ReachRxResearch
Home
Research
Sign Up
  1. Home
  2. Research Hub
  3. Tumor mutational burden as a predictor o…

Tumor mutational burden as a predictor of immune-related adverse events in patients with advanced non-small cell lung cancer receiving immune checkpoint inhibitors: a Brief Report

Journal of Thoracic Oncology·August 5
Respiratory SystemPractice changingNon-Small Cell Lung CancerCohort StudyChemotherapyImmune Checkpoint InhibitorAdult

Summary

View source

What was studied

This monocentric cohort study evaluated whether baseline tumor mutational burden (TMB), assessed by OncoPanel next-generation sequencing, predicts immune-related adverse events (irAEs) in 1,215 patients with advanced NSCLC receiving ICI ± chemotherapy. Logistic regression, Cox proportional hazard models, and multiplex immunofluorescence were used.

Key findings

34.7% of patients (421/1,215) developed irAEs. TMB ≥19 mut/Mb (90th percentile) was the strongest predictor: doubled irAE risk (aOR 2.14, p<0.001) and 58% earlier onset (aHR 1.58, p=0.004) vs. TMB <90th percentile. High-TMB tumors were also enriched in CD8+ cells (p=0.04).

Study limitations

Single-center design limits generalizability. irAE severity grading and organ-specific patterns are not detailed in the abstract. Causal directionality between CD8+ enrichment and irAEs cannot be confirmed from this observational data.

Clinical implications

Consider baseline TMB ≥19 mut/Mb as a flag for heightened irAE vigilance in advanced NSCLC patients starting ICI therapy. Earlier and more frequent monitoring may be warranted for this subgroup, independent of treatment duration.

Related Questions

Explore related topics

Which irAE types are most common in NSCLC patients with high tumor mutational burden on immunotherapy?How does TMB compare to PD-L1 as a biomarker for predicting irAEs in lung cancer?What monitoring strategies are recommended for high-TMB NSCLC patients receiving immune checkpoint inhibitors?

Publication Details

Year
2026
Journal
Journal of Thoracic Oncology
Sample Size
n=1,215
Source
View article
Keep scrolling
More content below.
Up Next