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Limited clinical utility of risk stratification for CT decision-making in patients ≥ 75 years with mild traumatic brain injury
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Limited clinical utility of risk stratification for CT decision-making in patients ≥ 75 years with mild traumatic brain injury

Injury·August 24Open Access
Emergency MedicinePractice changingMild Traumatic Brain InjuryRetrospective Cohort StudyComputed TomographyAdultOlder Adult

Summary

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What was studied

This retrospective cohort study examined whether multivariable risk stratification could meaningfully reduce head CT utilization in patients aged ≥75 years presenting to the ED with mild traumatic brain injury (GCS 13–15), using data from 3,088 consecutive patients seen between 2019 and 2022.

Key findings

Among patients ≥75 years (54.7% of the cohort, CT performed in 98.2%), the prediction model showed only moderate discrimination (optimism-corrected AUC 0.693; 95% CI 0.610–0.775). At 100% sensitivity, CT use could be reduced by just 1.5%; at 99% sensitivity, by only 10.6%.

Study limitations

Single-center retrospective design limits generalizability; the model was internally validated only (bootstrap), with no external validation cohort; the publisher page indicates full text was not available, so additional methodological details may be missing.

Clinical implications

For patients aged ≥75 with mTBI, clinical decision rules offer very limited ability to safely skip CT — clinicians should not rely on risk stratification tools to rule out imaging in this age group, as the potential CT reduction is minimal even at 99% sensitivity.

Caveats

  • CT was performed in 98.2% of very elderly patients, leaving very little variation to model — this ceiling effect inherently limits the discriminative capacity of any rule-out strategy in this subgroup
  • Over half (54.7%) of the cohort was aged ≥75 years, which may reflect a referral or regional demographic skew rather than a generalizable ED population
  • The model underwent bootstrap internal validation only; external validation in an independent cohort is needed before applying these conclusions more broadly

Related Questions

Explore related topics

What clinical decision rules are validated for mild TBI in elderly patients over 75?Can any CT decision rule safely reduce imaging in very elderly mTBI patients?What is the rate of intracranial injury on CT in older adults presenting with mild traumatic brain injury?

Publication Details

Year
2026
Journal
Injury
Sample Size
n=3,088
Source
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