This narrative review compared specific colpocleisis techniques for obliterative surgical management of primary uterovaginal prolapse, evaluating anatomical success, subjective bulge symptom improvement, and perioperative complications, covering literature published from December 2020 through November 2025.
Of 587 studies identified, only 24 cohort studies and case series met inclusion criteria; all were rated low quality by GRADE criteria. No meta-analysis was possible due to the absence of comparative trials. Two consensus statements were agreed upon via a modified Delphi process at the U-POP Conference.
All 24 included studies were low quality (GRADE); most relevant literature predates 2000; no comparative trials existed, preventing meta-analysis; significant variability in operative techniques across studies limits generalizability.
Colpocleisis remains a safe and effective option for women with uterovaginal prolapse who are not sexually active, but no high-quality evidence yet favors one specific technique over another. Clinicians should anticipate forthcoming standardization efforts and support enrollment in prospective comparative trials.
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