ReachRxResearch
Home
Research
Sign Up
  1. Home
  2. Research Hub
  3. Weight Loss Improves Predicted 10‐Year…

Weight Loss Improves Predicted 10‐Year MACE and Type 2 Diabetes Risk, but Benefits Partially Rebound at 1 Year

Obesity·August 23Open Access
Endocrinology & MetabolismPractice changingMajor Adverse Cardiovascular EventsOverweightType 2 DiabetesRandomized Controlled TrialAerobic ExerciseCaloric RestrictionResistance ExerciseAdult

Summary

View source

What was studied

Sedentary women with overweight (BMI ≥25, ages 21–49) were randomized to Diet+Aerobic, Diet+Resistance, or Diet-only (800 kcal/day until BMI <25 kg/m²) to quantify changes in predicted 10-year MACE and T2D risk across weight loss, post-weight loss, and 1-year follow-up.

Key findings

Mean BMI fell from 28.3 to 23.9 kg/m², then rebounded to 25.8 at 1 year. MACE and T2D risks improved in all groups post-weight loss (p<0.001), but both rebounded with weight regain. Only the Diet+Resistance group maintained a significant net T2D risk reduction at 1 year (p=0.003); Diet-only achieved greater MACE reduction than Diet+Resistance during the intervention (p=0.022). Higher follow-up exercise adherence was linked to less T2D risk rebound (p=0.024).

Study limitations

- All-female sample of sedentary women with overweight limits generalizability to men or other populations. - Predicted MACE and T2D risks are modeled estimates, not observed clinical events. - Weight regain and exercise adherence during follow-up were not experimentally controlled.

Clinical implications

Weight loss alone cuts cardiovascular and diabetes risk, but gains erode quickly with weight regain. Adding resistance exercise to a weight loss program may help sustain T2D risk reduction — encourage patients to maintain resistance training after reaching their goal weight.

Related Questions

Explore related topics

Does resistance training after weight loss help prevent type 2 diabetes better than aerobic exercise?How quickly does cardiovascular risk rebound after weight regain following a low-calorie diet?What exercise interventions best sustain cardiometabolic benefits after intentional weight loss in women?

Publication Details

Year
2026
Journal
Obesity
Sample Size
n=221
Source
View article
Keep scrolling
More content below.
Up Next