This paper evaluates the rationale for using combination therapy as the anchor of initial (front-loaded) treatment in lupus nephritis, examining whether early aggressive multi-drug regimens improve outcomes compared to sequential approaches.
No primary data are presented; conclusions are based on the authors' synthesis and perspective rather than a new clinical trial or systematic review.
Consider front-loading lupus nephritis treatment with combination therapy from the outset rather than escalating sequentially, as early aggressive induction may improve renal response rates and reduce long-term damage.
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