A Case of Taxane‐Induced Scleroderma Presenting in a Unilateral Upper Limb and a Literature Review
Clinical Summary
View sourceWhat was studied
A case report of unilateral upper-limb scleroderma after docetaxel for breast cancer, with a brief literature review.
Key findings
One 64-year-old woman developed edema, sclerosis, and finger contractures limited to the left arm after docetaxel; the right limbs were unaffected, Raynaud’s and periungual capillary changes were absent, and skin biopsy showed dermal thickening with swollen collagen fibers.
Study limitations
Single-patient report with no comparator or outcome data; details of the literature review are not provided in the abstract.
Clinical implications
Docetaxel can trigger localized, unilateral scleroderma without Raynaud’s or nailfold changes; consider biopsy to confirm when new, limb-limited sclerosis appears after taxane therapy.
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