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Patient Experience and Preferences for Treatments in Atopic Dermatitis
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Patient Experience and Preferences for Treatments in Atopic Dermatitis

Dermatology and Therapy·September 8Open Access
DermatologyLimited evidenceAtopic DermatitisCross-Sectional SurveyBiologicJAK InhibitorTopical TherapyMixedDupixentAbrocitinibDupilumabLebrikizumabNemolizumabTralokinumabUpadacitinib

Summary

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What was studied

A 32-question patient survey at the 2024 Eczema Expo assessed treatment goals, therapy-switching patterns, and interest in a predictive molecular test among adults (and some pediatric caregivers) with atopic dermatitis (AD), with no comparator group and a cross-sectional design.

Key findings

Among 43 participants, itch control (70%), skin clearance (58%), and safety (50%) were the top treatment priorities; 55% of systemic therapy users modified their first systemic due to inefficacy; and 94% of those open to a new systemic said they would use a molecular test to guide therapy selection.

Study limitations

Convenience sample from a single advocacy event (2024 Eczema Expo) likely skews toward more severe, treatment-experienced patients; very small sample (n=43) limits generalizability; cross-sectional design with recall bias and predominantly female respondents.

Clinical implications

Most patients on systemic AD therapy still experience inadequate itch and skin-clearance control, driving frequent treatment switching—clinicians should prioritize these outcomes in shared decision-making and consider that patients are highly receptive to precision tools (e.g., molecular testing) to guide systemic therapy selection.

Caveats

  • Participants were self-selected attendees of a patient advocacy expo, likely representing more severe or treatment-refractory cases—findings may not reflect the broader AD population
  • Sample size of 43 (with variable response rates per question) is too small for reliable quantitative conclusions; all percentages should be interpreted with caution
  • Study was funded by Castle Biosciences, Inc., a company developing molecular testing products for AD; multiple authors have financial ties to Castle Biosciences, which may introduce bias in framing patient interest in molecular testing

Related Questions

Explore related topics

What do patients with atopic dermatitis prioritize most when choosing a systemic therapy?How often do patients switch or discontinue biologic or JAK inhibitor therapy for atopic dermatitis in real-world practice?Is there a validated molecular or biomarker test to predict response to dupilumab or other targeted therapies in atopic dermatitis?

Publication Details

Year
2026
Journal
Dermatology and Therapy
Sample Size
n=43
Source
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