An invited commentary examining the downstream organ consequences of untreated primary hyperparathyroidism (PHPT), focusing on its effects on the kidney and skeleton over time.
Primary hyperparathyroidism affects approximately 1 in 400 women and 1 in 1200 men, accounting for more than 90% of chronic hypercalcemia; definitive treatment via parathyroidectomy is described as a straightforward outpatient procedure with low complication rates.
Only the publisher landing page is available — full commentary text is behind a paywall. No original data, outcomes, or quantitative analyses are accessible for review.
Clinicians should recognize PHPT as a gradually harmful condition — not a benign one — with cumulative effects on kidneys and bones, and consider parathyroidectomy as a low-risk, definitive intervention even in asymptomatic patients.
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