This cross-sectional study evaluated whether hematological inflammatory indices (NLR, PLR, SII, RDW, MPV) are associated with disease activity (EUSTAR index) and ILD in 51 SSc patients compared to 106 healthy controls.
NLR and SII were significantly elevated in SSc-ILD vs. non-ILD patients; on multivariable logistic regression, NLR remained independently associated with ILD (OR 2.63, 95% CI 1.01–6.85, p = 0.047), while anti-Scl-70 was the strongest independent predictor. ROC analysis showed moderate discrimination: SII AUC 0.72, NLR AUC 0.68. SII lost significance in the adjusted model.
- Small SSc sample (n=51) limits statistical power and generalizability. - Cross-sectional design prevents causal inference or assessment of longitudinal changes. - Full-text not available for review; details on ILD ascertainment method (e.g., HRCT criteria) are not reported in the abstract.
In SSc patients, a routinely available NLR from a standard CBC may help flag higher ILD risk, particularly alongside anti-Scl-70 serology. However, its moderate AUC (0.68) means it should supplement—not replace—established clinical and serological evaluation.
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