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Personalized prediction of response to three meditation practices: A randomized controlled trial

Behaviour Research and Therapy·August 10Open Access
Psychology, ClinicalConfirms priorNegative AffectSubjective WellbeingRandomized Controlled TrialGratitude MeditationMindfulness MeditationSelf-Compassion MeditationAdult

Summary

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What was studied

This preregistered RCT examined the effects of three brief (5–10 min) meditation practices — mindfulness, self-compassion, and gratitude — versus a control condition on subjective wellbeing in a demographically representative US and UK adult sample (N = 5,049). It also tested whether pre-intervention characteristics could predict individual response using a data-driven approach.

Key findings

Brief meditation practices modestly improved negative affect (a component of subjective wellbeing), and individual response to these interventions could be predicted from pre-intervention characteristics.

Study limitations

Effect sizes appear modest, limiting clinical magnitude; the study used brief single-session practices (5–10 min), which may not reflect outcomes of sustained meditation training; generalizability beyond self-reported subjective wellbeing outcomes is unclear.

Clinical implications

Brief meditation exercises (mindfulness, self-compassion, gratitude) can modestly reduce negative affect in the general adult population. Pre-intervention characteristics may help match individuals to the most effective practice — a promising but not yet clinically validated approach.

Caveats

  • Effect sizes for improvements in negative affect are described as 'modest' but no specific numerical estimates (e.g., Cohen's d, mean differences) are reported in the abstract — clinicians should consult the full paper for magnitude of benefit.
  • The predictive algorithm for personalized intervention assignment was not prospectively validated in a separate cohort within this trial — clinical utility remains to be confirmed.
  • The study uses a single brief session (5–10 min); findings may not generalize to multi-week meditation programs commonly used in clinical settings.

Related Questions

Explore related topics

Which meditation practice is most effective for reducing anxiety in adults?Can baseline patient characteristics predict response to mindfulness-based interventions?How do brief single-session mindfulness exercises compare to longer meditation programs for wellbeing?

Publication Details

Year
2026
Journal
Behaviour Research and Therapy
Sample Size
n=5,049
Source
View article
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