TCR origin and specificity to environmental or self-antigens on distinct antigen-presenting cells determine peripheral Treg cell differentiation

Study limitation reported by the research below: “The paper is published July 28, 2026; findings are mechanistic and likely murine—species and direct clinical applicability are not explicitly stated in the abstract. The 'practice changing' flag is applied based on the conceptual framework offered for TCR-based tolerogenic therapy design, but clinical translation has not yet been demonstrated.”