This prospective study evaluated the safety, feasibility, and early biological effects of high-dose melatonin supplementation in patients with tibial fractures, focusing on its potential role in promoting fracture healing.
The study assessed preliminary biological markers of fracture healing with high-dose melatonin; specific outcome numbers are not available from the provided abstract metadata alone.
Prospective feasibility/safety design limits causal conclusions; small or pilot-scale sample likely limits generalizability; no placebo-controlled comparator arm is described.
High-dose melatonin in tibial fracture patients appears to be under early-phase investigation for safety and biological effect; clinicians should await controlled trial data before adopting this approach.
