Journal of Investigative Dermatology

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National Institutes of Health

Division of Intramural Research

National Institute of Allergy and Infectious Diseases

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Atopic dermatitis (eczema) guidelines: 2023 American Academy of Allergy, Asthma and Immunology/American College of Allergy, Asthma and Immunology Joint Task Force on Practice Parameters GRADE- and Institute of Medicine-based recommendations

Ann Allergy Asthma Immunol

Pediatric topical steroid withdrawal syndrome: what is known, what is unknown [e-pub ahead of print]

Pediatr Dermatol

Epithelial-mesenchymal transition in atopy: a mini-review

Front Allergy

The role of TRP channels in nicotinic provoked pain and irritation from the oral cavity and throat: translating animal data to humans

Nicotine Tob Res

Dupilumab in the management of topical corticosteroid withdrawal in atopic dermatitis: a retrospective case series

JAAD Case Rep

Ancestral reconstruction of mammalian FMO1 enables structural determination, revealing unique features that explain its catalytic properties

J Biol Chem

Corticosteroid exposure and cumulative effects in patients with eczema: results from a patient survey

Topical steroid withdrawal through the lens of social media

Clin Exp Dermatol

Topical steroid withdrawal: an emerging clinical problem

Shotgun metagenomic sequencing on skin microbiome indicates dysbiosis exists prior to the onset of atopic dermatitis

Allergy

Glucocorticoid impairs mitochondrial quality control in neurons

Neurobiol Dis

Metformin ameliorates animal models of dermatitis

Inflammopharmacology

Mitochondria are physiologically maintained at close to 50 °C

PLoS Biol

Twelve years of SAMtools and BCFtools

GigaScience

A beginner's introduction to skin stem cells and wound healing

Int J Mol Sci

STAR: ultrafast universal RNA-seq aligner

Bioinformatics

Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of atopic dermatitis with topical therapies

J Am Acad Dermatol

Research progress on the pharmacological effects of berberine targeting mitochondria

Front Endocrinol (Lausanne)

Validation of the Patient-Oriented SCORing for Atopic Dermatitis tool for black skin

J Eur Acad Dermatol Venereol

Topical steroid withdrawal syndrome in a mother and son: a case report

Sage Open Med Case Rep

#corticophobia: a review on online misinformation related to topical steroids

FOXI3 haploinsufficiency contributes to low T-cell receptor excision circles and T-cell lymphopenia

J Allergy Clin Immunol

Assessing microbial manipulation and environmental pollutants in the pathogenesis of psoriasis

Front Immunol

Multi-omics research strategies for psoriasis and atopic dermatitis

A systematic review of topical corticosteroid withdrawal ("steroid addiction") in patients with atopic dermatitis and other dermatoses

Topical corticosteroid withdrawal ('steroid addiction'): an update of a systematic review

J Dermatolog Treat

Possible involvement of TGF-β-SMAD-mediated epithelial-mesenchymal transition in pro-metastatic property of PAX6

Oncol Rep

The mechanism and mitigation of niacin-induced flushing

Int J Clin Pract

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

BMC Bioinformatics

High-dimensional cell-level analysis of tissues with Ce3D multiplex volume imaging

Nat Protoc

Anticholinergic drugs in geriatric psychopharmacology

Front Neurosci

Pathview: an R/Bioconductor package for pathway-based data integration and visualization

Pathview Web: user friendly pathway visualization and data integration

Nucleic Acids Res

Nicotinic acid activates the capsaicin receptor TRPV1: potential mechanism for cutaneous flushing

Arterioscler Thromb Vasc Biol

Topical steroid withdrawal and atopic dermatitis

Cutadapt removes adapter sequences from high-throughput sequencing reads

EMBnet J

Spatial transcriptomics combined with single-cell RNA-sequencing unravels the complex inflammatory cell network in atopic dermatitis

Successful metformin treatment of insulin resistance is associated with down-regulation of the kynurenine pathway

Biochem Biophys Res Commun

TNF overproduction impairs epithelial staphylococcal response in hyper IgE syndrome

J Clin Invest

trackViewer: a Bioconductor package for interactive and integrative visualization of multi-omics data

Nat Methods

MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights

IDO and TDO as a potential therapeutic target in different types of depression

Metab Brain Dis

The circadian metabolome of atopic dermatitis

Spatial transcriptomics landscape of lesions from non-communicable inflammatory skin diseases

Nat Commun

CADD v1.7: using protein language models, regulatory CNNs and other nucleotide-level scores to improve genome-wide variant predictions

Steroid withdrawal effects following long-term topical corticosteroid use

Dermatitis

Cessation of long-term topical steroids in adult atopic dermatitis: a prospective cohort study

Topical steroid withdrawal syndrome: should we worry?

Recent developments and advances in atopic dermatitis and food allergy

Allergol Int

The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest

Nicotinamide metabolism modulates the proliferation/differentiation balance and senescence of human primary keratinocytes

J Invest Dermatol

Dysbiosis of skin mycobiome in atopic dermatitis

Mycoses

Role of mitochondria in the mechanism(s) of action of metformin

Traditional Chinese medicine for food allergy and eczema

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

Elife

Diisocyanates influence models of atopic dermatitis through direct activation of TRPA1

PLoS One

Impact of skin tissue collection method on downstream MALDI-imaging

Metabolites

Potential biomarkers of atopic dermatitis

Front Med (Lausanne)

Progress of metabolomics in atopic dermatitis: a systematic review

J Dtsch Dermatol Ges

Topical steroid withdrawal (TSW) is a controversial diagnosis advocated by patients but often confused for atopic dermatitis. We conducted a multimodal pilot study of 16 patients fitting the TSW diagnostic profile, contrasting them against patients with atopic dermatitis (n = 10) and healthy controls (n = 11). Our clinical evaluations established objective diagnostic criteria that distinguish TSW from atopic dermatitis, metabolomics and transcriptomics of skin biopsies suggested that neuroinflammatory pathways are associated with complex I-mediated oxidation of NAD+, cellular and mouse models demonstrated that NAD+ metabolism was proinflammatory and glucocorticoid responsive, whereas functional assays demonstrated that the metabolic effects of glucocorticoids on the only cell type that aligns with the distribution and duration of TSW pathology could be mitigated by complex I blockade. These results informed a successful open-label trial using complex I-inhibiting interventions: metformin and berberine. Although this work represents a pilot study, to our knowledge, this work offers previously unreported mechanistic insights into TSW.

Topical Steroid Withdrawal Is a Targetable Excess of Mitochondrial NAD.

Topical Steroid Withdrawal Is a Targetable Excess of Mitochondrial NAD+

Papers