This review evaluates the clinical and histopathologic features of neutrophilic dermatoses — including Sweet syndrome, pyoderma gangrenosum, VEXAS syndrome, and others — as cutaneous manifestations of underlying malignancy, along with current treatment options.
Multiple neutrophilic dermatoses (e.g., Sweet syndrome, pyoderma gangrenosum, neutrophilic eccrine hidradenitis, subcorneal pustular dermatosis, erythema elevatum diutinum, Behçet's disease, Bazex syndrome, VEXAS syndrome) can serve as cutaneous markers of occult or overt malignancy, and may precede the cancer diagnosis.
Narrative review without systematic methodology or meta-analysis; no original patient data or quantitative outcomes reported; conditions reviewed are rare and heterogeneous, limiting generalizable conclusions.
When a patient presents with a sterile neutrophilic dermatosis, consider workup for an underlying malignancy — especially hematologic — as the skin finding may precede the cancer diagnosis. Early recognition can prompt timely systemic evaluation and improve outcomes.
