Study limitation reported by the research below: “The study design is primarily preclinical (mouse models, organoids, xenografts); the epidemiological pioglitazone data is observational and may be subject to confounding. Level of evidence is set at 5 (preclinical/animal study with database validation). The impact flag 'practice changing' reflects the novel mechanistic findings and the pioglitazone epidemiological signal, but should be interpreted cautiously pending clinical trial validation.”
