Advances in Skin &amp; Wound Care

<jats:title>ABSTRACT</jats:title>
          <jats:sec>
            <jats:title>OBJECTIVE</jats:title>
            <jats:p>To explore the effect of topical cannabidiol (CBD) in treating digital ulcers in patients with systemic sclerosis (SSc).</jats:p>
          </jats:sec>
          <jats:sec>
            <jats:title>METHODS</jats:title>
            <jats:p>In total, 45 patients with SSc who had digital ulcers were consecutively enrolled between January 2019 and December 2019. Of the participants, 25 were treated with CBD during surgical debridement and 20 were treated with standard local therapy. A numeric rating scale for pain and Health Assessment Questionnaire Disability Index were administered at the baseline and at the end of treatment.</jats:p>
          </jats:sec>
          <jats:sec>
            <jats:title>RESULTS</jats:title>
            <jats:p>Local treatment with CBD was significantly associated with lower pain scores, higher health assessment scores, and an increase in participants’ total hours of sleep. Patients in the control group more frequently required additional analgesic therapy.</jats:p>
          </jats:sec>
          <jats:sec>
            <jats:title>CONCLUSIONS</jats:title>
            <jats:p>Topical CBD may be a valuable tool to treat pain related to digital ulcers in patients with SSc.</jats:p>
          </jats:sec>

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Review of local wound management for scleroderma-associated digital ulcers

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Classification criteria for systemic sclerosis: an American College of Rheumatology/European League against Rheumatism collaborative initiative

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The IASP classification of chronic pain for ICD-11: functioning properties of chronic pain

Pain

Measures of systemic sclerosis (scleroderma): Health Assessment Questionnaire (HAQ) and Scleroderma HAQ (SHAQ), physician- and patient-rated global assessments, Symptom Burden Index (SBI), University of California, Los Angeles, Scleroderma Clinical Trials Consortium Gastrointestinal Scale (UCLA SCTC GIT) 2.0, Baseline Dyspnea Index (BDI) and Transition Dyspnea Index (TDI) (Mahler’s index), Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR), and Raynaud’s Condition Score (RCS)

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Topical cannabis-based medicines—a novel adjuvant treatment for venous leg ulcers: an open-label trial

Therapeutic potential of cannabidiol (CBD) for skin health and disorders

Clin Cosmet Investig Dermatol

To explore the effect of topical cannabidiol (CBD) in treating digital ulcers in patients with systemic sclerosis (SSc).
In total, 45 patients with SSc who had digital ulcers were consecutively enrolled between January 2019 and December 2019. Of the participants, 25 were treated with CBD during surgical debridement and 20 were treated with standard local therapy. A numeric rating scale for pain and Health Assessment Questionnaire Disability Index were administered at the baseline and at the end of treatment.
Local treatment with CBD was significantly associated with lower pain scores, higher health assessment scores, and an increase in participants' total hours of sleep. Patients in the control group more frequently required additional analgesic therapy.
Topical CBD may be a valuable tool to treat pain related to digital ulcers in patients with SSc.

Topical Cannabidiol in the Treatment of Digital Ulcers in Patients with Scleroderma: Comparative Analysis and Literature Review.

Topical Cannabidiol in the Treatment of Digital Ulcers in Patients with Scleroderma: Comparative Analysis and Literature Review

Topical Cannabidiol in the Treatment of Digital Ulcers in Patients with Scleroderma: Comparative Analysis and Literature Review

Clinical Summary

What was studied

Key findings

Study limitations

Clinical implications

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