2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:T7b9,Botulinum toxin injections have transformed aesthetic treatments, improving patient confidence and emotional well-being. Eyebrow position plays a vital role in facial expression, yet botulinum toxin use in the forehead can cause issues like eyebrow ptosis or asymmetry. Recent research emphasizes the importance of a comprehensive pre-treatment assessment. The MOOSE technique, developed by the authors, incorporates new insights into muscle interactions to optimize botulinum toxin treatment for brow elevation while minimizing side effects like the omega sign. This study involved 202 patients (89.1% female, mean age 40) treated with the MOOSE technique, focusing on upper third facial wrinkles. Primary outcomes included brow position, forehead line severity, treatment duration, and patient satisfaction. Aesthetic outcomes were assessed using the Merz Aesthetic Scales (MAS) at baseline and at two weeks post-treatment, corresponding to the peak efficacy of the toxin. Patient satisfaction was evaluated at both the two-week and four-month follow-up. The MOOSE technique resulted in a significant improvement in brow position, with an average gain of 2 points on the MAS. Patient satisfaction was remarkably high, with 100% of patients reporting a positive outcome at 15 days and 99% at four months. The average botulinum toxin dosage was 66 units per patient (range: 54-78 units). No cases of brow or eyelid ptosis were observed, and only one patient (0.49%) experienced transient edema. Interrater reliability of evaluations was excellent, with intraclass correlation coefficients ranging from 0.94 to 1.00 across all measured outcomes. The MOOSE technique provides an anatomically guided approach to botulinum toxin injections, enhancing aesthetic results while reducing complications. Its effectiveness underscores the value of individualized treatment based on muscle dynamics. Further research is needed to refine its application and assess long-term effects.31:Ta47,ABSTRACT Introduction Botulinum toxin injections have transformed aesthetic treatments, improving patient confidence and emotional well‐being. Eyebrow position plays a vital role in facial expression, yet botulinum toxin use in the forehead can cause issues like eyebrow ptosis or asymmetry. Recent research emphasizes the importance of a comprehensive pre‐treatment assessment. The MOOSE technique, developed by the authors, incorporates new insights into muscle interactions to optimize botulinum toxin treatment for brow elevation while minimizing side effects like the omega sign. Methods This study involved 202 patients (89.1% female, mean age 40) treated with the MOOSE technique, focusing on upper third facial wrinkles. Primary outcomes included brow position, forehead line severity, treatment duration, and patient satisfaction. Aesthetic outcomes were assessed using the Merz Aesthetic Scales (MAS) at baseline and at two weeks post‐treatment, corresponding to the peak efficacy of the toxin. Patient satisfaction was evaluated at both the two‐week and four‐month follow‐up. Results The MOOSE technique resulted in a significant improvement in brow position, with an average gain of 2 points on the MAS. Patient satisfaction was remarkably high, with 100% of patients reporting a positive outcome at 15 days and 99% at four months. The average botulinum toxin dosage was 66 units per patient (range: 54–78 units). No cases of brow or eyelid ptosis were observed, and only one patient (0.49%) experienced transient edema. Interrater reliability of evaluations was excellent, with intraclass correlation coefficients ranging from 0.94 to 1.00 across all measured outcomes. Conclusion The MOOSE technique provides an anatomically guided approach to botulinum toxin injections, enhancing aesthetic results while reducing complications. Its effectiveness underscores the value of individualized treatment based on muscle dynamics. Further research is needed to refine its application and assess long‐term effects. 25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Prospective Case Series: study design Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Prospective Case Series (study design). Clinician-written summaries and actionable practice insights. 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Access-site complications occurred in 4% (pseudoaneurysms 1.5%, haematomas), with no arterial occlusions or surgical conversions.","limitations":"Single-arm, non-comparative design limits conclusions about superiority over standard closure approaches. The study is retrospective/feasibility in nature, so selection bias cannot be excluded. No prospective or randomised validation has been performed.","practice_takeaway":"For complex femoral access (heavy calcification, deep vessels, bifurcation variants), a structured ultrasound workflow with five defined checkpoints — from pre-access mapping through plug deployment and Doppler verification — can achieve high immediate haemostasis rates with low complication risk. Clinicians should consider extending ultrasound guidance beyond the puncture step to include anchor positioning and collagen release."}},{"doi":"10.1001/jamaophthalmol.2026.2245","pmid":"42348192","title":"Blood Pressure Assessment in Ophthalmology Clinics for Patients With Diabetes","journal_title":"JAMA Ophthalmology","journal_issn":"2168-6165","published_at":"2026-06-25T00:00:00.000Z","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13306482/","source_score":37,"is_retracted":false,"is_open_access":true,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-07-01T13:27:04.709Z","updated_at":"2026-07-01T13:27:04.709Z","tags":[{"paper_doi":"10.1001/jamaophthalmol.2026.2245","tag_type":"age_group","value":"older_adult","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2026.2245","tag_type":"category","value":"Ophthalmology","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2026.2245","tag_type":"condition","value":"Diabetes Mellitus","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2026.2245","tag_type":"condition","value":"Diabetic Retinopathy","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2026.2245","tag_type":"condition","value":"Hypertension","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2026.2245","tag_type":"impact_flag","value":"practice_changing","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2026.2245","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2026.2245","tag_type":"modality","value":"Blood Pressure Screening","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2026.2245","tag_type":"sample_size","value":"n=172","value_numeric":172},{"paper_doi":"10.1001/jamaophthalmol.2026.2245","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2026.2245","tag_type":"study_design","value":"Prospective Case Series","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2026.2245","tag_type":"warning","value":"Only an abstract was available; the full article text is embargoed until June 2027. All extracted data are based solely on the abstract and results section provided.","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2026.2245","tag_type":"warning","value":"Single BP measurement without repeat confirmation may overestimate hypertension prevalence due to white-coat effect — a limitation not explicitly acknowledged in the abstract.","value_numeric":null},{"paper_doi":"10.1001/jamaophthalmol.2026.2245","tag_type":"warning","value":"The older_adult age group tag reflects the mean age of 66.6 years, but the sample included adults ≥18 years, so the full range skews older.","value_numeric":null}],"summaries":{"what_studied":"A prospective case series evaluated the prevalence of elevated or uncontrolled blood pressure (BP) in 172 adult patients with diabetes (type 1 or 2) presenting to a single academic retina clinic (July–August 2024), using 2017 ACC/AHA criteria, alongside a structured patient survey on hypertension history, perceived control, and knowledge.","key_result":"Only 8.1% (14/172) had normal BP; 52.9% (91/172) had stage 2 hypertension and 10.5% (18/172) met hypertensive crisis criteria. Among 28 patients without a prior hypertension diagnosis, 85.7% had above-normal BP. Despite 69.4% of known hypertensives rating their control as good/excellent, 79.9% had stage 1 or higher BP. After screening, 59.9% were advised to contact their PCP and 11.6% required expedited follow-up.","limitations":"Single-center case series over just two months limits generalizability. No confirmatory repeat BP measurements or ambulatory monitoring were used, raising the possibility of white-coat effect. The study did not track downstream outcomes after referral.","practice_takeaway":"Opportunistic BP screening in ophthalmology clinics can detect uncontrolled or unrecognized hypertension in the majority of diabetic patients—even those already on treatment—who may otherwise believe their BP is well controlled. Consider routine BP measurement during diabetic eye exams as a low-cost cardiovascular risk intervention."}},{"doi":"10.1161/circep.126.014942","pmid":"42030455","title":"First-in-Human Clinical Experience With Focal Pulsed Field and Radiofrequency Dual-Modality Ablation for Treatment Refractory Left Ventricular Summit PVCs","journal_title":"Circulation: Arrhythmia and Electrophysiology","journal_issn":"1941-3149","published_at":"2026-04-24T00:00:00.000Z","url":"https://doi.org/10.1161/circep.126.014942","source_score":23,"is_retracted":false,"is_open_access":false,"raw_metadata":{"pubmed":true,"crossref":true,"unpaywall":true},"created_at":"2026-06-22T13:24:14.375Z","updated_at":"2026-06-22T13:24:14.375Z","tags":[{"paper_doi":"10.1161/circep.126.014942","tag_type":"age_group","value":"adult","value_numeric":null},{"paper_doi":"10.1161/circep.126.014942","tag_type":"brand","value":"TactiFlex Duo","value_numeric":null},{"paper_doi":"10.1161/circep.126.014942","tag_type":"category","value":"Cardiac & Cardiovascular Systems","value_numeric":null},{"paper_doi":"10.1161/circep.126.014942","tag_type":"condition","value":"Left Ventricular Summit Arrhythmia","value_numeric":null},{"paper_doi":"10.1161/circep.126.014942","tag_type":"condition","value":"Premature Ventricular Complexes","value_numeric":null},{"paper_doi":"10.1161/circep.126.014942","tag_type":"generic","value":"pulsed field ablation catheter","value_numeric":null},{"paper_doi":"10.1161/circep.126.014942","tag_type":"impact_flag","value":"safety_signal","value_numeric":null},{"paper_doi":"10.1161/circep.126.014942","tag_type":"level_of_evidence","value":"4","value_numeric":null},{"paper_doi":"10.1161/circep.126.014942","tag_type":"modality","value":"Pulsed Field Ablation","value_numeric":null},{"paper_doi":"10.1161/circep.126.014942","tag_type":"modality","value":"Radiofrequency Ablation","value_numeric":null},{"paper_doi":"10.1161/circep.126.014942","tag_type":"sample_size","value":"n=6","value_numeric":6},{"paper_doi":"10.1161/circep.126.014942","tag_type":"sex","value":"mixed","value_numeric":null},{"paper_doi":"10.1161/circep.126.014942","tag_type":"study_design","value":"Prospective Case Series","value_numeric":null},{"paper_doi":"10.1161/circep.126.014942","tag_type":"warning","value":"Compassionate use designation means this device (TactiFlex Duo) is not yet broadly approved for this indication as of the publication date.","value_numeric":null},{"paper_doi":"10.1161/circep.126.014942","tag_type":"warning","value":"Coronary vasospasm signal (2/5 patients with coronary-adjacent PF) is clinically relevant but event numbers are too small to estimate true incidence.","value_numeric":null},{"paper_doi":"10.1161/circep.126.014942","tag_type":"warning","value":"Sample size is only 6 patients under compassionate use; findings are preliminary and should be interpreted with caution.","value_numeric":null},{"paper_doi":"10.1161/circep.126.014942","tag_type":"warning","value":"The 'first-in-human' framing and prospective enrollment without randomization make this a case series, not a controlled trial; study design tag reflects this.","value_numeric":null}],"summaries":{"what_studied":"Assessed feasibility, efficacy, and safety of a novel dual-modality focal catheter (TactiFlex Duo, Abbott) combining monopolar pulsed field (PF) and radiofrequency (RF) ablation in 6 patients with left ventricular summit PVCs who had failed 1–2 prior RF ablations; 3-month follow-up.","key_result":"Acute PVC suppression was achieved in all 6 patients; all 6 had durable ≥80% PVC burden reduction with symptom resolution at 3 months. Transient, reversible left anterior descending coronary vasospasm occurred in 2 of 5 patients who received PF adjacent to a coronary artery, without ECG changes or hemodynamic consequences.","limitations":"Extremely small sample (n=6) under compassionate use limits generalizability. No control arm or comparison with repeat RF alone. Short 3-month follow-up may not capture late recurrence or delayed coronary effects.","practice_takeaway":"For refractory LV summit PVCs that have failed prior RF ablation, dual-modality PF+RF ablation appears feasible with durable short-term results. Clinicians should be prepared for transient coronary vasospasm during PF delivery near coronary arteries, even with prophylactic intracoronary nitroglycerin."}},{"doi":"10.1111/jocd.70511","pmid":"41186063","title":"Moose Technique: A New Anatomical Perspective Treatment in Botulinum Toxin","journal_title":"Journal of Cosmetic Dermatology","journal_issn":"1473-2130","published_at":"2025-11-04T00:00:00.000Z","url":"https://doi.org/10.1111/jocd.70511","source_score":1,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2025-11-09","doi":"10.1111/jocd.70511","days":"7","issn":"1473-2130","rank":"10","field":"Clinical Medicine","score":"1","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1111/jocd.70511","title":"Moose Technique: A New Anatomical Perspective Treatment in Botulinum Toxin.","journal":"Journal of cosmetic dermatology","methods":"","results":"The MOOSE technique resulted in a significant improvement in brow position, with an average gain of 2 points on the MAS. Patient satisfaction was remarkably high, with 100% of patients reporting a positive outcome at 15 days and 99% at four months. The average botulinum toxin dosage was 66 units per patient (range: 54-78 units). No cases of brow or eyelid ptosis were observed, and only one patient (0.49%) experienced transient edema. Interrater reliability of evaluations was excellent, with intraclass correlation coefficients ranging from 0.94 to 1.00 across all measured outcomes.","abstract":"$30","keywords":["MOOSE technique","botulinum toxin","dynamic wrinkles","incobotulinumtoxinA","injection technique","sad face"],"pubmed_id":"41186063","conclusions":"The MOOSE technique provides an anatomically guided approach to botulinum toxin injections, enhancing aesthetic results while reducing complications. Its effectiveness underscores the value of individualized treatment based on muscle dynamics. Further research is needed to refine its application and assess long-term effects.","publication_date":"2025-11-04T00:00:00"},"crossref":{"DOI":"10.1111/jocd.70511","URL":"https://doi.org/10.1111/jocd.70511","ISSN":["1473-2130","1473-2165"],"link":[{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/jocd.70511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":"11","score":1,"title":["Moose Technique: A New Anatomical Perspective Treatment in Botulinum Toxin"],"author":[{"given":"Nabil","family":"Fakih‐Gomez","sequence":"first","affiliation":[{"name":"Department of Surgery University of Salamanca Salamanca Spain"},{"name":"Department of Facial Plastic and Cranio‐Maxillo‐Facial Surgery Fakih Hospital Khaizaran Lebanon"}]},{"given":"Cristina","family":"Muñoz‐Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Salamanca Salamanca 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