2f:I[703058,["/_next/static/immutable/chunks/3bhq_5eh1d760.js","/_next/static/immutable/chunks/1855-ogyi8eh4.js","/_next/static/immutable/chunks/2pfsjpn6k6zlg.js","/_next/static/immutable/chunks/26c7v3_3uwnwu.js","/_next/static/immutable/chunks/25a3ozcrvi1ff.js","/_next/static/immutable/chunks/2r4wx50nvjh_4.js","/_next/static/immutable/chunks/23fsw06hsi5b1.js","/_next/static/immutable/chunks/06_yt270h41rg.js","/_next/static/immutable/chunks/3ezsiz-7shkna.js","/_next/static/immutable/chunks/20x2y96ldu5wx.js","/_next/static/immutable/chunks/2lxntcm3pd1_h.js","/_next/static/immutable/chunks/00dgco8irq3jw.js","/_next/static/immutable/chunks/00nwe-kq0rboc.js","/_next/static/immutable/chunks/2051ffx3xzio9.js"],"PaperListPageClient"] 30:Ta1c, Background Low‐level laser therapy (LLLT) has emerged as a nonpharmacologic intervention for androgenetic alopecia (AGA), but evidence on its long‐term efficacy remains limited. Objective To evaluate the 12‐month effectiveness and safety of a home‐use helmet‐type LLLT device in individuals with AGA. Materials and Methods This prospective, open‐label study enrolled 68 patients (51 men, 17 women) with mild to severe AGA. Participants used a helmet‐type LLLT device emitting red light (646–675 nm) three times per week for 20 min over 48 weeks. Hair density and shaft thickness were assessed using phototrichogram at predefined intervals. Additional evaluations included blinded global photographic assessments and patient‐reported outcomes. Results Hair density increased significantly from a baseline mean of 99.2 ± 27.7 to 124.2 ± 33.1 hairs/cm 2 at 48 weeks (mean change +25.0 ± 28.1, p < 0.0001). Mean hair shaft thickness rose from 65.1 ± 11.8 to 74.9 ± 12.6 μm ( p < 0.0001), reflecting an approximate 15% improvement. Gains were consistent across sexes and AGA severity levels. By Week 48, 59% of participants were rated as improved based on global photographs, and over 85% expressed satisfaction with treatment. No adverse events related to the device were reported, and adherence was high throughout the study. Conclusion Twelve months of home‐use LLLT resulted in sustained improvements in hair density and thickness with excellent tolerability. These findings support its role as a safe, effective, and user‐friendly long‐term therapeutic option for patients with AGA. 31:T921,Geographic atrophy due to age-related macular degeneration (AMD) is the leading cause of irreversible blindness and affects more than 5 million persons worldwide. No therapies to restore vision in such persons currently exist. The photovoltaic retina implant microarray (PRIMA) system combines a subretinal photovoltaic implant and glasses that project near-infrared light to the implant in order to restore sight to areas of central retinal atrophy. We conducted an open-label, multicenter, prospective, single-group, baseline-controlled clinical study in which the vision of participants with geographic atrophy and a visual acuity of at least 1.2 logMAR (logarithm of the minimum angle of resolution) was assessed with PRIMA glasses and without PRIMA glasses at 6 and 12 months. The primary end points were a clinically meaningful improvement in visual acuity (defined as ≥0.2 logMAR) from baseline to month 12 after implantation and the number and severity of serious adverse events related to the procedure or device through month 12. A total of 38 participants received a PRIMA implant, of whom 32 were assessed at 12 months. Of the 6 participants who were not assessed, 3 had died, 1 had withdrawn, and 2 were unavailable for testing. Among the 32 participants who completed 12 months of follow-up, the PRIMA system led to a clinically meaningful improvement in visual acuity from baseline in 26 (81%; 95% confidence interval, 64 to 93; P<0.001). Using multiple imputation to account for the 6 participants with missing data, we estimated that 80% (95% CI, 66 to 94; P<0.001) of all participants would have had a clinically meaningful improvement at 12 months. A total of 26 serious adverse events occurred in 19 participants. Twenty-one of these events (81%) occurred within 2 months after surgery, of which 20 (95%) resolved within 2 months after onset. The mean natural peripheral visual acuity after implantation was equivalent to that at baseline. In this study involving 38 participants with geographic atrophy due to AMD, the PRIMA system restored central vision and led to a significant improvement in visual acuity from baseline to month 12. (Funded by Science Corporation and the Moorfields National Institute for Health and Care Research Biomedical Research Centre; PRIMAvera ClinicalTrials.gov number, NCT04676854.).32:T5d6,The use of electromagnetic energy as an alternative to surgical procedures for subcutaneous fat reduction has gained popularity in recent years. In this pilot study, the effects of using amplified radio-frequency energy in the medium wave delivery range, in conjunction with exercise intervention, were investigated for their potential reduction of abdominal subcutaneous and visceral fat. The study aimed to evaluate the effects of combined intervention on the volume of abdominal fat, analyzing changes in lipid profile, metabolic factors, and inflammatory markers. Thirty-four participants were selected and assigned to a 10-day intervention utilizing a Capenergy device every weekday except Saturday and Sunday. This involved the application of amplified energy through a belt covering the abdominal area of 800 cm A statistically significant decrease was noted in both subcutaneous and visceral fat in the abdominal area, as well as a decrease in weight, waist-to-hip, and all biochemical values, without side effects, just a slight redness. These effects on abdominal fat were maintained at the 6-month follow-up with no reports of regaining fat. The utilization of amplified radiofrequency with an abdominal belt with static electrodes and temperature sensors, together with exercise intervention, has significant potential for reducing abdominal subcutaneous and visceral fat, while also improving associated factors safely and effectively, even after a follow-up period. NCT06377358.33:T8e4,ABSTRACTBackgroundThe use of electromagnetic energy as an alternative to surgical procedures for subcutaneous fat reduction has gained popularity in recent years. In this pilot study, the effects of using amplified radio‐frequency energy in the medium wave delivery range, in conjunction with exercise intervention, were investigated for their potential reduction of abdominal subcutaneous and visceral fat.ObjectivesThe study aimed to evaluate the effects of combined intervention on the volume of abdominal fat, analyzing changes in lipid profile, metabolic factors, and inflammatory markers.MethodsThirty‐four participants were selected and assigned to a 10‐day intervention utilizing a Capenergy device every weekday except Saturday and Sunday. This involved the application of amplified energy through a belt covering the abdominal area of 800 cm2 followed by a 45‐min submaximal aerobic exercise. Measurements were conducted pretreatment and after the intervention. Lipid profile, leptin, insulin, and protein C were measured. Body fat was measured by MRI of the entire abdomen. Follow‐up measurements were also taken at the 6‐month mark.ResultsA statistically significant decrease was noted in both subcutaneous and visceral fat in the abdominal area, as well as a decrease in weight, waist‐to‐hip, and all biochemical values, without side effects, just a slight redness. These effects on abdominal fat were maintained at the 6‐month follow‐up with no reports of regaining fat.ConclusionThe utilization of amplified radiofrequency with an abdominal belt with static electrodes and temperature sensors, together with exercise intervention, has significant potential for reducing abdominal subcutaneous and visceral fat, while also improving associated factors safely and effectively, even after a follow‐up period.Trial Registration: NCT0637735834:T779,Omega-3 fatty acids (ω-3 FA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), are essential nutrients known for their anti-inflammatory properties, which involve reducing pro-inflammatory cytokines, eicosanoids, and insulin-like growth factor-1. This suggests their potential to alleviate acne severity, especially when deficits are present. To elevate EPA/DHA levels in acne patients through dietary intervention and supplementation, observing subsequent clinical effects. Over 16 weeks, 60 patients without prescription medication (n = 23 acne comedonica [AC], n = 37 acne papulopustulosa [AP]) adhered to a Mediterranean diet, incorporating oral algae-derived ω-3 FA supplementation (600 mg DHA/300 mg EPA week 1-8, 800 mg DHA/400 mg EPA week 8-16). At four visits (V1-V4), blood EPA/DHA levels were tracked using the HS-omega 3 index® (EPA/DHA (%) of total identified fatty acids in erythrocytes; target 8%-11%, deficit <8%, severe deficit <4%), alongside clinical assessments and standardized questionnaires. At baseline, 98.3% of patients had an EPA/DHA deficit, with the mean HS-omega 3 index® rising from 4.9% at V1 to 8.3% at V4 (p < 0.001). AC showed significantly higher indices than AP at V4 (p = 0.035). Objective improvements in both inflammatory and non-inflammatory lesions were observed (p < 0.001). While self-reported appearance worsened in four patients, overall quality of life improved (p < 0.001), particularly in AP. Dietary triggers were more clearly defined than beneficial foods. Intake of cow's milk and dairy products reduced (p < 0.001). Compliance was good; no adverse events were reported. Many acne patients have a ω-3 FA deficit. The HS-omega 3 index® can be increased by a Mediterranean diet and oral supplementation with algae-derived ω-3 FA. Acne severity improved significantly in patients with target ω-3 FA levels.35:T9f0,AbstractBackgroundOmega‐3 fatty acids (ω‐3 FA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), are essential nutrients known for their anti‐inflammatory properties, which involve reducing pro‐inflammatory cytokines, eicosanoids, and insulin‐like growth factor‐1. This suggests their potential to alleviate acne severity, especially when deficits are present.AimsTo elevate EPA/DHA levels in acne patients through dietary intervention and supplementation, observing subsequent clinical effects.MethodsOver 16 weeks, 60 patients without prescription medication (n = 23 acne comedonica [AC], n = 37 acne papulopustulosa [AP]) adhered to a Mediterranean diet, incorporating oral algae‐derived ω‐3 FA supplementation (600 mg DHA/300 mg EPA week 1–8, 800 mg DHA/400 mg EPA week 8–16). At four visits (V1–V4), blood EPA/DHA levels were tracked using the HS‐omega 3 index® (EPA/DHA (%) of total identified fatty acids in erythrocytes; target 8%–11%, deficit <8%, severe deficit <4%), alongside clinical assessments and standardized questionnaires.ResultsAt baseline, 98.3% of patients had an EPA/DHA deficit, with the mean HS‐omega 3 index® rising from 4.9% at V1 to 8.3% at V4 (p < 0.001). AC showed significantly higher indices than AP at V4 (p = 0.035). Objective improvements in both inflammatory and non‐inflammatory lesions were observed (p < 0.001). While self‐reported appearance worsened in four patients, overall quality of life improved (p < 0.001), particularly in AP. Dietary triggers were more clearly defined than beneficial foods. Intake of cow's milk and dairy products reduced (p < 0.001). Compliance was good; no adverse events were reported.ConclusionMany acne patients have a ω‐3 FA deficit. The HS‐omega 3 index® can be increased by a Mediterranean diet and oral supplementation with algae‐derived ω‐3 FA. Acne severity improved significantly in patients with target ω‐3 FA levels.25:[[["$","script","0",{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@type\":\"CollectionPage\",\"name\":\"Single-Arm Interventional Study: study design Research & Clinical Takeaways\",\"description\":\"Explore peer-reviewed papers on Single-Arm Interventional Study (study design). 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generalizability.","value_numeric":null},{"paper_doi":"10.1155/dth/6621458","tag_type":"warning","value":"Primary outcome is not clearly prespecified in the abstract; multiple efficacy measures are reported.","value_numeric":null}],"summaries":{"what_studied":"A 12‑month, prospective open‑label trial tested a home‑use helmet low‑level laser therapy (646–675 nm), used 3 times per week for 20 minutes over 48 weeks, in 68 adults (51 men, 17 women) with mild to severe androgenetic alopecia. Outcomes included phototrichogram hair density and shaft thickness, blinded global photographic assessments, patient‑reported satisfaction, adherence, and adverse events.","key_result":"Hair density rose from 99.2±27.7 to 124.2±33.1 hairs/cm² at 48 weeks (mean change +25.0±28.1; p<0.0001), and mean shaft thickness increased from 65.1±11.8 to 74.9±12.6 μm (p<0.0001). By Week 48, 59% were rated improved on global photographs, >85% reported satisfaction, no device‑related adverse events occurred, and adherence was high.","limitations":"Single‑arm, open‑label design without a control group limits causal inference and comparison to standard therapies. Findings reflect a specific helmet device and dosing protocol, and the abstract does not prespecify a primary outcome.","practice_takeaway":"For adults with androgenetic alopecia, a home‑use helmet LLLT regimen (3 times/week, 20 minutes) over 12 months produced moderate gains in hair count (~+25 hairs/cm²) and ~15% thicker shafts with no reported device‑related harms in this uncontrolled study. Discuss as a well‑tolerated option while counseling patients about the limited comparative evidence."}},{"doi":"10.1056/nejmoa2501396","pmid":"41124203","title":"Subretinal Photovoltaic Implant to Restore Vision in Geographic Atrophy Due to AMD","journal_title":"New England Journal of Medicine","journal_issn":"0028-4793","published_at":"2025-10-22T00:00:00.000Z","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7618305/","source_score":2840,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2026-01-17","doi":"10.1056/nejmoa2501396","days":"7","issn":"0028-4793","rank":"1","field":"Clinical Medicine","score":"2840","category":"Medicine, General & Internal","categories":["Medicine, General & Internal"],"_categories":["Medicine, General & Internal"]},"pubmed":{"doi":"10.1056/NEJMoa2501396","title":"Subretinal Photovoltaic Implant to Restore Vision in Geographic Atrophy Due to AMD.","journal":"The New England journal of medicine","methods":"","results":"A total of 38 participants received a PRIMA implant, of whom 32 were assessed at 12 months. Of the 6 participants who were not assessed, 3 had died, 1 had withdrawn, and 2 were unavailable for testing. Among the 32 participants who completed 12 months of follow-up, the PRIMA system led to a clinically meaningful improvement in visual acuity from baseline in 26 (81%; 95% confidence interval, 64 to 93; P<0.001). Using multiple imputation to account for the 6 participants with missing data, we estimated that 80% (95% CI, 66 to 94; P<0.001) of all participants would have had a clinically meaningful improvement at 12 months. A total of 26 serious adverse events occurred in 19 participants. Twenty-one of these events (81%) occurred within 2 months after surgery, of which 20 (95%) resolved within 2 months after onset. The mean natural peripheral visual acuity after implantation was equivalent to that at baseline.","abstract":"$31","keywords":[],"pubmed_id":"41124203","conclusions":"","publication_date":"2025-10-22T00:00:00"},"crossref":{"DOI":"10.1056/nejmoa2501396","URL":"https://doi.org/10.1056/nejmoa2501396","ISSN":["0028-4793","1533-4406"],"link":[{"URL":"http://www.nejm.org/doi/pdf/10.1056/NEJMoa2501396","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":"232-242","type":"journal-article","issue":"3","score":1,"title":["Subretinal Photovoltaic Implant to Restore Vision in Geographic Atrophy Due to AMD"],"author":[{"given":"Frank G.","family":"Holz","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Bonn, Bonn, Germany"}]},{"given":"Yannick","family":"Le Mer","sequence":"additional","affiliation":[{"name":"Hôpital Fondation A. de Rothschild, Paris"}]},{"given":"Mahiul 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Primary endpoints were ≥0.2 logMAR visual acuity improvement at 12 months and procedure/device-related serious adverse events through 12 months.","key_result":"Of 38 implanted, 32 were assessed at 12 months; 26/32 (81%; 95% CI, 64–93; P<0.001) achieved a ≥0.2 logMAR improvement, with multiple imputation estimating 80% (95% CI, 66–94; P<0.001) for all participants. There were 26 serious adverse events in 19 participants; 21 (81%) occurred within 2 months after surgery and 20/21 (95%) resolved within 2 months; mean natural peripheral visual acuity was unchanged from baseline.","limitations":"Single-group, open-label, baseline-controlled design without a randomized comparator. Six participants lacked 12‑month assessments (including 3 deaths), and outcomes are reported to 12 months only.","practice_takeaway":"In geographic atrophy due to AMD, the PRIMA subretinal photovoltaic implant with near‑infrared projection improved central visual acuity at 12 months in most participants while preserving natural peripheral acuity. Expect most serious adverse events early after surgery, with most resolving within 2 months."}},{"doi":"10.1111/jocd.70490","pmid":"41059542","title":"Reduction of Subcutaneous and Visceral Fat With the Use of Energy‐Based Equipment With a High‐Power Amplifying Effect Plus an Exercise Regimen","journal_title":"Journal of Cosmetic Dermatology","journal_issn":"1473-2130","published_at":"2025-10-08T00:00:00.000Z","url":"https://doi.org/10.1111/jocd.70490","source_score":16,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2025-10-12","doi":"10.1111/jocd.70490","days":"14","issn":"1473-2130","rank":"4","field":"Clinical Medicine","score":"16","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1111/jocd.70490","title":"Reduction of Subcutaneous and Visceral Fat With the Use of Energy-Based Equipment With a High-Power Amplifying Effect Plus an Exercise Regimen.","journal":"Journal of cosmetic dermatology","methods":"","results":"A statistically significant decrease was noted in both subcutaneous and visceral fat in the abdominal area, as well as a decrease in weight, waist-to-hip, and all biochemical values, without side effects, just a slight redness. These effects on abdominal fat were maintained at the 6-month follow-up with no reports of regaining fat.","abstract":"$32","keywords":["Capenergy","abdominal fat loss","amplified radiofrequency","exercise","subcutaneous fat loss","visceral fat loss"],"pubmed_id":"41059542","conclusions":"The utilization of amplified radiofrequency with an abdominal belt with static electrodes and temperature sensors, together with exercise intervention, has significant potential for reducing abdominal subcutaneous and visceral fat, while also improving associated factors safely and effectively, even after a follow-up period.","publication_date":"2025-10-08T00:00:00"},"crossref":{"DOI":"10.1111/jocd.70490","URL":"https://doi.org/10.1111/jocd.70490","ISSN":["1473-2130","1473-2165"],"link":[{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/jocd.70490","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"page":null,"type":"journal-article","issue":"10","score":1,"title":["Reduction of Subcutaneous and Visceral Fat With the Use of Energy‐Based Equipment With a High‐Power Amplifying Effect Plus an Exercise Regimen"],"author":[{"given":"Jesús","family":"Rodriguez Lastra","sequence":"first","affiliation":[{"name":"Universidad Alfonso X El Sabio Madrid Spain"}]},{"given":"Sidra","family":"Kouser","sequence":"additional","affiliation":[{"name":"Clinical Researcher & Physiotherapist INNEO Clinic Barcelona Barcelona Spain"}]}],"issued":{"date-parts":[[2025,10]]},"member":"311","prefix":"10.1111","source":"Crossref","volume":"24","archive":["Portico"],"created":{"date-time":"2025-10-08T09:32:01Z","timestamp":1759915921000,"date-parts":[[2025,10,8]]},"indexed":{"date-time":"2025-10-08T10:10:20Z","timestamp":1759918220168,"date-parts":[[2025,10,8]]},"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","start":{"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000,"date-parts":[[2025,10,8]]},"delay-in-days":7,"content-version":"vor"}],"subject":[],"abstract":"$33","language":"en","relation":{},"resource":{"primary":{"URL":"https://onlinelibrary.wiley.com/doi/10.1111/jocd.70490"}},"subtitle":[],"assertion":[{"name":"received","group":{"name":"publication_history","label":"Publication History"},"label":"Received","order":0,"value":"2024-07-04"},{"name":"accepted","group":{"name":"publication_history","label":"Publication History"},"label":"Accepted","order":2,"value":"2025-09-27"},{"name":"published","group":{"name":"publication_history","label":"Publication History"},"label":"Published","order":3,"value":"2025-10-08"}],"deposited":{"date-time":"2025-10-08T09:32:03Z","timestamp":1759915923000,"date-parts":[[2025,10,8]]},"issn-type":[{"type":"print","value":"1473-2130"},{"type":"electronic","value":"1473-2165"}],"published":{"date-parts":[[2025,10]]},"publisher":"Wiley","reference":[{"DOI":"10.1007/s10103‐015‐1852‐0","key":"e_1_2_14_2_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.3390/nu14173498","key":"e_1_2_14_3_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s10103‐013‐1301‐x","key":"e_1_2_14_4_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/jocd.14203","key":"e_1_2_14_5_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1007/s00266‐023‐03730‐3","key":"e_1_2_14_6_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1111/jocd.13892","key":"e_1_2_14_7_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1038/oby.2012.168","key":"e_1_2_14_8_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1152/jappl.1998.85.1.115","key":"e_1_2_14_9_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":"10.1002/lsm.20925","key":"e_1_2_14_10_1","year":null,"issue":null,"author":null,"volume":null,"first-page":null,"unstructured":null,"article-title":null,"journal-title":null,"doi-asserted-by":"publisher"},{"DOI":null,"key":"e_1_2_14_11_1","year":"1989","issue":null,"author":"Gaylor D. 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MRI quantified total abdominal subcutaneous (SAT) and visceral fat (VAT) and labs (lipids, insulin, leptin, CRP) were measured pre- and post-intervention; 10 participants had 6‑month follow-up.","key_result":"From baseline to day 10, mean MRI fat decreased: SAT −652.4 cm³ (p=0.001) and −587.16 g (p=0.001); VAT −330.69 cm³ (p=0.001) and −387.62 g (p=0.001). Weight fell −2.07 kg (p=0.001); triglycerides −51.29 mg/dL (p=0.001); insulin −4.86 mIU/L (p=0.001); HDL/LDL changes were not significant; at 6 months (n=10), further reductions versus day 10 were reported (SAT −789.46 cm³, −710.52 g; VAT −322.53 cm³, −284.25 g; all p≤0.05); only transient mild erythema was noted.","limitations":"No control group or randomization; small sample with only 10/34 returning at 6 months; moderate interobserver agreement for MRI segmentation (kappa 0.476).","practice_takeaway":"In adults with overweight/obesity, a 2‑week course of high‑power radiofrequency belt plus 45‑min submaximal exercise reduced MRI‑measured abdominal SAT and VAT and lowered triglycerides and insulin with minimal short‑term adverse effects. Findings are preliminary and uncontrolled, so use for metabolic risk reduction should be considered experimental pending randomized trials."}},{"doi":"10.1111/jocd.16434","pmid":"38982829","title":"Exploring the potential of omega‐3 fatty acids in acne patients: A prospective intervention study","journal_title":"Journal of Cosmetic Dermatology","journal_issn":"1473-2130","published_at":"2024-07-10T00:00:00.000Z","url":"https://doi.org/10.1111/jocd.16434","source_score":495,"is_retracted":false,"is_open_access":true,"raw_metadata":{"ooir":{"day":"2024-07-15","doi":"10.1111/jocd.16434","days":"30","issn":"1473-2130","rank":"1","field":"Clinical Medicine","score":"495","category":"Dermatology","categories":["Dermatology"],"_categories":["Dermatology"]},"pubmed":{"doi":"10.1111/jocd.16434","title":"Exploring the potential of omega-3 fatty acids in acne patients: A prospective intervention study.","journal":"Journal of cosmetic dermatology","methods":"","results":"At baseline, 98.3% of patients had an EPA/DHA deficit, with the mean HS-omega 3 index® rising from 4.9% at V1 to 8.3% at V4 (p < 0.001). AC showed significantly higher indices than AP at V4 (p = 0.035). Objective improvements in both inflammatory and non-inflammatory lesions were observed (p < 0.001). While self-reported appearance worsened in four patients, overall quality of life improved (p < 0.001), particularly in AP. Dietary triggers were more clearly defined than beneficial foods. Intake of cow's milk and dairy products reduced (p < 0.001). Compliance was good; no adverse events were reported.","abstract":"$34","keywords":["Mediterranean diet","exposome factors","nutraceuticals","nutrition","supplementation"],"pubmed_id":"38982829","conclusions":"Many acne patients have a ω-3 FA deficit. The HS-omega 3 index® can be increased by a Mediterranean diet and oral supplementation with algae-derived ω-3 FA. 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Vulgaris","value_numeric":null},{"paper_doi":"10.1111/jocd.16434","tag_type":"impact_flag","value":"limited_evidence","value_numeric":null},{"paper_doi":"10.1111/jocd.16434","tag_type":"level_of_evidence","value":"6","value_numeric":null},{"paper_doi":"10.1111/jocd.16434","tag_type":"modality","value":"Omega-3 Fatty Acid","value_numeric":null},{"paper_doi":"10.1111/jocd.16434","tag_type":"sample_size","value":"n=60","value_numeric":60},{"paper_doi":"10.1111/jocd.16434","tag_type":"study_design","value":"Single-Arm Interventional Study","value_numeric":null},{"paper_doi":"10.1111/jocd.16434","tag_type":"warning","value":"Clinical improvements were reported without absolute lesion count or QoL changes.","value_numeric":null},{"paper_doi":"10.1111/jocd.16434","tag_type":"warning","value":"Diet and supplementation were combined, and dairy intake fell, so effects of omega‑3 alone are unclear.","value_numeric":null},{"paper_doi":"10.1111/jocd.16434","tag_type":"warning","value":"No comparator arm; study design classification is approximate.","value_numeric":null}],"summaries":{"what_studied":"A 16-week prospective, single-arm study in 60 acne patients not on prescription medication tested a Mediterranean diet plus algae-derived omega-3 supplementation (weeks 1–8: 600 mg DHA/300 mg EPA; weeks 8–16: 800 mg DHA/400 mg EPA), tracking HS‑Omega‑3 Index and clinical acne measures at four visits.","key_result":"At baseline, 98.3% had an EPA/DHA deficit; the mean HS‑Omega‑3 Index increased from 4.9% at V1 to 8.3% at V4 (p<0.001), with higher indices in comedonal than papulopustular acne at V4 (p=0.035). Objective improvements in inflammatory and non‑inflammatory lesions (p<0.001) and quality of life (p<0.001) were observed; dairy intake decreased (p<0.001), compliance was good, and no adverse events were reported.","limitations":"No control group and the combined intervention (diet plus supplementation with reduced dairy) prevent attributing effects to omega‑3 alone. The report provides p‑values without absolute changes in lesion counts or quality‑of‑life scores.","practice_takeaway":"Raising the HS‑Omega‑3 Index via a Mediterranean diet plus algae‑derived DHA/EPA to around 8% over 16 weeks was associated with improved acne severity and quality of life, with no reported harms; interpret as preliminary due to the uncontrolled design."}}],"initialOffset":4,"fetchConfig":{"kind":"tags","tags":[{"tag_type":"study_design","value":"Single-Arm Interventional Study"}]},"breadcrumbItems":[{"name":"Home","href":"/"},{"name":"Research Hub","href":"/hub"},{"name":"Study Designs","href":"/hub/tag/study_design"},{"name":"Single-Arm Interventional Study"}],"hrefConfig":{"basePath":"/hub/papers","webViewQueryParams":{"hub_ctx":"tag","hub_tag_type":"study_design","hub_tag_value":"Single-Arm Interventional Study"}}}]]

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