5%). Almost all caregivers (95.0%) reported the length was "just right" and 92.5% reported the amount of information was "just right". All caregivers completed the tool in the ED, using it for a mean of 8 min (SD = 3.4 min). All would recommend the tool to others. Ottawa Acceptability Scale scores demonstrated that 95.0% of caregivers found the options in Lock and Protect realistic, and 97.5% found the tool useful for changing home medication access. Follow-up was completed for 77.5% of caregivers, with 20/31 (64.5%) reporting safer home storage of medications. Lock and Protect, a web-based lethal means counseling decision aid, was feasible to administer in the pediatric ED and acceptable to caregivers of adolescents at risk for suicide.31:Ta5c,ABSTRACT Background Providing lethal means counseling to caregivers is an underutilized component of emergency department (ED)‐based suicide prevention. We assessed the feasibility and acceptability of Lock and Protect, a web‐based lethal means counseling decision aid, among caregivers of adolescents who presented to the ED for self‐injurious and/or suicidal thoughts and behaviors. Methods We conducted a pilot feasibility study of caregiver‐adolescent dyads in a pediatric ED. Adolescents were 13–17 years old with current suicidal ideation, suicide attempt, or non‐suicidal self‐injury. Caregivers received the Lock and Protect intervention plus usual care while their child was in the ED. Feasibility was measured via enrollment rates, duration of time caregivers interacted with Lock and Protect, and tool completion rates. Caregiver acceptability was measured with the Ottawa Acceptability Scale. Follow‐up assessments measured changes in home storage at 2‐ and 4‐weeks after enrollment. Results Of 47 caregivers screened and eligible, 40 enrolled (85.1%), of whom 39/40 and 1/40 reported home access to medications and firearms, respectively. Caregivers found Lock and Protect respectful of their family values about medications (100%) and firearms (97.5%). Almost all caregivers (95.0%) reported the length was “just right” and 92.5% reported the amount of information was “just right”. All caregivers completed the tool in the ED, using it for a mean of 8 min (SD = 3.4 min). All would recommend the tool to others. Ottawa Acceptability Scale scores demonstrated that 95.0% of caregivers found the options in Lock and Protect realistic, and 97.5% found the tool useful for changing home medication access. Follow‐up was completed for 77.5% of caregivers, with 20/31 (64.5%) reporting safer home storage of medications. Conclusions Lock and Protect, a web‐based lethal means counseling decision aid, was feasible to administer in the pediatric ED and acceptable to caregivers of adolescents at risk for suicide. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Pilot Feasibility Study: study design Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Pilot Feasibility Study (study design). Clinician-written summaries and actionable practice insights. 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the full text was not provided, so specific numerical results, sample size, and participant sex could not be extracted.","value_numeric":null}],"summaries":{"what_studied":"This pilot feasibility study evaluated affective and motivational responses in music therapy trainees when using immersive virtual reality (VR) compared to acoustic instruments as therapeutic modalities.","limitations":"Pilot feasibility design limits generalizability; trainee sample may not reflect clinical patient populations; small sample size typical of feasibility studies constrains statistical power.","practice_takeaway":"Findings are preliminary; clinicians considering VR tools in music therapy training should await larger controlled trials before adopting them as standard alternatives to acoustic instruments."}},{"doi":"10.1080/19490976.2026.2675764","pmid":"42157481","title":"Minimally invasive capsule-string device enables spatially resolved microbiome profiling across the upper gastrointestinal tract","journal_title":"Gut Microbes","journal_issn":"1949-0976","published_at":"2026-05-19T00:00:00.000Z","url":"https://doi.org/10.1080/19490976.2026.2675764","source_score":28,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-11T13:43:02.466Z","updated_at":"2026-06-11T13:43:02.466Z","tags":[{"paper_doi":"10.1080/19490976.2026.2675764","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1080/19490976.2026.2675764","tag_type":"brand","value":"EnteroTracker","value_numeric":null},{"paper_doi":"10.1080/19490976.2026.2675764","tag_type":"category","value":"Gastroenterology & Hepatology","value_numeric":null},{"paper_doi":"10.1080/19490976.2026.2675764","tag_type":"condition","value":"Gastrointestinal Dysbiosis","value_numeric":null},{"paper_doi":"10.1080/19490976.2026.2675764","tag_type":"condition","value":"Upper Gastrointestinal Microbiome","value_numeric":null},{"paper_doi":"10.1080/19490976.2026.2675764","tag_type":"generic","value":"capsule-string device","value_numeric":null},{"paper_doi":"10.1080/19490976.2026.2675764","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1080/19490976.2026.2675764","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.1080/19490976.2026.2675764","tag_type":"modality","value":"Microbiome Sampling Device","value_numeric":null},{"paper_doi":"10.1080/19490976.2026.2675764","tag_type":"sample_size","value":"n=24","value_numeric":24},{"paper_doi":"10.1080/19490976.2026.2675764","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1080/19490976.2026.2675764","tag_type":"study_design","value":"Pilot Feasibility Study","value_numeric":null},{"paper_doi":"10.1080/19490976.2026.2675764","tag_type":"warning","value":"No direct validation against endoscopic biopsy or aspiration was performed; compartment assignments were operationally defined using physiologic markers only.","value_numeric":null},{"paper_doi":"10.1080/19490976.2026.2675764","tag_type":"warning","value":"Pilot study with only 24 participants; findings should be considered hypothesis-generating and not definitive normative data.","value_numeric":null},{"paper_doi":"10.1080/19490976.2026.2675764","tag_type":"warning","value":"Publication date is 2026; this is a recent paper and independent replication has not yet been reported.","value_numeric":null},{"paper_doi":"10.1080/19490976.2026.2675764","tag_type":"warning","value":"Several authors hold equity interests in or serve as consultants for EnteroTrack LLC (the device manufacturer), representing a potential conflict of interest.","value_numeric":null},{"paper_doi":"10.1080/19490976.2026.2675764","tag_type":"warning","value":"Study population limited to healthy adults aged 18–64 at a single US center and single timepoint; generalizability to disease populations or other demographics is unknown.","value_numeric":null}],"summaries":{"what_studied":"A pilot study in 24 healthy adults evaluated a minimally invasive capsule-string device (EnteroTracker®, 140-cm extended version) for spatially resolved microbiome profiling across the esophagus, stomach, duodenum, and jejunum using 16S rRNA gene sequencing, with a ~3-hour dwell time.","key_result":"The device was completed without adverse events by all 24 participants (100%); 96% were willing to repeat it. Compartment-level bacterial load and community composition differed significantly across regions: esophagus had the highest bacterial load (LSM log₁₀ 5.94 ± 0.12 copies/reaction) vs. stomach (4.45), duodenum (4.89), and jejunum (4.74; all p < 0.001 vs. esophagus). Host identity explained 62.8–78.3% of beta-diversity variance vs. 5.4–8.7% for anatomical site, yet regional effects remained significant across all five diversity metrics (all p = 0.001 in partial PERMANOVA).","limitations":"- Anatomical localization relied on pH, bile staining, and string length rather than concurrent imaging or endoscopy, so some compartment misassignment cannot be excluded.\n- Small single-timepoint cohort of healthy adults only; no direct comparison with aspirate or biopsy.\n- 16S rRNA sequencing limits strain-level resolution and functional inference.","practice_takeaway":"For clinicians studying upper GI conditions (e.g., eosinophilic esophagitis, GERD, small-intestinal dysbiosis), this capsule-string approach offers a well-tolerated, endoscopy-free way to collect regionally resolved microbiome samples from esophagus through jejunum. It is best viewed as a complement to stool and biopsy, not a replacement, and appears suitable for longitudinal or large-scale studies where repeated endoscopy is impractical."}},{"doi":"10.1111/acem.70313","pmid":"42101340","title":"Lock and Protect, Reducing Access to Adolescent Means of Suicide: A Pilot Feasibility Study","journal_title":"Academic Emergency Medicine","journal_issn":"1069-6563","published_at":"2026-05-08T00:00:00.000Z","url":"https://doi.org/10.1111/acem.70313","source_score":3,"is_retracted":false,"is_open_access":false,"raw_metadata":{"ooir":{"day":"2026-05-09","doi":"10.1111/acem.70313","days":"7","issn":"1069-6563","rank":"4","field":"Clinical Medicine","score":"3","category":"Emergency Medicine","categories":["Emergency Medicine"],"_categories":["Emergency Medicine"]},"pubmed":{"doi":"10.1111/acem.70313","title":"Lock and Protect, Reducing Access to Adolescent Means of Suicide: A Pilot Feasibility Study.","journal":"Academic emergency medicine : official journal of the Society for Academic Emergency Medicine","methods":"","results":"Of 47 caregivers screened and eligible, 40 enrolled (85.1%), of whom 39/40 and 1/40 reported home access to medications and firearms, respectively. Caregivers found Lock and Protect respectful of their family values about medications (100%) and firearms (97.5%). Almost all caregivers (95.0%) reported the length was \"just right\" and 92.5% reported the amount of information was \"just right\". All caregivers completed the tool in the ED, using it for a mean of 8 min (SD = 3.4 min). All would recommend the tool to others. Ottawa Acceptability Scale scores demonstrated that 95.0% of caregivers found the options in Lock and Protect realistic, and 97.5% found the tool useful for changing home medication access. 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Over 60% of caregivers reported safer medication storage at follow-up, supporting its routine use as part of ED-based suicide prevention."}}],"initialOffset":3,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"study_design","value":"Pilot Feasibility Study"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Study Designs","href":"/hub/tag/study_design"},{"name":"Pilot Feasibility Study"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"study_design","hub_tag_value":"Pilot Feasibility Study"}}}]]

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