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Systemic interventions for treatment of Stevens-Johnson syndrome/toxic epidermal necrolysis: summary of a cochrane review

JAMA Dermatol

Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme

Arch Dermatol

Current perspectives on Stevens-Johnson syndrome and toxic epidermal necrolysis

Clin Rev Allergy Immunol

Epidermal Necrolysis (Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis)

Update on pathobiology in Stevens-Johnson syndrome and toxic epidermal necrolysis

Dermatol Sin

A review of the systemic treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis

Biomedicines

Cytotoxic proteins and therapeutic targets in severe cutaneous adverse reactions

Toxins (Basel)

Immunologic mediators in Stevens–Johnson syndrome and toxic epidermal necrolysis

Semin Ophthalmol

Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis

Nat Med

Soluble FAS ligand: a discriminating feature between drug-induced skin eruptions and viral exanthemas

J Invest Dermatol

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

Nature

Global percentage of asymptomatic SARS-CoV-2 infections among the tested population and individuals with confirmed COVID-19 diagnosis: a systematic review and meta-analysis

JAMA Netw Open

Association between EBV serological patterns and lymphocytic profile of SjS patients support a virally triggered autoimmune epithelitis

Sci Rep

COVID-19-induced toxic epidermal necrolysis

Clin Exp Dermatol

Case of erythema multiforme/Stevens–Johnson syndrome: an unusual presentation of Covid-19

J R Coll Physicians Edinb

Corona virus disease 2019-associated Stevens-Johnson syndrome: a case report

BMC Ophthalmol

Development of toxic epidermal necrolysis in a coronavirus disease 2019 patient with recurrence of positive SARS-CoV-2 viral RNA

J Dermatol

Stevens-Johnson syndrome as a primary skin manifestation of COVID-19

Postgrad Med J

T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

Epstein-Barr virus: the impact of scientific advances on clinical practice

Blood

Proinflammatory responses to self HLA epitopes are triggered by molecular mimicry to Epstein-Barr virus proteins in oligoarticular juvenile idiopathic arthritis

Arthritis Rheum

The influence of antiviral T-cell responses on the alloreactive repertoire

Immunol Today

Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) is a rare, potentially life threatening mucocutaneous hypersensitivity reaction resulting in desquamation of the skin and mucosa. These patients are managed on burns units due to the widespread desquamation. We report the largest case series of participants developing SJS/TEN in the setting of recent COVID infection or vaccination. We found a seven-fold increase in SJS/TEN since the COVID pandemic. This increase correlates with an increase in COVID infections and vaccination rates. We explore the immunopathological relationships between COVID and SJS/TEN and propose theories for possible associations.

The seven-fold rise in incidence of Stevens-Johnson syndrome & toxic epidermal necrolysis: Associations with COVID-19 and the vaccine.

The seven-fold rise in incidence of Stevens-Johnson syndrome &amp; toxic epidermal necrolysis: Associations with COVID-19 and the vaccine

The seven-fold rise in incidence of Stevens-Johnson syndrome & toxic epidermal necrolysis: Associations with COVID-19 and the vaccine

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