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Progressive Asymmetric Bilateral Violaceous Periorbital Edema
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Progressive Asymmetric Bilateral Violaceous Periorbital Edema

JAMA Ophthalmology·August 6
OphthalmologyLimited evidencePeriorbital EdemaViolaceous Periorbital DiscolorationCase ReportOlder Adult

Summary

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What was studied

A clinical challenge case report describing a 66-year-old man with 1 month of progressive, asymmetric bilateral violaceous periorbital edema and erythema, greater on the right side, with associated right eye chemosis and subconjunctival hemorrhage.

Key findings

The case presents examination findings — including right-sided indurated violaceous discoloration from forehead to cheek involving both eyelids, 20/40 visual acuity bilaterally, and mild temporal chemosis with subconjunctival hemorrhage — as a diagnostic challenge; the confirmed diagnosis is not disclosed in the available text.

Study limitations

Full text is behind a paywall; the diagnosis, workup, and management are not available in the publisher page text provided. No outcome or follow-up data can be extracted.

Clinical implications

Violaceous periorbital edema with induration in an older adult warrants a broad differential including inflammatory, infiltrative, and systemic conditions (e.g., dermatomyositis, lymphoma, sarcoidosis, angioedema). Prompt evaluation with imaging and tissue biopsy may be needed to reach a diagnosis.

Caveats

  • The DOI date (2026-08-06) is consistent with today's date context; no anachronism concerns, but this is a very recently published article with no indexing or citation context yet available.
  • The full text is paywalled; the confirmed diagnosis, diagnostic workup, and management are not available in the provided source text. Key clinical details (e.g., final diagnosis) cannot be extracted or confirmed.
  • This is a clinical challenge/quiz format — the diagnosis is intentionally withheld in the abstract and publisher page text, so the 'key result' cannot be completed accurately.

Related Questions

Explore related topics

What are the most common causes of violaceous periorbital edema in older adults?How do you differentiate dermatomyositis from other causes of periorbital discoloration and edema?When should a clinician biopsy periorbital skin lesions in cases of unexplained induration and erythema?

Publication Details

Year
2026
Journal
JAMA Ophthalmology
Sample Size
n=1
Source
View article
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