The Journal of Dermatology

<jats:title>ABSTRACT</jats:title><jats:p>A 64‐year‐old woman with progressive thickening of the skin on her left upper limb was referred to our clinic. She had previously undergone partial mastectomy and axillary lymph node dissection for left‐sided breast cancer, followed by postoperative radiation therapy and chemotherapy with docetaxel. She exhibited edema and sclerosis of the left arm and contracture limited to the fingers of the left hand, while her right arm and lower extremities remained unaffected. There were no signs of Raynaud's phenomenon or periungual capillary abnormalities suggestive of systemic sclerosis. Skin biopsy from the left forearm showed dermal thickening with swollen collagen fibers throughout the dermis. A diagnosis of unilateral docetaxel‐induced scleroderma was established. Taxane‐induced scleroderma typically manifests symmetrically in the lower limbs with prominent edema. This report describes a rare case of unilateral upper limb involvement and discusses its characteristics with a review of previously reported cases.</jats:p>

publication_history

received

accepted

published

Drug‐Induced Scleroderma‐Like Lesion

Allergology International

Scleroderma and the Taxanes. Is There Really a Link?

Clinical and Experimental Dermatology

Chemotherapy‐Induced Scleroderma: A Pleiomorphic Syndrome

Taxane‐Induced Scleroderma

British Journal of Dermatology

Paclitaxel‐Induced Diffuse Scleroderma With Possible Scleroderma‐Renal Crisis: A Case Report and Literature Review of Taxanes‐Induced Scleroderma

Clinical Rheumatology

A Case of Taxane‐Induced Scleroderma: A Different Expression Profile of Fli1 Proteins in Dermal Fibroblasts and Microvascular Endothelial Cells Compared With Systemic Sclerosis

Capillary Leak Syndrome: Etiologies, Pathophysiology, and Management

Kidney International

Glycosaminoglycan and Versican Deposits in Taxane‐Induced Sclerosis

Docetaxel‐Induced Scleroderma: A Case Report and Its Role in the Production of Extracellular Matrix

International Journal of Rheumatic Diseases

Docetaxel Promotes the Generation of Anti‐Tumorigenic Human Macrophages

Experimental Cell Research

Scleroderma‐Like Lesions in a Patient Undergoing Combined Pembrolizumab and Routine Chemotherapy: A Case Report and Literature Review

Medicina (Kaunas, Lithuania)

Limited Cutaneous Systemic Sclerosis Induced by Paclitaxel in a Patient With Breast Cancer

Archives of Dermatology

Docetaxel‐Induced Scleroderma in A Breast Cancer Patient: A Case Report

Journal of Breast Health

A 64-year-old woman with progressive thickening of the skin on her left upper limb was referred to our clinic. She had previously undergone partial mastectomy and axillary lymph node dissection for left-sided breast cancer, followed by postoperative radiation therapy and chemotherapy with docetaxel. She exhibited edema and sclerosis of the left arm and contracture limited to the fingers of the left hand, while her right arm and lower extremities remained unaffected. There were no signs of Raynaud's phenomenon or periungual capillary abnormalities suggestive of systemic sclerosis. Skin biopsy from the left forearm showed dermal thickening with swollen collagen fibers throughout the dermis. A diagnosis of unilateral docetaxel-induced scleroderma was established. Taxane-induced scleroderma typically manifests symmetrically in the lower limbs with prominent edema. This report describes a rare case of unilateral upper limb involvement and discusses its characteristics with a review of previously reported cases.

A Case of Taxane-Induced Scleroderma Presenting in a Unilateral Upper Limb and a Literature Review.

A Case of Taxane‐Induced Scleroderma Presenting in a Unilateral Upper Limb and a Literature Review

Papers