Randomized Controlled Trial: Research & Clinical Takeaways

Short-course taVNS improved clinician-rated erythema and mood symptoms versus sham in ETR with few adverse events; clinicians may discuss this...

When selecting retinol products for sensitive skin, co‑formulations with 2% PLG, 5% ceramides, 3% acetyl glucosamine, 2% panthenol, 0.2% TECA, or...

In women with epidermal melasma, a niacinamide/2‑mercaptonicotinyl glycine dermocosmetic achieved similar 6‑month MASI reductions to Kligman triple...

In this small split-body RCT, HIUS achieved similar improvement and pain scores as MFU-V for upper arm laxity/crepiness at 90 days, while taking less...

For adults who cannot take oral antifungals, an 8‑session diode laser plus red‑laser PDT protocol achieved higher clinical cure and faster healing...

For adults with mild to moderate psoriasis on stable topical therapy, a 16-week, dietitian-guided Mediterranean diet produced clinically meaningful...

Routine high-SPF sunscreen use over a year led to lower 25(OH)D and more deficiency than discretionary use; regular sunscreen users may need vitamin...

For infants, starting daily full‑body emollient before 9 weeks reduced physician‑diagnosed AD by about 7 percentage points by 24 months versus no...

Once-daily roflumilast foam 0.3% outperformed vehicle for scalp and limited body psoriasis over 8 weeks and reduced itch early, with low adverse...

For H1-antihistamine–refractory CSU, rilzabrutinib 1200 mg/d reduced itch and hive activity over 12 weeks vs placebo with early onset and mainly...

Over 8 weeks, both an oral synbiotic and a myoinositol‑based herbal supplement were associated with fewer acne lesions and higher SCFAs; the...

In high‑risk patients, adding 3D‑TBP and SDDI via teledermatology increased excisions/biopsies and keratinocyte cancer detection but did not produce...

In immunocompetent patients with numerous AKs, 9-valent HPV vaccination reduced existing AK burden over 12 months versus sham, but did not lower new...

In adults with moderate to severe papulopustular rosacea, 16 weeks of DFD-29 40 mg daily outperformed doxycycline 40 mg and placebo on IGA success...

In toddlers with mild-to-moderate atopic dermatitis, once-daily roflumilast 0.05% improved signs and itch by Week 4—and as early as 24 hours—while...

For adults with atopic dermatitis, a brief self-guided online CBT program was noninferior to clinician-guided CBT on POEM and required minimal...

Nemolizumab every 4 weeks improved itch and skin clearance by week 16 vs placebo in adults with moderate to severe prurigo nodularis, with mostly...

In adolescents with moderate to severe atopic dermatitis, upadacitinib 15–30 mg daily sustained high EASI-75 responses through 76 weeks, with safety...

Home narrowband UV-B was as effective as office-based therapy at 12 weeks, including across all skin phototypes, with higher adherence but more...

Zasocitinib ≥5 mg daily improved skin clearance vs placebo over 12 weeks in moderate to severe plaque psoriasis, with similar short-term safety and...

In adults who achieve complete clearance at weeks 20 and 28 on guselkumab, extending dosing to every 16 weeks maintained disease control to week 68...

At 24 hours, 21% of participants showed less erythema on nCBD-treated skin versus vehicle; nCBD reduced UV-A–induced epidermal hyperplasia (P=.01),...

For male AGA over 24 weeks, oral minoxidil 5 mg daily did not outperform topical 5% twice daily on hair density; a vertex photographic edge was small...

Topical pravibismane appears well tolerated with negligible systemic exposure in infected DFUs, but efficacy signals (ulcer size reduction and fewer...

For pemphigus, first-line rituximab (Ritux 3 regimen) achieved durable steroid-free control over 7 years with fewer relapses and SAEs than prednisone...

Once-daily topical PF-07038124 0.01% outperformed vehicle at 6 weeks in mild to moderate AD and plaque psoriasis. TEAEs were similar to vehicle (AD:...

In women similar to those studied, 12 weeks of Lumenato was associated with stronger skin barrier and improved firmness/elasticity versus placebo;...

A brief self-help habit replacement approach reduced BFRB severity over 6 weeks vs wait-list, with about half reporting global improvement; benefits...

For adolescents and adults with moderate-to-severe atopic dermatitis, adding lebrikizumab to low- to mid-potency topical steroids for 16 weeks...

Topical CBD was associated with less wound-related and incident pain, better sleep, and more healed ulcers at ~1 month, with only mild local...

Orismilast IR improved psoriasis signs but caused frequent GI AEs and high dropout; further development shifts to an MR tablet that kept similar...