A clinicopathological challenge case of a woman in her 30s with a 22-year history of recurrent giant tendinous masses (subcutaneous nodules up to 6–7 cm) involving Achilles tendons, elbows, wrists, knees, and iliac crests, accompanied by refractory hypercholesterolemia.
No diagnostic conclusion or treatment outcome is available in the accessible text; the case is presented as a clinical challenge prompt asking readers to identify the diagnosis.
Only the abstract and publisher preview are available — full text, diagnostic workup, histopathology, and management details are behind a paywall and not accessible.
Progressive giant tendinous xanthomas appearing in adolescence alongside refractory hypercholesterolemia should raise strong suspicion for familial hypercholesterolemia or a related lipid storage disorder. Early lipid screening and genetic evaluation are warranted in such presentations.
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