This study compared peripheral immune cell signatures between patients with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA), two related but distinct spondyloarthritis subtypes, to identify immunological differences at the cellular level.
Despite belonging to the same disease family, axSpA and PsA showed distinct peripheral immune signatures, suggesting divergent underlying immunopathology between the two conditions.
Specific sample size, control comparators, and granular quantitative outcomes are not available from the provided metadata alone; the cross-sectional nature of peripheral blood studies may not fully reflect tissue-level immune activity.
AxSpA and PsA should not be treated as immunologically interchangeable — their distinct peripheral immune profiles may have implications for treatment selection and biomarker development.
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