This review covers the clinical presentation, histology, associated systemic conditions, and management of erythema elevatum diutinum (EED), a rare chronic cutaneous vasculitis.
EED is strongly associated with systemic diseases — including IgA monoclonal gammopathy, multiple myeloma, non-Hodgkin lymphoma, HIV, and streptococcal infection. First-line treatment is dapsone; corticosteroids and immunosuppressives are used for resistant cases. Lesions can persist for decades, but treating the underlying condition can alter disease course.
No specific patient data, outcomes, or comparative treatment efficacy figures are reported — this is a narrative review without original trial data or sample population.
When EED is diagnosed, actively screen for serious underlying conditions such as hematologic malignancies and HIV, as addressing them may improve skin disease. Dapsone remains the go-to first-line therapy for the skin lesions themselves.
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