Monoclonal Cryoglobulinemia Clinically Mimicking Leukocytoclastic Vasculitis: A Case Report and Literature Review
Clinical Summary
View sourceWhat was studied
A single case of a 48-year-old woman with a recurrent, symmetric hemorrhagic papular eruption clinically mimicking leukocytoclastic vasculitis was evaluated with skin biopsy, direct immunofluorescence, and systemic testing.
Key findings
Findings supported monoclonal cryoglobulinemia; labs showed elevated kappa free light chains with an IgM kappa monoclonal component, and bone marrow was consistent with lymphoplasmacytic lymphoma.
Study limitations
Single-patient report with no treatment course or outcomes reported. Literature review content is not detailed in the abstract.
Clinical implications
In vasculitic-appearing eruptions, consider monoclonal cryoglobulinemia and assess for an underlying B‑cell lymphoproliferative disorder when biopsy/DIF suggest this pattern, including serum protein studies and bone marrow evaluation.
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